Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0289 | 0.4431 | 0.3869 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0613 | 1 | 1 |
Onchocerca volvulus | 0.0613 | 1 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0613 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0059 | 0.047 | 0.0776 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0289 | 0.4431 | 0.3869 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0289 | 0.4431 | 0.3869 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0289 | 0.4431 | 0.4189 |
Brugia malayi | conserved hypotetical protein | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0613 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0613 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0613 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0087 | 0.0959 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0613 | 1 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0087 | 0.0959 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0613 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0087 | 0.0959 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0613 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0056 | 0.0429 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0289 | 0.4431 | 0.4157 |
Brugia malayi | nuclear receptor NHR-88 | 0.0289 | 0.4431 | 0.3869 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0613 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0324 | 0.5028 | 0.4783 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0289 | 0.4431 | 0.3869 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0613 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0289 | 0.4431 | 0.4157 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Brugia malayi | hypothetical protein | 0.0324 | 0.5028 | 0.4525 |
Brugia malayi | hypothetical protein | 0.0324 | 0.5028 | 0.4525 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0289 | 0.4431 | 0.3869 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0056 | 0.0429 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0613 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0613 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0613 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0613 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0087 | 0.0959 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0324 | 0.5028 | 0.4783 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.5028 | 0.4525 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0289 | 0.4431 | 0.3869 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0613 | 1 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0059 | 0.047 | 0.0054 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0289 | 0.4431 | 0.4189 |
Entamoeba histolytica | protein kinase, putative | 0.0087 | 0.0959 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0289 | 0.4431 | 0.4189 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Schistosoma mansoni | nuclear hormone receptor | 0.0289 | 0.4431 | 0.4157 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0289 | 0.4431 | 0.4189 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0289 | 0.4431 | 0.3869 |
Brugia malayi | ecdysone receptor | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0613 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0059 | 0.047 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0613 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0289 | 0.4431 | 0.4157 |
Brugia malayi | nuclear hormone receptor | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0613 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0087 | 0.0959 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0289 | 0.4431 | 0.4189 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0613 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0087 | 0.0959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0289 | 0.4431 | 0.4189 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0613 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0087 | 0.0959 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.5028 | 0.4525 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0324 | 0.5028 | 0.4525 |
Brugia malayi | nuclear receptor NHR-88 | 0.0613 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0613 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0324 | 0.5028 | 0.4525 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0613 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0613 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0289 | 0.4431 | 0.4189 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0613 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0613 | 1 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0059 | 0.047 | 0.0054 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0059 | 0.047 | 0.0776 |
Schistosoma mansoni | coup transcription factor | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0324 | 0.5028 | 0.4525 |
Brugia malayi | nuclear receptor RXR | 0.0289 | 0.4431 | 0.3869 |
Trichomonas vaginalis | AGC family protein kinase | 0.0087 | 0.0959 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0613 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0056 | 0.0429 | 0.0011 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0289 | 0.4431 | 0.4189 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0613 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0289 | 0.4431 | 0.4189 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0613 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0613 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0613 | 1 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0056 | 0.0429 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0613 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0613 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0613 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0289 | 0.4431 | 0.4189 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0289 | 0.4431 | 0.4157 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0613 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0613 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0087 | 0.0959 | 0.0045 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0324 | 0.5028 | 0.4811 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0613 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0613 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0613 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0613 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.0085 | 0.0918 | 0.5 |
Brugia malayi | tailless protein | 0.0289 | 0.4431 | 0.3869 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0613 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0087 | 0.0959 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0085 | 0.0918 | 0.9224 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0613 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0289 | 0.4431 | 0.3869 |
Schistosoma mansoni | thyroid hormone receptor | 0.0613 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Schistosoma mansoni | zinc finger protein | 0.0289 | 0.4431 | 0.4157 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0613 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0289 | 0.4431 | 0.4189 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0056 | 0.0429 | 0.0011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0613 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Trypanosoma cruzi | Protein kinase B | 0.0059 | 0.047 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0324 | 0.5028 | 0.4811 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0289 | 0.4431 | 0.4157 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0289 | 0.4431 | 0.4157 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0613 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0289 | 0.4431 | 0.4189 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.5028 | 0.4525 |
Echinococcus granulosus | FTZ F1 alpha | 0.0613 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0613 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0613 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0613 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0056 | 0.0429 | 0.0011 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0324 | 0.5028 | 0.4525 |
Brugia malayi | nuclear receptor NHR-67 | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0613 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0087 | 0.0959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.4431 | 0.3869 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.5028 | 0.4525 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.5028 | 0.4525 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta MST (functional) | = 0.5 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 40 mg/kg. | ChEMBL. | 6502605 |
Delta MST (functional) | = 0.5 day | Change in mean survival of Plasmodium berghei infected mice following 20 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 0.5 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 40 mg/kg. | ChEMBL. | 6502605 |
Delta MST (functional) | = 0.5 day | Change in mean survival of Plasmodium berghei infected mice following 20 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 3.1 day | Change in mean survival of Plasmodium berghei infected mice following 80 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 3.1 day | Change in mean survival of Plasmodium berghei infected mice following 80 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 8.3 day | Change in mean survival of Plasmodium berghei infected mice following 160 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 8.3 day | Change in mean survival of Plasmodium berghei infected mice following 160 mg/kg s.c. administration 72 hr after inoculation. | ChEMBL. | 6502605 |
Delta MST (functional) | = 11.5 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 320 mg/kg | ChEMBL. | 6502605 |
Delta MST (functional) | = 11.5 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 320 mg/kg | ChEMBL. | 6502605 |
Delta MST (functional) | = 13.9 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 640 mg/kg | ChEMBL. | 6502605 |
Delta MST (functional) | = 13.9 day | Antimalarial activity against drug-sensitive strain of Plasmodium berghei in mice after 72 hr (s.c.). The mean survival time of treated mice minus mean survival time of control mice at 640 mg/kg | ChEMBL. | 6502605 |
MIC (functional) | > 25 ug ml-1 | In vitro antibacterial activity against Streptococcus faecalis MGH-2. | ChEMBL. | 6502605 |
MIC (functional) | > 25 ug ml-1 | In vitro antibacterial acitivity against Streptococcus aureus U.C-76. | ChEMBL. | 6502605 |
MIC (functional) | > 25 ug ml-1 | In vitro antibacterial activity against Streptococcus aureus S 18713. | ChEMBL. | 6502605 |
MIC (functional) | > 25 ug ml-1 | In vitro against Pseudomonas aeruginosa 28. by gradient-plate test | ChEMBL. | 6502605 |
MIC (functional) | > 25 ug ml-1 | Tested in vitro against Escherichia coli Vogel. by gradient-plate test | ChEMBL. | 6502605 |
MIC (functional) | > 25 ug ml-1 | In vitro antibacterial activity against Shigella sonnei C-10. | ChEMBL. | 6502605 |
MIC (functional) | > 25 ug ml-1 | In vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. | ChEMBL. | 6502605 |
MIC (functional) | > 25 ug ml-1 | Tested in vitro against Escherichia coli Vogel. by gradient-plate test | ChEMBL. | 6502605 |
MIC (functional) | > 25 ug ml-1 | In vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. | ChEMBL. | 6502605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.