Detailed information for compound 706970

Basic information

Technical information
  • TDR Targets ID: 706970
  • Name: N-(2-tert-butyl-5,5-dioxo-4,6-dihydrothieno[3 ,4-d]pyrazol-3-yl)-N'-(3-propan-2-yloxypropyl )oxamide
  • MW: 400.493 | Formula: C17H28N4O5S
  • H donors: 2 H acceptors: 5 LogP: 0.14 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OCCCNC(=O)C(=O)Nc1n(nc2c1CS(=O)(=O)C2)C(C)(C)C)C
  • InChi: 1S/C17H28N4O5S/c1-11(2)26-8-6-7-18-15(22)16(23)19-14-12-9-27(24,25)10-13(12)20-21(14)17(3,4)5/h11H,6-10H2,1-5H3,(H,18,22)(H,19,23)
  • InChiKey: KDAGOUFZEPOACF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-tert-butyl-5,5-dioxo-4,6-dihydrothieno[3,4-d]pyrazol-3-yl)-N'-(3-isopropoxypropyl)oxamide
  • N-(2-tert-butyl-5,5-diketo-4,6-dihydrothieno[3,4-d]pyrazol-3-yl)-N'-(3-isopropoxypropyl)oxamide
  • N-(2-tert-butyl-5,5-dioxo-4,6-dihydrothieno[3,4-d]pyrazol-3-yl)-N'-(3-propan-2-yloxypropyl)ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0304 0.1809 0.9299
Echinococcus granulosus glycoprotein Antigen 5 0.0056 0.0292 0.1479
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0385 0.1101
Echinococcus multilocularis laminin 0.0304 0.1809 0.1806
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Loa Loa (eye worm) notch protein 0.0116 0.0659 0.3372
Echinococcus granulosus neurogenic locus protein delta 0.0116 0.0659 0.3372
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0336 0.1103
Schistosoma mansoni hypothetical protein 0.0063 0.0336 0.1117
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Brugia malayi CXXC zinc finger family protein 0.0058 0.0303 0.0994
Schistosoma mansoni septate junction protein 0.0116 0.0659 0.2193
Schistosoma mansoni ap endonuclease 0.0018 0.0061 0.0203
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.05 0.3006 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0061 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0385 0.225
Schistosoma mansoni hypothetical protein 0.0063 0.0336 0.1117
Onchocerca volvulus Putative cubilin 0.0116 0.0659 0.2421
Echinococcus granulosus cpg binding protein 0.0061 0.0323 0.164
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0195 0.1143 0.5864
Onchocerca volvulus 0.0116 0.0659 0.2421
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0385 0.1101
Schistosoma mansoni ferritin light chain 0.0009 0.0005 0.0017
Onchocerca volvulus Arrow homolog 0.0304 0.1809 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0239 0.0604
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0385 0.1266
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.05 0.3006 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0699 0.2326
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0304 0.1809 0.9299
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.2734 0.9093
Brugia malayi beta-lactamase 0.0071 0.0385 0.1268
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0116 0.0659 0.2181
Brugia malayi glutaminase DH11.1 0.0285 0.1694 0.5629
Brugia malayi Trypsin family protein 0.0056 0.0292 0.0956
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0037 0.0168
Echinococcus multilocularis GPCR, family 2 0.0063 0.0336 0.0331
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0292 0.097
Echinococcus multilocularis transmembrane protease serine 3 0.0056 0.0292 0.0287
Schistosoma mansoni apoferritin-2 0.0009 0.0005 0.0017
Entamoeba histolytica hypothetical protein 0.0036 0.0171 0.1019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.0906 0.4644
Schistosoma mansoni hypothetical protein 0.0116 0.0659 0.2193
Brugia malayi hypothetical protein 0.0056 0.0292 0.0956
Loa Loa (eye worm) hypothetical protein 0.0304 0.1809 0.9299
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0385 0.0381
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0292 0.097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0029 0.0144
Loa Loa (eye worm) hypothetical protein 0.0056 0.0292 0.1479
Echinococcus multilocularis neurogenic locus notch protein 0.0116 0.0659 0.0655
Brugia malayi GCC2 and GCC3 family protein 0.0116 0.0659 0.2181
Loa Loa (eye worm) hypothetical protein 0.0071 0.0385 0.1961
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.117 0.3884
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0195 0.1143 0.3674
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0037 0.0123
Brugia malayi Cadherin domain containing protein 0.0116 0.0659 0.2181
Echinococcus granulosus enteropeptidase 0.0056 0.0292 0.1479
Schistosoma mansoni ap endonuclease 0.0018 0.0061 0.0203
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1945 0.6472
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.1143 0.6736
Loa Loa (eye worm) hypothetical protein 0.0304 0.1809 0.9299
Brugia malayi EGF-like domain containing protein 0.0116 0.0659 0.2181
Schistosoma mansoni hypothetical protein 0.0165 0.0955 0.3178
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0543 0.2772
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0215 0.257
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.05 0.3006 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0029 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0144
Plasmodium falciparum dihydroorotate dehydrogenase 0.05 0.3006 1
Echinococcus multilocularis protein jagged 2 0.0116 0.0659 0.0655
Schistosoma mansoni cpg binding protein 0.0061 0.0323 0.1074
Echinococcus granulosus ferritin 0.0009 0.0005 0.0003
Onchocerca volvulus 0.0116 0.0659 0.2421
Echinococcus granulosus laminin 0.0304 0.1809 0.9299
Echinococcus multilocularis Mastin 0.0056 0.0292 0.0287
Loa Loa (eye worm) hypothetical protein 0.0071 0.0385 0.1961
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0292 0.097
Brugia malayi EGF-like domain containing protein 0.0116 0.0659 0.2181
Brugia malayi Trypsin family protein 0.0056 0.0292 0.0956
Schistosoma mansoni cpg binding protein 0.0061 0.0323 0.1074
Echinococcus granulosus neurogenic locus notch protein 0.0116 0.0659 0.3372
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.1143 0.6736
Brugia malayi Calcium binding EGF domain containing protein 0.0116 0.0659 0.2181
Echinococcus multilocularis neurogenic locus notch protein 4 0.0116 0.0659 0.0655
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Loa Loa (eye worm) beta-lactamase 0.0071 0.0385 0.1961
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0144
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0029 0.0144
Echinococcus granulosus tar DNA binding protein 0.0327 0.1945 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0303 0.1537
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.0934 0.3096
Schistosoma mansoni hypothetical protein 0.0116 0.0659 0.2193
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0195 0.1143 0.6736
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Onchocerca volvulus Neurogenic locus notch homolog 0.0116 0.0659 0.2421
Leishmania major hypothetical protein, conserved 0.0071 0.0385 0.1101
Schistosoma mansoni hypothetical protein 0.0056 0.0292 0.097
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0385 0.225
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0385 0.225
Echinococcus multilocularis protein jagged 1 0.0116 0.0659 0.0655
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0056 0.0292 0.1479
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0327 0.1945 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0171 0.057
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0057 0.0176
Echinococcus multilocularis Tolloid protein 1 0.0304 0.1809 0.1806
Loa Loa (eye worm) hypothetical protein 0.0056 0.0292 0.1479
Mycobacterium ulcerans hypothetical protein 0.0056 0.0292 0.0955
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0144
Onchocerca volvulus 0.0071 0.0385 0.0617
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0543 0.1805
Brugia malayi Delta serrate ligand family protein 0.0116 0.0659 0.2181
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.076 0.3892
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0385 0.1268
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Brugia malayi hypothetical protein 0.0036 0.0171 0.0555
Echinococcus granulosus Mastin 0.0056 0.0292 0.1479
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0061 0.0291
Trichomonas vaginalis glutaminase, putative 0.0285 0.1694 1
Schistosoma mansoni hypothetical protein 0.0056 0.0292 0.097
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0336 0.1103
Echinococcus granulosus neural cadherin 0.0116 0.0659 0.3372
Brugia malayi beta-lactamase family protein 0.0071 0.0385 0.1268
Brugia malayi Trypsin family protein 0.0056 0.0292 0.0956
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.05 0.3006 1
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1945 0.6472
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0239 0.1383
Schistosoma mansoni hypothetical protein 0.0116 0.0659 0.2193
Brugia malayi EGF-like domain containing protein 0.0116 0.0659 0.2181
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0385 0.1101
Schistosoma mansoni cell polarity protein 0.0116 0.0659 0.2193
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.1143 0.6736
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0543 0.1805
Echinococcus granulosus GPCR family 2 0.0063 0.0336 0.1706
Echinococcus multilocularis neurogenic locus protein delta 0.0116 0.0659 0.0655
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0784 0.2597
Loa Loa (eye worm) trypsin family protein 0.0056 0.0292 0.1479
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Loa Loa (eye worm) hypothetical protein 0.0304 0.1809 0.9299
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0643 0.1977
Onchocerca volvulus 0.0071 0.0385 0.0617
Schistosoma mansoni hypothetical protein 0.0116 0.0659 0.2193
Loa Loa (eye worm) hypothetical protein 0.0056 0.0292 0.1479
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0171 0.0859
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1945 0.6472
Schistosoma mansoni ferritin light chain 0.0009 0.0005 0.0017
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0056 0.0292 0.097
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0385 0.1266
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0061 0.0331
Brugia malayi Muscle positioning protein 4 0.0116 0.0659 0.2181
Loa Loa (eye worm) glutaminase 2 0.0285 0.1694 0.8705
Loa Loa (eye worm) hypothetical protein 0.0071 0.0385 0.1961
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0239 0.1207
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0239 0.0604
Loa Loa (eye worm) hypothetical protein 0.0056 0.0292 0.1479
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0336 0.1706
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0292 0.097
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0144
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0116 0.0659 0.2421
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0195 0.1143 1
Echinococcus granulosus Tolloid protein 1 0.0304 0.1809 0.9299
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0029 0.0144
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.1143 0.6736
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0304 0.1809 0.602
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0037 0.0033
Echinococcus multilocularis geminin 0.0165 0.0955 0.0951
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0056 0.0292 0.0956
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.0934 0.0929
Schistosoma mansoni smad1 5 8 and 0.0009 0.0005 0.0015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0059 0.0054
Loa Loa (eye worm) Notch2 0.0116 0.0659 0.3372
Echinococcus granulosus geminin 0.0165 0.0955 0.4898
Loa Loa (eye worm) TAR-binding protein 0.0327 0.1945 1
Schistosoma mansoni notch 0.0116 0.0659 0.2193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0543 0.2772
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Brugia malayi EGF-like domain containing protein 0.0116 0.0659 0.2181
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0029 0.0144
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0385 0.1266
Echinococcus granulosus expressed protein 0.0009 0.0005 0.0003
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0239 0.0604
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0292 0.097
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0144
Schistosoma mansoni notch 0.0116 0.0659 0.2193
Loa Loa (eye worm) acetyltransferase 0.0161 0.0934 0.4787
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0292 0.097
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0304 0.1809 0.9299
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.117 0.3884
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.05 0.3006 1
Schistosoma mansoni glutaminase 0.0285 0.1694 0.5636
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0061 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0037 0.0033
Mycobacterium leprae Probable lipase LipE 0.0071 0.0385 0.1266
Giardia lamblia High cysteine protein 0.0116 0.0659 1
Trichomonas vaginalis helicase, putative 0.0013 0.0029 0.0144
Echinococcus granulosus neurogenic locus notch protein 0.0116 0.0659 0.3372
Echinococcus granulosus transmembrane protease serine 3 0.0056 0.0292 0.1479
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0059 0.0279
Mycobacterium ulcerans hypothetical protein 0.0071 0.0385 0.1266
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0144
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0336 0.0331
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0385 0.1961
Mycobacterium ulcerans beta-lactamase 0.0071 0.0385 0.1266
Brugia malayi EGF-like domain containing protein 0.0116 0.0659 0.2181
Brugia malayi Calcium binding EGF domain containing protein 0.0304 0.1809 0.6014
Schistosoma mansoni hypothetical protein 0.0116 0.0659 0.2193
Toxoplasma gondii ABC1 family protein 0.0071 0.0385 0.1101
Loa Loa (eye worm) hypothetical protein 0.0071 0.0385 0.1961
Echinococcus granulosus protein jagged 1 0.0116 0.0659 0.3372
Echinococcus granulosus slit 2 protein 0.0116 0.0659 0.3372
Entamoeba histolytica hypothetical protein 0.0036 0.0171 0.1019
Schistosoma mansoni ferritin 0.0009 0.0005 0.0017
Onchocerca volvulus Slit protein homolog 0.0116 0.0659 0.2421
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.076 0.3892
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0061 0.0186
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0385 0.1266
Loa Loa (eye worm) hypothetical protein 0.0071 0.0385 0.1961
Schistosoma mansoni hypothetical protein 0.0063 0.0336 0.1117
Loa Loa (eye worm) hypothetical protein 0.0063 0.0336 0.1706
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1945 0.6472
Brugia malayi Zinc finger, C2H2 type family protein 0.0195 0.1143 0.3793
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Schistosoma mansoni notch 0.0116 0.0659 0.2193
Schistosoma mansoni tar DNA-binding protein 0.0327 0.1945 0.6472
Loa Loa (eye worm) glutaminase 0.0285 0.1694 0.8705
Echinococcus multilocularis fibrillin 1 0.0304 0.1809 0.1806
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0543 0.1793
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0116 0.0659 0.2193
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0029 0.0144
Schistosoma mansoni hypothetical protein 0.0063 0.0336 0.1117
Echinococcus granulosus notch 0.0116 0.0659 0.3372
Brugia malayi RNA binding protein 0.0327 0.1945 0.6467
Echinococcus granulosus delta-like protein 1 0.0116 0.0659 0.3372
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.0934 0.3106
Echinococcus multilocularis fat cadherin tumor suppressor 0.0116 0.0659 0.0655
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0005 0.0015
Toxoplasma gondii calcium binding egf domain-containing protein 0.0304 0.1809 0.5938
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0385 0.1266
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.1143 0.6736
Brugia malayi Calcium binding EGF domain containing protein 0.0116 0.0659 0.2181
Echinococcus multilocularis enteropeptidase 0.0056 0.0292 0.0287
Brugia malayi Fibulin-1 precursor 0.0304 0.1809 0.6014
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0543 0.0538
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.05 0.3006 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0195 0.1143 0.1139
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0061 0.0291
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0171 0.0167
Echinococcus multilocularis slit 2 protein 0.0116 0.0659 0.0655
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Loa Loa (eye worm) hypothetical protein 0.0304 0.1809 0.9299
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Schistosoma mansoni hypothetical protein 0.0165 0.0955 0.3178
Echinococcus multilocularis notch 0.0116 0.0659 0.0655
Schistosoma mansoni smad 0.0009 0.0005 0.0015
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.05 0.3006 1
Brugia malayi Cadherin domain containing protein 0.0116 0.0659 0.2181
Mycobacterium tuberculosis Conserved protein 0.0071 0.0385 0.1266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0543 0.1805
Brugia malayi notch-like transmembrane receptor 0.0116 0.0659 0.2181
Schistosoma mansoni Smad4 0.0009 0.0005 0.0015
Echinococcus multilocularis cpg binding protein 0.0061 0.0323 0.0319
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0292 0.0287
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0336 0.1706
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0059 0.0279
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0292 0.097
Schistosoma mansoni ferritin 0.0009 0.0005 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0144
Echinococcus multilocularis fibropellin Ia 0.0116 0.0659 0.0655
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0385 0.1961
Echinococcus multilocularis glycoprotein Antigen 5 0.0056 0.0292 0.0287
Loa Loa (eye worm) RNA binding protein 0.0327 0.1945 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0239 0.1383
Mycobacterium ulcerans glutaminase 0.0285 0.1694 0.5629
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0215 0.0522
Schistosoma mansoni hypothetical protein 0.0137 0.0784 0.2608
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0304 0.1809 0.6014
Loa Loa (eye worm) hypothetical protein 0.0304 0.1809 0.9299
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Schistosoma mansoni hypothetical protein 0.0116 0.0659 0.2193
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Loa Loa (eye worm) hypothetical protein 0.02 0.117 0.6007
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0056 0.0292 0.1479
Onchocerca volvulus 0.0116 0.0659 0.2421
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0061 0.0188
Brugia malayi MH2 domain containing protein 0.0133 0.076 0.2517
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.05 0.3006 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.05 0.3006 1
Schistosoma mansoni hypothetical protein 0.0036 0.0171 0.057
Schistosoma mansoni cpg binding protein 0.0058 0.0303 0.1007
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0195 0.1143 0.5864
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0061 0.0186
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Echinococcus multilocularis ferritin 0.0009 0.0005 0.0001
Schistosoma mansoni dihydroorotate dehydrogenase 0.05 0.3006 1
Echinococcus multilocularis neurogenic locus notch protein 0.0116 0.0659 0.0655
Echinococcus multilocularis protein jagged 1 0.0116 0.0659 0.0655
Mycobacterium tuberculosis Conserved protein 0.0071 0.0385 0.1266
Echinococcus granulosus neurogenic locus notch protein 4 0.0116 0.0659 0.3372
Schistosoma mansoni apoferritin-2 0.0009 0.0005 0.0017
Schistosoma mansoni laminin gamma-3 chain 0.0116 0.0659 0.2193
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0385 0.1266
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0385 0.1266
Echinococcus multilocularis neural cadherin 0.0116 0.0659 0.0655
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0385 0.225
Echinococcus multilocularis neurogenic locus protein delta 0.0116 0.0659 0.0655
Leishmania major dihydroorotate dehydrogenase 0.05 0.3006 1
Schistosoma mansoni hypothetical protein 0.0116 0.0659 0.2193
Echinococcus granulosus protein jagged 2 0.0116 0.0659 0.3372
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0037 0.0168
Brugia malayi TAR-binding protein 0.0327 0.1945 0.6467
Brugia malayi Trypsin-like protease protein 5 0.0056 0.0292 0.0956
Toxoplasma gondii EGF family domain-containing protein 0.0116 0.0659 0.2031
Trichomonas vaginalis esterase, putative 0.0071 0.0385 0.225
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.05 0.3006 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0029 0.0144
Echinococcus multilocularis tar DNA binding protein 0.0327 0.1945 0.1942
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0029 0.0144
Mycobacterium tuberculosis Conserved protein 0.0071 0.0385 0.1266
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0385 0.1266
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0385 0.225
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0385 0.1266
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0336 0.0331
Loa Loa (eye worm) hypothetical protein 0.0071 0.0385 0.1961
Loa Loa (eye worm) hypothetical protein 0.0056 0.0292 0.1479
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.05 0.3006 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0144
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0061 0.0331
Brugia malayi RNA recognition motif domain containing protein 0.0327 0.1945 0.6467
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0543 0.2772
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0195 0.1143 0.1139
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0385 0.1281
Schistosoma mansoni smad1 5 8 and 0.0009 0.0005 0.0015
Echinococcus granulosus protein jagged 1 0.0116 0.0659 0.3372
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0543 0.0538
Brugia malayi EGF-like domain containing protein 0.0116 0.0659 0.2181
Echinococcus granulosus protein jagged 2 0.0116 0.0659 0.3372
Onchocerca volvulus 0.0116 0.0659 0.2421
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0144
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0056 0.0292 0.0287
Loa Loa (eye worm) hypothetical protein 0.0116 0.0659 0.3372
Loa Loa (eye worm) hypothetical protein 0.0056 0.0292 0.1479
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.117 0.6007
Schistosoma mansoni notch 0.0116 0.0659 0.2193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0385 0.1281
Schistosoma mansoni smad1 5 8 and 0.0009 0.0005 0.0015
Entamoeba histolytica hypothetical protein 0.0036 0.0171 0.1019
Echinococcus multilocularis expressed protein 0.0009 0.0005 0.0001
Echinococcus granulosus fibropellin Ia 0.0116 0.0659 0.3372
Schistosoma mansoni egf-like domain protein 0.0304 0.1809 0.602
Schistosoma mansoni slit 0.0116 0.0659 0.2193
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0336 0.1706
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0385 0.1101
Loa Loa (eye worm) hypothetical protein 0.0056 0.0292 0.1479
Schistosoma mansoni ferritin 0.0009 0.0005 0.0017
Onchocerca volvulus 0.0058 0.0303 0.0074
Schistosoma mansoni notch 0.0116 0.0659 0.2193
Brugia malayi EGF-like domain containing protein 0.0116 0.0659 0.2181
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Schistosoma mansoni ferritin 0.0009 0.0005 0.0017
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0385 0.1266
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0061 0.0186
Mycobacterium ulcerans lipase LipD 0.0071 0.0385 0.1266
Loa Loa (eye worm) hypothetical protein 0.0137 0.0784 0.4016
Schistosoma mansoni cercarial elastase (S01 family) 0.0056 0.0292 0.097
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0215 0.1421
Onchocerca volvulus 0.0071 0.0385 0.0617
Entamoeba histolytica hypothetical protein 0.0036 0.0171 0.1019
Brugia malayi Trypsin family protein 0.0056 0.0292 0.0956
Toxoplasma gondii calcium binding egf domain-containing protein 0.0304 0.1809 0.5938
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.05 0.3006 1
Schistosoma mansoni notch 0.0116 0.0659 0.2193
Brugia malayi beta-lactamase family protein 0.0071 0.0385 0.1268
Onchocerca volvulus 0.0116 0.0659 0.2421
Brugia malayi Calcium binding EGF domain containing protein 0.0116 0.0659 0.2181

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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