TDR Targets

Basic information

Technical information

TDR Targets ID: 708281
Name: 4-[(E)-3-[2,3,5,6-tetrafluoro-4-(4-propoxyphe noxy)phenyl]prop-2-enyl]morpholine
MW: 425.417 | Formula: C22H23F4NO3
H donors: 0 H acceptors: 0 LogP: 4.82 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1ccc(cc1)Oc1c(F)c(F)c(c(c1F)F)C=CCN1CCOCC1
InChi: 1S/C22H23F4NO3/c1-2-12-29-15-5-7-16(8-6-15)30-22-20(25)18(23)17(19(24)21(22)26)4-3-9-27-10-13-28-14-11-27/h3-8H,2,9-14H2,1H3/b4-3+
InChiKey: QTFHZMOQTBLZJF-ONEGZZNKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[3-[2,3,5,6-tetrafluoro-4-(4-propoxyphenoxy)phenyl]prop-2-enyl]morpholine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0025	0.0206	0.0237
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0025	0.0206	0.0578
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0025	0.0206	0.0578
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0129	0.3561	0.3561
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0457	0.0457
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0457	0.2777
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0457	0.1283
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0457	0.0457
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0457	0.0525
Echinococcus multilocularis	zinc finger protein Ran binding	0.0025	0.0206	0.0206
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0457	0.2777
Echinococcus granulosus	pyruvate kinase	0.0033	0.0457	0.0457
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0028	0.0309	0.0867
Schistosoma mansoni	hypothetical protein	0.007	0.1644	0.3691
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0025	0.0206	0.0578
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0457	0.1745
Leishmania major	pyruvate kinase	0.0033	0.0457	0.1283
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0	0.5
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.007	0.1644	1
Entamoeba histolytica	hypothetical protein	0.0035	0.053	0.1488
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0025	0.0206	0.0206
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.2276	0.2617
Onchocerca volvulus		0.007	0.1644	1
Chlamydia trachomatis	DNA topoisomerase I	0.007	0.1644	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0025	0.0206	0.0578
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0129	0.3561	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0025	0.0206	0.0578
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0028	0.0309	0.0867
Echinococcus multilocularis	SWI:SNF matrix associated	0.007	0.1644	0.1644
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.2276	0.2276
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.3561	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0081	0.2014	0.5656
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0961	0.1105
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0129	0.3561	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0206	0.0237
Brugia malayi	hypothetical protein	0.0035	0.053	0.0609
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0457	0.1283
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0057	0.1253	0.352
Plasmodium falciparum	pyruvate kinase	0.0033	0.0457	0.2777
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0457	0.1283
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0129	0.3561	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0028	0.0309	0.0867
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.053	0.1189
Leishmania major	pyruvate kinase	0.0033	0.0457	0.1283
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.2276	0.2276
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0206	0.0578
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.1644	0.4619
Echinococcus granulosus	zinc finger protein Ran binding	0.0025	0.0206	0.0206
Leishmania major	hypothetical protein, conserved	0.0025	0.0206	0.0578
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.007	0.1644	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0206	0.0237
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0457	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.007	0.1644	0.1644
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0028	0.0309	0.0867
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0129	0.3561	0.3561
Echinococcus multilocularis	SWI:SNF matrix associated	0.007	0.1644	0.1644
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0356	0.041
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0084	0.2093	0.5879
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.007	0.1644	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0025	0.0206	0.0237
Schistosoma mansoni	RNA binding protein	0.0025	0.0206	0.0462
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.2276	0.2276
Loa Loa (eye worm)	phosphatidylinositol 3	0.0026	0.0229	0.0263
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0025	0.0206	0.1251
Chlamydia trachomatis	SWIB complex protein	0.007	0.1644	1
Schistosoma mansoni	fusion	0.0025	0.0206	0.0462
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0028	0.0309	0.0355
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.053	0.053
Schistosoma mansoni	hypothetical protein	0.0129	0.3561	0.7991
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0054	0.1148	0.1148
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0084	0.2093	0.5879
Brugia malayi	brahma associated protein 60 kDa	0.007	0.1644	0.1891
Giardia lamblia	Rrm3p helicase	0.0129	0.3561	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0084	0.2093	0.5879
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0028	0.0309	0.0692
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0025	0.0206	0.0237
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0457	0.0525
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0025	0.0206	0.0237
Leishmania major	hypothetical protein, conserved	0.0025	0.0206	0.0578
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0028	0.0309	0.0867
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0206	0.0578
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.007	0.1644	1
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0129	0.3561	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0026	0.0229	0.0644
Loa Loa (eye worm)	hypothetical protein	0.029	0.8698	1
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0457	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.053	0.053
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0206	0.0578
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0	0.5
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0054	0.1148	0.1148
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0157	0.4456	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0457	0.0525
Loa Loa (eye worm)	phosphatidylinositol 3	0.014	0.3908	0.4493
Loa Loa (eye worm)	brahma associated protein	0.007	0.1644	0.1891
Brugia malayi	brahma associated protein 60 kDa	0.007	0.1644	0.1891
Leishmania major	hypothetical protein, conserved	0.0025	0.0206	0.0578
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0028	0.0309	0.0867
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0236	0.0236
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0129	0.3561	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0457	0.1745
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0457	0.0525
Toxoplasma gondii	ran binding protein	0.0025	0.0206	0.1251
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.002	0.0039	0.0108
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.004	0.0706	0.1982
Echinococcus granulosus	ring and YY1 binding protein	0.0025	0.0206	0.0206
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0157	0.4456	0.4456
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.2276	0.2276
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0206	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0206	0.0237
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0457	0.1283
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0129	0.3561	1
Plasmodium vivax	hypothetical protein, conserved	0.007	0.1644	1
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0025	0.0206	0.0578
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.007	0.1644	0.1891
Loa Loa (eye worm)	hypothetical protein	0.0023	0.014	0.0161
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0084	0.2093	0.5879
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0057	0.1253	0.352
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0067	0.1546	0.4341
Echinococcus multilocularis	tumor protein p63	0.033	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0037	0.0601	0.1687
Schistosoma mansoni	hypothetical protein	0.007	0.1644	0.3691
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0457	0.0525
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0025	0.0206	0.0206
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0206	0.0578
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0457	0.5
Echinococcus multilocularis	muscleblind protein	0.029	0.8698	0.8698
Echinococcus granulosus	SWI:SNF matrix associated	0.007	0.1644	0.1644
Entamoeba histolytica	hypothetical protein	0.0035	0.053	0.1488
Onchocerca volvulus		0.0048	0.0961	0.5251
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.2276	0.5109
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.007	0.1644	1
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0457	0.0525
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.2276	0.5109
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0074	0.1774	0.2039
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0084	0.2093	0.5879
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.014	0.0394
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0025	0.0206	0.0578
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.1148	0.132
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1148	0.132
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0457	0.1283
Entamoeba histolytica	hypothetical protein	0.0035	0.053	0.1488
Entamoeba histolytica	hypothetical protein	0.0067	0.1546	0.4341
Echinococcus multilocularis	muscleblind protein 1	0.029	0.8698	0.8698
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0025	0.0206	0.0578
Giardia lamblia	Pyruvate kinase	0.0033	0.0457	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0206	0.0237
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.014	0.0161
Schistosoma mansoni	pyruvate kinase	0.0033	0.0457	0.1025
Echinococcus granulosus	Zinc finger RanBP2 type	0.0025	0.0206	0.0206
Leishmania major	hypothetical protein, conserved	0.0025	0.0206	0.0578
Schistosoma mansoni	zinc finger protein	0.0025	0.0206	0.0462
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0457	0.1283
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0028	0.0309	0.0867
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0129	0.3561	1
Echinococcus granulosus	pyruvate kinase	0.0033	0.0457	0.0457
Schistosoma mansoni	hypothetical protein	0.0035	0.053	0.1189
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0206	0.0578
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.007	0.1644	0.1644
Schistosoma mansoni	pyruvate kinase	0.0033	0.0457	0.1025
Schistosoma mansoni	brg-1 associated factor	0.007	0.1644	0.3691
Echinococcus multilocularis	ring and YY1 binding protein	0.0025	0.0206	0.0206
Schistosoma mansoni	hypothetical protein	0.0025	0.0206	0.0462
Echinococcus granulosus	muscleblind protein	0.029	0.8698	0.8698
Brugia malayi	Muscleblind-like protein	0.029	0.8698	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.007	0.1644	0.1644
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0157	0.4456	0.4456
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0025	0.0206	0.0206
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.2093	0.2407
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0084	0.2093	0.5879
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0457	0.1745
Brugia malayi	SWIB/MDM2 domain containing protein	0.007	0.1644	0.1891
Leishmania major	hypothetical protein, conserved	0.0025	0.0206	0.0578
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.2276	0.5109
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0025	0.0206	0.1251
Trypanosoma cruzi	WLM domain containing protein, putative	0.0025	0.0206	0.0578
Loa Loa (eye worm)	hypothetical protein	0.029	0.8698	1
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0129	0.3561	1
Schistosoma mansoni	hypothetical protein	0.007	0.1644	0.3691
Entamoeba histolytica	hypothetical protein, conserved	0.0129	0.3561	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.2276	0.2617
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0961	0.2157
Entamoeba histolytica	hypothetical protein	0.0035	0.053	0.1488
Brugia malayi	YY1-associated factor 2	0.0025	0.0206	0.0237
Schistosoma mansoni	TRABID protein (C64 family)	0.0025	0.0206	0.0462

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 708281