Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1569 | 0.237 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.1249 | 0.1479 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.2677 | 0.2677 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1569 | 0.1569 |
Schistosoma mansoni | rotamase | 0.0037 | 0.0922 | 0.0922 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0037 | 0.0922 | 0.1347 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0198 | 0.0198 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.2916 | 0.2916 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.1091 | 0.1091 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.3413 | 0.5284 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.087 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1569 | 0.2009 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0036 | 0.087 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.6395 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0071 | 0.0071 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.3698 | 0.5534 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.6395 | 0.5 |
Brugia malayi | hypothetical protein | 0.0127 | 0.6395 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.6395 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.087 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.6395 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.2677 | 0.2677 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1412 | 0.2121 |
Echinococcus granulosus | expressed protein | 0.0037 | 0.0922 | 0.0922 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0037 | 0.0922 | 0.0938 |
Echinococcus multilocularis | expressed protein | 0.0037 | 0.0922 | 0.0922 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0198 | 0.0198 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1569 | 0.1569 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1569 | 0.1569 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1254 | 0.1871 |
Trichomonas vaginalis | rotamase, putative | 0.0037 | 0.0922 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1569 | 0.1569 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1569 | 0.1569 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1569 | 0.1569 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0922 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0036 | 0.087 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0036 | 0.087 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.1091 | 0.1091 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1539 | 0.2322 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0036 | 0.087 | 0.5 |
Echinococcus multilocularis | geminin | 0.0187 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1569 | 0.1569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.