Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.4874 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0014 | 0.0028 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.626 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0186 | 0.4874 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.4874 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0014 | 0.0028 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.4874 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0186 | 0.4874 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0186 | 0.4874 | 1 |
Brugia malayi | RNA binding protein | 0.0186 | 0.4874 | 1 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0186 | 0.4874 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.4874 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0186 | 0.4874 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.033 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.4874 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.