Detailed information for compound 70647

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.892 | Formula: C22H25ClNO2-
  • H donors: 1 H acceptors: 2 LogP: 3.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1CCCN(C1)CCC=C(c1ccccc1)c1ccccc1.[Cl-]
  • InChi: 1S/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H/p-1
  • InChiKey: SNGGBKYQZVAQKA-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0122 0.1347 0.1333
Loa Loa (eye worm) patched family protein 0.0019 0.0058 0.0058
Brugia malayi Importin beta-1 subunit 0.0031 0.0208 0.0192
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0149 0.1693 0.1708
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0339 0.0324
Plasmodium vivax plasmepsin IV, putative 0.0018 0.005 0.0078
Echinococcus granulosus ecdysone induced protein 78C 0.0326 0.3907 0.3941
Echinococcus multilocularis para nitrobenzyl esterase 0.0049 0.0436 0.0439
Echinococcus multilocularis expressed conserved protein 0.0293 0.3495 0.3526
Leishmania major cytochrome p450-like protein 0.0106 0.1147 0.2561
Mycobacterium leprae Conserved hypothetical protein 0.0088 0.0923 0.2767
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.2186 0.2186
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0149 0.1693 0.1651
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.0792
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0145 0.0292
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0539 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0266 0.0336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0433 0.0433
Brugia malayi hypothetical protein 0.0018 0.005 0.0034
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.3058 0.3047
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0339 0.0378
Brugia malayi PXA domain containing protein 0.0041 0.0339 0.0324
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0149 0.1693 0.1651
Brugia malayi hypothetical protein 0.0049 0.0436 0.042
Brugia malayi Carboxylesterase family protein 0.0049 0.0436 0.042
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0266 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0326 0.3907 0.3941
Mycobacterium ulcerans beta-lactamase 0.0035 0.0266 0.0336
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0367 0.4431 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0326 0.3907 0.3907
Brugia malayi Doublecortin family protein 0.0021 0.0082 0.0066
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0053 0.0482 0.0434
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0367 0.4431 0.7639
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.1166 0.1166
Schistosoma mansoni DNA polymerase eta 0.0017 0.0033 0.0037
Onchocerca volvulus 0.0019 0.0058 0.0008
Loa Loa (eye worm) hypothetical protein 0.0326 0.3907 0.3907
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0082
Echinococcus multilocularis protein dispatched 1 0.0219 0.2564 0.2586
Brugia malayi Sodium:neurotransmitter symporter family protein 0.021 0.2452 0.244
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0398 0.4809 0.4851
Loa Loa (eye worm) hypothetical protein 0.0049 0.0436 0.0436
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0266 0.0336
Brugia malayi nuclear hormone receptor family member odr-7 0.0149 0.1693 0.168
Onchocerca volvulus 0.0082 0.0848 0.0802
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0232 0.2734 0.8833
Leishmania major DNA polymerase kappa, putative 0.0025 0.013 0.0258
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0367 0.4431 1
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0135 0.0147
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0326 0.3907 0.3876
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0016
Leishmania major DNA topoisomerase ii 0.0065 0.0641 0.1416
Loa Loa (eye worm) norepinephrine transporter 0.021 0.2452 0.2452
Loa Loa (eye worm) hypothetical protein 0.0258 0.3058 0.3058
Loa Loa (eye worm) hypothetical protein 0.0042 0.0345 0.0345
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0339 0.0378
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.0339 0.0503
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0539 0.0539
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0049 0.0436 0.1363
Brugia malayi hypothetical protein 0.0149 0.1693 0.168
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0033 0.0037
Brugia malayi nuclear receptor NHR-88 0.0149 0.1693 0.168
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0043 0.0366 0.0792
Brugia malayi Patched protein homolog 1 0.0019 0.0058 0.0042
Loa Loa (eye worm) cytochrome P450 family protein 0.0106 0.1147 0.1147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Echinococcus granulosus FTZ F1 alpha 0.0326 0.3907 0.3941
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2186 0.2437
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0045
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0176 0.2035 0.2053
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0339 0.0342
Loa Loa (eye worm) hypothetical protein 0.029 0.3459 0.3459
Loa Loa (eye worm) hypothetical protein 0.0036 0.0277 0.0277
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0261 0.3093 0.6969
Schistosoma mansoni hypothetical protein 0.0129 0.1439 0.1604
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0326 0.3907 0.4356
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0122 0.1347 0.2261
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0277 0.3743
Brugia malayi Pre-SET motif family protein 0.006 0.058 0.0565
Loa Loa (eye worm) hypothetical protein 0.0176 0.2035 0.2035
Trypanosoma cruzi cytochrome P450, putative 0.0106 0.1147 0.2561
Echinococcus granulosus para nitrobenzyl esterase 0.0049 0.0436 0.0439
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0052 0.0471 0.0525
Brugia malayi polk-prov protein 0.0036 0.0277 0.0261
Brugia malayi RNA, U transporter 1 0.0088 0.0921 0.0907
Mycobacterium tuberculosis Probable oxidoreductase 0.0144 0.1632 0.5252
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0266 0.0566
Mycobacterium leprae Probable lipase LipE 0.0035 0.0266 0.0145
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.079 0.1752
Leishmania major mitochondrial DNA topoisomerase II 0.0057 0.0538 0.1182
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0367 0.4431 1
Schistosoma mansoni hypothetical protein 0.0082 0.0845 0.0942
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0109
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0848 0.1885
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0145 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0366 0.055
Brugia malayi hypothetical protein 0.0021 0.0082 0.0066
Loa Loa (eye worm) patched family protein 0.0019 0.0058 0.0058
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.005 0.0056
Plasmodium falciparum plasmepsin VIII, putative 0.0018 0.005 0.0078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0339 0.0339
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0539 0.0543
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0043 0.0366 0.055
Echinococcus granulosus acetylcholinesterase 0.029 0.3459 0.3489
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0208 0.021
Brugia malayi nuclear receptor RXR 0.0149 0.1693 0.168
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.016 0.1829 0.4107
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0261 0.3093 0.6969
Echinococcus multilocularis sterol regulatory element binding protein 0.02 0.2326 0.2347
Schistosoma mansoni hypothetical protein 0.0088 0.0923 0.1029
Schistosoma mansoni memapsin-2 (A01 family) 0.0456 0.554 0.6176
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0731 0.0737
Brugia malayi Synaptic glycoprotein SC2 0.0043 0.0366 0.035
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.149 0.1503
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0394 0.4769 0.4811
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0082 0.0848 0.0848
Echinococcus granulosus thyroid hormone receptor alpha 0.0149 0.1693 0.1708
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0033 0.0056
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.0792
Loa Loa (eye worm) hypothetical protein 0.0676 0.8299 0.8299
Loa Loa (eye worm) DR-78 0.0149 0.1693 0.1693
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0073 0.0733 0.0739
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0845 0.0845
Plasmodium vivax importin-beta 2, putative 0.0031 0.0208 0.0434
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0345 0.0348
Echinococcus multilocularis snurportin 1 0.0329 0.3952 0.3986
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0845 0.0852
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0339 0.0342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.058 0.0646
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Schistosoma mansoni nuclear receptor 0.0149 0.1693 0.1887
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0277 0.0396
Echinococcus granulosus Niemann Pick C1 protein 0.0312 0.3733 0.3765
Brugia malayi laminin alpha chain 0.0052 0.0471 0.0456
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0339 0.0342
Brugia malayi hypothetical protein 0.0041 0.0339 0.0324
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0043 0.0366 0.0408
Onchocerca volvulus 0.0049 0.0436 0.0387
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Onchocerca volvulus 0.0475 0.5787 0.5765
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0907 0.0893
Schistosoma mansoni inositol monophosphatase 0.0036 0.0277 0.0309
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0033 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0475 0.5785 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0848 0.0848
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0075 0.0763 0.1243
Onchocerca volvulus 0.0035 0.0266 0.0216
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0018 0.005 0.0078
Schistosoma mansoni intermediate filament proteins 0.0087 0.0907 0.1012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0149 0.1693 0.1708
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0431 0.0481
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Loa Loa (eye worm) hypothetical protein 0.0041 0.0339 0.0339
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0033 0.0017
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.2186 0.2173
Echinococcus granulosus lamin 0.0087 0.0907 0.0915
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0339 0.0378
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2186 0.2437
Schistosoma mansoni rab6-interacting 0.0021 0.0082 0.0092
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0082 0.0848 0.1885
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0339 0.0342
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0431 0.0481
Echinococcus granulosus serotonin transporter 0.021 0.2452 0.2474
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0339 0.0503
Brugia malayi Pepsin A precursor 0.0018 0.005 0.0034
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.016 0.1829 0.1845
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.005 0.0056
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0082 0.0848 0.0946
Loa Loa (eye worm) hypothetical protein 0.0049 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0082 0.0845 0.0845
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Brugia malayi orphan nuclear receptor NR2E1 0.0149 0.1693 0.168
Onchocerca volvulus Protein ultraspiracle homolog 0.0326 0.3907 0.3876
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.0792
Echinococcus multilocularis slit 2 protein 0.0052 0.0471 0.0475
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0122 0.1347 0.3552
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.0339 0.0339
Echinococcus granulosus RUN 0.0021 0.0082 0.0083
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.5062 0.5062
Loa Loa (eye worm) steroid hormone receptor 0.0326 0.3907 0.3907
Brugia malayi hypothetical protein 0.0176 0.2035 0.2022
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0398 0.4809 0.4809
Echinococcus multilocularis FTZ F1 alpha 0.0326 0.3907 0.3941
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0149 0.1693 0.168
Echinococcus granulosus sodium and chloride dependent glycine 0.0082 0.0848 0.0856
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0845 0.0852
Brugia malayi Niemann-Pick C1 protein precursor 0.0312 0.3733 0.3722
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0326 0.3907 0.3897
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0232 0.2734 0.6062
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0088 0.0923 0.2946
Schistosoma mansoni polycystin 1-related 0.0021 0.0082 0.0092
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0049 0.0436 0.0439
Echinococcus granulosus BC026374 protein S09 family 0.0049 0.0436 0.0439
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.0641 0.1416
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Plasmodium falciparum plasmepsin VI 0.0018 0.005 0.0078
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0088 0.0923 0.2946
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0398 0.4809 0.4801
Loa Loa (eye worm) hypothetical protein 0.0043 0.0366 0.0366
Echinococcus multilocularis sodium and chloride dependent glycine 0.0082 0.0848 0.0856
Brugia malayi hypothetical protein 0.0019 0.0058 0.0042
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0339 0.0378
Schistosoma mansoni nuclear receptor 0.0149 0.1693 0.1887
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.016 0.1829 0.4107
Entamoeba histolytica hypothetical protein 0.0078 0.0794 0.2055
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0232 0.2734 0.8833
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0339 0.0378
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0794 0.08
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0232 0.2734 0.6062
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0403 0.0403
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0106 0.0203
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.0339 0.0342
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0127 0.142 0.4563
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0326 0.3907 0.3941
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.079 0.0797
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0339 0.0342
Loa Loa (eye worm) hypothetical protein 0.0176 0.2035 0.2035
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0088 0.0923 0.2946
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0394 0.4769 0.5317
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0122 0.1348 0.3018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0075 0.0763 0.152
Entamoeba histolytica hypothetical protein 0.0078 0.0794 0.2055
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0088 0.0923 0.186
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0539 0.1184
Schistosoma mansoni thyroid hormone receptor 0.0459 0.5576 0.6217
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.079 0.088
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0232 0.2734 0.8833
Loa Loa (eye worm) hypothetical protein 0.0052 0.0471 0.0471
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.058 0.1277
Brugia malayi hypothetical protein 0.0026 0.0145 0.0129
Loa Loa (eye worm) hypothetical protein 0.029 0.3459 0.3459
Plasmodium falciparum polyprenol reductase, putative 0.0043 0.0366 0.0792
Mycobacterium tuberculosis Conserved protein 0.0035 0.0266 0.0812
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0043 0.0366 0.0899
Echinococcus multilocularis BC026374 protein (S09 family) 0.0049 0.0436 0.0439
Trypanosoma cruzi cytochrome P450, putative 0.0106 0.1147 0.2561
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0339 0.0342
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0367 0.4431 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0339 0.0324
Brugia malayi Carboxylesterase family protein 0.0049 0.0436 0.042
Entamoeba histolytica hypothetical protein 0.0025 0.0135 0.0274
Onchocerca volvulus 0.003 0.0202 0.0152
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.058 0.0585
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0043 0.0366 0.0899
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0118 0.1304 0.2918
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0082 0.0848 0.0834
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0367 0.4431 0.447
Schistosoma mansoni hypothetical protein 0.0717 0.8815 0.9828
Mycobacterium ulcerans hypothetical protein 0.0043 0.0366 0.0568
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0041 0.0339 0.0827
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0176 0.2035 0.2035
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Schistosoma mansoni cathepsin D (A01 family) 0.0018 0.005 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.058 0.0646
Brugia malayi nuclear receptor NHR-88 0.0326 0.3907 0.3897
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0122 0.1347 0.1502
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0539 0.1184
Brugia malayi Patched related family protein 4 0.0019 0.0058 0.0042
Loa Loa (eye worm) hypothetical protein 0.0052 0.0471 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.02 0.2326 0.3969
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0266 0.0336
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0043 0.0366 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0339 0.0503
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0033 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0794 0.08
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0277 0.0592
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0394 0.4769 0.4769
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2186 0.2437
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0073 0.0733 0.0739
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0033 0.0039
Loa Loa (eye worm) hypothetical protein 0.0326 0.3907 0.3907
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0145 0.0292
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0053 0.0482 0.0434
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0327 0.0704
Toxoplasma gondii patched family protein 0.0019 0.0058 0.0095
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0122 0.1347 0.3015
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0339 0.0503
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0122 0.1347 0.1359
Loa Loa (eye worm) hypothetical protein 0.0176 0.2035 0.2035
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0403 0.0387
Echinococcus multilocularis lamin dm0 0.0087 0.0907 0.0915
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Onchocerca volvulus 0.0035 0.0266 0.0216
Loa Loa (eye worm) hypothetical protein 0.0031 0.0208 0.0208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0266 0.0296
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.2034 0.2021
Loa Loa (eye worm) aspartyl protease 6 0.0018 0.005 0.005
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0345 0.0348
Loa Loa (eye worm) hypothetical protein 0.016 0.1829 0.1829
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0053 0.0482 0.0434
Onchocerca volvulus 0.0021 0.0082 0.0032
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0339 0.0378
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Loa Loa (eye worm) acetylcholinesterase 1 0.029 0.3459 0.3459
Echinococcus granulosus GPCR family 2 0.0082 0.0845 0.0852
Brugia malayi CHE-14 protein 0.02 0.2326 0.2314
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0509 0.6201 0.6201
Schistosoma mansoni sodium/chloride dependent transporter 0.0082 0.0848 0.0946
Echinococcus granulosus importin subunit beta 1 0.0031 0.0208 0.021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.005 0.0056
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0326 0.3907 0.3907
Leishmania major GTP-binding protein, putative 0.0023 0.0106 0.0203
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0082 0.0848 0.1885
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0731 0.0737
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0266 0.0376
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.0792
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.3058 0.3047
Schistosoma mansoni cathepsin D (A01 family) 0.0018 0.005 0.0056
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0394 0.4769 0.4811
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0907 0.0907
Mycobacterium leprae putative cytochrome p450 0.0232 0.2734 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0339 0.0342
Echinococcus granulosus dna polymerase kappa 0.0048 0.0424 0.0427
Loa Loa (eye worm) hypothetical protein 0.004 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0085 0.0888 0.0888
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0539 0.0969
Echinococcus granulosus geminin 0.0717 0.8815 0.8892
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Schistosoma mansoni cell polarity protein 0.0052 0.0471 0.0525
Entamoeba histolytica Ran family GTPase 0.0023 0.0106 0.0196
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.0339 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0277 0.0591
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0149 0.1693 0.1708
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0043 0.0366 0.0792
Schistosoma mansoni nuclear receptor nhr-48 0.0149 0.1693 0.1887
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2664 0.8606
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0424 0.0702
Echinococcus multilocularis serotonin transporter 0.021 0.2452 0.2474
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0106 0.0203
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0326 0.3907 0.4356
Entamoeba histolytica hypothetical protein 0.0041 0.0339 0.0827
Brugia malayi tailless protein 0.0149 0.1693 0.168
Schistosoma mansoni hypothetical protein 0.0082 0.0845 0.0942
Echinococcus multilocularis protein patched 0.02 0.2326 0.2347
Echinococcus granulosus slit 2 protein 0.0052 0.0471 0.0475
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0326 0.3907 0.3941
Mycobacterium ulcerans carboxylesterase, LipT 0.0049 0.0436 0.073
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0082 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.2259 0.2279
Plasmodium falciparum DNA gyrase subunit B 0.0024 0.0121 0.0238
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0049 0.0436 0.0486
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0232 0.2734 0.6062
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0065 0.0641 0.1416
Brugia malayi steroid hormone receptor 0.0326 0.3907 0.3897
Schistosoma mansoni zinc finger protein 0.0149 0.1693 0.1887
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0845 0.0852
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0326 0.3907 0.3941
Onchocerca volvulus Bile acid receptor homolog 0.0811 1 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0049 0.0436 0.0671
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0553 0.0558
Plasmodium vivax amine transporter, putative 0.0082 0.0848 0.1885
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0339 0.0378
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0088 0.0923 0.2946
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Brugia malayi Nuclear hormone receptor-like 1 0.0326 0.3907 0.3897
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0016 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Loa Loa (eye worm) abnormal epIthelia family member 0.0052 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0087 0.0907 0.0907
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2186 0.2437
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0339 0.0339
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0539 0.0851
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.058 0.0585
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0122 0.1347 0.1359
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.0339 0.0378
Brugia malayi nuclear hormone receptor 0.0326 0.3907 0.3897
Loa Loa (eye worm) patched family protein 0.0019 0.0058 0.0058
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0845 0.083
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Onchocerca volvulus 0.006 0.058 0.0532
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Echinococcus multilocularis ecdysone induced protein 78C 0.0326 0.3907 0.3941
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.055
Loa Loa (eye worm) hypothetical protein 0.021 0.2452 0.2452
Leishmania major hypothetical protein, conserved 0.0035 0.0266 0.0566
Schistosoma mansoni ap endonuclease 0.0057 0.0539 0.0601
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0043 0.0366 0.0792
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0794 0.0885
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0398 0.4809 0.4851
Brugia malayi aspartic protease BmAsp-2, identical 0.0018 0.005 0.0034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0033 0.0034
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.079 0.0797
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.079 0.1752
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.5243 0.5289
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0232 0.2734 0.6062
Echinococcus multilocularis Niemann Pick C1 protein 0.0312 0.3733 0.3765
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.038 0.0383
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0088 0.0923 0.2946
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0326 0.3907 0.3897
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0082 0.0848 0.0856
Brugia malayi hypothetical protein 0.0019 0.0058 0.0042
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0135 0.0268
Echinococcus granulosus ubiquitin specific protease 41 0.0122 0.1347 0.1359
Mycobacterium tuberculosis Conserved protein 0.0035 0.0266 0.0812
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0326 0.3907 0.3941
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Loa Loa (eye worm) hypothetical protein 0.0326 0.3907 0.3907
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Echinococcus multilocularis lamin 0.0087 0.0907 0.0915
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0539 0.0851
Brugia malayi Nuclear hormone receptor-like 1 0.0176 0.2035 0.2022
Loa Loa (eye worm) hypothetical protein 0.0811 1 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.021 0.2452 0.2452
Plasmodium falciparum plasmepsin VII 0.0018 0.005 0.0078
Schistosoma mansoni hypothetical protein 0.0176 0.2034 0.2267
Brugia malayi hypothetical protein 0.0019 0.0058 0.0042
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0339 0.0342
Onchocerca volvulus 0.0149 0.1693 0.1651
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0049 0.0436 0.1363
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0339 0.0378
Echinococcus multilocularis nuclear receptor nhr 48 0.0149 0.1693 0.1708
Echinococcus granulosus Nuclear hormone receptor HR96 0.0149 0.1693 0.1708
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0339 0.0378
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.029 0.3459 0.3856
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0232 0.2734 0.8833
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0514 0.6267 0.6987
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.0339 0.0378
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0367 0.4431 0.447
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0266 0.0812
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0326 0.3907 0.3897
Echinococcus granulosus microtubule associated protein 2 0.0729 0.8969 0.9048
Schistosoma mansoni sodium/chloride dependent transporter 0.021 0.2452 0.2734
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.079 0.0775
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.3058 0.3058
Trichomonas vaginalis esterase, putative 0.0035 0.0266 0.0376
Echinococcus multilocularis geminin 0.0717 0.8815 0.8892
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0082 0.0083
Loa Loa (eye worm) hypothetical protein 0.0082 0.0848 0.0848
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0266 0.0566
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0339 0.0378
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.024 0.2832 0.6378
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0326 0.3907 0.3897
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.024 0.2832 0.629
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0082 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0326 0.3907 0.3941
Schistosoma mansoni sodium-dependent amino acid transporter 0.0082 0.0848 0.0946
Echinococcus granulosus snurportin 1 0.0329 0.3952 0.3986
Onchocerca volvulus 0.0043 0.0366 0.0317
Onchocerca volvulus 0.0326 0.3907 0.3876
Plasmodium falciparum importin beta, putative 0.0031 0.0208 0.0434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.2259 0.2259
Brugia malayi hypothetical protein 0.0082 0.0848 0.0834
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0049 0.0436 0.0671
Plasmodium falciparum DNA topoisomerase 2 0.0073 0.0733 0.1624
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0232 0.2734 0.6062
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0075 0.0763 0.1243
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0232 0.2734 0.6062
Brugia malayi Patched related family protein 10 0.0019 0.0058 0.0042
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.005 0.0056
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0232 0.2734 0.6062
Echinococcus granulosus Nuclear hormone receptor HR96 0.0149 0.1693 0.1708
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0082 0.0848 0.0834
Echinococcus multilocularis tar DNA binding protein 0.0189 0.2186 0.2205
Mycobacterium tuberculosis Carboxylesterase LipT 0.0049 0.0436 0.1363
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0326 0.3907 0.4356
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.2259 0.2519
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0277 0.0592
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0082 0.015
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.016 0.1829 0.1816
Onchocerca volvulus 0.0035 0.0266 0.0216
Loa Loa (eye worm) hypothetical protein 0.0041 0.0339 0.0339
Schistosoma mansoni nuclear hormone receptor 0.0326 0.3907 0.4356
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0367 0.4431 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0266 0.0812
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0326 0.3907 0.3897
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.016 0.1829 0.3963
Brugia malayi Carboxylesterase family protein 0.0049 0.0436 0.042
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.016 0.1829 0.4107
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.058 0.0646
Onchocerca volvulus 0.0049 0.0436 0.0387
Schistosoma mansoni hypothetical protein 0.0129 0.1439 0.1604
Plasmodium vivax plasmepsin V, putative 0.0018 0.005 0.0078
Loa Loa (eye worm) cytochrome P450 family protein 0.0106 0.1147 0.1147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Onchocerca volvulus 0.0149 0.1693 0.1651
Schistosoma mansoni nuclear hormone receptor 0.0149 0.1693 0.1887
Loa Loa (eye worm) TOPoisomerase family member 0.0073 0.0733 0.0733
Schistosoma mansoni hypothetical protein 0.0133 0.149 0.1661
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0326 0.3907 0.3897
Toxoplasma gondii cytochrome p450 superfamily protein 0.0088 0.0923 0.2053
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.0792
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0261 0.3093 0.6969
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.013 0.0258
Onchocerca volvulus 0.0049 0.0436 0.0387
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Echinococcus granulosus sterol regulatory element binding protein 0.02 0.2326 0.2347
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0149 0.1693 0.1887
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0367 0.4431 0.494
Toxoplasma gondii aspartyl protease ASP1 0.0018 0.005 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0424 0.0923
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0424 0.0923
Brugia malayi ecdysone receptor 0.0149 0.1693 0.168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Brugia malayi Nuclear hormone receptor E75 0.0149 0.1693 0.168
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0088 0.0923 0.2946
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Brugia malayi Carboxylesterase family protein 0.029 0.3459 0.3448
Echinococcus granulosus Niemann Pick C1 protein 0.0511 0.6238 0.6293
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0018 0.005 0.0051
Echinococcus multilocularis sodium and chloride dependent glycine 0.0082 0.0848 0.0856
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0109
Echinococcus multilocularis GPCR, family 2 0.0082 0.0845 0.0852
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.005 0.0056
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Loa Loa (eye worm) hypothetical protein 0.0326 0.3907 0.3907
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0043 0.0366 0.055
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0122 0.1347 0.1359
Loa Loa (eye worm) hypothetical protein 0.0043 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.02 0.2326 0.2326
Echinococcus granulosus neuroligin 0.0049 0.0436 0.0439
Echinococcus multilocularis 0.0088 0.0923 0.0931
Brugia malayi beta-lactamase family protein 0.0035 0.0266 0.025
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0539 0.1184
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0539 0.0543
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0232 0.2734 0.6062
Loa Loa (eye worm) hypothetical protein 0.0032 0.0224 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Brugia malayi EGF-like domain containing protein 0.0052 0.0471 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.013 0.0258
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0145 0.0292
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0149 0.1693 0.1708
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0048 0.0424 0.0651
Schistosoma mansoni importin beta-1 0.0031 0.0208 0.0232
Loa Loa (eye worm) RNA binding protein 0.0189 0.2186 0.2186
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0082 0.0848 0.0946
Loa Loa (eye worm) hypothetical protein 0.0312 0.3733 0.3733
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0082 0.0083
Onchocerca volvulus Protein patched homolog 0.0019 0.0058 0.0008
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0018 0.005 0.0078
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0266 0.0812
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0277 0.0592
Brugia malayi Carboxylesterase family protein 0.0049 0.0436 0.042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Brugia malayi nuclear receptor NHR-67 0.0149 0.1693 0.168
Plasmodium vivax aspartyl protease, putative 0.0018 0.005 0.0078
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0339 0.0342
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0277 0.0592
Loa Loa (eye worm) hypothetical protein 0.004 0.0325 0.0325
Echinococcus granulosus tar DNA binding protein 0.0189 0.2186 0.2205
Loa Loa (eye worm) hypothetical protein 0.0049 0.0436 0.0436
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2186 0.2437
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0845 0.083
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.038 0.0383
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0261 0.3093 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.2259 0.2519
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0106 0.0203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0539 0.1184
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.055
Schistosoma mansoni hypothetical protein 0.0432 0.5243 0.5846
Loa Loa (eye worm) hypothetical protein 0.021 0.2452 0.2452
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0082 0.0848 0.0946
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0208 0.0434
Brugia malayi Cytochrome P450 family protein 0.0107 0.1166 0.1152
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0539 0.1001
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0266 0.0376
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0277 0.066
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0266 0.0296
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0122 0.1347 0.1359
Brugia malayi Eukaryotic aspartyl protease family protein 0.0018 0.005 0.0034
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.0339 0.0324
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.016 0.1829 0.1845
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0266 0.0812
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0073 0.0733 0.0718
Schistosoma mansoni acetylcholinesterase 0.0049 0.0436 0.0486
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.8969 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0383 0.462 0.5151
Onchocerca volvulus 0.0049 0.0436 0.0387
Echinococcus granulosus cpg binding protein 0.0032 0.0223 0.0225
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0088 0.0923 0.186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.2259 0.2519
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.005 0.0056
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0539 0.0969
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0367 0.4431 0.7639
Brugia malayi Cytochrome P450 family protein 0.0106 0.1147 0.1133
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0424 0.0702
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.055
Loa Loa (eye worm) hypothetical protein 0.0052 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0049 0.0436 0.0436
Brugia malayi hypothetical protein 0.0149 0.1693 0.168
Onchocerca volvulus Protein patched homolog 0.0019 0.0058 0.0008
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0057 0.0538 0.1182
Echinococcus multilocularis cpg binding protein 0.0032 0.0223 0.0225
Brugia malayi nuclear hormone receptor 0.0149 0.1693 0.168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Onchocerca volvulus 0.0019 0.0058 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0266 0.0812
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0367 0.4431 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0367 0.4431 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0266 0.0268
Brugia malayi TAR-binding protein 0.0189 0.2186 0.2173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0326 0.3907 0.3897
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0145
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0106 0.0203
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0149 0.1693 0.1693
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0033 0.0034
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0232 0.2734 0.6062
Toxoplasma gondii hypothetical protein 0.0082 0.0848 0.1885
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0261 0.3093 0.6969
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.038 0.0364
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0539 0.1184
Schistosoma mansoni hypothetical protein 0.0717 0.8815 0.9828
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0149 0.1693 0.1708
Schistosoma mansoni hypothetical protein 0.0078 0.0794 0.0885
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0082 0.0848 0.0946
Onchocerca volvulus 0.0019 0.0058 0.0008
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.013 0.037
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0145 0.0292
Toxoplasma gondii aspartyl protease ASP3 0.0018 0.005 0.0078
Brugia malayi Myosin head containing protein 0.0019 0.0058 0.0042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0326 0.3907 0.3941
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0018 0.005 0.0051
Brugia malayi Carboxylesterase family protein 0.029 0.3459 0.3448
Echinococcus granulosus dna polymerase eta 0.0017 0.0033 0.0034
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.057 0.1254
Brugia malayi hypothetical protein 0.0018 0.005 0.0034
Toxoplasma gondii hypothetical protein 0.0019 0.0058 0.0095
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0082 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0266 0.0812
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.2259 0.2279
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0367 0.4431 0.4431
Echinococcus multilocularis neurogenic locus notch protein 0.0052 0.0471 0.0475
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0266 0.0566
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0106 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0088 0.0923 0.2946
Brugia malayi hypothetical protein 0.0078 0.0794 0.0779
Brugia malayi protein C24B5.3 0.0019 0.0058 0.0042
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0208 0.0434
Loa Loa (eye worm) RGS-3 protein 0.0041 0.0339 0.0339
Brugia malayi Nuclear hormone receptor-like 1 0.0176 0.2035 0.2022
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0232 0.2734 0.8833
Onchocerca volvulus 0.021 0.2452 0.2414
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0075 0.0763 0.1243
Onchocerca volvulus 0.0087 0.0907 0.0861
Brugia malayi protein C24B5.3 0.0019 0.0058 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.1347 0.3015
Schistosoma mansoni cpg binding protein 0.0032 0.0223 0.0249
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0277 0.028
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0122 0.1347 0.1502
Loa Loa (eye worm) TAR-binding protein 0.0189 0.2186 0.2186
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0043 0.0366 0.055
Onchocerca volvulus 0.0082 0.0848 0.0802
Schistosoma mansoni gliotactin 0.0049 0.0436 0.0486
Loa Loa (eye worm) hypothetical protein 0.0041 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0326 0.3907 0.3907
Brugia malayi hypothetical protein 0.0017 0.003 0.0014
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.079 0.1752
Loa Loa (eye worm) hypothetical protein 0.0049 0.0433 0.0433
Echinococcus granulosus neurogenic locus notch protein 0.0052 0.0471 0.0475
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Onchocerca volvulus 0.0019 0.0058 0.0008
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0082 0.0848 0.1885
Echinococcus granulosus expressed conserved protein 0.0293 0.3495 0.3526
Plasmodium vivax aspartyl protease, putative 0.0018 0.005 0.0078
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0339 0.0342
Onchocerca volvulus 0.0019 0.0058 0.0008
Onchocerca volvulus 0.0019 0.0058 0.0008
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0232 0.2734 0.6062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0656 0.0731
Trypanosoma brucei DNA topoisomerase ii 0.0057 0.0538 0.1182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0339 0.0339
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0043 0.0366 0.0899
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0176 0.2035 0.2053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0232 0.2734 0.6062
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0082 0.0848 0.1688
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0277 0.0591
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.0339 0.0342
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.2259 0.2247
Leishmania major importin beta-1 subunit, putative 0.0025 0.0135 0.0268
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0018 0.005 0.005
Toxoplasma gondii exonuclease III APE 0.0057 0.0539 0.1184
Plasmodium falciparum plasmepsin IV 0.0018 0.005 0.0078
Brugia malayi Probable DNA topoisomerase II 0.0073 0.0733 0.0718
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.021 0.2452 0.2734
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0082 0.0848 0.0848
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0016 0.0016
Plasmodium falciparum transporter, putative 0.0082 0.0848 0.1885
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0049 0.0436 0.0439
Entamoeba histolytica hypothetical protein 0.0078 0.0794 0.2055
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0088 0.0923 0.2946
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0052 0.0471 0.0456
Loa Loa (eye worm) hypothetical protein 0.0176 0.2034 0.2034
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0339 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Loa Loa (eye worm) hypothetical protein 0.0043 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0845 0.0852
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0312 0.3733 1
Loa Loa (eye worm) hypothetical protein 0.0326 0.3907 0.3907
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0266 0.0268
Leishmania major hypothetical protein, conserved 0.0026 0.0145 0.0292
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0149 0.1693 0.1708
Loa Loa (eye worm) serotonin transporter b 0.021 0.2452 0.2452
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0266 0.0376
Echinococcus granulosus acetylcholinesterase 0.029 0.3459 0.3489
Schistosoma mansoni rab6-interacting 0.0021 0.0082 0.0092
Brugia malayi Pre-SET motif family protein 0.0418 0.5062 0.5054
Onchocerca volvulus 0.0049 0.0436 0.0387
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0016 0.0016
Plasmodium vivax aspartyl protease, putative 0.0018 0.005 0.0078
Echinococcus multilocularis acetylcholinesterase 0.029 0.3459 0.3489
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0106 0.0107
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0106 0.009
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0277 0.0396
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.0339 0.0342
Mycobacterium ulcerans oxidoreductase 0.0144 0.1632 0.3506
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0326 0.3907 0.4356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0326 0.3907 0.3907
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0149 0.1693 0.1887
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.005 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0326 0.3907 0.3941
Loa Loa (eye worm) nuclear hormone receptor 0.0149 0.1693 0.1693
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0394 0.4769 0.5317
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1347 0.2261
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.1347 0.3015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0326 0.3907 0.3897
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0043 0.0366 0.0369
Toxoplasma gondii patched family protein 0.0019 0.0058 0.0095
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0033 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0339 0.0378
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0232 0.2734 0.8833
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0232 0.2734 0.6062
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0232 0.2734 0.8833
Brugia malayi PXA domain containing protein 0.0041 0.0339 0.0324
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0553 0.0558
Brugia malayi Cytochrome P450 family protein 0.0088 0.0923 0.0908
Echinococcus multilocularis expressed protein 0.0804 0.9913 1
Plasmodium falciparum plasmepsin II 0.0018 0.005 0.0078
Loa Loa (eye worm) patched family protein 0.0019 0.0058 0.0058
Brugia malayi aspartic protease BmAsp-1, identical 0.0018 0.005 0.0034
Plasmodium vivax polyprenol reductase, putative 0.0043 0.0366 0.0792
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0135 0.0147
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.058 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0339 0.0503
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0367 0.4431 1
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0043 0.0366 0.0408
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0043 0.0366 0.0792
Schistosoma mansoni cytochrome P450 0.0088 0.0923 0.1029
Loa Loa (eye worm) hypothetical protein 0.0082 0.0848 0.0848
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0232 0.2734 0.6062
Entamoeba histolytica DNA topoisomerase II, putative 0.0073 0.0733 0.1892
Loa Loa (eye worm) carboxylesterase 0.029 0.3459 0.3459
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0043 0.0366 0.0792
Trichomonas vaginalis DNA topoisomerase II, putative 0.0073 0.0733 0.119
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0082 0.0848 0.0834
Schistosoma mansoni hypothetical protein 0.0021 0.0082 0.0092
Schistosoma mansoni sodium/chloride dependent transporter 0.0082 0.0848 0.0946
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0229 0.0694
Echinococcus granulosus carboxylesterase 5A 0.029 0.3459 0.3489
Loa Loa (eye worm) hypothetical protein 0.0176 0.2035 0.2035
Loa Loa (eye worm) hypothetical protein 0.0394 0.4769 0.4769
Onchocerca volvulus 0.0021 0.0082 0.0032
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0367 0.4431 0.7639
Brugia malayi laminin-like protein K08C7.3 precursor 0.0052 0.0471 0.0456
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0065 0.0641 0.1416
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Schistosoma mansoni cpg binding protein 0.003 0.0202 0.0225
Brugia malayi intermediate filament protein 0.0087 0.0907 0.0893
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0082 0.015
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0057 0.0538 0.1182
Brugia malayi nuclear receptor RXR 0.0176 0.2035 0.2022
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0266 0.0376
Leishmania major cytochrome p450-like protein 0.0088 0.0923 0.2053
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0106 0.0203
Plasmodium vivax aspartyl proteinase, putative 0.0018 0.005 0.0078
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0232 0.2734 0.6062
Loa Loa (eye worm) hypothetical protein 0.0049 0.0436 0.0436
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.0339 0.0339
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0049 0.0436 0.0486
Onchocerca volvulus 0.0019 0.0058 0.0008
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0122 0.1347 0.2871
Loa Loa (eye worm) hypothetical protein 0.006 0.058 0.058
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0232 0.2734 0.8833
Brugia malayi Patched related family protein 12 0.0019 0.0058 0.0042
Brugia malayi nuclear hormone receptor family member nhr-6 0.0149 0.1693 0.168
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0024 0.0121 0.0238
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.0339 0.0324
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0073 0.0733 0.0718
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0907 0.0907
Onchocerca volvulus 0.0082 0.0848 0.0802
Schistosoma mansoni hypothetical protein 0.0113 0.1241 0.1384
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0343 0.051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Plasmodium falciparum plasmepsin X 0.0018 0.005 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.0326 0.3907 0.4356
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.0641 0.1416
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0082 0.0848 0.0856
Trypanosoma brucei unspecified product 0.004 0.0327 0.0704
Brugia malayi cytochrome P450 0.0088 0.0923 0.0908
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0176 0.2035 0.2269
Schistosoma mansoni hypothetical protein 0.0329 0.3952 0.4406
Trichomonas vaginalis ran, putative 0.0023 0.0106 0.0096
Plasmodium vivax SET domain protein, putative 0.006 0.058 0.1277
Loa Loa (eye worm) hypothetical protein 0.0326 0.3907 0.3907
Echinococcus multilocularis acetylcholinesterase 0.029 0.3459 0.3489
Treponema pallidum sodium- and chloride- dependent transporter 0.021 0.2452 0.5409
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0149 0.1693 0.1708
Schistosoma mansoni inositol monophosphatase 0.0036 0.0277 0.0309
Loa Loa (eye worm) hypothetical protein 0.0049 0.0436 0.0436
Schistosoma mansoni DNA topoisomerase II 0.0073 0.0733 0.0817
Giardia lamblia DINP protein human, muc B family 0.0025 0.013 0.0057
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0232 0.2734 0.6062
Plasmodium vivax DNA gyrase subunit B, putative 0.0024 0.0121 0.0238
Schistosoma mansoni neuroligin 3 (S09 family) 0.0049 0.0436 0.0486
Loa Loa (eye worm) hypothetical protein 0.0149 0.1693 0.1693
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0394 0.4769 0.5317
Loa Loa (eye worm) hypothetical protein 0.0122 0.1347 0.1347
Brugia malayi Cytochrome P450 family protein 0.0106 0.1147 0.1133
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0339 0.0324
Loa Loa (eye worm) cytochrome P450 0.0088 0.0923 0.0923
Plasmodium falciparum plasmepsin IX 0.0018 0.005 0.0078
Echinococcus multilocularis synaptic glycoprotein sc2 0.0043 0.0366 0.0369
Entamoeba histolytica hypothetical protein 0.0041 0.0339 0.0827
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0326 0.3907 0.4356
Plasmodium falciparum plasmepsin V 0.0018 0.005 0.0078
Echinococcus granulosus synaptic glycoprotein sc2 0.0043 0.0366 0.0369
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.149 0.1503
Schistosoma mansoni lipoxygenase 0.0058 0.0553 0.0616
Schistosoma mansoni slit 0.0052 0.0471 0.0525
Trypanosoma brucei cytochrome P450, putative 0.0106 0.1147 0.2561
Loa Loa (eye worm) hypothetical protein 0.0164 0.1877 0.1877
Schistosoma mansoni lipoxygenase 0.0021 0.0082 0.0092
Trichomonas vaginalis DNA polymerase eta, putative 0.0048 0.0424 0.0651
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0539 0.0523
Brugia malayi small heat shock protein 0.0676 0.8299 0.8296
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0122 0.1347 0.2261
Loa Loa (eye worm) patched family protein 0.0019 0.0058 0.0058
Loa Loa (eye worm) carboxylesterase 0.0049 0.0436 0.0436
Brugia malayi photoreceptor-specific nuclear receptor 0.0326 0.3907 0.3897
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0176 0.2035 0.2269
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0082 0.0082
Echinococcus multilocularis neuroligin 0.0049 0.0436 0.0439
Brugia malayi hypothetical protein 0.0021 0.0082 0.0066
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0106 0.0107
Echinococcus granulosus pikachurin 0.0052 0.0471 0.0475
Echinococcus multilocularis Niemann Pick C1 protein 0.0511 0.6238 0.6293
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Echinococcus multilocularis dna polymerase eta 0.0017 0.0033 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0326 0.3907 0.3897
Loa Loa (eye worm) CYP4Cod1 0.0106 0.1147 0.1147
Plasmodium vivax patched family protein, putative 0.0019 0.0058 0.0095
Echinococcus granulosus cytochrome P450 2K1 0.0088 0.0923 0.0931
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0106 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0339 0.0378
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0082 0.0848 0.0856
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0339 0.0342
Loa Loa (eye worm) hypothetical protein 0.0032 0.0224 0.0224
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0082 0.0848 0.0848
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0343 0.051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0326 0.3907 0.3907
Entamoeba histolytica hypothetical protein 0.0043 0.0366 0.0899
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0326 0.3907 0.3941
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Plasmodium vivax aspartyl proteinase, putative 0.0018 0.005 0.0078
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0382 0.0385
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0367 0.4431 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.058 0.0646
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0277 0.028
Toxoplasma gondii patched family protein 0.0019 0.0058 0.0095
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.005 0.0056
Schistosoma mansoni patched 1 0.02 0.2326 0.2594
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0326 0.3907 0.4356
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.079 0.1752
Schistosoma mansoni loxhd1 0.0021 0.0082 0.0092
Echinococcus granulosus lamin dm0 0.0087 0.0907 0.0915
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0539 0.1184
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0106 0.1147 0.238
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0082 0.0848 0.0856
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0082 0.0845 0.0942
Brugia malayi follicle stimulating hormone receptor 0.0509 0.6201 0.6195
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0266 0.0266
Echinococcus multilocularis ubiquitin specific protease 41 0.0122 0.1347 0.1359
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.038 0.038
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0266 0.0376
Brugia malayi glucose-6-phosphate dehydrogenase 0.0367 0.4431 0.4422
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0326 0.3907 0.3897
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0088 0.0923 0.2053
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0382 0.0385
Brugia malayi hypothetical protein 0.0041 0.0339 0.0324
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0544 0.0549
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0043 0.0366 0.0369
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0266 0.0812
Onchocerca volvulus 0.0087 0.0907 0.0861
Toxoplasma gondii ABC1 family protein 0.0035 0.0266 0.0566
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0266 0.025
Loa Loa (eye worm) beta-lactamase 0.0035 0.0266 0.0266
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0049 0.0436 0.0486
Schistosoma mansoni lamin 0.0087 0.0907 0.1012
Schistosoma mansoni laminin gamma-3 chain 0.0052 0.0471 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0339 0.0503
Brugia malayi CXXC zinc finger family protein 0.003 0.0202 0.0186
Schistosoma mansoni cpg binding protein 0.0032 0.0223 0.0249
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0016
Giardia lamblia Synaptic glycoprotein SC2 0.0043 0.0366 0.0601
Schistosoma mansoni thyroid hormone receptor 0.0459 0.5576 0.6217
Loa Loa (eye worm) inositol-1 0.0036 0.0277 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0339 0.0503
Loa Loa (eye worm) hypothetical protein 0.0326 0.3907 0.3907
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0232 0.2734 0.6062
Brugia malayi RNA binding protein 0.0189 0.2186 0.2173
Schistosoma mansoni ran 0.0023 0.0106 0.0118
Brugia malayi Nuclear hormone receptor E75 0.0149 0.1693 0.168
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.016 0.1829 0.4107
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0088 0.0923 0.186
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0088 0.0923 0.2946
Schistosoma mansoni BC026374 protein (S09 family) 0.0049 0.0436 0.0486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0326 0.3907 0.3907
Brugia malayi hypothetical protein 0.0176 0.2035 0.2022
Brugia malayi beta-lactamase family protein 0.0035 0.0266 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0398 0.4809 0.5362
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0266 0.0566
Schistosoma mansoni hypothetical protein 0.0082 0.0845 0.0942
Entamoeba histolytica hypothetical protein 0.0078 0.0794 0.2055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0306 0.0306
Schistosoma mansoni hypothetical protein 0.0129 0.1439 0.1604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0326 0.3907 0.3907
Echinococcus granulosus nuclear receptor nhr 48 0.0149 0.1693 0.1708
Loa Loa (eye worm) hypothetical protein 0.0041 0.0339 0.0339
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0232 0.2734 0.8833
Loa Loa (eye worm) hypothetical protein 0.0176 0.2035 0.2035
Brugia malayi Inositol-1 0.0036 0.0277 0.0262
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.0339 0.0342
Echinococcus multilocularis thyroid hormone receptor alpha 0.0459 0.5576 0.5625
Toxoplasma gondii DNA topoisomerase 2, putative 0.0073 0.0733 0.1624
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0366 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Loa Loa (eye worm) hypothetical protein 0.0082 0.0848 0.0848
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0339 0.0342
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.005 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0424 0.0923
Chlamydia trachomatis DNA gyrase subunit B 0.0039 0.0316 0.0452
Plasmodium falciparum plasmepsin III 0.0018 0.005 0.0078
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0339 0.0342
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.0339 0.0324
Brugia malayi conserved hypotetical protein 0.0149 0.1693 0.168
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0326 0.3907 0.3897
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0082 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0326 0.3907 0.3897
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0208 0.0434
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0539 0.1366
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0145 0.0292
Schistosoma mansoni coup transcription factor 0.0326 0.3907 0.4356
Loa Loa (eye worm) hypothetical protein 0.0049 0.0436 0.0436
Echinococcus granulosus intermediate filament protein 0.0087 0.0907 0.0915
Schistosoma mansoni hypothetical protein 0.0129 0.1439 0.1604
Echinococcus granulosus expressed protein 0.0804 0.9913 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0277 0.0592
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.079 0.079
Brugia malayi hypothetical protein 0.0019 0.0058 0.0042
Toxoplasma gondii aspartyl protease 0.0018 0.005 0.0078
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Schistosoma mansoni lamin 0.0087 0.0907 0.1012
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0539 0.1698
Toxoplasma gondii hypothetical protein 0.0082 0.0848 0.1885
Plasmodium falciparum lipid/sterol:H+ symporter 0.0019 0.0058 0.0095
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.055
Leishmania major cytochrome p450-like protein 0.0088 0.0923 0.2053
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0326 0.3907 0.3941
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0145 0.0292
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0082 0.0848 0.0856
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0266 0.0812
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0326 0.3907 0.3941
Loa Loa (eye worm) carboxylesterase 0.0049 0.0436 0.0436
Echinococcus multilocularis musashi 0.0087 0.0907 0.0915
Brugia malayi Patched family protein 0.0019 0.0058 0.0042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0135 0.0147
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0018 0.005 0.005
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.3952 0.3952
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0016
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0024 0.0121 0.0341
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Schistosoma mansoni ap endonuclease 0.0057 0.0539 0.0601
Schistosoma mansoni steroid hormone receptor ad4bp 0.0326 0.3907 0.4356
Loa Loa (eye worm) hypothetical protein 0.021 0.2452 0.2452
Giardia lamblia DNA topoisomerase II 0.0069 0.0693 0.1357
Loa Loa (eye worm) hypothetical protein 0.0041 0.0339 0.0339
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0082 0.0848 0.0834
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.2259 0.2279
Plasmodium vivax DNA topoisomerase II, putative 0.0073 0.0733 0.1624
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0326 0.3907 0.3941
Loa Loa (eye worm) nuclear receptor NHR-67 0.0149 0.1693 0.1693
Echinococcus multilocularis dna polymerase kappa 0.0048 0.0424 0.0427
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0232 0.2734 0.8833
Echinococcus multilocularis carboxylesterase 5A 0.029 0.3459 0.3489
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0277 0.0396
Plasmodium falciparum plasmepsin I 0.0018 0.005 0.0078
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0082 0.0848 0.0946
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.8969 0.9048
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.02 0.2326 0.2326
Mycobacterium ulcerans hypothetical protein 0.0035 0.0266 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0109
Schistosoma mansoni retinoic acid receptor RXR 0.0326 0.3907 0.4356
Plasmodium falciparum amino acid transporter, putative 0.0082 0.0848 0.1885
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0082
Echinococcus granulosus sodium and chloride dependent glycine 0.0082 0.0848 0.0856
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.079 0.2045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0326 0.3907 0.3941
Echinococcus multilocularis pikachurin 0.0052 0.0471 0.0475
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.2259 0.2279
Echinococcus multilocularis RUN 0.0021 0.0082 0.0083
Echinococcus granulosus Protein patched homolog 1 0.02 0.2326 0.2347
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.016 0.1829 0.2039
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0367 0.4431 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0277 0.0363
Toxoplasma gondii patched family protein 0.0019 0.0058 0.0095
Leishmania major DNA polymerase eta, putative 0.0017 0.0033 0.0039
Brugia malayi beta-lactamase 0.0035 0.0266 0.025
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0366 0.0792
Schistosoma mansoni ran 0.0023 0.0106 0.0118
Echinococcus granulosus dnaJ subfamily B 0.0432 0.5243 0.5289
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0326 0.3907 0.3897
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.1347 0.3015
Brugia malayi Steroid receptor seven-up type 2 0.0326 0.3907 0.3897
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0261 0.3093 0.6895
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 3.1 mg kg-1 In vivo anticonvulsant effect of DMCM-induced clonic seizures in mice at 15 mg/kg intraperitoneal dose expressed as effective dose ChEMBL. 8510100
ED50 (functional) = 3.1 mg kg-1 Anticonvulsant activity measured by the inhibition of DMCM-induced seizures in mice. ChEMBL. 10543872
ED50 (functional) = 3.1 mg kg-1 Dose that protected 50% of the mice against seizures induced by intraperitoneally administered DMCM (15 mg/Kg) 30 min after intraperitoneal administration ChEMBL. 10479278
ED50 (functional) = 3.1 mg kg-1 In vivo anticonvulsant effect measured as inhibition of DMCM -induced seizures in mice after ip administration. ChEMBL. 11405652
IC50 (functional) = 330 nM In vitro inhibition of [3H]-GABA uptake in rat synaptosomes ChEMBL. 8510100
IC50 (binding) = 330 nM In vitro inhibition of [3H]-GABA uptake in rat synaptosomes ChEMBL. 10543872
IC50 (functional) = 330 nM In vitro inhibition of [3H]-GABA uptake in rat synaptosomes was determined ChEMBL. 11405652
Ki (binding) = 328 nM In vitro inhibition of [3H]-GABA uptake at the Sodium- and chloride-dependent GABA transporter 1 (GAT-1) uptake site in rat brain synaptosomes ChEMBL. 10479278

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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