Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.1741 | 0.1741 |
Echinococcus multilocularis | 0.001 | 0.0096 | 0.0096 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.368 | 0.368 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.001 | 0.0096 | 0.0096 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.001 | 0.0096 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.001 | 0.0096 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.001 | 0.0096 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.001 | 0.0096 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.001 | 0.0096 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.001 | 0.0096 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.1741 | 0.1741 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.001 | 0.0096 | 0.0096 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.001 | 0.0096 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.001 | 0.0096 | 0.0096 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Brugia malayi | cytochrome P450 | 0.001 | 0.0096 | 0.0096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.001 | 0.0096 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.001 | 0.0096 | 0.0096 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.001 | 0.0096 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.001 | 0.0096 | 0.0096 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.001 | 0.0096 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.001 | 0.0096 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.368 | 0.368 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.001 | 0.0096 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.1741 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.001 | 0.0096 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0.1741 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.001 | 0.0096 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0019 | 0.1741 | 0.1741 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.001 | 0.0096 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.1741 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.1741 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.001 | 0.0096 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.001 | 0.0096 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.001 | 0.0096 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.001 | 0.0096 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.1741 | 0.1741 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.1741 | 0.1741 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.001 | 0.0096 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0.1741 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.001 | 0.0096 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.001 | 0.0096 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.001 | 0.0096 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.