Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0258 | 0.0142 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0222 | 0.0088 | 0.0088 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.6923 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0258 | 0.0142 | 0.0142 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0222 | 0.0088 | 0.0088 |
Echinococcus granulosus | histone deacetylase 6 | 0.0235 | 0.0108 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.6923 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0222 | 0.0088 | 0.0088 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0235 | 0.0108 | 0.0019 |
Brugia malayi | Histone deacetylase 1 | 0.0258 | 0.0142 | 0.0142 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.3248 | 0.4564 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.6923 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.2049 | 0.2791 | 0.2791 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0258 | 0.0142 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0258 | 0.0142 | 0.0142 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0222 | 0.0088 | 0.0088 |
Trypanosoma brucei | histone deacetylase 1 | 0.0258 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | histone deacetylase | 0.0222 | 0.0088 | 0.0088 |
Schistosoma mansoni | patched 1 | 0.285 | 0.3976 | 0.3976 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.3248 | 0.4564 | 1 |
Brugia malayi | CHE-14 protein | 0.285 | 0.3976 | 0.3976 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.285 | 0.3976 | 0.3976 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0222 | 0.0088 | 0.619 |
Trichomonas vaginalis | conserved hypothetical protein | 0.285 | 0.3976 | 0.867 |
Echinococcus granulosus | histone deacetylase 8 | 0.2049 | 0.2791 | 0.2727 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0258 | 0.0142 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0222 | 0.0088 | 0.0088 |
Trypanosoma brucei | histone deacetylase 3 | 0.0222 | 0.0088 | 0.0088 |
Echinococcus multilocularis | histone deacetylase 8 | 0.2049 | 0.2791 | 0.2727 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0258 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0142 | 0.0142 |
Echinococcus multilocularis | protein patched | 0.285 | 0.3976 | 0.3922 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0222 | 0.0088 | 0.0088 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0258 | 0.0142 | 0.0142 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0162 | 0 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.285 | 0.3976 | 0.3922 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.285 | 0.3976 | 0.3922 |
Schistosoma mansoni | histone deacetylase | 0.0258 | 0.0142 | 0.0142 |
Leishmania major | histone deacetylase, putative | 0.0258 | 0.0142 | 0.0055 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0258 | 0.0142 | 0.0142 |
Echinococcus granulosus | histone deacetylase 3 | 0.0258 | 0.0142 | 0.0055 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0258 | 0.0142 | 0.0142 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.3248 | 0.4564 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.6923 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.6923 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.6923 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.6923 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.6923 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0222 | 0.0088 | 0.0088 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0258 | 0.0142 | 0.0055 |
Echinococcus multilocularis | protein dispatched 1 | 0.285 | 0.3976 | 0.3922 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.3248 | 0.4564 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0258 | 0.0142 | 0.0142 |
Plasmodium vivax | histone deacetylase, putative | 0.0222 | 0.0088 | 0.619 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0235 | 0.0108 | 0.0108 |
Entamoeba histolytica | histone deacetylase, putative | 0.0258 | 0.0142 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.6923 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0258 | 0.0142 | 0.0055 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.285 | 0.3976 | 0.3922 |
Plasmodium falciparum | histone deacetylase 1 | 0.0258 | 0.0142 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0258 | 0.0142 | 0.0055 |
Trypanosoma brucei | histone deacetylase, putative | 0.0222 | 0.0088 | 0.0088 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.285 | 0.3976 | 0.3922 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.285 | 0.3976 | 0.3976 |
Brugia malayi | Histone deacetylase family protein | 0.0222 | 0.0088 | 0.0088 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0222 | 0.0088 | 0.619 |
Echinococcus granulosus | Protein patched homolog 1 | 0.285 | 0.3976 | 0.3922 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0222 | 0.0088 | 0.0088 |
Echinococcus granulosus | histone deacetylase 1 | 0.0258 | 0.0142 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.285 | 0.3976 | 0.3976 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta MST (functional) | = 0.5 day | Change in mean survival of Plasmodium berghei infected mice following 20 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 0.5 day | Change in mean survival of Plasmodium berghei infected mice following 20 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 0.7 day | Change in mean survival of Plasmodium berghei infected mice following 40 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 0.7 day | Change in mean survival of Plasmodium berghei infected mice following 40 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 4 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 80 mg/kg. | ChEMBL. | 6502605 |
Delta MST (functional) | = 4 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 80 mg/kg. | ChEMBL. | 6502605 |
Delta MST (functional) | = 6.9 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 320 mg/kg | ChEMBL. | 6502605 |
Delta MST (functional) | = 6.9 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 320 mg/kg | ChEMBL. | 6502605 |
Delta MST (functional) | = 7.3 day | Change in mean survival of Plasmodium berghei infected mice following 160 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 7.3 day | Change in mean survival of Plasmodium berghei infected mice following 160 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.