Detailed information for compound 708772

Basic information

Technical information
  • TDR Targets ID: 708772
  • Name: 1-(2-chloro-6-nitrophenyl)-4-(4-fluorophenyl) sulfonylpiperazine
  • MW: 399.824 | Formula: C16H15ClFN3O4S
  • H donors: 0 H acceptors: 4 LogP: 3.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1c(Cl)cccc1[N+](=O)[O-]
  • InChi: 1S/C16H15ClFN3O4S/c17-14-2-1-3-15(21(22)23)16(14)19-8-10-20(11-9-19)26(24,25)13-6-4-12(18)5-7-13/h1-7H,8-11H2
  • InChiKey: MMGBWDDOYHZOCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-chloro-6-nitro-phenyl)-4-(4-fluorophenyl)sulfonyl-piperazine
  • STK206150
  • ZINC04741011

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0022 0.0098 0.005
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0098 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0562 0.4038
Schistosoma mansoni thyroid hormone receptor 0.002 0.0083 0.0033
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0313 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0083 0.0148
Trypanosoma brucei NADH dehydrogenase 0.0021 0.0093 0.0342
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0313 0.0344
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0526 0.6192 0.8961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0083 0.0188
Leishmania major acetoin dehydrogenase e3 component-like protein 0.008 0.0802 0.2915
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0093 0.0155
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0823 0.0863
Echinococcus granulosus dna polymerase eta 0.002 0.0079 0.0088
Plasmodium falciparum glutathione reductase 0.023 0.2623 1
Schistosoma mansoni glutamate synthase 0.0021 0.0093 0.0045
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.105 0.3878
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.1746 0.3961
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0114 0.0296
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0093 0.0094
Brugia malayi ecdysteroid receptor 0.002 0.0083 0.0148
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0098 0.0222
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0021 0.0093 0.012
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0021 0.0093 0.0104
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.008 0.0802 0.0895
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0083 0.0093
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.0567 0.0633
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0098 0.0173
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0083 0.0033
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0114 0.0237
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.105 0.105
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0083 0.0148
Echinococcus multilocularis GPCR, family 2 0.005 0.0441 0.0441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0926 0.0926
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0114 0.0296
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0083 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0368 0.4282 1
Leishmania major cathepsin L-like protease 0.0068 0.0662 0.2367
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0313 0.1959
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.0567 0.0567
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0083 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0662 0.2367
Schistosoma mansoni hypothetical protein 0.005 0.0441 0.0435
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0313 0.0615
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.008 0.0802 1
Mycobacterium ulcerans monoxygenase 0.0021 0.0093 0.012
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0021 0.0093 0.0342
Schistosoma mansoni rab6-interacting 0.0022 0.0098 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0079 0.0099
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0079 0.0099
Onchocerca volvulus 0.0022 0.0098 0.0578
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0021 0.0093 0.0093
Brugia malayi Cathepsin L-like precursor 0.0018 0.0053 0.0081
Schistosoma mansoni hypothetical protein 0.005 0.0441 0.0435
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0662 0.2367
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0926 0.1032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0441 0.0492
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.008 0.0802 0.6042
Trichomonas vaginalis glutamate synthase, putative 0.0021 0.0093 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0098 0.0173
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0053 0.0121
Loa Loa (eye worm) hypothetical protein 0.0378 0.4407 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0021 0.0093 0.0021
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0083 0.0033
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.008 0.0802 0.6042
Echinococcus multilocularis microtubule associated protein 2 0.0755 0.8969 0.8969
Leishmania major DNA polymerase eta, putative 0.002 0.0079 0.0099
Brugia malayi beta-lactamase 0.0039 0.0313 0.0673
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0079 0.0139
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0021 0.0093 0.0342
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0021 0.0093 0.0155
Echinococcus multilocularis dna polymerase eta 0.002 0.0079 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0083 0.0148
Plasmodium falciparum thioredoxin reductase 0.008 0.0802 0.2915
Plasmodium falciparum ferrodoxin reductase-like protein 0.0021 0.0093 0.0155
Echinococcus granulosus FTZ F1 alpha 0.002 0.0083 0.0093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0083 0.0093
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.1276 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0169 0.0383
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0053 0.0059
Leishmania major NADH dehydrogenase, putative 0.0021 0.0093 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0083 0.0148
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0021 0.0093 0.0093
Mycobacterium tuberculosis Probable dehydrogenase 0.0526 0.6192 0.8961
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.008 0.0802 0.1061
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0053 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0114 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0093 0.0155
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.105 0.1171
Toxoplasma gondii NADPH-glutathione reductase 0.008 0.0802 0.2915
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0021 0.0093 0.0155
Loa Loa (eye worm) ctsf protein 0.0018 0.0053 0.0121
Brugia malayi nuclear hormone receptor 0.002 0.0083 0.0148
Loa Loa (eye worm) hypothetical protein 0.0158 0.1746 0.3961
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0313 0.0344
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0053 0.0053
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0098 0.0098
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.105 0.105
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Echinococcus granulosus GPCR family 2 0.005 0.0441 0.0492
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0526 0.6192 0.8961
Schistosoma mansoni hypothetical protein 0.0021 0.0093 0.0045
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0021 0.0093 0.0093
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0441 0.0492
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0021 0.0093 0.0021
Echinococcus multilocularis dna polymerase kappa 0.002 0.0079 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0562 0.4038
Echinococcus granulosus thioredoxin glutathione reductase 0.0231 0.2636 0.2939
Brugia malayi Cathepsin L-like precursor 0.0018 0.0053 0.0081
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0313 0.0673
Brugia malayi Cathepsin L-like precursor 0.0018 0.0053 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0188
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.105 0.3878
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.008 0.0802 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0313 0.0344
Brugia malayi Cathepsin L-like precursor 0.0018 0.0053 0.0081
Schistosoma mansoni lipoxygenase 0.006 0.0567 0.0577
Entamoeba histolytica hypothetical protein 0.0023 0.0114 1
Toxoplasma gondii ABC1 family protein 0.0039 0.0313 0.1012
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0098 0.0098
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0021 0.0093 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0093 0.0342
Leishmania major trypanothione reductase 0.023 0.2623 1
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.5863 0.5863
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0021 0.0093 0.0104
Trypanosoma cruzi trypanothione reductase, putative 0.023 0.2623 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.008 0.0802 0.3049
Loa Loa (eye worm) beta-lactamase 0.0039 0.0313 0.0711
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0584 0.6901 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0083 0.0148
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0021 0.0093 0.0342
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0656 0.1453
Mycobacterium ulcerans hypothetical protein 0.0039 0.0313 0.1959
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0313 0.0344
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0083 0.0083
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0175 0.0397
Echinococcus granulosus RUN 0.0022 0.0098 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Schistosoma mansoni lamin 0.0028 0.0175 0.0136
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0059 0.0546 0.1203
Onchocerca volvulus 0.002 0.0083 0.0386
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0021 0.0093 0.0155
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0021 0.0093 0.6545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0083 0.0188
Loa Loa (eye worm) RNA binding protein 0.0068 0.0656 0.1488
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0021 0.0093 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0313 0.1012
Brugia malayi glutamate synthase 0.0021 0.0093 0.0171
Schistosoma mansoni rab6-interacting 0.0022 0.0098 0.005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0083 0.0148
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.008 0.0802 0.3049
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Loa Loa (eye worm) programmed cell death 8 0.0021 0.0093 0.0211
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0313 0.1182
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0021 0.0093 0.012
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0114 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0083 0.0148
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0079 0.0088
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0079 0.0099
Trichomonas vaginalis mercuric reductase, putative 0.008 0.0802 0.1771
Brugia malayi Latrophilin receptor protein 2 0.005 0.0441 0.0964
Leishmania major cathepsin L-like protease 0.0068 0.0662 0.2367
Brugia malayi intermediate filament protein 0.0028 0.0175 0.0358
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0083 0.0386
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0211
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0021 0.0093 0.0155
Mycobacterium ulcerans hypothetical protein 0.0021 0.0093 0.012
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0313 0.0615
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0441 0.0441
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.105 0.3878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Loa Loa (eye worm) hypothetical protein 0.0022 0.0098 0.0222
Leishmania major hypothetical protein, conserved 0.0021 0.0093 0.0155
Schistosoma mansoni hypothetical protein 0.0108 0.1142 0.1221
Echinococcus granulosus tar DNA binding protein 0.0068 0.0656 0.0731
Giardia lamblia Glutamate synthase 0.0021 0.0093 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0121
Onchocerca volvulus 0.0039 0.0313 0.3379
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0021 0.0093 0.012
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.008 0.0802 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0053 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0179
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0021 0.0093 0.0104
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0021 0.0093 0.6545
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0083 0.0033
Echinococcus granulosus microtubule associated protein 2 0.0755 0.8969 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0079 0.0287
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0083 0.0093
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0021 0.0093 0.0171
Leishmania major DNA polymerase kappa, putative 0.002 0.0079 0.0099
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0252 0.2881 0.4107
Schistosoma mansoni thyroid hormone receptor 0.002 0.0083 0.0033
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0562 0.1981
Mycobacterium ulcerans lipase LipD 0.0039 0.0313 0.1959
Loa Loa (eye worm) hypothetical protein 0.0039 0.0313 0.0711
Trichomonas vaginalis esterase, putative 0.0039 0.0313 0.0615
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0079 0.0179
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0313 0.0615
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0313 0.0711
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Loa Loa (eye worm) hypothetical protein 0.0234 0.2662 0.604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0926 0.1032
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0021 0.0093 0.0155
Echinococcus multilocularis lamin 0.0028 0.0175 0.0175
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0021 0.0093 0.0021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0083 0.0033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0083 0.0083
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0098 0.0109
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0562 0.1981
Giardia lamblia NADH oxidase lateral transfer candidate 0.008 0.0802 0.7451
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0021 0.0093 0.6545
Leishmania major dihydrolipoamide dehydrogenase, putative 0.008 0.0802 0.2915
Schistosoma mansoni microtubule-associated protein tau 0.0755 0.8969 1
Schistosoma mansoni hypothetical protein 0.0048 0.0413 0.0404
Schistosoma mansoni polycystin 1-related 0.0022 0.0098 0.005
Leishmania major hypothetical protein, conserved 0.0021 0.0093 0.0155
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0114 0.0296
Schistosoma mansoni DNA polymerase eta 0.002 0.0079 0.0029
Echinococcus multilocularis glutamate synthase 0.0021 0.0093 0.0093
Echinococcus multilocularis musashi 0.0028 0.0175 0.0175
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0079 0.0099
Leishmania major hypothetical protein, conserved 0.0039 0.0313 0.1012
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0021 0.0093 0.0094
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0093 0.0094
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.008 0.0802 0.3049
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0083 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0079 0.0287
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.2706 0.614
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0083 0.0148
Echinococcus granulosus cathepsin l1 0.0018 0.0053 0.0059
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.1276 0.1423
Brugia malayi Thioredoxin reductase 0.023 0.2623 0.5935
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.008 0.0802 0.2915
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0021 0.0093 0.0155
Giardia lamblia Kinase, CMGC MAPK 0.01 0.105 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0021 0.0093 0.0342
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0656 0.0676
Trypanosoma cruzi NADH dehydrogenase, putative 0.0021 0.0093 0.0155
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0093 0.0094
Schistosoma mansoni sulfide quinone reductase 0.0021 0.0093 0.0045
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0053 0.0121
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0083 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0059 0.0546 0.1203
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0093 0.0155
Loa Loa (eye worm) thioredoxin reductase 0.023 0.2623 0.5951
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.008 0.0802 0.084
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0188
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0083 0.0083
Trichomonas vaginalis glutathione reductase, putative 0.008 0.0802 0.1771
Trichomonas vaginalis CMGC family protein kinase 0.01 0.105 0.2357
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2662 0.2968
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0175 0.0397
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0083 0.0188
Schistosoma mansoni intermediate filament proteins 0.0028 0.0175 0.0136
Trypanosoma cruzi trypanothione reductase, putative 0.008 0.0802 0.2915
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0441 0.1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0018 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0021 0.0093 0.0093
Treponema pallidum NADH oxidase 0.008 0.0802 1
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0662 0.2367
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0083 0.0083
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0083 0.0033
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0485 0.168
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0188
Giardia lamblia Thioredoxin reductase 0.0021 0.0093 0.0148
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0021 0.0093 0.012
Mycobacterium ulcerans beta-lactamase 0.0039 0.0313 0.1959
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0083 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0313 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0926 0.0979
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0079 0.0099
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0656 0.1488
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0021 0.0093 0.0155
Trypanosoma brucei protein kinase, putative 0.01 0.105 0.3994
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.059 0.2089
Plasmodium vivax thioredoxin reductase, putative 0.023 0.2623 1
Trichomonas vaginalis CMGC family protein kinase 0.01 0.105 0.2357
Leishmania major hypothetical protein, conserved 0.0021 0.0093 0.0155
Schistosoma mansoni loxhd1 0.0022 0.0098 0.005
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0053 0.0053
Mycobacterium ulcerans ferredoxin reductase 0.0021 0.0093 0.012
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0021 0.0093 0.0155
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0093 0.0094
Loa Loa (eye worm) hypothetical protein 0.0022 0.0098 0.0222
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0313 0.0344
Loa Loa (eye worm) fibroinase 0.0018 0.0053 0.0121
Schistosoma mansoni sulfide quinone reductase 0.0021 0.0093 0.0045
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0175 0.0358
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0079 0.0099
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.1276 0.1276
Onchocerca volvulus 0.0021 0.0093 0.0517
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0083 0.0033
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0021 0.0093 0.0093
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0313 0.0349
Leishmania major dihydrolipoamide dehydrogenase, putative 0.008 0.0802 0.2915
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0021 0.0093 0.0171
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.105 0.3878
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0083 0.0148
Onchocerca volvulus 0.0039 0.0313 0.3379
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0083 0.0148
Trichomonas vaginalis CMGC family protein kinase 0.01 0.105 0.2357
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.5863 0.6537
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0441 0.0441
Toxoplasma gondii selenide, water dikinase 0.0021 0.0093 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.01 0.105 0.2357
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0079 0.0079
Echinococcus granulosus glutamate synthase 0.0021 0.0093 0.0104
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0188
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.105 0.3878
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0313 0.1012
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0188
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0093 0.0094
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.008 0.0802 0.1787
Brugia malayi steroid hormone receptor 0.002 0.0083 0.0148
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0083 0.0188
Schistosoma mansoni coup transcription factor 0.002 0.0083 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0562 0.4038
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0313 0.0344
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0188
Brugia malayi beta-lactamase family protein 0.0039 0.0313 0.0673
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0021 0.0093 0.012
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0111 0.1179 0.2676
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0083 0.0386
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0093 0.0094
Toxoplasma gondii thioredoxin reductase 0.023 0.2623 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0083 0.0033
Echinococcus multilocularis thioredoxin glutathione reductase 0.0231 0.2636 0.2636
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0021 0.0093 0.6545
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.023 0.2623 0.3729
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0114 0.0237
Trypanosoma brucei unspecified product 0.002 0.0079 0.0287
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0313 0.0313
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0313 0.0615
Brugia malayi nuclear receptor NHR-88 0.002 0.0083 0.0148
Mycobacterium tuberculosis Conserved protein 0.0039 0.0313 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0021 0.0093 0.0211
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0188
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0083 0.0083
Brugia malayi hypothetical protein 0.0022 0.0098 0.0182
Echinococcus multilocularis lamin dm0 0.0028 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0083 0.0148
Brugia malayi beta-lactamase family protein 0.0039 0.0313 0.0673
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0114 0.0237
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0079 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0656 0.0676
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0098 0.0109
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0119 0.1276 0.1755
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0021 0.0093 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Echinococcus granulosus intermediate filament protein 0.0028 0.0175 0.0195
Loa Loa (eye worm) hypothetical protein 0.0039 0.0313 0.0711
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0083 0.0148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0313 0.0292
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0021 0.0093 0.0171
Plasmodium vivax ferrodoxin reductase, putative 0.0021 0.0093 0.0155
Brugia malayi hypothetical protein 0.0234 0.2662 0.6024
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.105 0.3878
Schistosoma mansoni lamin 0.0028 0.0175 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0926 0.0979
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0823 0.1834
Brugia malayi Doublecortin family protein 0.0022 0.0098 0.0182
Loa Loa (eye worm) hypothetical protein 0.005 0.0441 0.1
Echinococcus granulosus lamin dm0 0.0028 0.0175 0.0195
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.008 0.0802 0.2915
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0021 0.0093 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0083 0.0188
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0562 0.0571
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.008 0.0802 0.2915
Schistosoma mansoni lipoxygenase 0.0022 0.0098 0.005
Leishmania major cathepsin L-like protease 0.0068 0.0662 0.2367
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0021 0.0093 0.0155
Mycobacterium tuberculosis Conserved protein 0.0039 0.0313 0.0344
Loa Loa (eye worm) hypothetical protein 0.0108 0.1142 0.2591
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0083 0.0093
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0021 0.0093 0.0155
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0114 0.0031
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0093 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0083 0.0188
Echinococcus multilocularis cysteine protease 0.0018 0.0053 0.0053
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0083 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0021 0.0093 0.0021
Echinococcus granulosus mitogen activated protein kinase 0.01 0.105 0.1171
Trichomonas vaginalis glutamate synthase, putative 0.0021 0.0093 0.0094
Brugia malayi follicle stimulating hormone receptor 0.0237 0.2706 0.6125
Schistosoma mansoni serine/threonine protein kinase 0.01 0.105 0.1118
Brugia malayi glutathione reductase 0.023 0.2623 0.5935
Loa Loa (eye worm) hypothetical protein 0.0039 0.0313 0.0711
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0021 0.0093 0.6545
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0021 0.0093 0.0094
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0584 0.6901 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0926 0.2101
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0079 0.0029
Schistosoma mansoni disulfide oxidoreductase 0.0021 0.0093 0.0045
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0119 0.1276 0.2867
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0114 0.0296
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0926 0.0926
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0562 0.0571
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0083 0.0148
Echinococcus multilocularis RUN 0.0022 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0082 0.0823 0.1867
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0656 0.0676
Trichomonas vaginalis apoptosis inducing factor, putative 0.0021 0.0093 0.0094
Loa Loa (eye worm) glutathione reductase 0.023 0.2623 0.5951
Onchocerca volvulus 0.0028 0.0175 0.158
Echinococcus granulosus lamin 0.0028 0.0175 0.0195
Loa Loa (eye worm) hypothetical protein 0.0028 0.0175 0.0397
Echinococcus granulosus dna polymerase kappa 0.002 0.0079 0.0088
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0021 0.0093 0.012
Brugia malayi TAR-binding protein 0.0068 0.0656 0.1453
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0021 0.0093 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0313 0.1012
Plasmodium falciparum thioredoxin reductase 0.023 0.2623 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.008 0.0802 0.2915
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0083 0.0083
Schistosoma mansoni survival motor neuron protein 0.0048 0.0413 0.0404
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0584 0.6901 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0083 0.0093
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0562 0.0709
Loa Loa (eye worm) hypothetical protein 0.0039 0.0313 0.0711
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0562 0.0627
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0098 0.0098
Mycobacterium leprae Probable lipase LipE 0.0039 0.0313 0.0323
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0926 0.2068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0083 0.0033
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.1746 0.3937
Mycobacterium ulcerans flavoprotein disulfide reductase 0.008 0.0802 0.6042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0313 0.0711
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0313 0.0615
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0526 0.6192 0.8961
Echinococcus granulosus neuropeptide s receptor 0.0498 0.5863 0.6537
Entamoeba histolytica thioredoxin reductase, putative 0.0021 0.0093 0.6545
Trypanosoma cruzi NADH dehydrogenase, putative 0.0021 0.0093 0.0155
Entamoeba histolytica disulphide oxidoreductase, putative 0.0021 0.0093 0.6545
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0802 0.2915
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0188
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0823 0.0823
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.008 0.0802 0.0802
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0079 0.0139
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0114 0.0237
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0079 0.0287
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0802 0.2915
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0802 0.2915
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0656 0.1488
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0093 0.0155
Loa Loa (eye worm) hypothetical protein 0.0039 0.0313 0.0711
Onchocerca volvulus 0.0048 0.0413 0.4676
Mycobacterium ulcerans dehydrogenase 0.0021 0.0093 0.012
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0083 0.0386
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0526 0.6192 0.8958
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0083 0.0148
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0526 0.6192 0.8961
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.5863 0.5863
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.008 0.0802 0.2915
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0021 0.0093 0.0021
Brugia malayi MAP kinase sur-1 0.01 0.105 0.2351
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.1142 0.256
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0053 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0802 0.2915
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0021 0.0093 0.0104
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.008 0.0802 0.2915
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0079 0.0287
Schistosoma mansoni glutamate synthase 0.0021 0.0093 0.0045
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0823 0.0917
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0083 0.0033
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0021 0.0093 0.0093
Mycobacterium ulcerans NADH dehydrogenase 0.0021 0.0093 0.012
Schistosoma mansoni hypothetical protein 0.005 0.0441 0.0435
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0656 0.0676
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0021 0.0093 0.0104
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0021 0.0093 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0114 0.0422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0926 0.0979
Plasmodium vivax glutathione reductase, putative 0.023 0.2623 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0119 0.1276 0.4759
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.008 0.0802 0.2915
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.008 0.0802 0.3049
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0021 0.0093 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0656 0.0676
Mycobacterium tuberculosis Probable reductase 0.0526 0.6192 0.8961
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0441 0.0964
Brugia malayi Cathepsin L-like precursor 0.0018 0.0053 0.0081
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0021 0.0093 0.0155
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0053 0.0053
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.1276 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0413 0.09
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0114 0.0296
Brugia malayi RNA binding protein 0.0068 0.0656 0.1453
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.105 0.3878
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.105 0.2382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0662 0.2512
Mycobacterium tuberculosis Probable oxidoreductase 0.0584 0.6901 1
Schistosoma mansoni hypothetical protein 0.005 0.0441 0.0435
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0313 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0083 0.0148
Brugia malayi hypothetical protein 0.0022 0.0098 0.0182
Onchocerca volvulus 0.0022 0.0098 0.0578
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0079 0.0287
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0562 0.0562
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0119 0.1276 0.1372
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0079 0.006
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.008 0.0802 0.2915
Trypanosoma brucei trypanothione reductase 0.023 0.2623 1
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2662 0.2662
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0378 0.4407 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0079 0.006
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.105 0.3994
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0079 0.4179
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0656 0.0656
Echinococcus multilocularis cysteine protease 0.0018 0.0053 0.0053
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0021 0.0093 0.0148
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0662 0.2367
Onchocerca volvulus 0.0028 0.0175 0.158
Schistosoma mansoni glutamate synthase 0.0021 0.0093 0.0045
Plasmodium falciparum glutathione reductase 0.008 0.0802 0.2915
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0802 0.2915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0083 0.0188
Mycobacterium ulcerans glutamate synthase subunit beta 0.0021 0.0093 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.008 0.0802 0.2915
Mycobacterium tuberculosis Conserved protein 0.0039 0.0313 0.0344
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.1746 0.3937
Loa Loa (eye worm) cysteine protease 0.0018 0.0053 0.0121
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0313 0.1959
Onchocerca volvulus 0.0039 0.0313 0.3379
Onchocerca volvulus 0.0082 0.0823 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0083 0.0188
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0053 0.0081

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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