Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.1735 | 0.3215 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0534 | 0.06 |
Schistosoma mansoni | loxhd1 | 0.0021 | 0.0024 | 0.0042 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.092 | 0.1705 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1405 | 0.1605 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0048 | 0.1169 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0923 | 0.162 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1365 | 0.1559 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0923 | 0.1048 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0923 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1316 | 0.1502 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0025 | 0.0187 | 0.02 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.1735 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0923 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0483 | 0.0896 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0058 | 0.1563 | 0.2896 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0534 | 0.0937 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0024 | 0.0044 |
Brugia malayi | Doublecortin family protein | 0.0021 | 0.0024 | 0.0012 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0923 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1735 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0027 | 0.028 | 0.0492 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.092 | 0.1616 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0024 | 0.0042 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0048 | 0.1169 | 0.2165 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0053 | 0.1365 | 0.2529 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0074 | 0.2236 | 0.3927 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1316 | 0.1502 |
Brugia malayi | Bromodomain containing protein | 0.0049 | 0.1193 | 0.136 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0923 | 0.162 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.023 | 0.8685 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0024 | 0.0012 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0042 | 0.0896 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0013 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1039 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0636 | 0.0718 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0021 | 0.0024 | 0.012 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0158 | 0.5693 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0534 | 0.0937 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0923 | 0.1709 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0048 | 0.1169 | 0.1157 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0013 | 0.5 |
Loa Loa (eye worm) | doublecortin family protein | 0.0021 | 0.0024 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.2616 | 0.3002 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0024 | 0.0042 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.1365 | 0.2397 |
Brugia malayi | Pre-SET motif family protein | 0.023 | 0.8685 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0021 | 0.0024 | 0.0042 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0048 | 0.1169 | 0.6711 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0636 | 0.0718 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0048 | 0.1169 | 0.6711 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1312 | 0.1497 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0021 | 0.0024 | 0.0092 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0534 | 0.3022 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0175 | 0.0307 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1735 | 0.3048 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0074 | 0.2236 | 0.4142 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0268 | 0.0496 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.1735 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0058 | 0.1563 | 0.2746 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0268 | 0.047 |
Echinococcus multilocularis | RUN | 0.0021 | 0.0024 | 0.0042 |
Trichomonas vaginalis | set domain proteins, putative | 0.0262 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1735 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0042 | 0.0896 | 0.9713 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0048 | 0.1169 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1316 | 0.1502 |
Onchocerca volvulus | 0.0033 | 0.0534 | 0.0511 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.1735 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1735 | 1 |
Brugia malayi | PHD-finger family protein | 0.0033 | 0.054 | 0.0607 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1735 | 0.3048 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0534 | 0.4503 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0024 | 0.0012 |
Echinococcus granulosus | RUN | 0.0021 | 0.0024 | 0.0044 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0013 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0013 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0024 | 0.0012 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0013 | 0.5 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0021 | 0.0024 | 0.0044 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0024 | 0.0042 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0013 | 0.0025 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0534 | 0.0937 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0053 | 0.1365 | 0.2397 |
Schistosoma mansoni | lipoxygenase | 0.0058 | 0.1563 | 0.2746 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0158 | 0.5693 | 0.655 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.015 | 0.5398 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0158 | 0.5693 | 0.655 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0158 | 0.5693 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0092 | 0.2982 | 0.3423 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0923 | 0.162 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0024 | 0.0044 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0268 | 0.047 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0013 | 0.0023 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.1735 | 0.3048 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0013 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1316 | 0.1502 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0024 | 0.0012 |
Echinococcus granulosus | zinc finger protein | 0.0027 | 0.028 | 0.0519 |
Schistosoma mansoni | zinc finger protein | 0.0027 | 0.028 | 0.0492 |
Schistosoma mansoni | polycystin 1-related | 0.0021 | 0.0024 | 0.0042 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0024 | 0.0042 |
Schistosoma mansoni | bromodomain containing protein | 0.0078 | 0.2411 | 0.4234 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0923 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0636 | 0.1118 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0042 | 0.0896 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0013 | 0.0023 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0024 | 0.0042 |
Schistosoma mansoni | lipoxygenase | 0.0021 | 0.0024 | 0.0042 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0053 | 0.1365 | 0.2397 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0175 | 0.0186 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.