Detailed information for compound 710098

Basic information

Technical information
  • TDR Targets ID: 710098
  • Name: 1-(3-butan-2-yl-4-methoxyphenyl)sulfonyl-4-ph enylpiperazine
  • MW: 388.524 | Formula: C21H28N2O3S
  • H donors: 0 H acceptors: 2 LogP: 4.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(c1cc(ccc1OC)S(=O)(=O)N1CCN(CC1)c1ccccc1)C
  • InChi: 1S/C21H28N2O3S/c1-4-17(2)20-16-19(10-11-21(20)26-3)27(24,25)23-14-12-22(13-15-23)18-8-6-5-7-9-18/h5-11,16-17H,4,12-15H2,1-3H3
  • InChiKey: MJCBAJUVMORIQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-methoxy-3-sec-butyl-phenyl)sulfonyl-4-phenyl-piperazine
  • 1-(4-methoxy-3-sec-butylphenyl)sulfonyl-4-phenylpiperazine
  • 1-(3-butan-2-yl-4-methoxy-phenyl)sulfonyl-4-phenyl-piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.3258 0.4427
Schistosoma mansoni zinc finger protein 0.0023 0.0435 0.0546
Brugia malayi Bromodomain containing protein 0.0044 0.3667 0.2673
Echinococcus granulosus zinc finger protein 0.0023 0.0435 0.0592
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.736 1
Echinococcus multilocularis zinc finger protein 0.0023 0.0435 0.0592
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.2938 0.183
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.566 0.6111
Loa Loa (eye worm) hypothetical protein 0.0057 0.566 0.6111
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0947 0.1287
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0947 0.1287
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.736 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.9262 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.566 0.4979
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0618 0.0667
Loa Loa (eye worm) hypothetical protein 0.0047 0.4087 0.4413
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0106 0.0114
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.3258 0.4427
Schistosoma mansoni hypothetical protein 0.0039 0.2938 0.3683
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0947 0.1188
Schistosoma mansoni bromodomain containing protein 0.0073 0.7978 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.3679 0.3972
Loa Loa (eye worm) hypothetical protein 0.0049 0.4417 0.4769
Loa Loa (eye worm) hypothetical protein 0.0039 0.2938 0.3172
Schistosoma mansoni hypothetical protein 0.0024 0.0618 0.0774
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.566 0.4979

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.