Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosylhomocysteinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.5921 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0157 | 0.5962 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0217 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.5921 | 0.9931 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1956 | 0.181 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0156 | 0.5921 | 1 |
Onchocerca volvulus | Arrow homolog | 0.007 | 0.0178 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0156 | 0.5921 | 0.5847 |
Brugia malayi | Adenosylhomocysteinase | 0.0156 | 0.5921 | 0.5847 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0156 | 0.5921 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0156 | 0.5921 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.5921 | 0.9931 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1956 | 0.181 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0156 | 0.5921 | 0.5847 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1956 | 0.181 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0217 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0156 | 0.5921 | 0.5847 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0217 | 1 | 1 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0217 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0156 | 0.5921 | 0.5847 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.5921 | 1 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0217 | 1 | 1 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0217 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0156 | 0.5921 | 0.5847 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1956 | 0.181 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.5921 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0156 | 0.5921 | 0.5 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0156 | 0.5921 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0156 | 0.5921 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0156 | 0.5921 | 0.5847 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Evaluated for the 50% inhibition of bovine-liver S-Adenosylhomocysteine (AdoHcy) hydrolase; Not applicable | ChEMBL. | 3411600 |
IC50 (binding) | NA 0 uM | Evaluated for the 50% inhibition of bovine-liver S-Adenosylhomocysteine (AdoHcy) hydrolase; Not applicable | ChEMBL. | 3411600 |
IC50 (binding) | = 200 uM | Evaluated for the 50% inhibition of S-Adenosylhomocysteine (AdoHcy) hydrolase L929 lysate from murine L-929 cells | ChEMBL. | 3411600 |
IC50 (binding) | = 200 uM | Evaluated for the 50% inhibition of S-Adenosylhomocysteine (AdoHcy) hydrolase L929 lysate from murine L-929 cells | ChEMBL. | 3411600 |
IC50 (functional) | = 220 uM | Evaluated for 50% plaque inhibition of vaccinia virus replication in murine L929 cells | ChEMBL. | 3411600 |
Ki (binding) | = 170 nM | Inhibition against bovine-liver S-Adenosylhomocysteine (AdoHcy) hydrolase | ChEMBL. | 3411600 |
Ki (binding) | = 170 nM | Inhibition against bovine-liver S-Adenosylhomocysteine (AdoHcy) hydrolase | ChEMBL. | 3411600 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.