Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.5536 | 0.6056 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0463 | 0.0207 |
Echinococcus multilocularis | geminin | 0.0167 | 0.5536 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.126 | 0.1025 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0463 | 0.0338 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0463 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.037 | 0.2517 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.4643 | 0.4499 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0463 | 0.023 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0638 | 0.0884 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.126 | 0.1025 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0164 | 0.1113 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.3899 | 0.421 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0463 | 0.0207 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0463 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0269 | 0.9035 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0638 | 0.0535 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0262 | 0.5651 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0638 | 0.0429 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0638 | 0.0884 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.5187 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.147 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0638 | 0.0535 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0463 | 0.0338 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0297 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0638 | 0.0429 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0463 | 0.0558 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.126 | 0.1025 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0463 | 0.0338 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0463 | 0.7958 |
Mycobacterium ulcerans | glutaminase | 0.0269 | 0.9035 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0463 | 0.023 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.054 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0297 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.126 | 0.1025 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0164 | 0.1113 |
Brugia malayi | glutaminase DH11.1 | 0.0269 | 0.9035 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.4643 | 0.4499 |
Loa Loa (eye worm) | glutaminase | 0.0269 | 0.9035 | 1 |
Schistosoma mansoni | glutaminase | 0.0269 | 0.9035 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0297 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.5536 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0463 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0463 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0463 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.1573 | 0.1346 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0463 | 0.3151 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.4643 | 0.4499 |
Trichomonas vaginalis | glutaminase, putative | 0.0269 | 0.9035 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.5187 | 0.5511 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0468 | 0.0343 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0463 | 0.0207 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0463 | 0.0558 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0463 | 0.0207 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.5536 | 0.6056 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0463 | 0.0338 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.