TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 545.543 | Formula: C28H27N5O7
H donors: 2 H acceptors: 5 LogP: 1.21 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCOc1ccc2c(c1)[C@@H](N([C@@H]2c1ccc2c(c1)OCO2)CC(=O)O)c1ccc(cc1OCc1nn[nH]n1)OC
InChi: 1S/C28H27N5O7/c1-3-37-18-6-7-19-21(11-18)28(20-8-5-17(36-2)12-23(20)38-14-25-29-31-32-30-25)33(13-26(34)35)27(19)16-4-9-22-24(10-16)40-15-39-22/h4-12,27-28H,3,13-15H2,1-2H3,(H,34,35)(H,29,30,31,32)/t27-,28+/m1/s1
InChiKey: DKZVMSFPFHQYJP-IZLXSDGUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	endothelin receptor type B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0068	0.0047	0.0047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0013	0.0013
Leishmania major	protein kinase, putative	0.0068	0.0048	0.0057
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Onchocerca volvulus		0.0028	0.0013	0.0604
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0068	0.0047	0.0119
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.14	0.1218	1
Entamoeba histolytica	cysteine surface protein, putative	0.0068	0.0047	0.7806
Giardia lamblia	Kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	protein dispatched 1	0.1229	0.1067	0.1067
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0047	0.0047
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0068	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.0028	0.0013	0.0013
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Onchocerca volvulus		0.0028	0.0013	0.0604
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0047	0.0047
Onchocerca volvulus		0.0028	0.0013	0.0604
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0068	0.0048	0.0057
Schistosoma mansoni	amine GPCR	0.0028	0.0013	0.0013
Loa Loa (eye worm)	serine/threonine protein kinase	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0015	0.0001	0.0001
Brugia malayi	G-protein coupled receptor	0.0028	0.0013	0.0012
Brugia malayi	ephrin receptor 1 precursor	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Echinococcus granulosus	ecdysone induced protein 78C	0.0015	0.0001	0.0001
Onchocerca volvulus		0.0028	0.0013	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.0013	0.0013
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0248	0.0206	0.0205
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.0013	0.0013
Plasmodium falciparum	protein kinase, putative	0.0068	0.0047	0.9667
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.2985	0.2609	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0068	0.0047	0.0119
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	tyrosine kinase	1.1399	1	1
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0068	0.0048	0.0048
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.0013	0.0013
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.0013	0.0012
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0013	0.0013
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.0013	0.0013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0015	0.0001	0.0000060276
Schistosoma mansoni	tyrosine kinase	0.6126	0.5369	0.5369
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0077	0.0055	0.0055
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Trichomonas vaginalis	CAMK family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.0013	0.0012
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0013	0.0013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0015	0.0001	0.0000060276
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0001	0.0001
Echinococcus granulosus	cyclin dependent kinase	0.0052	0.0033	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.0013	0.0013
Onchocerca volvulus		0.0166	0.0133	0.6807
Brugia malayi	Melatonin receptor type 1A	0.0028	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	sex peptide receptor	0.0028	0.0013	0.0013
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus granulosus	tyrosine protein kinase csk	0.0068	0.0047	0.0047
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Echinococcus granulosus	raf serine:threonine protein kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0033	0.0033
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0047	0.0119
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0015	0.0001	0.0001
Schistosoma mansoni	myosin xvIII	0.0028	0.0013	0.0013
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.0013	0.0013
Brugia malayi	G-protein coupled receptor	0.0028	0.0013	0.0012
Onchocerca volvulus		0.0028	0.0013	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	retinoic acid receptor RXR	0.0015	0.0001	0.0001
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0015	0.0001	0.0001
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0047	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0047	0.0119
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0068	0.0048	0.0057
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0001	0.0001
Echinococcus multilocularis		0.3527	0.3086	0.3086
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Brugia malayi	Raf kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0077	0.0055	0.0055
Leishmania major	protein kinase, putative	0.0068	0.0047	0.0055
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0068	0.0047	0.0047
Brugia malayi	RE15519p	0.0028	0.0013	0.0012
Loa Loa (eye worm)	TK/INSR protein kinase	0.3645	0.3189	0.3189
Brugia malayi	Dopamine receptor protein 1	0.0028	0.0013	0.0012
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0013	0.0013
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0013	0.0013
Echinococcus granulosus	protein tyrosine kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK/FAK protein kinase	0.0068	0.0047	0.0047
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0068	0.0048	0.0057
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0072	0.0051	0.0051
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0068	0.0047	0.0047
Brugia malayi	SH2 domain containing protein	0.0072	0.0051	0.0051
Schistosoma mansoni	amine GPCR	0.0028	0.0013	0.0013
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0015	0.0001	0.0001
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	protein kinase	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	larval opioid receptor	0.0028	0.0013	0.0012
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.3645	0.3189	0.3189
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0028	0.0013	0.0604
Brugia malayi	GnHR receptor homolog	0.0028	0.0013	0.0012
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0068	0.0047	0.0047
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.0013	0.0012
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0068	0.0047	0.0047
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0072	0.0051	0.0051
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0077	0.0055	0.0055
Echinococcus multilocularis	activin receptor type	0.0068	0.0048	0.0048
Onchocerca volvulus		0.0028	0.0013	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Echinococcus granulosus	tyrosine protein kinase HCK	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Schistosoma mansoni	plexin	0.0021	0.0006	0.0006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0013	0.0013
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0068	0.0047	0.2392
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	protein kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.0013	0.0013
Schistosoma mansoni	ephrin receptor	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Plasmodium falciparum	tyrosine kinase-like protein	0.0068	0.0047	0.9667
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0077	0.0055	0.0055
Entamoeba histolytica	protein kinase domain containing protein	0.0072	0.0051	0.9649
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Schistosoma mansoni	protein kinase	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.2985	0.2609	1
Onchocerca volvulus		0.0068	0.0047	0.2392
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0068	0.0047	0.0119
Brugia malayi	Protein kinase domain containing protein	0.0072	0.0051	0.0051
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.0013	0.0013
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0052	0.0033	0.0033
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	c src tyrosine kinase	0.0077	0.0055	0.0055
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0068	0.0047	0.0047
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.14	0.1218	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0072	0.0051	1
Loa Loa (eye worm)	hypothetical protein	0.1229	0.1067	0.1066
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	tyrosine kinase	0.0072	0.0051	0.0051
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.0013	0.0013
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0001	0.0001
Schistosoma mansoni	RAR-like nuclear receptor	0.0015	0.0001	0.0001
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0068	0.0047	0.0047
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	protein kinase	0.0068	0.0048	0.0048
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Onchocerca volvulus		0.0072	0.0051	0.2596
Echinococcus multilocularis	protein kinase	0.0068	0.0047	0.0047
Schistosoma mansoni	adenoreceptor	0.0028	0.0013	0.0013
Giardia lamblia	Protein 21.1	0.0068	0.0047	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Echinococcus granulosus	fmrfamide receptor	0.0028	0.0013	0.0013
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0013	0.0013
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0015	0.0001	0.0001
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0068	0.0048	0.0048
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0013	0.0013
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.2985	0.2609	0.2609
Schistosoma mansoni	opsin-like receptor	0.0028	0.0013	0.0013
Toxoplasma gondii	protein kinase	0.0068	0.0047	0.9667
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0047	0.7806
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0015	0.0001	0.0000060276
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Toxoplasma gondii	protein kinase domain-containing protein	0.0068	0.0047	0.9667
Schistosoma mansoni	tyrosine kinase	0.0077	0.0055	0.0055
Echinococcus granulosus	tyrosine kinase	0.0068	0.0047	0.0047
Trypanosoma cruzi	protein kinase, putative	0.0068	0.0047	0.0055
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0001	0.0000060276
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0001	0.0000060276
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0068	0.0048	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0001	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0015	0.0001	0.0000060276
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.0013	0.0012
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0068	0.0047	1
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Echinococcus granulosus	allatostatin A receptor	0.0028	0.0013	0.0013
Giardia lamblia	Kinase, NEK	0.0068	0.0047	0.0119
Brugia malayi	neuropeptide F receptor	0.0028	0.0013	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0068	0.0047	0.0047
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.0013	0.0013
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0068	0.0047	0.0047
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0068	0.0047	0.0047
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0013	0.0013
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Echinococcus multilocularis	activated cdc42 kinase 1	0.0068	0.0047	0.0047
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.0013	0.0013
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0068	0.0047	0.0047
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.6126	0.5369	0.5369
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.0013	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0068	0.0047	0.0119
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Echinococcus granulosus	Niemann Pick C1 protein	0.1229	0.1067	0.1067
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.0013	0.0013
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0068	0.0047	0.0047
Echinococcus multilocularis	plexin a4	0.0025	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0001	0.0000060276
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0015	0.0001	0.0001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0077	0.0055	0.0055
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Trichomonas vaginalis	TK family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	CHE-14 protein	0.1229	0.1067	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0015	0.0001	0.0001
Onchocerca volvulus		0.0068	0.0047	0.2392
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.0013	0.0012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Echinococcus multilocularis	protein patched	0.1229	0.1067	0.1067
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0068	0.0047	0.0047
Onchocerca volvulus		0.0028	0.0013	0.0604
Schistosoma mansoni	protein tyrosine kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK protein kinase	0.0071	0.005	0.0049
Echinococcus granulosus	insulin receptor	0.3645	0.3189	0.3189
Onchocerca volvulus		0.0028	0.0013	0.0604
Echinococcus multilocularis	FL cytokine receptor	0.0068	0.0047	0.0047
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Plasmodium falciparum	protein kinase, putative	0.0068	0.0048	1
Schistosoma mansoni	protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	tyrosine protein kinase Blk	0.0072	0.0051	0.0051
Schistosoma mansoni	amine GPCR	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.0013	0.0013
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0047	0.7806
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0047	0.0047
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0047	0.7806
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0068	0.0047	0.0047
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.2985	0.2609	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Onchocerca volvulus		0.0068	0.0047	0.2392
Entamoeba histolytica	receptor protein kinase, putative	0.0068	0.0047	0.7806
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Onchocerca volvulus		0.0021	0.0006	0.0264
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0068	0.0047	0.0047
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0068	0.0047	0.0047
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0001	0.0001
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.0013	0.0013
Echinococcus multilocularis	cyclin dependent kinase 5	0.0052	0.0033	0.0033
Entamoeba histolytica	tyrosin kinase, putative	0.0068	0.0047	0.7806
Brugia malayi	Tyrosine-protein kinase abl-1	0.0077	0.0055	0.0054
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0013	0.0013
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK/DDR protein kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Entamoeba histolytica	tyrosin kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	histamine h1 receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	opsin-like receptor	0.0028	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0072	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	serine/threonine RGC	0.0068	0.0047	0.0047
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0015	0.0001	0.0000060276
Brugia malayi	Protein kinase domain containing protein	0.0072	0.0051	0.0051
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Trichomonas vaginalis	conserved hypothetical protein	0.1229	0.1067	0.8728
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus multilocularis	tyrosine protein kinase csk	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	hypothetical protein	0.0068	0.0047	0.0047
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus granulosus	cyclin dependent kinase 1	0.0052	0.0033	0.0033
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.005	0.0049
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0071	0.005	0.005
Echinococcus multilocularis	serotonin receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0015	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0033	0.0033
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0068	0.0047	0.0047
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.0013	0.0012
Loa Loa (eye worm)	TK/ACK protein kinase	0.0068	0.0047	0.0047
Entamoeba histolytica	tyrosin kinase, putative	0.0068	0.0047	0.7806
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0015	0.0001	0.0001
Echinococcus granulosus	plexin a4	0.0025	0.0009	0.0009
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	Plexin repeat family protein	0.0021	0.0006	0.0005
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0051	0.0051
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0013	0.0013
Echinococcus multilocularis	serotonin receptor	0.0028	0.0013	0.0013
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Onchocerca volvulus		0.0028	0.0013	0.0604
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0013	0.0012
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.0013	0.0012
Schistosoma mansoni	tyrosine kinase	0.0077	0.0055	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0047	0.0119
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0068	0.0047	0.0047
Echinococcus multilocularis	cyclin dependent kinase	0.0052	0.0033	0.0033
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0068	0.0047	0.0047
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.0013	0.0012
Echinococcus granulosus	kinase suppressor of Ras 1	0.0068	0.0047	0.0047
Echinococcus granulosus	cyclin dependent kinase 5	0.0052	0.0033	0.0033
Brugia malayi	putative neuropeptide receptor	0.0028	0.0013	0.0012
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0013	0.0013
Brugia malayi	Guanylyl cyclase protein 23	0.0068	0.0047	0.0047
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0013	0.0013
Onchocerca volvulus		0.0072	0.0051	0.2596
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0001	0.0001
Schistosoma mansoni	tyrosine kinase	0.0077	0.0055	0.0055
Echinococcus multilocularis	tyrosine protein kinase csk	0.0068	0.0047	0.0047
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0001	0.0000060276
Entamoeba histolytica	ankyrin repeat protein	0.0068	0.0047	0.7806
Onchocerca volvulus		0.0068	0.0047	0.2392
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0068	0.0047	0.0047
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Echinococcus granulosus	Protein patched homolog 1	0.1229	0.1067	0.1067
Echinococcus granulosus	epidermal growth factor receptor	0.6126	0.5369	0.5369
Brugia malayi	Receptor family ligand binding region containing protein	0.0068	0.0047	0.0047
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0013	0.0013
Brugia malayi	sulfakinin receptor protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.14	0.1218	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	receptor protein kinase, putative	0.0068	0.0047	0.7806
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0077	0.0055	0.0055
Brugia malayi	neuropeptide F receptor	0.0028	0.0013	0.0012
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0001	0.0001
Echinococcus granulosus	tyrosine protein kinase csk	0.0068	0.0047	0.0047
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0013	0.0013
Echinococcus granulosus	tyrosine protein kinase Srms	0.0072	0.0051	0.0051
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Schistosoma mansoni	protein kinase	0.0068	0.0048	0.0048
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.2985	0.2609	0.2609
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0068	0.0047	0.7806
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Brugia malayi	Protein kinase domain containing protein	0.0072	0.0051	0.0051
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0051	0.0051
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0047	0.0047
Brugia malayi	integrin-linked kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.0013	0.0013
Echinococcus granulosus	FTZ F1 alpha	0.0015	0.0001	0.0001
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0077	0.0055	0.0055
Echinococcus multilocularis	integrin linked protein kinase	0.0068	0.0047	0.0047
Plasmodium falciparum	protein kinase, putative	0.0068	0.0047	0.9667
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0001	0.0001
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0047	0.0047
Onchocerca volvulus		0.0028	0.0013	0.0604
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	tyrosine protein kinase pr2	0.0068	0.0047	0.0047
Loa Loa (eye worm)	steroid hormone receptor	0.0015	0.0001	0.0000060276
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0077	0.0055	0.0055
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0013	0.0013
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0052	0.0033	0.0033
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0068	0.0047	0.0047
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	Dopamine receptor	0.0028	0.0013	0.0012
Onchocerca volvulus		0.0072	0.0051	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	tyrosine protein kinase csk	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Toxoplasma gondii	STE kinase	0.0068	0.0047	0.9667
Schistosoma mansoni	protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	protein tyrosine kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0001	0.0000060276
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0072	0.0051	0.0051
Echinococcus multilocularis	c src tyrosine kinase	0.0077	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	patched 1	0.1229	0.1067	0.1067
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0013	0.0013
Echinococcus granulosus	hypothetical protein	0.0028	0.0013	0.0013
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0015	0.0001	0.0001
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0077	0.0055	0.0055
Echinococcus granulosus	ephrin type A receptor 4 A	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0001	0.0000060276
Echinococcus granulosus	activated cdc42 kinase 1	0.0068	0.0047	0.0047
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	tyrosine kinase	0.0074	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0072	0.0051	0.0051
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0013	0.0013
Echinococcus granulosus	sterol regulatory element binding protein	0.1229	0.1067	0.1067
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0033	0.0033
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.2985	0.2609	0.2609
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0013	0.0013
Onchocerca volvulus		0.0028	0.0013	0.0604
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0015	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Schistosoma mansoni	protein kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK/RYK protein kinase	0.0068	0.0047	0.0047
Entamoeba histolytica	tyrosin kinase, putative	0.0072	0.0051	0.9649
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Echinococcus granulosus	tyrosine protein kinase shark	0.0072	0.0051	0.0051
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.3645	0.3189	0.3189
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0071	0.005	0.005
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0013	0.0012
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0013	0.0013
Trypanosoma brucei	protein kinase, putative	0.0068	0.0048	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0248	0.0206	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.0013	0.0013
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	tyrosine kinase	0.6126	0.5369	0.5369
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0068	0.0047	0.0047
Echinococcus multilocularis	heat shock protein 70	0.0068	0.0047	0.0047
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus granulosus	somatostatin receptor	0.0028	0.0013	0.0013
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.0013	0.0013
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0033	0.0032
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0068	0.0047	0.0047
Schistosoma mansoni	amine GPCR	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Echinococcus granulosus	epidermal growth factor receptor	1.1399	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Onchocerca volvulus		0.0072	0.0051	0.2596
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Onchocerca volvulus		0.0068	0.0047	0.2392
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0047	0.0119
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Echinococcus multilocularis	tyrosine kinase	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus multilocularis	transfer RNA-Thr	0.0068	0.0047	0.0047
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.0013	0.0013
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	STE family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0001	0.0000060276
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0068	0.0047	0.0047
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0013	0.0013
Brugia malayi	SH2 domain containing protein	0.0072	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0028	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0072	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.2985	0.2609	1
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0077	0.0055	0.0055
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	TK/ROR protein kinase	0.0071	0.005	0.0049
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.0013	0.0013
Schistosoma mansoni	ephrin receptor	0.0068	0.0047	0.0047
Onchocerca volvulus		0.0072	0.0051	0.2596
Brugia malayi	AKH receptor	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.14	0.1218	1
Onchocerca volvulus		0.0028	0.0013	0.0604
Onchocerca volvulus		0.0072	0.0051	0.2596
Echinococcus granulosus	tyrosine protein kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0047	0.0119
Loa Loa (eye worm)	TK protein kinase	0.0068	0.0047	0.0047
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.2985	0.2609	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Plasmodium falciparum	tyrosine kinase-like protein	0.0068	0.0047	0.9667
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0068	0.0047	0.0055
Echinococcus multilocularis	protein kinase	0.0068	0.0047	0.0047
Schistosoma mansoni	coup transcription factor	0.0015	0.0001	0.0001
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	C-terminal src kinase protein 1	0.0068	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.0028	0.0013	0.0013
Leishmania major	hypothetical protein, conserved	0.0068	0.0047	0.0055
Loa Loa (eye worm)	TK/EGFR protein kinase	1.1399	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0047	0.0119
Echinococcus multilocularis	somatostatin receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0047	0.7806
Entamoeba histolytica	ankyrin repeat protein	0.0068	0.0047	0.7806
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus granulosus	serotonin receptor	0.0028	0.0013	0.0013
Brugia malayi	plexin A	0.0025	0.0009	0.0008
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0072	0.0051	0.0051
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	plexin A	0.0025	0.0009	0.0009
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0077	0.0055	0.0055
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0077	0.0055	0.0055
Loa Loa (eye worm)	TK/FER protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0077	0.0055	0.0055
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0015	0.0001	0.0000060276
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.0013	0.0012
Echinococcus granulosus	receptor type guanylyl cyclase	0.0068	0.0047	0.0047
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0013	0.0013
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Schistosoma mansoni	protein kinase	0.0068	0.0047	0.0047
Onchocerca volvulus		0.0028	0.0013	0.0604
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Schistosoma mansoni	tyrosine kinase	0.0072	0.0051	0.0051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0013	0.0013
Brugia malayi	Dopamine receptor protein 2	0.0028	0.0013	0.0012
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0048	0.8075
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0013	0.0013
Echinococcus multilocularis	epidermal growth factor receptor	0.6126	0.5369	0.5369
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0077	0.0056	0.0056
Onchocerca volvulus	Tyrosine kinase homolog	0.0237	0.0195	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	tyrosine kinase	0.3645	0.3189	0.3189
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0077	0.0055	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0013	0.0012
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	tyrosine kinase	0.6058	0.5309	0.5309
Brugia malayi	Serotonin receptor	0.0028	0.0013	0.0012
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0068	0.0047	0.0047
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.2985	0.2609	1
Trypanosoma brucei	Pseudokinase, putative	0.0068	0.0047	0.0055
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0077	0.0055	0.0055
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.0013	0.0013
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0072	0.0051	0.0051
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TK/EPH protein kinase	0.0068	0.0047	0.0047
Schistosoma mansoni	tyrosine kinase	0.0077	0.0055	0.0055
Plasmodium vivax	protein kinase, putative	0.0068	0.0047	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0068	0.0047	0.0047
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.0013	0.0012
Brugia malayi	Protein kinase domain containing protein	0.0072	0.0051	0.0051
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0015	0.0001	0.0001
Echinococcus granulosus	tyrosine kinase	0.0072	0.0051	0.0051
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.0013	0.0013
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0033	0.0033
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0015	0.0001	0.0001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0013	0.0013
Echinococcus multilocularis	tyrosine protein kinase shark	0.0072	0.0051	0.0051
Echinococcus granulosus	tyrosine kinase	0.0072	0.0051	0.0051
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0068	0.0047	0.7806
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Brugia malayi	Serotonin receptor	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	TK/ALK protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0013	0.0013
Schistosoma mansoni	tyrosine protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.0013	0.0013
Onchocerca volvulus		0.0028	0.0013	0.0604
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0015	0.0001	0.0001
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0068	0.0047	0.0047
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	tyrosine kinase	0.6058	0.5309	0.5309
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0068	0.0047	0.0047
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.0013	0.0013
Echinococcus granulosus	sex peptide receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.0013	0.0013
Echinococcus multilocularis	ecdysone induced protein 78C	0.0015	0.0001	0.0001
Echinococcus granulosus	orexin receptor type 2	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	SRC-1	0.0077	0.0055	0.0054
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0068	0.0047	0.2392
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0077	0.0055	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Brugia malayi	protein-tyrosine kinase	0.0072	0.0051	0.0051
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.2985	0.2609	0.2609
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Echinococcus granulosus	protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0013	0.0012
Schistosoma mansoni	opsin-like receptor	0.0028	0.0013	0.0013
Onchocerca volvulus		0.0068	0.0047	0.2392
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Onchocerca volvulus		0.0028	0.0013	0.0604
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.0013	0.0013
Echinococcus granulosus	activin receptor type	0.0068	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0068	0.0047	0.0119
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0013	0.0013
Echinococcus granulosus	tyrosine protein kinase csk	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0068	0.0047	0.0047
Echinococcus granulosus	roundabout 2	0.0018	0.0003	0.0003
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0068	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.0028	0.0013	0.0013
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0077	0.0055	0.0055
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Schistosoma mansoni	tyrosine kinase	0.3645	0.3189	0.3189
Brugia malayi	ORL1-like opioid receptor	0.0028	0.0013	0.0012
Brugia malayi	cell division control protein 2 homolog	0.0052	0.0033	0.0032
Loa Loa (eye worm)	TK/CSK protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0077	0.0055	0.0055
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.1229	0.1067	0.1066
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0068	0.0047	0.0055
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Loa Loa (eye worm)	TK protein kinase	0.0072	0.0051	0.0051
Echinococcus multilocularis	epidermal growth factor receptor	1.1399	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0068	0.0047	1
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0013	0.0013
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0068	0.0047	0.9667
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	natriuretic peptide receptor 1	0.0068	0.0047	0.0047
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Echinococcus multilocularis	sterol regulatory element binding protein	0.1229	0.1067	0.1067
Onchocerca volvulus		0.0068	0.0047	0.2392
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Schistosoma mansoni	amine GPCR	0.0028	0.0013	0.0013
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0068	0.0047	0.0047
Echinococcus granulosus	integrin linked protein kinase	0.0068	0.0047	0.0047
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0015	0.0001	0.0001
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0072	0.0051	0.0051
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.0013	0.0013
Trypanosoma cruzi	protein kinase, putative	0.0068	0.0047	0.0055
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0013	0.0013
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0033	0.0032
Entamoeba histolytica	tyrosine kinase, putative	0.0068	0.0047	0.7806
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0015	0.0001	0.0001
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.1229	0.1067	0.1067
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0001	0.0001
Onchocerca volvulus		0.0028	0.0013	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0033	0.0033
Echinococcus multilocularis	FTZ F1 alpha	0.0015	0.0001	0.0001
Entamoeba histolytica	serine/threonine kinase, putative	0.0068	0.0047	0.7806
Echinococcus granulosus	activated cdc42 kinase 1	0.0068	0.0047	0.0047
Brugia malayi	SRC-1	0.0077	0.0055	0.0054
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0047	0.0047
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.0013	0.0013
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0068	0.0047	0.0047
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.0013	0.0013
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0072	0.0051	0.0051
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Onchocerca volvulus		0.0068	0.0047	0.2392
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0047	0.0047
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0068	0.0047	0.0119
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0013	0.0013
Brugia malayi	Tyrosine-protein kinase PR2	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Schistosoma mansoni	tyrosine kinase	0.0072	0.0051	0.0051
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0077	0.0055	0.0055
Brugia malayi	G protein-coupled receptor	0.0028	0.0013	0.0012
Entamoeba histolytica	hypothetical protein, conserved	0.0068	0.0047	0.7806
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0015	0.0001	0.0001
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0077	0.0055	0.0055
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0028	0.0013	0.0604
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.0013	0.0012
Brugia malayi	hypothetical protein	0.0068	0.0047	0.0047
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0068	0.0047	0.9667
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.0013	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0072	0.0051	0.0051
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0015	0.0001	0.0000060276
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0047	0.0119
Echinococcus multilocularis	insulin receptor	0.3645	0.3189	0.3189
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0068	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0001	0.0000060276
Echinococcus multilocularis	Niemann Pick C1 protein	0.1229	0.1067	0.1067
Schistosoma mansoni	tyrosine kinase	0.0068	0.0047	0.0047
Giardia lamblia	Kinase, NEK	0.0068	0.0047	0.0119
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0013	0.0013
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0068	0.0048	0.0048
Schistosoma mansoni	tyrosine kinase	0.6058	0.5309	0.5309
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0068	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.3645	0.3189	0.3189
Entamoeba histolytica	protein kinase, putative	0.0068	0.0047	0.7806
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0068	0.0047	0.7806
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0068	0.0047	0.0047
Echinococcus multilocularis	tyrosine protein kinase csk	0.0068	0.0047	0.0047
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0068	0.0047	0.0047
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0013	0.0013
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0013	0.0013
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0047	0.7806
Loa Loa (eye worm)	TK/ABL protein kinase	0.0072	0.0051	0.0051
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0013	0.0013
Loa Loa (eye worm)	TK/Met protein kinase	0.0068	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Brugia malayi	hypothetical protein	0.0028	0.0013	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0068	0.0047	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Onchocerca volvulus		0.0068	0.0047	0.2392
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0068	0.0047	0.0047
Entamoeba histolytica	hypothetical protein	0.0068	0.0047	0.7806
Onchocerca volvulus		0.0028	0.0013	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0013	0.0012
Echinococcus multilocularis	roundabout 2	0.0018	0.0003	0.0003

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 1000 nM	In vitro inhibition of [125I]-ET-1 binding to CHO cells expressing recombinant human Endothelin A receptor	ChEMBL.	11425549
IC50 (binding)	> 1000 nM	In vitro inhibition of [125I]-ET-1 binding to CHO cells expressing recombinant human Endothelin A receptor	ChEMBL.	11425549
Inhibition (binding)	= 37 %	Inhibition of [125I]-ET-1 binding to CHO cells expressing human Endothelin B receptor at a concentration of 1 uM	ChEMBL.	11425549
Inhibition (binding)	= 37 %	Inhibition of [125I]-ET-1 binding to CHO cells expressing human Endothelin B receptor at a concentration of 1 uM	ChEMBL.	11425549

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL299095

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 70791