Detailed information for compound 70971

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.566 | Formula: C28H32N2O2
  • H donors: 1 H acceptors: 2 LogP: 5.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)Nc1ccc2c(c1)[C@]13CCCC[C@H]3[C@@H](C2=O)N(CC1)CC1CCC1
  • InChi: 1S/C28H32N2O2/c31-26-22-13-12-21(29-27(32)20-9-2-1-3-10-20)17-24(22)28-14-5-4-11-23(28)25(26)30(16-15-28)18-19-7-6-8-19/h1-3,9-10,12-13,17,19,23,25H,4-8,11,14-16,18H2,(H,29,32)/t23-,25-,28+/m0/s1
  • InChiKey: HMZOMKWKBKHNRX-YRLRHBCXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References
Cavia porcellus Mu opioid receptor Starlite/ChEMBL References
Cavia porcellus Kappa opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Mu opioid receptor   98 aa 80 aa 28.8 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Mu opioid receptor   98 aa 96 aa 32.3 %
Schistosoma mansoni peptide (allatostatin)-like receptor Mu opioid receptor   98 aa 96 aa 36.5 %
Onchocerca volvulus Mu opioid receptor   98 aa 79 aa 31.6 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Mu opioid receptor   98 aa 96 aa 31.2 %
Schistosoma japonicum Neuropeptide Y receptor type 2, putative Mu opioid receptor   98 aa 79 aa 31.6 %
Brugia malayi Melatonin receptor type 1A Mu opioid receptor   98 aa 80 aa 22.5 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 98 aa 31.6 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Mu opioid receptor   98 aa 92 aa 32.6 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 96 aa 31.2 %
Echinococcus multilocularis rhodopsin orphan GPCR Mu opioid receptor   98 aa 80 aa 23.8 %
Onchocerca volvulus Mu opioid receptor   98 aa 80 aa 35.0 %
Schistosoma mansoni rhodopsin-like orphan GPCR Kappa opioid receptor   380 aa 379 aa 22.4 %
Echinococcus granulosus somatostatin receptor Kappa opioid receptor   380 aa 342 aa 19.6 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Mu opioid receptor   98 aa 98 aa 34.7 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Kappa opioid receptor   380 aa 334 aa 25.4 %
Schistosoma mansoni thyrotropin-releasing hormone receptor Mu opioid receptor   98 aa 100 aa 27.0 %
Onchocerca volvulus Mu opioid receptor   98 aa 85 aa 24.7 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 92 aa 23.9 %
Schistosoma mansoni biogenic amine (dopamine) receptor Mu opioid receptor   98 aa 88 aa 39.8 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 319 aa 21.6 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 85 aa 37.6 %
Schistosoma japonicum Neuropeptide Y receptor, putative Mu opioid receptor   98 aa 100 aa 29.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Mu opioid receptor   98 aa 90 aa 28.9 %
Schistosoma japonicum Neuropeptide Y receptor, putative Mu opioid receptor   98 aa 88 aa 23.9 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Kappa opioid receptor   380 aa 313 aa 26.2 %
Echinococcus multilocularis tachykinin peptides receptor 99D Mu opioid receptor   98 aa 93 aa 25.8 %
Schistosoma japonicum ko:K04282 thyrotropin-releasing hormone receptor, putative Mu opioid receptor   98 aa 100 aa 28.0 %
Onchocerca volvulus Mu opioid receptor   98 aa 79 aa 21.5 %
Echinococcus granulosus biogenic amine 5HT receptor Mu opioid receptor   98 aa 96 aa 30.2 %
Echinococcus multilocularis biogenic amine (5HT) receptor Mu opioid receptor   98 aa 96 aa 30.2 %
Echinococcus granulosus biogenic amine 5HT receptor Mu opioid receptor   98 aa 97 aa 35.1 %
Echinococcus multilocularis neuropeptide FF receptor 2 Mu opioid receptor   98 aa 84 aa 31.0 %
Echinococcus granulosus neuropeptide FF receptor 2 Mu opioid receptor   98 aa 84 aa 31.0 %
Schistosoma mansoni biogenic amine receptor Mu opioid receptor   98 aa 91 aa 38.5 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 24.2 %
Schistosoma mansoni amine GPCR Mu opioid receptor   98 aa 86 aa 32.6 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Kappa opioid receptor   380 aa 352 aa 20.2 %
Loa Loa (eye worm) TYRA-2 protein Mu opioid receptor   98 aa 87 aa 31.0 %
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor Mu opioid receptor   98 aa 80 aa 37.5 %
Schistosoma mansoni opsin-like receptor Mu opioid receptor   98 aa 80 aa 25.0 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Mu opioid receptor   98 aa 93 aa 33.3 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 27.4 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 92 aa 31.5 %
Loa Loa (eye worm) melatonin receptor type 1A Mu opioid receptor   98 aa 80 aa 22.5 %
Schistosoma mansoni histamine-responsive GPCR (AAF21638) Mu opioid receptor   98 aa 99 aa 36.4 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 79 aa 29.1 %
Onchocerca volvulus Mu opioid receptor   98 aa 81 aa 33.3 %
Schistosoma japonicum Octopamine receptor, putative Mu opioid receptor   98 aa 88 aa 37.5 %
Onchocerca volvulus Mu opioid receptor   98 aa 100 aa 25.0 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Mu opioid receptor   98 aa 85 aa 32.9 %
Echinococcus multilocularis neuropeptide Y receptor Mu opioid receptor   98 aa 95 aa 32.6 %
Schistosoma mansoni neuropeptide receptor Mu opioid receptor   98 aa 95 aa 32.6 %
Schistosoma japonicum FMRFamide receptor, putative Mu opioid receptor   98 aa 109 aa 28.4 %
Brugia malayi G protein-coupled receptor Mu opioid receptor   98 aa 90 aa 31.1 %
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Mu opioid receptor   98 aa 97 aa 36.1 %
Onchocerca volvulus Kappa opioid receptor   380 aa 374 aa 27.5 %
Loa Loa (eye worm) neuropeptide F receptor Mu opioid receptor   98 aa 80 aa 33.8 %
Schistosoma mansoni hypothetical protein Mu opioid receptor   98 aa 100 aa 23.0 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Mu opioid receptor   98 aa 80 aa 31.2 %
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a Mu opioid receptor   98 aa 96 aa 29.2 %
Echinococcus granulosus thyrotropin releasing hormone receptor Kappa opioid receptor   380 aa 392 aa 25.8 %
Schistosoma mansoni biogenic amine (5HT) receptor Mu opioid receptor   98 aa 97 aa 34.0 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 320 aa 20.6 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 81 aa 35.8 %
Echinococcus granulosus alpha 1A adrenergic receptor Mu opioid receptor   98 aa 92 aa 21.7 %
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Mu opioid receptor   98 aa 97 aa 37.1 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Mu opioid receptor   98 aa 89 aa 38.2 %
Onchocerca volvulus Phospholipase d-related homolog Kappa opioid receptor   380 aa 326 aa 20.9 %
Schistosoma mansoni neuropeptide receptor Mu opioid receptor   98 aa 93 aa 24.7 %
Onchocerca volvulus Mu opioid receptor   98 aa 86 aa 33.7 %
Onchocerca volvulus Programmed cell death protein 5 homolog Kappa opioid receptor   380 aa 316 aa 22.2 %
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor Mu opioid receptor   98 aa 100 aa 29.0 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Kappa opioid receptor   380 aa 326 aa 25.2 %
Schistosoma mansoni biogenic amine (dopamine) receptor Mu opioid receptor   98 aa 97 aa 35.1 %
Echinococcus multilocularis allatostatin A receptor Kappa opioid receptor   380 aa 313 aa 27.2 %
Schistosoma japonicum Muscarinic acetylcholine receptor M1, putative Mu opioid receptor   98 aa 95 aa 30.5 %
Onchocerca volvulus Mu opioid receptor   98 aa 96 aa 28.1 %
Schistosoma mansoni rhodopsin-like orphan GPCR Mu opioid receptor   98 aa 85 aa 25.9 %
Echinococcus granulosus neuropeptide Y receptor Mu opioid receptor   98 aa 95 aa 32.6 %
Echinococcus multilocularis g protein coupled receptor Mu opioid receptor   98 aa 81 aa 24.7 %
Onchocerca volvulus Mu opioid receptor   98 aa 79 aa 27.8 %
Brugia malayi GnHR receptor homolog Kappa opioid receptor   380 aa 341 aa 20.2 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Mu opioid receptor   98 aa 79 aa 36.7 %
Schistosoma japonicum Octopamine receptor, putative Mu opioid receptor   98 aa 98 aa 37.8 %
Schistosoma mansoni biogenic amine receptor Mu opioid receptor   98 aa 97 aa 38.1 %
Echinococcus multilocularis serotonin receptor Mu opioid receptor   98 aa 97 aa 35.1 %
Onchocerca volvulus Mu opioid receptor   98 aa 81 aa 25.9 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Mu opioid receptor   98 aa 89 aa 40.4 %
Onchocerca volvulus Mu opioid receptor   98 aa 101 aa 20.8 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Kappa opioid receptor   380 aa 403 aa 23.3 %
Schistosoma mansoni neuropeptide receptor Mu opioid receptor   98 aa 81 aa 34.6 %
Echinococcus granulosus tachykinin peptides receptor 99D Mu opioid receptor   98 aa 93 aa 25.8 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Onchocerca volvulus Mitogen-activated protein kinase kinase kinase 8 homolog Kappa opioid receptor   380 aa 395 aa 20.3 %
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a Mu opioid receptor   98 aa 96 aa 29.2 %
Schistosoma mansoni biogenic amine (5HT) receptor Mu opioid receptor   98 aa 97 aa 36.1 %
Onchocerca volvulus Mu opioid receptor   98 aa 80 aa 22.5 %
Echinococcus multilocularis neuropeptide receptor Mu opioid receptor   98 aa 88 aa 22.7 %
Schistosoma mansoni biogenic amine receptor Mu opioid receptor   98 aa 98 aa 35.7 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 93 aa 30.1 %
Brugia malayi larval opioid receptor Mu opioid receptor   98 aa 100 aa 24.0 %
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Mu opioid receptor   98 aa 79 aa 34.2 %
Onchocerca volvulus Mu opioid receptor   98 aa 87 aa 32.2 %
Onchocerca volvulus Mu opioid receptor   98 aa 79 aa 27.8 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   98 aa 85 aa 32.9 %
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor Mu opioid receptor   98 aa 100 aa 29.0 %
Echinococcus multilocularis g protein coupled receptor Mu opioid receptor   98 aa 92 aa 26.1 %
Schistosoma mansoni adenoreceptor Mu opioid receptor   98 aa 88 aa 38.6 %
Schistosoma japonicum Probable G-protein coupled receptor No9, putative Mu opioid receptor   98 aa 95 aa 28.4 %
Onchocerca volvulus Mu opioid receptor   98 aa 93 aa 36.6 %
Brugia malayi ORL1-like opioid receptor Kappa opioid receptor   380 aa 312 aa 25.3 %
Schistosoma japonicum Rhodopsin, putative Kappa opioid receptor   380 aa 329 aa 23.1 %
Echinococcus granulosus g protein coupled receptor Mu opioid receptor   98 aa 81 aa 24.7 %
Echinococcus granulosus g protein coupled receptor Mu opioid receptor   98 aa 92 aa 26.1 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Kappa opioid receptor   380 aa 389 aa 25.7 %
Schistosoma mansoni growth hormone secretagogue receptor Mu opioid receptor   98 aa 93 aa 24.7 %
Onchocerca volvulus Mu opioid receptor   98 aa 89 aa 31.5 %
Echinococcus granulosus neuropeptide receptor Mu opioid receptor   98 aa 88 aa 22.7 %
Echinococcus granulosus allatostatin A receptor Kappa opioid receptor   380 aa 317 aa 28.4 %
Onchocerca volvulus Phosphoinositide 3-kinase adapter subunit homolog Kappa opioid receptor   380 aa 323 aa 22.6 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 25.8 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Mu opioid receptor   98 aa 93 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin F (C01 family) 0.1525 0.2477 0.225
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4358 1 1
Brugia malayi Cathepsin L-like precursor 0.1525 0.2477 0.225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Loa Loa (eye worm) hypothetical protein 0.1525 0.2477 0.225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2228 0.4343 1
Plasmodium vivax vivapain-2 0.2228 0.4343 1
Leishmania major cathepsin L-like protease 0.2893 0.6111 1
Onchocerca volvulus 0.2228 0.4343 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2228 0.4343 1
Loa Loa (eye worm) hypothetical protein 0.2228 0.4343 0.4172
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.122 0.1667 0.1416
Brugia malayi cathepsin Z-like cysteine proteinase 0.0731 0.0369 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2228 0.4343 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0715 0.0326 0.0751
Schistosoma mansoni cathepsin F (C01 family) 0.2228 0.4343 0.4172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0715 0.0326 0.0751
Onchocerca volvulus 0.2228 0.4343 1
Loa Loa (eye worm) cysteine protease 0.2228 0.4343 0.4172
Trypanosoma cruzi cysteine peptidase, putative 0.122 0.1667 0.1416
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0731 0.0369 0.0078
Brugia malayi cathepsin L-like precursor 0.1525 0.2477 0.225
Onchocerca volvulus Cathepsin F homolog 0.2228 0.4343 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.2228 0.4343 0.4172
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1705 0.2955 0.2743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Echinococcus multilocularis cathepsin L cysteine protease 0.2228 0.4343 0.428
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0715 0.0326 0.0034
Echinococcus granulosus cysteine protease 0.122 0.1667 0.1575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2228 0.4343 1
Giardia lamblia Cathepsin B precursor 0.1705 0.2955 1
Leishmania major cathepsin L-like protease 0.2228 0.4343 0.4398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2228 0.4343 1
Trypanosoma cruzi cysteine peptidase, putative 0.2893 0.6111 0.5994
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4358 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2228 0.4343 0.428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0731 0.0369 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Trypanosoma cruzi cysteine peptidase, putative 0.2893 0.6111 0.5994
Trypanosoma brucei cysteine peptidase C (CPC) 0.1705 0.2955 0.2899
Entamoeba histolytica cysteine proteinase, putative 0.2228 0.4343 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0731 0.0369 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.122 0.1667 0.3653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Giardia lamblia Cathepsin B precursor 0.1705 0.2955 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.2228 0.4343 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4358 1 1
Onchocerca volvulus 0.2228 0.4343 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0715 0.0326 0.0751
Leishmania major cathepsin L-like protease 0.2228 0.4343 0.4398
Leishmania major cathepsin L-like protease 0.2228 0.4343 0.4398
Brugia malayi Papain family cysteine protease containing protein 0.122 0.1667 0.1416
Plasmodium vivax unspecified product 0.122 0.1667 0.3838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Echinococcus granulosus cathepsin b 0.4358 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1525 0.2477 0.5574
Leishmania major cathepsin L-like protease 0.2228 0.4343 0.4398
Brugia malayi Cathepsin L-like precursor 0.2228 0.4343 0.4172
Echinococcus multilocularis cysteine protease 0.2228 0.4343 0.428
Echinococcus multilocularis cathepsin b 0.4358 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.1525 0.2477 0.225
Echinococcus granulosus cathepsin L 0.122 0.1667 0.1575
Brugia malayi Papain family cysteine protease containing protein 0.122 0.1667 0.1416
Plasmodium vivax vivapain-2 0.2228 0.4343 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0715 0.0326 0.1103
Onchocerca volvulus Cathepsin L homolog 0.2228 0.4343 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.122 0.1667 0.1416
Echinococcus granulosus cathepsin b 0.4358 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.2893 0.6111 0.5994
Brugia malayi Cathepsin L-like precursor 0.2228 0.4343 0.4172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2228 0.4343 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Toxoplasma gondii cathepsin B 0.1705 0.2955 0.6804
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.122 0.1667 0.1416
Onchocerca volvulus 0.2228 0.4343 1
Trypanosoma cruzi cysteine protease, putative 0.122 0.1667 0.1416
Brugia malayi Cathepsin L-like precursor 0.2228 0.4343 0.4172
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2228 0.4343 0.428
Brugia malayi cathepsin Z-like cysteine proteinase 0.0731 0.0369 0.0078
Brugia malayi Cathepsin L-like precursor 0.2228 0.4343 0.4172
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.2191 0.4245 0.4071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1525 0.2477 0.5574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Brugia malayi Cathepsin L-like precursor 0.2228 0.4343 0.4172
Echinococcus granulosus cathepsin L cysteine proteinase 0.2228 0.4343 0.428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2228 0.4343 1
Loa Loa (eye worm) hypothetical protein 0.1525 0.2477 0.225
Trypanosoma cruzi cysteine proteinase, putative 0.122 0.1667 0.1416
Schistosoma mansoni cathepsin F (C01 family) 0.2228 0.4343 0.4172
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2228 0.4343 1
Onchocerca volvulus 0.2228 0.4343 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.2228 0.4343 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Plasmodium vivax vivapain-3 0.122 0.1667 0.3838
Echinococcus granulosus cathepsin l1 0.2228 0.4343 0.428
Giardia lamblia Cathepsin B precursor 0.1705 0.2955 1
Trypanosoma cruzi major cysteine proteinase, putative 0.1183 0.1569 0.1314
Leishmania major cathepsin L-like protease 0.2893 0.6111 1
Loa Loa (eye worm) hypothetical protein 0.4358 1 1
Toxoplasma gondii cathepsin CPC1 0.0715 0.0326 0.0751
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0731 0.0369 0.0574
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4358 1 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0715 0.0326 0.0751
Loa Loa (eye worm) papain family cysteine protease containing protein 0.2228 0.4343 0.4172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.2228 0.4343 0.428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Loa Loa (eye worm) hypothetical protein 0.1525 0.2477 0.225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0731 0.0369 0.0574
Echinococcus multilocularis cathepsin L cysteine protease 0.2228 0.4343 0.428
Onchocerca volvulus 0.2228 0.4343 1
Echinococcus multilocularis cathepsin L 0.122 0.1667 0.1575
Leishmania major cysteine peptidase A (CPA) 0.2228 0.4343 0.4398
Leishmania major cathepsin L-like protease 0.2893 0.6111 1
Giardia lamblia Cathepsin B precursor 0.0731 0.0369 0.1248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2228 0.4343 1
Plasmodium vivax unspecified product 0.0703 0.0293 0.0674
Entamoeba histolytica cysteine proteinase, putative 0.2228 0.4343 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2228 0.4343 1
Echinococcus granulosus cathepsin L cysteine protease 0.122 0.1667 0.1575
Leishmania major cathepsin L-like protease 0.2228 0.4343 0.4398
Loa Loa (eye worm) fibroinase 0.2228 0.4343 0.4172
Echinococcus multilocularis cysteine protease 0.2228 0.4343 0.428
Plasmodium falciparum cysteine proteinase falcipain 3 0.2228 0.4343 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Echinococcus granulosus cathepsin l1 0.1525 0.2477 0.2394
Trypanosoma cruzi cysteine peptidase, putative 0.2893 0.6111 0.5994
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.122 0.1667 0.3653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2228 0.4343 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4358 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.122 0.1667 0.3838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Brugia malayi Papain family cysteine protease containing protein 0.2228 0.4343 0.4172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Brugia malayi Cathepsin L-like precursor 0.1525 0.2477 0.225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2228 0.4343 1
Loa Loa (eye worm) cathepsin B 0.1705 0.2955 0.2743
Onchocerca volvulus Cathepsin L homolog 0.2228 0.4343 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2893 0.6111 1
Plasmodium vivax vivapain-1 0.122 0.1667 0.3838
Echinococcus multilocularis cathepsin b 0.4358 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0715 0.0326 0.0751
Toxoplasma gondii cathepsin CPL 0.2228 0.4343 1
Trypanosoma cruzi cysteine proteinase, putative 0.122 0.1667 0.1416
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1705 0.2955 0.6708
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.122 0.1667 0.1416
Brugia malayi Cathepsin L-like precursor 0.2228 0.4343 0.4172
Onchocerca volvulus 0.2228 0.4343 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1705 0.2955 0.2743
Trypanosoma cruzi cysteine peptidase, putative 0.2228 0.4343 0.4172
Entamoeba histolytica cysteine protease, putative 0.2228 0.4343 1
Entamoeba histolytica cysteine proteinase, putative 0.1525 0.2477 0.3027
Loa Loa (eye worm) ctsf protein 0.2228 0.4343 0.4172

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4.4 nM Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes. ChEMBL. 14695830
Ki (binding) = 4.4 nM Binding affinity against opioid receptor mu 1 using [3H]-DAMGO as radioligand in guinea pig brain membranes. ChEMBL. 14695830
Ki (binding) = 7.7 nM Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes. ChEMBL. 14695830
Ki (binding) = 7.7 nM Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes. ChEMBL. 14695830
Ki (binding) = 380 nM Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes. ChEMBL. 14695830
Ki (binding) = 380 nM Binding affinity against opioid receptor delta 1 using [3H]-naltrindole as radioligand in guinea pig brain membranes. ChEMBL. 14695830
Selectivity (binding) = 49 Selectivity ratio expressed as Ki of delta opioid receptor to that of kappa opioid receptor. ChEMBL. 14695830
Selectivity (binding) = 86 Selectivity ratio expressed as Ki of delta opioid receptor to that of mu opioid receptor. ChEMBL. 14695830

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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