Detailed information for compound 707001

Basic information

Technical information
  • TDR Targets ID: 707001
  • Name: 1-(2-ethoxy-5-iodophenyl)-N-(phenylmethyl)met hanamine
  • MW: 367.225 | Formula: C16H18INO
  • H donors: 1 H acceptors: 0 LogP: 3.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1CNCc1ccccc1)I
  • InChi: 1S/C16H18INO/c1-2-19-16-9-8-15(17)10-14(16)12-18-11-13-6-4-3-5-7-13/h3-10,18H,2,11-12H2,1H3
  • InChiKey: DZOLIXZJRSSBQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-ethoxy-5-iodo-phenyl)-N-(phenylmethyl)methanamine
  • benzyl-(2-ethoxy-5-iodo-benzyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi intermediate filament protein 0.0026 0.0114 0.0215
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0241 0.0227
Schistosoma mansoni microtubule-associated protein tau 0.1377 1 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0094 0.1901
Onchocerca volvulus 0.0467 0.334 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0111 0.2263
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0391 0.8381
Entamoeba histolytica hypothetical protein 0.004 0.0213 0.8839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0469
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0241 0.0524
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0222 0.0483
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0029 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0111 0.2263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0113 0.2304
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0159 0.3437
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0054 0.0877
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0241 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0391 0.0391
Brugia malayi follicle stimulating hormone receptor 0.0237 0.1658 0.3585
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0241 0.5039
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0308
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0207 0.4284
Brugia malayi hypothetical protein 0.0467 0.334 0.7254
Loa Loa (eye worm) hypothetical protein 0.0041 0.0222 0.0483
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0029 0.0014
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0463 1
Loa Loa (eye worm) beta-lactamase 0.0074 0.0463 0.1007
Loa Loa (eye worm) runx1 0.0059 0.0351 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0094 0.1896
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0032
Onchocerca volvulus 0.0049 0.0284 0.0527
Echinococcus multilocularis thyroid hormone receptor alpha 0.0131 0.0884 0.087
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0222 0.4619
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0129 0.254
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0075 0.148
Entamoeba histolytica hypothetical protein 0.004 0.0213 0.8839
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0213 0.0213
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0075 1
Schistosoma mansoni hypothetical protein 0.0241 0.1685 0.1685
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0463 1
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0222 0.0451
Mycobacterium ulcerans hypothetical protein 0.0074 0.0463 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0222 0.014
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0241 0.5039
Schistosoma mansoni tar DNA-binding protein 0.0639 0.4599 0.4599
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0222 0.4619
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0207 0.4379
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0308
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0222 0.4619
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0213 0.0199
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0213
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0075 0.1335
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0241 0.5039
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0463 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0463 1
Schistosoma mansoni DNA helicase recq5 0.0021 0.0075 0.0075
Mycobacterium tuberculosis Conserved protein 0.0074 0.0463 0.0893
Loa Loa (eye worm) hypothetical protein 0.0241 0.1685 0.3664
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0025 0.0054
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0241 0.0227
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0241 1
Schistosoma mansoni hypothetical protein 0.0122 0.0812 0.0812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0241 0.5121
Schistosoma mansoni thyroid hormone receptor 0.0131 0.0884 0.0884
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0391 0.8381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0159 0.3328
Schistosoma mansoni intermediate filament proteins 0.0026 0.0114 0.0114
Onchocerca volvulus 0.0074 0.0463 0.1083
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0073 0.1287
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0222 0.4619
Leishmania major DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Echinococcus granulosus bloom syndrome protein 0.0021 0.0075 0.0061
Loa Loa (eye worm) hypothetical protein 0.0074 0.0463 0.1007
Brugia malayi beta-lactamase family protein 0.0074 0.0463 0.0977
Echinococcus multilocularis Protein lozenge 0.0059 0.0351 0.0337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0469
Loa Loa (eye worm) TAR-binding protein 0.0639 0.4599 1
Loa Loa (eye worm) inositol-1 0.0039 0.0207 0.045
Schistosoma mansoni tar DNA-binding protein 0.0639 0.4599 0.4599
Trypanosoma brucei unspecified product 0.0028 0.0129 0.254
Loa Loa (eye worm) hypothetical protein 0.0074 0.0463 0.1007
Brugia malayi Inositol-1 0.0039 0.0207 0.0419
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0222 0.4709
Loa Loa (eye worm) latrophilin receptor protein 2 0.0112 0.0738 0.1605
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0207 0.4379
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0352 0.2501 0.5424
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0129 0.254
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Leishmania major hypothetical protein, conserved 0.0074 0.0463 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0207 0.4284
Brugia malayi latrophilin 2 splice variant baaae 0.0241 0.1685 0.3643
Brugia malayi RNA binding protein 0.0639 0.4599 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0391 0.0377
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0463 0.0893
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0207 0.4284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0094 0.1896
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0222 0.0208
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0112 0.0738 0.1577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0094 0.1901
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0308
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0463 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0812 0.0799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0129 0.2666
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0075 0.013
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0075 0.1335
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0463 0.0463
Leishmania major DNA polymerase eta, putative 0.0041 0.0222 0.4619
Echinococcus granulosus dna polymerase kappa 0.0041 0.0222 0.0208
Echinococcus multilocularis dna polymerase eta 0.0041 0.0222 0.0208
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0463 0.0893
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0075 0.148
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0241 0.5039
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.1658 0.3606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0469
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0112 0.0738 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0159 0.3328
Schistosoma mansoni tar DNA-binding protein 0.0639 0.4599 0.4599
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0114 0.0215
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0463 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0075 0.0061
Mycobacterium tuberculosis Conserved protein 0.0074 0.0463 0.0893
Mycobacterium ulcerans beta-lactamase 0.0074 0.0463 1
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0075 0.3113
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0112 0.0738 0.0725
Loa Loa (eye worm) hypothetical protein 0.0074 0.0463 0.1007
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0463 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0176 0.3689
Entamoeba histolytica hypothetical protein 0.004 0.0213 0.8839
Onchocerca volvulus 0.0074 0.0463 0.1083
Brugia malayi TAR-binding protein 0.0639 0.4599 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0463 0.0893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0113 0.2304
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0463 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0159 0.3328
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0075 1
Schistosoma mansoni hypothetical protein 0.0112 0.0738 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0241 0.5121
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0176 0.3588
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0222 0.4619
Loa Loa (eye worm) hypothetical protein 0.0021 0.0075 0.0163
Echinococcus granulosus tumor protein p63 0.0338 0.2393 0.2382
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0222 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0176 0.3689
Brugia malayi beta-lactamase 0.0074 0.0463 0.0977
Loa Loa (eye worm) RecQ helicase 0.0021 0.0075 0.0163
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0222 0.4619
Schistosoma mansoni lamin 0.0026 0.0114 0.0114
Entamoeba histolytica hypothetical protein 0.004 0.0213 0.8839
Brugia malayi RNA recognition motif domain containing protein 0.0639 0.4599 1
Mycobacterium ulcerans lipase LipD 0.0074 0.0463 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0222 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0176 0.3689
Schistosoma mansoni hypothetical protein 0.0112 0.0738 0.0738
Giardia lamblia DINP protein human, muc B family 0.0041 0.0222 0.9168
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0222 0.0222
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0029 0.0014
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0075 0.0061
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0463 0.0893
Loa Loa (eye worm) hypothetical protein 0.0352 0.2501 0.5439
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0639 0.4599 1
Giardia lamblia GTOR 0.0044 0.0241 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0015 0.0328
Echinococcus multilocularis lamin 0.0026 0.0114 0.0099
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0812 0.0799
Schistosoma mansoni hypothetical protein 0.0112 0.0738 0.0738
Echinococcus multilocularis musashi 0.0026 0.0114 0.0099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0241 0.0492
Schistosoma mansoni lozenge 0.0059 0.0351 0.0351
Schistosoma mansoni DNA helicase recq1 0.0021 0.0075 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0129 0.254
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Loa Loa (eye worm) hypothetical protein 0.0112 0.0738 0.1605
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0213 0.0199
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0222 0.9221
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0222 0.4619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0113 0.2304
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0176 0.3588
Mycobacterium leprae Probable lipase LipE 0.0074 0.0463 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0114 0.0247
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0207 0.4284
Loa Loa (eye worm) hypothetical protein 0.0049 0.0284 0.0617
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0222 0.0208
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0029 0.0063
Treponema pallidum ATP-dependent DNA helicase 0.0011 0 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0463 1
Onchocerca volvulus 0.0074 0.0463 0.1083
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0391 0.0391
Echinococcus multilocularis lamin dm0 0.0026 0.0114 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0469
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0391 0.8381
Toxoplasma gondii ABC1 family protein 0.0074 0.0463 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0308
Echinococcus granulosus lamin 0.0026 0.0114 0.0099
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0463 0.0977
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0112 0.0738 0.0725
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0075 0.148
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.3379 1
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0222 0.0451
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0075 0.1619
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0463 0.0449
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0075 0.265
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0241 0.5039
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Schistosoma mansoni tar DNA-binding protein 0.0639 0.4599 0.4599
Loa Loa (eye worm) hypothetical protein 0.0467 0.334 0.7263
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0207 0.0193
Echinococcus granulosus tar DNA binding protein 0.0639 0.4599 0.4591
Echinococcus granulosus GPCR family 2 0.0112 0.0738 0.0725
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0176 0.3689
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0015 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0159 0.3328
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0207 0.4471
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0207 0.5
Schistosoma mansoni thyroid hormone receptor 0.0131 0.0884 0.0884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0094 0.1896
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0075 0.1335
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0075 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0015 0.0328
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0463 0.0893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0094 0.1901
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0159 0.3328
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0463 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0207 0.8597
Echinococcus multilocularis tumor protein p63 0.0338 0.2393 0.2382
Echinococcus granulosus lamin dm0 0.0026 0.0114 0.0099
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0391 0.8381
Trichomonas vaginalis esterase, putative 0.0074 0.0463 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0463 0.1007
Echinococcus granulosus dna polymerase eta 0.0041 0.0222 0.0208
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0241 0.5039
Mycobacterium tuberculosis Conserved protein 0.0074 0.0463 0.0893
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0029 0.0308
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0284 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0094 0.1901
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0075 0.1619
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0463 0.0893
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0241 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0159 0.3328
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0391 0.0667
Trypanosoma brucei unspecified product 0.0041 0.0222 0.4619
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0391 0.8434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0159 0.3328
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0033
Brugia malayi hypothetical protein 0.004 0.0213 0.0431
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0029 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0222 0.4709
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0075 0.0163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0207 0.4284
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0463 0.1007
Schistosoma mansoni tar DNA-binding protein 0.0639 0.4599 0.4599
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Schistosoma mansoni DNA polymerase eta 0.0041 0.0222 0.0222
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0207 0.0193
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0075 0.0061
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0075 0.013
Echinococcus multilocularis tar DNA binding protein 0.0639 0.4599 0.4591
Schistosoma mansoni hypothetical protein 0.0112 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0074 0.0463 0.1007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0463 0.0449
Trypanosoma brucei unspecified product 0.0028 0.0129 0.254
Brugia malayi beta-lactamase family protein 0.0074 0.0463 0.0977
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0112 0.0738 0.0725
Echinococcus granulosus intermediate filament protein 0.0026 0.0114 0.0099
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0114 0.0247
Brugia malayi Latrophilin receptor protein 2 0.0112 0.0738 0.1577
Loa Loa (eye worm) hypothetical protein 0.0074 0.0463 0.1007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0029 0.0469
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0025 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0352 0.2501 0.5439
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0029 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0241 0.5121
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0391 0.0377
Loa Loa (eye worm) RNA binding protein 0.0639 0.4599 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0207 0.4379
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0222 0.4619
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0075 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0222 0.4619
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0075 0.013
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0176 0.3689
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0015 0.0328
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0114 0.0247
Brugia malayi Calcitonin receptor-like protein seb-1 0.0352 0.2501 0.5424
Schistosoma mansoni lamin 0.0026 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0467 0.334 0.7263
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0015 0.0015
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0463 0.0893
Echinococcus multilocularis GPCR, family 2 0.0112 0.0738 0.0725
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0463 0.0463
Schistosoma mansoni inositol monophosphatase 0.0039 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0194 0.4098
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0222 0.014
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0463 1
Echinococcus multilocularis microtubule associated protein 2 0.1377 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0136 0.2817
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0463 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0176 0.3588

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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