Detailed information for compound 709238

Basic information

Technical information
  • TDR Targets ID: 709238
  • Name: 3-[(4-methylphenyl)amino]-1-thiophen-2-ylprop -2-en-1-one
  • MW: 243.324 | Formula: C14H13NOS
  • H donors: 1 H acceptors: 1 LogP: 4.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)N/C=C/C(=O)c1cccs1
  • InChi: 1S/C14H13NOS/c1-11-4-6-12(7-5-11)15-9-8-13(16)14-3-2-10-17-14/h2-10,15H,1H3/b9-8+
  • InChiKey: FVTLKKXKLCRCRQ-CMDGGOBGSA-N  


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Synonyms

  • (E)-3-[(4-methylphenyl)amino]-1-thiophen-2-ylprop-2-en-1-one
  • (E)-3-[(4-methylphenyl)amino]-1-(2-thienyl)prop-2-en-1-one
  • 3-[(4-methylphenyl)amino]-1-(2-thienyl)prop-2-en-1-one
  • 3-[(4-methylphenyl)amino]-1-thiophen-2-yl-prop-2-en-1-one
  • (E)-3-[(4-methylphenyl)amino]-1-thiophen-2-yl-prop-2-en-1-one
  • 3-[(4-methylphenyl)amino]-1-(2-thienyl)-2-propen-1-one
  • MLS000671966
  • SMR000294473
  • ZINC02857687

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photuris pennsylvanica Luciferase Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 0, group B, member 1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Babesia bovis acetyl-CoA synthetase, putative Luciferase   552 aa 545 aa 21.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 451 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 481 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferase   552 aa 476 aa 25.4 %
Neospora caninum hypothetical protein Luciferase   552 aa 529 aa 22.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Plasmodium vivax long-chain fatty acid CoA ligase, putative Luciferase   552 aa 453 aa 24.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) Luciferase   552 aa 512 aa 22.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania mexicana long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative Luciferase   552 aa 472 aa 21.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferase   552 aa 491 aa 23.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Giardia lamblia Long chain fatty acid CoA ligase 5 Luciferase   552 aa 491 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 481 aa 25.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferase   552 aa 492 aa 24.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferase   552 aa 468 aa 20.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Schistosoma mansoni long-chain-fatty-acid--CoA ligase Luciferase   552 aa 526 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Theileria parva acetyl-coenzyme A synthetase, putative Luciferase   552 aa 580 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative Luciferase   552 aa 544 aa 21.7 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferase   552 aa 510 aa 23.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 483 aa 23.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferase   552 aa 481 aa 23.7 %
Onchocerca volvulus Luciferase   552 aa 553 aa 24.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 470 aa 25.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0025 0.0087 0.0309
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0074 0.0308
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.1086 0.1086
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0043 0.0082
Entamoeba histolytica hypothetical protein 0.0024 0.0078 0.1139
Giardia lamblia Pyruvate kinase 0.0021 0.0056 0.0966
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0182 0.0387
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0078 0.0739
Loa Loa (eye worm) RNA binding protein 0.0447 0.2771 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0178 0.2347
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0223 0.0782
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0181 0.1089
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.058 0.574
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0142
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0017 0.0031 0.0035
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0017 0.0031 0.006
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0314 0.3105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0043 0.0153
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.0446 0.1588
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0178 0.1766
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0043 0.0082
Trypanosoma cruzi malic enzyme, putative 0.0023 0.0074 0.0675
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0056 0.0554
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.0446 0.0851
Schistosoma mansoni ran 0.0022 0.0063 0.0121
Entamoeba histolytica Ran family GTPase 0.0022 0.0063 0.0931
Loa Loa (eye worm) NADP-malic enzyme 0.0017 0.0035 0.0103
Chlamydia trachomatis pyruvate kinase 0.004 0.0181 0.138
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0133
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0178 0.0341
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.1086 0.2076
Entamoeba histolytica malic enzyme, putative 0.0012 0.0001 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0043 0.0043
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0178 0.2347
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0211 0.309
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0002 0.0004
Brugia malayi NAD-dependent malic enzyme, mitochondrial precursor, putative 0.0023 0.0074 0.0263
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0181 0.065
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0169 0.2921
Loa Loa (eye worm) hypothetical protein 0.018 0.1073 0.3859
Echinococcus multilocularis neuropeptide receptor A26 0.0479 0.2979 0.2979
Brugia malayi hypothetical protein 0.0013 0.0006 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0043 0.0082
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0074 0.0524
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0001 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0043 0.0153
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0178 0.2347
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0063 0.0628
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0685 0.4291 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0292 0.1783 0.4134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0182 0.0387
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.1086 0.3906
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0006 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0111 0.0212
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0043 0.0153
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0017 0.0031 0.0503
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.1095
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0314 0.0695
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0031 0.0035
Brugia malayi NAD-dependent malic enzyme, mitochondrial precursor, putative 0.0023 0.0074 0.0263
Trypanosoma brucei protein kinase, putative 0.0103 0.058 0.8756
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0211 0.15
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0178 0.1766
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0031 0.011
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0087 0.0857
Mycobacterium ulcerans acetyl-CoA synthetase 0.0017 0.0031 0.0503
Schistosoma mansoni hypothetical protein 0.0082 0.0446 0.0851
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.0446 0.1605
Onchocerca volvulus 0.0029 0.0111 0.0579
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0091 0.0646
Schistosoma mansoni pyruvate kinase 0.004 0.0181 0.0346
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.058 0.1107
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0263 0.1597 0.3697
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0211 0.309
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1744 0.3332
Echinococcus multilocularis NADP dependent malic enzyme 0.0023 0.0074 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0031 0.0503
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0608 0.329
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0178 0.0638
Echinococcus granulosus heat shock protein 90 0.0038 0.0169 0.0323
Leishmania major importin beta-1 subunit, putative 0.0024 0.0078 0.0739
Trypanosoma brucei heat shock protein, putative 0.0045 0.0211 0.2864
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0115 0.0606
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.0178 0.2925
Brugia malayi hypothetical protein 0.0036 0.0153 0.0549
Schistosoma mansoni patched 1 0.0051 0.0249 0.0476
Echinococcus granulosus GPCR family 2 0.0019 0.0046 0.0087
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0043 0.0082
Schistosoma mansoni hypothetical protein 0.0317 0.1943 0.3714
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0289 0.424
Echinococcus granulosus pyruvate kinase 0.004 0.0181 0.0346
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0043 0.0197 0.0422
Plasmodium vivax acyl-CoA synthetase, putative 0.0043 0.0197 0.1949
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0046 0.0087
Entamoeba histolytica acyl-coA synthetase, putative 0.0057 0.0289 0.424
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.058 0.1107
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0249 0.0879
Echinococcus granulosus endoplasmin 0.0042 0.0193 0.0369
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0608 0.1161
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0608 0.4326
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0115 0.1328
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0043 0.0133
Trypanosoma brucei heat shock protein, putative 0.0045 0.0211 0.2864
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.058 1
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0223 0.0426
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0608 0.4326
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0608 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0292 0.1783 1
Brugia malayi hypothetical protein 0.0286 0.1744 0.629
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0178 0.0638
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.0178 0.2925
Plasmodium vivax thioredoxin reductase, putative 0.0115 0.0657 0.6511
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0043 0.0082
Leishmania major hypothetical protein, conserved 0.0107 0.0608 0.9206
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0031 0.0503
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0608 0.1383
Loa Loa (eye worm) hypothetical protein 0.0043 0.0197 0.0689
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.1943 0.7006
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0178 0.3077
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0308 0.1108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0314 0.5152
Schistosoma mansoni apoptosis regulator bax 0.0082 0.0446 0.0851
Schistosoma mansoni importin beta-1 0.003 0.0113 0.0217
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0006 0.0006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0111 0.1098
Loa Loa (eye worm) hypothetical protein 0.0107 0.0608 0.2175
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0178 0.1759
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1007 0.1007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0314 0.5152
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0074 0.0308
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0043 0.0197 0.3229
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0314 0.0314
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0111 0.0397
Schistosoma mansoni endoplasmin 0.0045 0.0211 0.0403
Plasmodium vivax heat shock protein 90, putative 0.003 0.0115 0.1134
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0043 0.0197 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.0446 0.0446
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0063 0.0121
Leishmania major heat shock protein, putative 0.003 0.0115 0.1328
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0006 0.002
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0063 0.0628
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0074 0.0524
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0031 0.0503
Plasmodium vivax heat shock protein, putative 0.017 0.101 1
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0211 0.2864
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0608 0.1383
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0043 0.0085
Trypanosoma cruzi malic enzyme, putative 0.0023 0.0074 0.0675
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0001 0.0006
Schistosoma mansoni pyruvate kinase 0.0021 0.0056 0.0107
Loa Loa (eye worm) TAR-binding protein 0.0447 0.2771 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0295 0.0564
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0031 0.0503
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0133
Brugia malayi Importin beta-1 subunit 0.003 0.0113 0.0406
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0087 0.0857
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0043 0.0133
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0178 0.0341
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0178 0.1766
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0289 0.4749
Brugia malayi Endoplasmin precursor 0.0045 0.0211 0.0757
Mycobacterium tuberculosis Conserved protein 0.0107 0.0608 0.1383
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0378
Brugia malayi beta-lactamase family protein 0.0107 0.0608 0.2191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0111 0.0212
Trypanosoma brucei NADP-dependent malic enzyme, cytosolic 0.0023 0.0074 0.0675
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.004 0.0178 0.0379
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0043 0.0085
Trypanosoma brucei heat shock protein, putative 0.0045 0.0211 0.2864
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0043 0.0082
Brugia malayi TAR-binding protein 0.0447 0.2771 1
Brugia malayi hypothetical protein 0.0016 0.0029 0.0102
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0181 0.0853
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0103 0.035
Loa Loa (eye worm) hypothetical protein 0.018 0.1073 0.3859
Loa Loa (eye worm) hypothetical protein 0.0051 0.0249 0.0879
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0043 0.0082
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.058 0.058
Echinococcus multilocularis NADP dependent malic enzyme 0.0023 0.0074 0.0074
Onchocerca volvulus 0.0057 0.0289 0.1876
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.0031 0.009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0308 0.1108
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0043 0.0082
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0181 0.065
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0223 0.2205
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0201 0.0384
Plasmodium vivax pyruvate kinase, putative 0.004 0.0181 0.1791
Leishmania major pyruvate kinase 0.004 0.0181 0.2388
Echinococcus granulosus NADP dependent malic enzyme 0.0023 0.0074 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0447 0.2771 0.5295
Schistosoma mansoni hypothetical protein 0.0049 0.0238 0.0454
Loa Loa (eye worm) pyruvate kinase 0.004 0.0181 0.0631
Schistosoma mansoni endoplasmin 0.0045 0.0211 0.0403
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.058 0.4125
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0289 0.4749
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0608 0.4326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0043 0.0133
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0043 0.0043
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0211 0.2864
Leishmania major hypothetical protein, conserved 0.0025 0.0087 0.0881
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0111 0.0397
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0017 0.0031 0.0503
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0169 0.1205
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0608 0.1383
Brugia malayi RNA binding protein 0.0447 0.2771 1
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0193 0.1374
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0017 0.0031 0.0503
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0017 0.0031 0.0035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.035
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0263 0.1597 0.3697
Brugia malayi hypothetical protein 0.0043 0.0201 0.0723
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0044 0.0205
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0178 0.2347
Echinococcus multilocularis protein patched 0.0051 0.0249 0.0249
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0263 0.1597 0.3697
Echinococcus multilocularis thioredoxin glutathione reductase 0.0117 0.0667 0.0667
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0608 0.9206
Schistosoma mansoni hypothetical protein 0.0049 0.0238 0.0454
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0211 0.3635
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0211 0.2864
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0211 0.2864
Onchocerca volvulus 0.0232 0.1405 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0031 0.0503
Schistosoma mansoni hypothetical protein 0.0041 0.0186 0.0356
Brugia malayi MAP kinase sur-1 0.0103 0.058 0.2089
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.058 0.8756
Echinococcus granulosus geminin 0.0516 0.321 0.6134
Echinococcus multilocularis pyruvate kinase 0.0021 0.0056 0.0056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0178 0.2347
Plasmodium vivax acetyl-CoA synthetase, putative 0.0017 0.0031 0.0311
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0608 0.6019
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0091 0.0899
Loa Loa (eye worm) hypothetical protein 0.0043 0.0197 0.0689
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0074 0.0524
Echinococcus multilocularis heat shock protein 90 0.0038 0.0169 0.0169
Plasmodium falciparum acyl-CoA synthetase 0.0043 0.0197 0.1949
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0314 0.4507
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.058 0.1107
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0181 0.0385
Echinococcus multilocularis GPCR, family 2 0.0019 0.0046 0.0046
Trichomonas vaginalis esterase, putative 0.0107 0.0608 0.4326
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0193 0.0413
Onchocerca volvulus 0.0107 0.0608 0.4197
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0133
Echinococcus multilocularis pyruvate kinase 0.0032 0.0127 0.0127
Echinococcus multilocularis heat shock protein 0.0045 0.0211 0.0211
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0178 0.2347
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0133
Plasmodium falciparum endoplasmin, putative 0.0033 0.0132 0.1309
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0017 0.0031 0.0311
Schistosoma mansoni malic enzyme 0.0023 0.0074 0.0141
Loa Loa (eye worm) hypothetical protein 0.0025 0.0087 0.029
Echinococcus granulosus pyruvate kinase 0.0021 0.0056 0.0107
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0132 0.094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.1086 0.2076
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0387
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0289 0.1471
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0447 0.2771 1
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0043 0.0085
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0181 0.2388
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0608 0.4326
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0017 0.0031 0.0311
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.058 0.8756
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0017 0.0031 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.1086 0.2076
Echinococcus multilocularis pyruvate kinase 0.0021 0.0056 0.0056
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0046 0.0046
Mycobacterium ulcerans hypothetical protein 0.0057 0.0289 0.4749
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0181 0.1288
Giardia lamblia Pyruvate kinase 0.004 0.0181 0.3121
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Schistosoma mansoni hypothetical protein 0.0082 0.0446 0.0851
Brugia malayi Pre-SET motif family protein 0.0029 0.0111 0.0397
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0295 0.1063
Onchocerca volvulus 0.0058 0.0295 0.1922
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0043 0.0082
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0292 0.1783 0.4134
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0046 0.0162
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0074 0.0524
Mycobacterium tuberculosis Probable reductase 0.0263 0.1597 0.3697
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0043 0.0153
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0057 0.0289 0.0638
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.058 0.8756
Schistosoma mansoni hypothetical protein 0.0516 0.321 0.6134
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0289 0.424
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0181 0.1089
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0043 0.0082
Loa Loa (eye worm) hypothetical protein 0.0043 0.0197 0.0689
Schistosoma mansoni malic enzyme 0.0012 0.0001 0.0002
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0211 0.2086
Echinococcus granulosus muscleblind protein 0.018 0.1073 0.2051
Loa Loa (eye worm) hypothetical protein 0.0107 0.0608 0.2175
Leishmania major malic enzyme, putative 0.0023 0.0074 0.0675
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0043 0.0153
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0017 0.0031 0.0035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0043 0.0043
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0211 0.2086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0043 0.0153
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0056 0.0554
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0211 0.2086
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0043 0.0043
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0181 0.1288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.1086 0.2076
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0006 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0031 0.0035
Schistosoma mansoni hypothetical protein 0.0043 0.0201 0.0384
Entamoeba histolytica hypothetical protein 0.0043 0.0201 0.2949
Trichomonas vaginalis antibiotic synthetase, putative 0.0017 0.0031 0.0223
Echinococcus multilocularis heat shock protein 90 0.0045 0.0211 0.0211
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0001 0.0006
Echinococcus multilocularis expressed protein 0.0047 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0107 0.0608 0.2175
Echinococcus granulosus pyruvate kinase 0.004 0.0181 0.0346
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0178 0.1766
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0223 0.2205
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0178 0.2347
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0043 0.0043
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0193 0.2583
Loa Loa (eye worm) oxidoreductase 0.0017 0.0031 0.009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0043 0.0082
Plasmodium falciparum importin beta, putative 0.003 0.0113 0.1123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0608 0.0608
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0608 0.1383
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0001 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0043 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.058 0.4125
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0193 0.0923
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0043 0.0082
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0043 0.0043
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0056 0.0554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0043 0.0133
Schistosoma mansoni hypothetical protein 0.0049 0.0238 0.0454
Brugia malayi Pre-SET motif family protein 0.0204 0.1225 0.4419
Onchocerca volvulus 0.0107 0.0608 0.4197
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0178 0.2347
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0608 0.2175
Schistosoma mansoni hypothetical protein 0.0049 0.0238 0.0454
Brugia malayi ecdysteroid receptor 0.0019 0.0043 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0043 0.0153
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Schistosoma mansoni hypothetical protein 0.0516 0.321 0.6134
Echinococcus multilocularis importin subunit beta 1 0.003 0.0113 0.0113
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0031 0.0035
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0057 0.0289 0.4749
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0211 0.2864
Loa Loa (eye worm) hypothetical protein 0.0082 0.0446 0.1588
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.058 0.8756
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.1086 0.3918
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0178 0.2347
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0078 0.0553
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0608 0.1383
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0031 0.011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0043 0.0153
Loa Loa (eye worm) hypothetical protein 0.0107 0.0608 0.2175
Schistosoma mansoni tar DNA-binding protein 0.0447 0.2771 0.5295
Plasmodium vivax SET domain protein, putative 0.0029 0.0111 0.1098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0289 0.0638
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Echinococcus granulosus importin subunit beta 1 0.003 0.0113 0.0217
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0178 0.1766
Echinococcus multilocularis expressed conserved protein 0.0112 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.009
Plasmodium falciparum thioredoxin reductase 0.004 0.0178 0.1766
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0017 0.0031 0.0503
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0031 0.011
Echinococcus multilocularis snurportin 1 0.0317 0.1943 0.1943
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0289 0.4116
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0087
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0111 0.0111
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0057 0.0289 0.4749
Mycobacterium tuberculosis Conserved protein 0.0107 0.0608 0.1383
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1405 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0211 0.2864
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0178 0.2347
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0043 0.0153
Plasmodium falciparum glutathione reductase 0.0115 0.0657 0.6511
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.058 0.8756
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0043 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0289 0.104
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0182 0.0387
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0043 0.0082
Loa Loa (eye worm) hypothetical protein 0.0119 0.0682 0.2442
Trichomonas vaginalis ran, putative 0.0022 0.0063 0.0452
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0046 0.0046
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0314 0.0599
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0017 0.0031 0.0311
Trypanosoma brucei trypanothione reductase 0.0115 0.0657 1
Schistosoma mansoni heat shock protein 0.0045 0.0211 0.0403
Plasmodium falciparum heat shock protein 90, putative 0.017 0.101 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0263 0.1597 0.3697
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0178 0.2347
Trypanosoma brucei heat shock protein, putative 0.0045 0.0211 0.2864
Loa Loa (eye worm) beta-lactamase 0.0107 0.0608 0.2175
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0169 0.0323
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0169 0.2203
Leishmania major trypanothione reductase 0.0115 0.0657 1
Entamoeba histolytica hypothetical protein 0.0043 0.0201 0.2949
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0043 0.0133
Echinococcus granulosus expressed protein 0.0047 0.0223 0.0426
Loa Loa (eye worm) hypothetical protein 0.0057 0.0289 0.1022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0133
Mycobacterium ulcerans beta-lactamase 0.0107 0.0608 1
Brugia malayi steroid hormone receptor 0.0019 0.0043 0.0153
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0178 0.1269
Treponema pallidum heat shock protein 90 0.0042 0.0193 1
Giardia lamblia Grp94/Hsp90 0.0042 0.0193 0.3331
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0178 0.2347
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0211 0.2864
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0087
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0113 0.1123
Echinococcus granulosus NADP dependent malic enzyme 0.0023 0.0074 0.0141
Plasmodium falciparum thioredoxin reductase 0.0115 0.0657 0.6511
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0031 0.0503
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0043 0.0153
Plasmodium falciparum pyruvate kinase 0.004 0.0181 0.1791
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0074 0.0308
Echinococcus multilocularis muscleblind protein 1 0.018 0.1073 0.1073
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0193 1
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0043 0.0082
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0249 0.0249
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0178 0.0178
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0074 0.0524
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Toxoplasma gondii ABC1 family protein 0.0107 0.0608 0.6019
Echinococcus multilocularis NADP dependent malic enzyme 0.0023 0.0074 0.0074
Brugia malayi Thioredoxin reductase 0.0115 0.0657 0.237
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.058 0.2073
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0289 0.4116
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0087 0.0857
Schistosoma mansoni tar DNA-binding protein 0.0447 0.2771 0.5295
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.058 0.4125
Mycobacterium tuberculosis Probable [NAD] dependent malate oxidoreductase Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarbo 0.0023 0.0074 0.0134
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0017 0.0031 0.0503
Echinococcus granulosus neuropeptide s receptor 0.0479 0.2979 0.5692
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0115 0.1134
Echinococcus granulosus thioredoxin glutathione reductase 0.0117 0.0667 0.1275
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.058 0.4125
Loa Loa (eye worm) hypothetical protein 0.006 0.0308 0.109
Schistosoma mansoni tar DNA-binding protein 0.0447 0.2771 0.5295
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.1086 0.1086
Schistosoma mansoni hypothetical protein 0.0058 0.0295 0.0564
Echinococcus multilocularis geminin 0.0516 0.321 0.321
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0682 0.1303
Schistosoma mansoni acetyl-CoA synthetase 0.0017 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0107 0.0608 0.2175
Schistosoma mansoni malic enzyme 0.0012 0.0001 0.0002
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0115 0.0115
Trichomonas vaginalis antibiotic synthetase, putative 0.0017 0.0031 0.0223
Brugia malayi RNA, U transporter 1 0.0084 0.0462 0.1665
Brugia malayi Hsp90 protein 0.003 0.0115 0.041
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0169 0.2203
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0249 0.0476
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0043 0.0153
Trypanosoma cruzi trypanothione reductase, putative 0.0115 0.0657 1
Brugia malayi Muscleblind-like protein 0.018 0.1073 0.3872
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Plasmodium vivax glutathione reductase, putative 0.0115 0.0657 0.6511
Brugia malayi hypothetical protein 0.0013 0.0006 0.002
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0608 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0178 0.0619
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0063 0.0063
Plasmodium falciparum heat shock protein 90 0.0045 0.0211 0.2086
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0314 0.0599
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0608 0.2191
Schistosoma mansoni hypothetical protein 0.004 0.0178 0.0339
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0133
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5233 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.0446 0.0851
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0186 0.067
Mycobacterium ulcerans malate dehydrogenase 0.0023 0.0074 0.1199
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.0446 0.0446
Trypanosoma cruzi malic enzyme 0.0023 0.0074 0.0675
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0078 0.0553
Plasmodium vivax endoplasmin, putative 0.0045 0.0211 0.2086
Brugia malayi CHE-14 protein 0.0051 0.0249 0.0897
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0178 0.1759
Trypanosoma brucei heat shock protein, putative 0.0045 0.0211 0.2864
Echinococcus granulosus snurportin 1 0.0317 0.1943 0.3714
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0087 0.0881
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0078 0.0553
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0314 0.0599
Brugia malayi beta-lactamase 0.0107 0.0608 0.2191
Echinococcus granulosus pyruvate kinase 0.0021 0.0056 0.0107
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0031 0.011
Loa Loa (eye worm) hypothetical protein 0.0062 0.0322 0.1143
Loa Loa (eye worm) hypothetical protein 0.0286 0.1744 0.6283
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0103 0.1514
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0043 0.0133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0608 0.1161
Plasmodium vivax importin-beta 2, putative 0.003 0.0113 0.1123
Onchocerca volvulus 0.0107 0.0608 0.4197
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0017 0.0031 0.0035
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0682 1
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0178 0.1759
Echinococcus multilocularis pyruvate kinase 0.004 0.0181 0.0181
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0087 0.0857
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0113 0.131
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0292 0.1783 0.4134
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0046 0.0162
Brugia malayi beta-lactamase family protein 0.0107 0.0608 0.2191
Mycobacterium tuberculosis Conserved protein 0.0107 0.0608 0.1383
Toxoplasma gondii propionate-CoA ligase 0.0017 0.0031 0.0311
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0223 0.2205
Brugia malayi nuclear hormone receptor 0.0019 0.0043 0.0153
Plasmodium falciparum glutathione reductase 0.004 0.0178 0.1766
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0308 0.109
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0201 0.0201
Echinococcus granulosus heat shock protein 90 0.0045 0.0211 0.0403
Brugia malayi heat shock protein 90 0.0045 0.0211 0.0757
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0608 0.1383
Loa Loa (eye worm) pyruvate kinase 0.004 0.0181 0.0631
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5233 0.5233
Loa Loa (eye worm) hypothetical protein 0.0107 0.0608 0.2175
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0289 0.4749
Loa Loa (eye worm) hypothetical protein 0.0041 0.0186 0.0651
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0223 0.0801
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0043 0.0153
Echinococcus multilocularis endoplasmin 0.0042 0.0193 0.0193
Loa Loa (eye worm) endoplasmin 0.0045 0.0211 0.0739
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0043 0.0043
Leishmania major pyruvate kinase 0.004 0.0181 0.2388
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0043 0.0153
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0513
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0628
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0178 0.2347
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0111 0.0212
Trypanosoma cruzi heat shock protein, putative 0.003 0.0115 0.1328
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0132 0.094
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5233 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0087 0.0881
Echinococcus granulosus expressed conserved protein 0.0112 0.0636 0.1215
Loa Loa (eye worm) hypothetical protein 0.0057 0.0289 0.1022
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1007 0.1924
Echinococcus multilocularis pyruvate kinase 0.004 0.0181 0.0181
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1225 0.4408
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.009
Onchocerca volvulus 0.0019 0.0043 0.0085
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0181 0.1089
Brugia malayi RNA recognition motif domain containing protein 0.0447 0.2771 1
Loa Loa (eye worm) glutathione reductase 0.0115 0.0657 0.2355
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0181 0.2388
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0017 0.0031 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0043 0.0082
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0513
Trypanosoma brucei pyruvate kinase 1 0.004 0.0181 0.2388
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0043 0.0082
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0178 0.2347
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.0178 0.2925
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0031 0.011
Schistosoma mansoni ran 0.0022 0.0063 0.0121
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0001 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0249 0.1774
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0178 0.2347
Loa Loa (eye worm) hypothetical protein 0.0043 0.0197 0.0689
Brugia malayi nuclear receptor NHR-88 0.0019 0.0043 0.0153
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0226
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0608 0.9206
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.0031 0.009
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0017 0.0031 0.0503
Echinococcus multilocularis tar DNA binding protein 0.0447 0.2771 0.2771
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0289 0.104
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0682 0.0682
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0197 0.0689
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0182 0.0387
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.101 1
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0087
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0178 0.1766
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0178 0.0638
Echinococcus multilocularis neuropeptide s receptor 0.0479 0.2979 0.2979
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0043 0.0153
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0031 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0111 0.0212
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0289 0.4749
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0211 0.2864
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0115 0.168
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0017 0.0031 0.0503
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0211 0.2864
Echinococcus multilocularis protein dispatched 1 0.0058 0.0295 0.0295
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0608 0.4326
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0043 0.0082
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0057 0.0289 0.4749
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0043 0.0082
Mycobacterium ulcerans hypothetical protein 0.0107 0.0608 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0289 0.4116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0046 0.0142
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0006 0.002
Mycobacterium leprae Probable lipase LipE 0.0107 0.0608 0.329
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0115 0.0657 0.15
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0017 0.0031 0.0503
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Loa Loa (eye worm) heat shock protein 75 0.003 0.0115 0.0391
Schistosoma mansoni heat shock protein 0.003 0.0115 0.0219
Toxoplasma gondii thioredoxin reductase 0.0115 0.0657 0.6511
Leishmania major heat shock protein 83-1 0.0045 0.0211 0.2864
Giardia lamblia Malic enzyme 0.0023 0.0074 0.127
Leishmania major GTP-binding protein, putative 0.0022 0.0063 0.0513
Mycobacterium ulcerans lipase LipD 0.0107 0.0608 1
Schistosoma mansoni hypothetical protein 0.0082 0.0446 0.0851
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.1086 0.2076
Trichomonas vaginalis malic enzyme, putative 0.0017 0.0035 0.0249
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0031 0.0503
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0193 0.1374
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0223 0.2205
Entamoeba histolytica hypothetical protein 0.0043 0.0201 0.2949
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0006 0.0012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0178 0.2347
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0046 0.0087
Brugia malayi glutathione reductase 0.0115 0.0657 0.237
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0017 0.0031 0.0035
Echinococcus granulosus heat shock protein 0.0045 0.0211 0.0403
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0178 0.0641
Entamoeba histolytica malic enzyme, putative 0.0012 0.0001 0.0012
Schistosoma mansoni heat shock protein 0.0045 0.0211 0.0403
Schistosoma mansoni coup transcription factor 0.0019 0.0043 0.0082
Trypanosoma brucei heat shock protein, putative 0.0045 0.0211 0.2864
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0206
Loa Loa (eye worm) hypothetical protein 0.004 0.0181 0.0631
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0289 0.104
Echinococcus granulosus neuropeptide receptor A26 0.0479 0.2979 0.5692
Schistosoma mansoni tar DNA-binding protein 0.0447 0.2771 0.5295
Echinococcus granulosus pyruvate kinase 0.0021 0.0056 0.0107
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0113 0.131
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.004 0.0178 0.9233
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.058 0.8756
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0017 0.0031 0.0035
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0115 0.0219
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0263 0.1597 0.8935
Mycobacterium ulcerans pyruvate kinase 0.004 0.0181 0.2967
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0043 0.0043
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.0446 0.0851
Echinococcus granulosus tar DNA binding protein 0.0447 0.2771 0.5295
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0017 0.0031 0.046
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0043 0.0133
Brugia malayi hypothetical protein 0.0036 0.0153 0.0549
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0608 0.1161
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0017 0.0031 0.011
Echinococcus granulosus NADP dependent malic enzyme 0.0023 0.0074 0.0141
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0693 0.1325
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0133
Trypanosoma brucei heat shock protein, putative 0.0045 0.0211 0.2864
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.058 0.8756
Loa Loa (eye worm) thioredoxin reductase 0.0115 0.0657 0.2355
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0513
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0682 0.2458
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0181 0.2388
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0074 0.0524
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0104 0.0199
Brugia malayi nuclear receptor RXR 0.0013 0.0006 0.002
Loa Loa (eye worm) pyruvate kinase 0.004 0.0181 0.0631
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0201 0.0384
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0074 0.0308
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.058 0.058
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0608 0.9206
Loa Loa (eye worm) hypothetical protein 0.0057 0.0289 0.1022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0111 0.0212
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0181 0.1791
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0211 0.0739
Echinococcus multilocularis pyruvate kinase 0.0021 0.0056 0.0056
Echinococcus multilocularis muscleblind protein 0.018 0.1073 0.1073
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0031 0.0503
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0289 0.1471
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0043 0.0082
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0314 0.5152
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0263 0.1597 0.3697
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0043 0.0082
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0249 0.0476
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0193 0.3167
Trypanosoma brucei malic enzyme 0.0023 0.0074 0.0675
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0087 0.0881
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0043 0.0133
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0608 0.1383
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0001 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0043 0.0153
Schistosoma mansoni pyruvate kinase 0.004 0.0181 0.0346
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0178 0.1269
Entamoeba histolytica hypothetical protein 0.0043 0.0201 0.2949
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1744 0.1744
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0178 0.2347
Trypanosoma cruzi malic enzyme 0.0023 0.0074 0.0675
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.004 0.0178 0.9233

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1.166 um PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] ChEMBL. No reference
IC50 (functional) > 0.27773 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 39 uM PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 60.3 uM PubChem BioAssay. Dose ResponseConfirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.12 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 0.1413 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1635 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 0.3696 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.631 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 1.8356 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: Counterscreen for Luciferase (Kinase-Glo TM) Inhibition. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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