Detailed information for compound 706999

Basic information

Technical information
  • TDR Targets ID: 706999
  • Name: 1-(3-hydroxyphenyl)-2-methyl-1H-chromeno[2,3- c]pyrrole-3,9-dione
  • MW: 307.3 | Formula: C18H13NO4
  • H donors: 1 H acceptors: 3 LogP: 2.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)C1N(C)C(=O)c2c1c(=O)c1c(o2)cccc1
  • InChi: 1S/C18H13NO4/c1-19-15(10-5-4-6-11(20)9-10)14-16(21)12-7-2-3-8-13(12)23-17(14)18(19)22/h2-9,15,20H,1H3
  • InChiKey: CDFIAMWLXXKWBN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-hydroxyphenyl)-2-methyl-1H-chromeno[2,3-c]pyrrole-3,9-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0049 0.0981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0129 0.2599
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0036 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0075 0.1461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0075 0.1461
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0579 0.056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0063 0.1202
Echinococcus multilocularis tumor protein p63 0.0343 0.1585 0.1568
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0049 0.0029
Entamoeba histolytica hypothetical protein 0.0072 0.0292 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0143 0.2951
Brugia malayi beta-lactamase family protein 0.0111 0.0481 0.17
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0049 0.0916
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0481 0.1309
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0053 0.1106
Onchocerca volvulus 0.0111 0.0481 0.1398
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0002 0.0042
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.002 0.0037
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0123 0.0224
Brugia malayi RNA recognition motif domain containing protein 0.0583 0.2733 1
Loa Loa (eye worm) beta-lactamase 0.0111 0.0481 0.1753
Entamoeba histolytica hypothetical protein 0.0072 0.0292 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0049 0.0172
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0143 0.2709
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0481 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0063 0.1202
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0133 0.0114
Schistosoma mansoni hypothetical protein 0.0111 0.0479 0.0477
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2733 0.2732
Loa Loa (eye worm) TAR-binding protein 0.0583 0.2733 1
Brugia malayi hypothetical protein 0.0488 0.2281 0.8334
Loa Loa (eye worm) hypothetical protein 0.0022 0.0053 0.0187
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0053 0.1106
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0172
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0143 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.016 0.3248
Schistosoma mansoni DNA polymerase eta 0.0021 0.0049 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0063 0.1206
Loa Loa (eye worm) inositol-1 0.0041 0.0143 0.0517
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0269 0.0267
Leishmania major DNA polymerase eta, putative 0.0021 0.0049 0.0637
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.016 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.016 0.3248
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0053 0.0034
Mycobacterium ulcerans lipase LipD 0.0111 0.0481 1
Brugia malayi Latrophilin receptor protein 2 0.0111 0.0479 0.1694
Loa Loa (eye worm) hypothetical protein 0.0111 0.0481 0.1753
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0049 0.0029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0292 0.0273
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0049 0.168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0481 0.0479
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0269 0.5585
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0269 0.5397
Loa Loa (eye worm) hypothetical protein 0.005 0.0188 0.0682
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0049 0.0981
Schistosoma mansoni hypothetical protein 0.0122 0.0532 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0106 0.2111
Toxoplasma gondii ABC1 family protein 0.0111 0.0481 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0143 0.2184
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.002 0.0367
Loa Loa (eye worm) hypothetical protein 0.0111 0.0481 0.1753
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0481 0.1309
Schistosoma mansoni DNA helicase recq5 0.0022 0.0053 0.0051
Brugia malayi Inositol-1 0.0041 0.0143 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0086 0.1691
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Loa Loa (eye worm) hypothetical protein 0.0488 0.2281 0.8344
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.0479 0.0461
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0053 0.0124
Loa Loa (eye worm) hypothetical protein 0.0111 0.0481 0.1753
Echinococcus multilocularis microtubule associated protein 2 0.2105 1 1
Brugia malayi beta-lactamase family protein 0.0111 0.0481 0.17
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0053 0.0034
Schistosoma mansoni lozenge 0.0061 0.0241 0.0239
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0351 0.1625 0.5943
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0292 0.029
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.016 0.3066
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0053 0.0378
Brugia malayi TAR-binding protein 0.0583 0.2733 1
Onchocerca volvulus 0.0111 0.0481 0.1398
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.0479 0.0461
Echinococcus multilocularis dna polymerase eta 0.0021 0.0049 0.0029
Loa Loa (eye worm) hypothetical protein 0.0351 0.1625 0.5943
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.002 0.0298
Echinococcus granulosus dna polymerase eta 0.0021 0.0049 0.0029
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0143 0.298
Schistosoma mansoni DNA helicase recq1 0.0022 0.0053 0.0051
Brugia malayi RNA binding protein 0.0583 0.2733 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0481 0.1309
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0143 0.29
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0143 0.2682
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0053 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0106 0.2111
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0002 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0074 0.1435
Schistosoma mansoni inositol monophosphatase 0.0041 0.0143 0.0141
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0481 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0481 0.1309
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0053 0.0034
Mycobacterium ulcerans beta-lactamase 0.0111 0.0481 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0481 0.0479
Trypanosoma brucei unspecified product 0.0021 0.0049 0.0672
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0049 0.0672
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.002 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.002 0.0298
Onchocerca volvulus 0.0111 0.0481 0.1398
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2733 0.2732
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.016 0.3296
Trichomonas vaginalis esterase, putative 0.0111 0.0481 1
Mycobacterium tuberculosis Conserved protein 0.0111 0.0481 0.1309
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0117 0.2398
Loa Loa (eye worm) hypothetical protein 0.0111 0.0481 0.1753
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0188 0.0186
Entamoeba histolytica hypothetical protein 0.0072 0.0292 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0053 0.0034
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.016 0.548
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0053 0.1004
Brugia malayi hypothetical protein 0.0072 0.0292 0.1003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0269 0.5084
Echinococcus granulosus dna polymerase kappa 0.0021 0.0049 0.0029
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0002 0.0069
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0481 0.17
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0481 0.1309
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0269 0.0249
Mycobacterium leprae Probable lipase LipE 0.0111 0.0481 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0049 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0133 0.0131
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0143 0.2951
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Brugia malayi Calcitonin receptor-like protein seb-1 0.0351 0.1625 0.5917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0133 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0481 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0063 0.1202
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0133 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2733 0.2732
Brugia malayi follicle stimulating hormone receptor 0.0252 0.1151 0.4169
Loa Loa (eye worm) RNA binding protein 0.0583 0.2733 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0075 0.1461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0063 0.1206
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.016 0.0141
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0053 0.1004
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2733 0.2732
Echinococcus granulosus GPCR family 2 0.0111 0.0479 0.0461
Loa Loa (eye worm) RecQ helicase 0.0022 0.0053 0.0187
Schistosoma mansoni hypothetical protein 0.0111 0.0479 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0074 0.1435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0106 0.2111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0133 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0106 0.2111
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0481 0.1309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0117 0.234
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.0479 0.0461
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0117 0.2137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0117 0.234
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0712 0.3348 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.016 0.0141
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0579 0.0577
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.016 0.548
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0532 0.0513
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0049 0.0029
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0269 0.0267
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0053 0.0124
Loa Loa (eye worm) hypothetical protein 0.0111 0.0481 0.1753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.002 0.0298
Giardia lamblia GTOR 0.0044 0.016 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.002 0.0298
Brugia malayi beta-lactamase 0.0111 0.0481 0.17
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0481 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.002 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0481 1
Brugia malayi latrophilin 2 splice variant baaae 0.024 0.1095 0.3962
Echinococcus multilocularis Protein lozenge 0.0061 0.0241 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.016 0.3248
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0269 0.0666
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0049 0.0981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0117 0.234
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.016 0.3296
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.0479 0.1747
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.0479 0.0461
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0053 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0106 0.2111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0106 0.2111
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.1151 0.4207
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0269 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0117 0.234
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0579 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.009 0.1787
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0292 0.0273
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.016 0.3041
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.016 0.0158
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0049 0.0664
Schistosoma mansoni microtubule-associated protein tau 0.2105 1 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0053 0.0728
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0049 0.0981
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0269 0.5084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0049 0.0981
Loa Loa (eye worm) hypothetical protein 0.0488 0.2281 0.8344
Leishmania major DNA polymerase kappa, putative 0.0021 0.0049 0.0637
Schistosoma mansoni hypothetical protein 0.0072 0.0292 0.029
Loa Loa (eye worm) runx1 0.0061 0.0241 0.0876
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.016 0.3041
Schistosoma mansoni hypothetical protein 0.024 0.1095 0.1093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0063 0.1206
Onchocerca volvulus 0.0488 0.2281 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0053 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.00000000015755
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0143 0.29
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0106 0.22
Schistosoma mansoni tar DNA-binding protein 0.0583 0.2733 0.2732
Leishmania major hypothetical protein, conserved 0.0111 0.0481 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.016 0.0517
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0133 0.0114
Echinococcus granulosus bloom syndrome protein 0.0022 0.0053 0.0034
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.002 0.0037
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0481 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.002 0.0298
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0481 0.0462
Echinococcus granulosus tar DNA binding protein 0.0583 0.2733 0.2719
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0351 0.1625 0.5917
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0053 0.0124
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0143 0.5
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0481 0.0462
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0039 0.0133 0.0418
Mycobacterium ulcerans hypothetical protein 0.0111 0.0481 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0049 0.0672
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0143 0.0124
Loa Loa (eye worm) hypothetical protein 0.0111 0.0481 0.1753
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0053 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0106 0.2111
Echinococcus multilocularis tar DNA binding protein 0.0583 0.2733 0.2719
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0481 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0133 0.0114
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.002 0.0064
Echinococcus granulosus tumor protein p63 0.0343 0.1585 0.1568
Schistosoma mansoni hypothetical protein 0.0111 0.0479 0.0477
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0053 0.1069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0269 0.5084
Schistosoma mansoni hypothetical protein 0.0111 0.0479 0.0477
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0049 0.0672
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0053 0.0187
Loa Loa (eye worm) hypothetical protein 0.024 0.1095 0.4001
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.016 0.3066
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0481 0.1309
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0049 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0481 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0049 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Mycobacterium tuberculosis Conserved protein 0.0111 0.0481 0.1309
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0481 0.1753
Echinococcus multilocularis GPCR, family 2 0.0111 0.0479 0.0461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0583 0.2733 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0053 0.1004
Mycobacterium tuberculosis Conserved protein 0.0111 0.0481 0.1309
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0049 0.0672
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0143 0.29
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0049 0.0672
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0481 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.0479 0.1694
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0053 0.0034
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0532 0.0513
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0143 0.4913
Entamoeba histolytica hypothetical protein 0.0072 0.0292 1
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0481 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0049 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0063 0.1206
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0117 0.2109
Schistosoma mansoni inositol monophosphatase 0.0041 0.0143 0.0141
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0481 1
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0002 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0039 0.0133 0.0479
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0049 0.0637
Loa Loa (eye worm) hypothetical protein 0.0111 0.0479 0.1747
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0117 0.234

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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