TDR Targets

Basic information

Technical information

TDR Targets ID: 706791
Name: N-(1,3-benzothiazol-5-yl)-4-methylsulfanylben zamide
MW: 300.399 | Formula: C15H12N2OS2
H donors: 1 H acceptors: 2 LogP: 3.73 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CSc1ccc(cc1)C(=O)Nc1ccc2c(c1)ncs2
InChi: 1S/C15H12N2OS2/c1-19-12-5-2-10(3-6-12)15(18)17-11-4-7-14-13(8-11)16-9-20-14/h2-9H,1H3,(H,17,18)
InChiKey: FIFJDPCSKOBYRK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(1,3-benzothiazol-5-yl)-4-methylsulfanyl-benzamide
N-(1,3-benzothiazol-5-yl)-4-(methylthio)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.4014	0.4014
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.431	0.9271
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0033	0.1683	0.1683
Trypanosoma brucei	DNA polymerase IV, putative	0.0059	0.431	0.9153
Brugia malayi	hypothetical protein	0.0019	0.0294	0.045
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0081	0.6528	0.6528
Echinococcus multilocularis	RUN	0.0019	0.0294	0.0294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.1299	0.1629
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0294	0.045
Leishmania major	DNA polymerase kappa, putative	0.0039	0.2335	0.5021
Brugia malayi	ImpB/MucB/SamB family protein	0.0033	0.1683	0.2578
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0294	0.0294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0033	0.1683	0.2578
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.431	0.9271
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.431	0.9153
Schistosoma mansoni	hypothetical protein	0.0081	0.6528	0.6528
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0017	0.0033	1
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0294	1
Echinococcus granulosus	dna polymerase kappa	0.0059	0.431	0.431
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.431	0.9153
Trypanosoma brucei	DNA polymerase IV, putative	0.0052	0.3658	0.7524
Brugia malayi	hypothetical protein	0.0019	0.0294	0.045
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.431	0.9271
Leishmania major	DNA polymerase eta, putative	0.0033	0.1683	0.3619
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0081	0.6528	0.6528
Trypanosoma brucei	DNA polymerase IV, putative	0.0059	0.431	0.9153
Giardia lamblia	DINP protein human, muc B family	0.0039	0.2335	0.5
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.33	0.7098
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.4014	0.6149
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0294	0.0294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0039	0.2335	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0081	0.6528	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0294	0.045
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.431	0.9153
Onchocerca volvulus		0.0019	0.0294	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.2335	0.4217
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0039	0.2335	0.5021
Leishmania major	cathepsin L-like protease	0.0062	0.4649	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.431	0.9153
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0081	0.6528	0.6528
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.431	0.9271
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0081	0.6528	0.6528
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0081	0.6528	0.6528
Leishmania major	cathepsin L-like protease	0.0062	0.4649	1
Schistosoma mansoni	DNA polymerase eta	0.0033	0.1683	0.1683
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.4014	0.4014
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0033	0.1683	0.1683
Brugia malayi	polk-prov protein	0.0036	0.2009	0.3077
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.2009	0.3403
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0033	0.1683	0.2578
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0294	0.0294
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.4649	1
Mycobacterium ulcerans	DNA polymerase IV	0.0059	0.431	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.1683	0.3619
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.2009	0.3403
Schistosoma mansoni	rab6-interacting	0.0019	0.0294	0.0294
Mycobacterium ulcerans	DNA polymerase IV	0.0059	0.431	1
Schistosoma mansoni	apoptosis regulator bax	0.0081	0.6528	0.6528
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0033	0.1683	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.431	0.9153
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1683	0.2578
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.1299	0.1629
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Schistosoma mansoni	loxhd1	0.0019	0.0294	0.0294
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0115	1	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	0.4014	0.8634
Loa Loa (eye worm)	hypothetical protein	0.0036	0.2009	0.3077
Schistosoma mansoni	rab6-interacting	0.0019	0.0294	0.0294
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0294	0.0294
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.3633	0.5564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0294	0.0294
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.4649	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0033	0.1683	0.1683
Echinococcus multilocularis	dna polymerase eta	0.0033	0.1683	0.1683
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.431	0.9153
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0294	0.0294
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.4649	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.4014	1
Leishmania major	cathepsin L-like protease	0.0062	0.4649	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.4649	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0059	0.431	1
Schistosoma mansoni	hypothetical protein	0.0081	0.6528	0.6528
Echinococcus granulosus	RUN	0.0019	0.0294	0.0294
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.431	0.9153
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0033	0.1683	0.1683
Trypanosoma brucei	unspecified product	0.0052	0.3658	0.7524
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0294	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.1299	0.1629
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0081	0.6528	1
Schistosoma mansoni	lipoxygenase	0.008	0.6493	0.6493
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.431	0.9153
Trypanosoma brucei	DNA polymerase eta, putative	0.0033	0.1683	0.2588
Echinococcus multilocularis	dna polymerase kappa	0.0059	0.431	0.431
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0294	0.045
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0294	0.0294
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.4649	1
Schistosoma mansoni	polycystin 1-related	0.0019	0.0294	0.0294
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.4014	0.4014
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.431	0.9153
Trichomonas vaginalis	DNA polymerase eta, putative	0.0059	0.431	1
Schistosoma mansoni	lipoxygenase	0.0115	1	1
Schistosoma mansoni	hypothetical protein	0.0081	0.6528	0.6528
Brugia malayi	Doublecortin family protein	0.0019	0.0294	0.045
Onchocerca volvulus		0.0019	0.0294	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.4102	0.8824
Loa Loa (eye worm)	apoptosis regulator protein	0.0081	0.6528	1
Echinococcus granulosus	dna polymerase eta	0.0033	0.1683	0.1683

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 706791