TDR Targets

Basic information

Technical information

TDR Targets ID: 710397
Name: N-[3-(4-chlorophenoxy)propyl]cyclopentanamine
MW: 253.768 | Formula: C14H20ClNO
H donors: 1 H acceptors: 0 LogP: 3.72 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)OCCCNC1CCCC1
InChi: 1S/C14H20ClNO/c15-12-6-8-14(9-7-12)17-11-3-10-16-13-4-1-2-5-13/h6-9,13,16H,1-5,10-11H2
InChiKey: NWYMTPBRXLHNQW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(4-chlorophenoxy)propyl-cyclopentyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.1728	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.1223	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.1728	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.9116	0.9116
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.111	0.5
Schistosoma mansoni	hypothetical protein	0.0032	0.2673	0.2932
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.1728	1
Mycobacterium ulcerans	hypothetical protein	0.0023	0.1728	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.9116	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.9116	1
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.111	0.9078
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.2673	0.2932
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.1223	0.7073
Schistosoma mansoni	ap endonuclease	0.0018	0.1223	0.1341
Loa Loa (eye worm)	hypothetical protein	0.0017	0.111	0.111
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.1223	0.1223
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.1728	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.1728	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.1223	0.7073
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.101	0.5844
Loa Loa (eye worm)	hypothetical protein	0.0017	0.111	0.111
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.6364	0.6364
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.1728	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.1728	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	1	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.1223	0.7073
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.101	0.5844
Loa Loa (eye worm)	RNA binding protein	0.0067	0.6364	0.6364
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1728	0.1728
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.1728	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.2673	0.2673
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.1728	1
Echinococcus multilocularis	GPCR, family 2	0.0032	0.2673	0.2932
Toxoplasma gondii	exonuclease III APE	0.0018	0.1223	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.111	0.6421
Schistosoma mansoni	hypothetical protein	0.0032	0.2673	0.2932
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.1728	1
Schistosoma mansoni	ap endonuclease	0.0018	0.1223	0.1341
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.2673	0.2932
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.2673	0.2932
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.101	0.5844
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.6364	0.6981
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.1223	0.1223
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.6364	0.6364
Loa Loa (eye worm)	hypothetical protein	0.0017	0.111	0.111
Schistosoma mansoni	hypothetical protein	0.0032	0.2673	0.2932
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.1223	0.5
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.111	0.6421
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.1728	0.1728
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.1728	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.111	0.111
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.101	0.5844
Loa Loa (eye worm)	hypothetical protein	0.0069	0.6609	0.6609
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.1728	0.1728
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.6609	0.6609
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.1223	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.9116	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.1223	1
Onchocerca volvulus		0.0023	0.1728	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.111	0.9078
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1728	0.1728
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.1728	1
Brugia malayi	TAR-binding protein	0.0067	0.6364	0.6364
Brugia malayi	RNA binding protein	0.0067	0.6364	0.6364
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.1728	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.9116	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.1223	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.6364	0.6981
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.9116	0.9116
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.6364	0.6981
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.1728	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.2673	0.2673
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.1728	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.1223	0.1341
Loa Loa (eye worm)	hypothetical protein	0.0017	0.111	0.111
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.1223	1
Loa Loa (eye worm)	hypothetical protein	0.0101	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.9116	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.1223	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.1223	0.7073
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.1223	0.1341
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.6364	0.6981
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.2673	0.2932
Schistosoma mansoni	hypothetical protein	0.0069	0.6609	0.7249
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.6364	0.6981
Loa Loa (eye worm)	hypothetical protein	0.0023	0.1728	0.1728
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.1728	0.1728
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.1223	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.1728	1
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.1223	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.1728	1
Schistosoma mansoni	hypothetical protein	0.0032	0.2673	0.2932
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.9116	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.2673	0.2673
Echinococcus granulosus	GPCR family 2	0.0032	0.2673	0.2932
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.2673	0.2673
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.9116	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.6364	0.6981
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.1223	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.6364	0.6364
Echinococcus granulosus	tar DNA binding protein	0.0067	0.6364	0.6981

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 710397