Detailed information for compound 707754

Basic information

Technical information
  • TDR Targets ID: 707754
  • Name: 8-Chloro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro- 3H-cyclopenta[c]quinoline
  • MW: 282.767 | Formula: C17H15ClN2
  • H donors: 1 H acceptors: 1 LogP: 3.93 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)C1C=CCC1C(N2)c1cccnc1
  • InChi: 1S/C17H15ClN2/c18-12-6-7-16-15(9-12)13-4-1-5-14(13)17(20-16)11-3-2-8-19-10-11/h1-4,6-10,13-14,17,20H,5H2
  • InChiKey: HXRTXXXBRLLKPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-chloro-4-(3-pyridyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
  • BAS 06592047
  • EU-0081208

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.2093 0.3668
Loa Loa (eye worm) hypothetical protein 0.004 0.1034 0.1132
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0537 0.0894
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0537 0.0894
Entamoeba histolytica hypothetical protein 0.0037 0.0918 0.9282
Loa Loa (eye worm) hypothetical protein 0.0074 0.2604 0.2951
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0537 0.2354
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0918 0.1528
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0985 1
Onchocerca volvulus 0.0029 0.0537 0.0476
Schistosoma mansoni bromodomain containing protein 0.0069 0.2408 0.4006
Plasmodium vivax SET domain protein, putative 0.0029 0.0537 0.3972
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.1364 0.227
Schistosoma mansoni lipoxygenase 0.0019 0.0064 0.0107
Schistosoma mansoni hypothetical protein 0.0019 0.0064 0.0107
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.1364 0.2391
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0174 0.0134
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.2093 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.1364 0.227
Schistosoma mansoni zinc finger protein 0.0024 0.0287 0.0478
Echinococcus granulosus zinc finger protein 0.0024 0.0287 0.0503
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0058 0.0101
Loa Loa (eye worm) hypothetical protein 0.0046 0.1314 0.1456
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0266 0.0443
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.5707 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0287 0.0478
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0266 0.0467
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.601 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.2093 0.3483
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0916 0.1524
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0266 0.0443
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.2093 1
Schistosoma mansoni ap endonuclease 0.0019 0.0058 0.0096
Loa Loa (eye worm) hypothetical protein 0.0048 0.1407 0.1563
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0194 0.0158
Schistosoma mansoni hypothetical protein 0.0036 0.0843 0.1402
Loa Loa (eye worm) hypothetical protein 0.0047 0.1364 0.1514
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0916 0.1605
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0537 0.0894
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0064 0.0054
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0985 1
Entamoeba histolytica hypothetical protein 0.0037 0.0918 0.9282
Entamoeba histolytica hypothetical protein 0.0037 0.0918 0.9282
Schistosoma mansoni rab6-interacting 0.0019 0.0064 0.0107
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.2234 0.3915
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.167 0.2926
Brugia malayi hypothetical protein 0.0019 0.0064 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0058 0.5
Brugia malayi Pre-SET motif family protein 0.0029 0.0537 0.0555
Schistosoma mansoni polycystin 1-related 0.0019 0.0064 0.0107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1616 0.1806
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0058 0.0096
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.601 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0985 1
Echinococcus multilocularis RUN 0.0019 0.0064 0.0107
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.1264 0.1214
Brugia malayi Doublecortin family protein 0.0019 0.0064 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.2093 1
Schistosoma mansoni loxhd1 0.0019 0.0064 0.0107
Brugia malayi Bromodomain containing protein 0.0043 0.1196 0.1319
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.1264 0.1214
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0918 0.1528
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0064 0.0113
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0064 0.0107
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0843 0.091
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.1264 0.5928
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0064 0.0113
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0058 0.5
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.1264 0.2216
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0064 0.0071
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.2093 0.3483
Brugia malayi Bromodomain containing protein 0.0082 0.2976 0.3383
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0918 0.1609
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0058 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.8686 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0064 0.0107
Trichomonas vaginalis set domain proteins, putative 0.0232 1 1
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.601 0.6899
Schistosoma mansoni ap endonuclease 0.0019 0.0058 0.0096
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0008
Schistosoma mansoni rab6-interacting 0.0019 0.0064 0.0107
Brugia malayi PHD-finger family protein 0.0029 0.0546 0.0566
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.2093 1
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0064 0.0008
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.167 0.2778
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0058 0.5
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0064 0.0107
Loa Loa (eye worm) acetyltransferase 0.0147 0.601 0.6899
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.1264 1
Entamoeba histolytica hypothetical protein 0.0037 0.0918 0.9282
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.2093 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1616 0.1806
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0058 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0008
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0487 0.0853
Loa Loa (eye worm) hypothetical protein 0.0036 0.0843 0.091
Brugia malayi Pre-SET motif family protein 0.0204 0.8686 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1616 0.1806
Schistosoma mansoni lipoxygenase 0.0054 0.167 0.2778
Loa Loa (eye worm) hypothetical protein 0.0052 0.1616 0.1806
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.1364 0.227
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.2093 0.3483
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.1264 0.5928
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0064 0.0113
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.2234 0.3717
Schistosoma mansoni hypothetical protein 0.0021 0.0174 0.0289
Schistosoma mansoni hypothetical protein 0.0037 0.0918 0.1528
Echinococcus granulosus RUN 0.0019 0.0064 0.0113
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.2093 1
Brugia malayi hypothetical protein 0.0037 0.0918 0.0997
Brugia malayi hypothetical protein 0.0019 0.0064 0.0008

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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