Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0047 | 0.0733 | 0.1396 |
Onchocerca volvulus | 0.0047 | 0.0733 | 0.5 | |
Schistosoma mansoni | ABC transporter | 0.0008 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0733 | 0.1442 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0733 | 0.1442 |
Entamoeba histolytica | ABC transporter, putative | 0.001 | 0.0029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0733 | 0.1442 |
Trypanosoma brucei | RNA helicase, putative | 0.0544 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0733 | 0.1442 |
Schistosoma mansoni | acetylcholinesterase | 0.0047 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0733 | 0.1442 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0047 | 0.0733 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0047 | 0.0733 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.028 | 0.5074 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0047 | 0.0733 | 1 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.001 | 0.0029 | 0.0029 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0733 | 0.0733 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | carboxylesterase | 0.0047 | 0.0733 | 0.1442 |
Brugia malayi | Carboxylesterase family protein | 0.028 | 0.5074 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.5074 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.5074 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.028 | 0.5074 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.028 | 0.5074 | 1 |
Trypanosoma cruzi | ABC transporter, putative | 0.001 | 0.0029 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0047 | 0.0733 | 0.0733 |
Echinococcus granulosus | neuroligin | 0.0047 | 0.0733 | 0.1396 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0047 | 0.0733 | 0.1396 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0733 | 0.1442 |
Echinococcus granulosus | carboxylesterase 5A | 0.028 | 0.5074 | 1 |
Onchocerca volvulus | 0.0047 | 0.0733 | 0.5 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0047 | 0.0733 | 0.1396 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.001 | 0.0029 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0047 | 0.0733 | 0.1396 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0047 | 0.0733 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0733 | 0.1442 |
Leishmania major | ATP-binding cassette protein subfamily G, member 6, putative | 0.001 | 0.0029 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0733 | 0.1442 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0047 | 0.0733 | 0.1396 |
Onchocerca volvulus | 0.0047 | 0.0733 | 0.5 | |
Giardia lamblia | ABC transporter | 0.0009 | 0.0027 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0047 | 0.0733 | 0.1442 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0047 | 0.0733 | 1 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0733 | 0.1442 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG84 | 0.001 | 0.0029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0733 | 0.1442 |
Echinococcus granulosus | acetylcholinesterase | 0.028 | 0.5074 | 1 |
Onchocerca volvulus | 0.0047 | 0.0733 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.028 | 0.5074 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.028 | 0.5074 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.028 | 0.5074 | 1 |
Echinococcus multilocularis | neuroligin | 0.0047 | 0.0733 | 0.1396 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0047 | 0.0733 | 1 |
Onchocerca volvulus | 0.0047 | 0.0733 | 0.5 | |
Plasmodium vivax | ABC transporter G family member 2, putative | 0.001 | 0.0029 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0047 | 0.0733 | 0.0733 |
Echinococcus multilocularis | acetylcholinesterase | 0.028 | 0.5074 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0047 | 0.0733 | 0.1396 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0733 | 0.1442 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0733 | 0.1442 |
Leishmania major | ATP-binding cassette protein subfamily G, member 4, putative | 0.001 | 0.0029 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.028 | 0.5074 | 0.5074 |
Plasmodium falciparum | ABC transporter G family member 2 | 0.001 | 0.0029 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0047 | 0.0733 | 0.0733 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0733 | 0.0733 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Incorporation (binding) | = 70 % | Ability to act as substrate of rat liver tRNA-Guanine Transglycosylase. | ChEMBL. | 3746821 |
Incorporation (binding) | = 70 % | Ability to act as substrate of rat liver tRNA-Guanine Transglycosylase. | ChEMBL. | 3746821 |
Inhibition (functional) | < 10 % | Inhibition of L5178Y cell growth at 10 ug/L. | ChEMBL. | 3746821 |
Inhibition (functional) | < 10 % | Inhibition of L5178Y cell growth at 10 ug/L. | ChEMBL. | 3746821 |
Inhibition (functional) | = 53 % | Inhibition of L5178Y cell growth at 100 ug/L. | ChEMBL. | 3746821 |
Inhibition (functional) | = 53 % | Inhibition of L5178Y cell growth at 100 ug/L. | ChEMBL. | 3746821 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.