Detailed information for compound 710814

Basic information

Technical information
  • TDR Targets ID: 710814
  • Name: N-(3-methylsulfanylphenyl)-2-[methylsulfonyl- [4-(phenylmethoxy)phenyl]amino]acetamide
  • MW: 456.578 | Formula: C23H24N2O4S2
  • H donors: 1 H acceptors: 3 LogP: 3.95 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1cccc(c1)NC(=O)CN(S(=O)(=O)C)c1ccc(cc1)OCc1ccccc1
  • InChi: 1S/C23H24N2O4S2/c1-30-22-10-6-9-19(15-22)24-23(26)16-25(31(2,27)28)20-11-13-21(14-12-20)29-17-18-7-4-3-5-8-18/h3-15H,16-17H2,1-2H3,(H,24,26)
  • InChiKey: IXSVXOYOUWQKQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[methylsulfonyl-[4-(phenylmethoxy)phenyl]amino]-N-[3-(methylthio)phenyl]acetamide
  • 2-[[4-(benzyloxy)phenyl]-mesyl-amino]-N-[3-(methylthio)phenyl]acetamide
  • N-(3-methylsulfanylphenyl)-2-[methylsulfonyl-[4-(phenylmethoxy)phenyl]amino]ethanamide
  • ZINC03016995

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.084 0.084
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.014 0.014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0482 0.1214
Brugia malayi intermediate filament protein 0.0031 0.0067 0.01
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0067 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3489 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0251 0.303 1
Schistosoma mansoni ap endonuclease 0.0062 0.0482 0.0482
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.1081 0.1272
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0137 0.0081
Brugia malayi Cytochrome P450 family protein 0.0116 0.1212 0.1798
Echinococcus granulosus pyruvate kinase 0.0036 0.013 0.0192
Loa Loa (eye worm) hypothetical protein 0.0051 0.0336 0.0499
Schistosoma mansoni tar DNA-binding protein 0.0062 0.049 0.049
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.014 0.0207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0774 0.0884
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0285 0.3489 0.5177
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0594 0.0877
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0083 0.0774 0.1763
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0086 0.0814 0.0951
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0061 0.0475 0.0706
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.056 0.0827
Loa Loa (eye worm) thioredoxin reductase 0.024 0.2893 0.4293
Schistosoma mansoni pyruvate kinase 0.0036 0.013 0.013
Echinococcus multilocularis musashi 0.0031 0.0067 0.0099
Brugia malayi exodeoxyribonuclease III family protein 0.0062 0.0482 0.0715
Echinococcus multilocularis GPCR, family 2 0.007 0.0594 0.0877
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.1096 0.1626
Trichomonas vaginalis glutathione reductase, putative 0.0083 0.0774 0.1916
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.013 0.0299
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.014 0.0031
Echinococcus granulosus lamin dm0 0.0031 0.0067 0.0099
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0137 0.0217
Trypanosoma cruzi trypanothione reductase, putative 0.024 0.2893 0.3557
Echinococcus multilocularis pyruvate kinase 0.0036 0.013 0.0192
Onchocerca volvulus Glucosylceramidase homolog 0.0187 0.2169 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.1546 0.2293
Toxoplasma gondii exonuclease III APE 0.0062 0.0482 0.1385
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.033 0.0487
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0122 0.1292 0.1538
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0251 0.303 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0067 0.01
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0774 0.0884
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.014 0.0086
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0061 0.0475 0.0706
Plasmodium falciparum glutathione reductase 0.024 0.2893 0.953
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.3046 0.452
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0334 0.0496
Echinococcus multilocularis neuropeptide s receptor 0.0528 0.6769 1
Echinococcus granulosus dna polymerase eta 0.0051 0.0343 0.0506
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0083 0.0774 0.0899
Echinococcus granulosus thioredoxin glutathione reductase 0.0241 0.29 0.4284
Leishmania major cytochrome p450-like protein 0.0051 0.0334 0.033
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0824 0.0948
Trichomonas vaginalis mercuric reductase, putative 0.0083 0.0774 0.1916
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.061 0.7874 1
Echinococcus granulosus neuropeptide receptor A26 0.0528 0.6769 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0083 0.0774 0.0884
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0549 0.7048 0.8942
Schistosoma mansoni hypothetical protein 0.007 0.0594 0.0594
Brugia malayi follicle stimulating hormone receptor 0.0252 0.3046 0.452
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.056 0.056
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.014 0.0207
Schistosoma mansoni hypothetical protein 0.0031 0.0072 0.0072
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.049 0.0727
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0594 0.0877
Echinococcus multilocularis lamin 0.0031 0.0067 0.0099
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0594 0.0877
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0293 0.3603 0.4452
Brugia malayi cytochrome P450 0.0031 0.0072 0.0108
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0336 0.0497
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0083 0.0774 0.1145
Onchocerca volvulus 0.0051 0.0336 0.1281
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0343 0.0341
Echinococcus multilocularis lamin dm0 0.0031 0.0067 0.0099
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0083 0.0774 0.222
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.013 0.0299
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2169 0.607
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0067 0.01
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0432 0.0637
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0482 0.1048
Loa Loa (eye worm) hypothetical protein 0.0251 0.303 0.4495
Schistosoma mansoni hypothetical protein 0.007 0.0594 0.0594
Loa Loa (eye worm) transcription factor SMAD2 0.0381 0.4789 0.7105
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0122 0.1292 0.3067
Schistosoma mansoni ap endonuclease 0.0062 0.0482 0.0482
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.014 0.0086
Echinococcus granulosus intermediate filament protein 0.0031 0.0067 0.0099
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0251 0.303 1
Brugia malayi Probable ClpP-like protease 0.0251 0.303 0.4495
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0774 0.0884
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0824 0.0948
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0213 0.2524 0.3728
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.033 0.0487
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.011 0.113 0.1676
Loa Loa (eye worm) MBCTL1 0.0058 0.0432 0.064
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0336 0.0336
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2169 0.607
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.01
Onchocerca volvulus 0.0088 0.084 0.3678
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0482 0.1214
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0122 0.1292 0.1563
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0083 0.0774 0.1143
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.013 0.0073
Loa Loa (eye worm) hypothetical protein 0.0141 0.1546 0.2293
Loa Loa (eye worm) TAR-binding protein 0.0062 0.049 0.0727
Echinococcus granulosus pyruvate kinase 0.0036 0.013 0.0192
Brugia malayi Latrophilin receptor protein 2 0.007 0.0594 0.0881
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.033 0.0487
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0083 0.0774 0.222
Brugia malayi Cytochrome P450 family protein 0.0051 0.0334 0.0496
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.06 0.0665
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0164 0.1865 0.2298
Loa Loa (eye worm) cytochrome P450 0.0031 0.0072 0.0108
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.061 0.7874 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0774 0.0884
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0083 0.0774 0.0884
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.014 0.016
Schistosoma mansoni jumonji domain containing protein 0.0067 0.056 0.056
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.013 0.0074
Leishmania major DNA polymerase eta, putative 0.0051 0.0343 0.0341
Brugia malayi mbt repeat family protein 0.0051 0.0336 0.0499
Mycobacterium tuberculosis Probable dehydrogenase 0.0549 0.7048 0.8942
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0251 0.303 0.7435
Brugia malayi hypothetical protein 0.0141 0.1546 0.2293
Loa Loa (eye worm) hypothetical protein 0.0221 0.2633 0.3906
Brugia malayi RNA binding protein 0.0062 0.049 0.0727
Brugia malayi Thioredoxin reductase 0.024 0.2893 0.4293
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0251 0.303 0.4476
Schistosoma mansoni cytochrome P450 0.0031 0.0072 0.0072
Echinococcus multilocularis pyruvate kinase 0.0028 0.0029 0.0043
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0432 0.064
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0062 0.0482 0.0712
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3489 1
Leishmania major trypanothione reductase 0.024 0.2893 0.3557
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.014 0.0086
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.013 0.0299
Schistosoma mansoni pyruvate kinase 0.0036 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0526 0.6739 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.084 0.1241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.033 0.0487
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0122 0.1292 0.1917
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0549 0.7048 0.8942
Brugia malayi jmjC domain containing protein 0.0067 0.056 0.0831
Plasmodium falciparum thioredoxin reductase 0.0083 0.0774 0.222
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0083 0.0774 0.1148
Echinococcus multilocularis dna polymerase eta 0.0051 0.0343 0.0506
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0336 0.0497
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0062 0.0482 0.103
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0062 0.049 0.049
Leishmania major pyruvate kinase 0.0036 0.013 0.0073
Loa Loa (eye worm) pyruvate kinase 0.0036 0.013 0.0193
Echinococcus multilocularis 0.0031 0.0072 0.0107
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0062 0.0482 0.0712
Brugia malayi MH2 domain containing protein 0.0381 0.4789 0.7105
Echinococcus multilocularis tar DNA binding protein 0.0062 0.049 0.0724
Echinococcus granulosus neuropeptide s receptor 0.0528 0.6769 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.014 0.014
Echinococcus granulosus lamin 0.0031 0.0067 0.0099
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0213 0.2524 0.3728
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0251 0.303 1
Toxoplasma gondii thioredoxin reductase 0.024 0.2893 0.9539
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.06 0.0665
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.056 0.0827
Treponema pallidum NADH oxidase 0.0083 0.0774 0.1145
Schistosoma mansoni tar DNA-binding protein 0.0062 0.049 0.049
Schistosoma mansoni peptidase Clp (S14 family) 0.0251 0.303 0.303
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0619 0.8003 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0164 0.1865 0.2298
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.056 0.0827
Brugia malayi TAR-binding protein 0.0062 0.049 0.0727
Mycobacterium ulcerans pyruvate kinase 0.0036 0.013 0.0145
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0432 0.0432
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0619 0.8003 1
Schistosoma mansoni survival motor neuron protein 0.0107 0.1096 0.1096
Brugia malayi jmjC domain containing protein 0.0067 0.056 0.0831
Echinococcus multilocularis neuropeptide receptor A26 0.0528 0.6769 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0432 0.064
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.014 0.0208
Leishmania major pyruvate kinase 0.0036 0.013 0.0073
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0122 0.1292 0.3067
Loa Loa (eye worm) hypothetical protein 0.007 0.0594 0.0881
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.0814 0.236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.033 0.033
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0083 0.0774 0.1763
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.02 0.0295
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0432 0.0637
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0062 0.0482 0.5467
Schistosoma mansoni tar DNA-binding protein 0.0062 0.049 0.049
Schistosoma mansoni DNA polymerase eta 0.0051 0.0343 0.0343
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.014 0.0207
Toxoplasma gondii hypothetical protein 0.01 0.0997 0.3127
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0122 0.1292 0.1909
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0293 0.3603 0.4452
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0814 0.236
Trypanosoma brucei pyruvate kinase 1 0.0036 0.013 0.0073
Echinococcus granulosus survival motor neuron protein 1 0.0526 0.6739 0.9956
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.06 0.06
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0814 0.1304
Echinococcus granulosus transcription factor Dp 1 0.0041 0.02 0.0295
Plasmodium vivax glutathione reductase, putative 0.024 0.2893 0.953
Plasmodium falciparum thioredoxin reductase 0.024 0.2893 0.953
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0122 0.1292 0.1909
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0336 0.1281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0774 0.0884
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.014 0.0207
Onchocerca volvulus 0.0107 0.1096 0.4895
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3489 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0083 0.0774 0.0884
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.014 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0062 0.049 0.049
Loa Loa (eye worm) CYP4Cod1 0.0051 0.0334 0.0496
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0594 0.0877
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0334 0.0496
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0594 0.0881
Mycobacterium ulcerans hypothetical protein 0.0326 0.405 1
Echinococcus granulosus peptidase Clp S14 family 0.0164 0.1865 0.2755
Echinococcus granulosus GPCR family 2 0.007 0.0594 0.0877
Trypanosoma brucei trypanothione reductase 0.024 0.2893 0.3557
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0083 0.0774 0.222
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.013 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0083 0.0774 0.0884
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0619 0.8003 1
Toxoplasma gondii hypothetical protein 0.0086 0.0814 0.2509
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.06 0.089
Schistosoma mansoni hypothetical protein 0.007 0.0594 0.0594
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0083 0.0774 0.1145
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.033 0.0489
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.06 0.089
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0824 0.0948
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0336 0.0497
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0336 0.0336
Plasmodium vivax thioredoxin reductase, putative 0.024 0.2893 0.953
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2305 0.6474
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2169 0.607
Schistosoma mansoni lamin 0.0031 0.0067 0.0067
Echinococcus multilocularis pyruvate kinase 0.0036 0.013 0.0192
Schistosoma mansoni hypothetical protein 0.0322 0.3992 0.3992
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0824 0.0948
Loa Loa (eye worm) hypothetical protein 0.0088 0.084 0.1247
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3489 1
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3489 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.084 0.1247
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0062 0.0482 0.0516
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0122 0.1292 0.1292
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0062 0.0482 0.0516
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2305 0.6474
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.013 0.0195
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0336 0.0336
Schistosoma mansoni lamin 0.0031 0.0067 0.0067
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0083 0.0774 0.1143
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0083 0.0774 0.2372
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0336 0.0499
Loa Loa (eye worm) hypothetical protein 0.0151 0.1689 0.2506
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.1212 0.1798
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0164 0.1865 0.2298
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.014 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.033 0.033
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0549 0.7048 0.8942
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.013 0.0074
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.06 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.014 0.0207
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.049 0.0727
Mycobacterium tuberculosis Probable oxidoreductase 0.061 0.7874 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.024 0.2893 0.3616
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.06 0.0665
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0083 0.0774 0.0774
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0251 0.303 0.4476
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.056 0.056
Echinococcus multilocularis survival motor neuron protein 1 0.0526 0.6739 0.9956
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0062 0.0482 0.0525
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0083 0.0774 0.0884
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0083 0.0774 0.0884
Brugia malayi Calcitonin receptor-like protein seb-1 0.0221 0.2633 0.3906
Schistosoma mansoni hypothetical protein 0.007 0.0594 0.0594
Mycobacterium tuberculosis Conserved hypothetical protein 0.0326 0.405 0.5098
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0549 0.7048 0.8942
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0083 0.0774 0.0884
Loa Loa (eye worm) hypothetical protein 0.0036 0.014 0.0208
Onchocerca volvulus Huntingtin homolog 0.0141 0.1546 0.7034
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2169 0.607
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.06 0.0886
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0336 0.0497
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0432 0.0637
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0083 0.0774 0.1763
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0285 0.3489 0.5177
Leishmania major DNA polymerase eta, putative 0.0036 0.0137 0.0081
Brugia malayi latrophilin 2 splice variant baaae 0.0151 0.1689 0.2506
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3489 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.049 0.0727
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0083 0.0774 0.222
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0334 0.033
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0051 0.0334 0.0658
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.013 0.0073
Loa Loa (eye worm) glutathione reductase 0.024 0.2893 0.4293
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.0774 0.0884
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.06 0.0886
Giardia lamblia NADH oxidase lateral transfer candidate 0.0083 0.0774 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0221 0.2633 0.3906
Trypanosoma brucei cytochrome P450, putative 0.0051 0.0334 0.033
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.013 0.0193
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0088
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.084 0.1241
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0293 0.3603 0.4452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.033 0.033
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.013 0.0193
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0251 0.303 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0062 0.0482 0.0516
Leishmania major mitochondrial DNA polymerase beta 0.0619 0.8003 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0062 0.0482 0.7432
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.014 0.0207
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2169 0.607
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.0343 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2169 0.607
Schistosoma mansoni hypothetical protein 0.0151 0.1689 0.1689
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0334 0.033
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0251 0.303 0.7435
Brugia malayi glutathione reductase 0.024 0.2893 0.4293
Echinococcus multilocularis thioredoxin glutathione reductase 0.0241 0.29 0.4284
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0062 0.0482 0.0516
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.06 0.0665
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0221 0.2633 0.3906
Mycobacterium tuberculosis Probable reductase 0.0549 0.7048 0.8942
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2169 0.607
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.014 0.0031
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0432 0.0637
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0083 0.0774 0.0884
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0251 0.303 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0062 0.0482 0.0715
Schistosoma mansoni intermediate filament proteins 0.0031 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0051 0.0343 0.0508
Brugia malayi Cytochrome P450 family protein 0.0031 0.0072 0.0108
Schistosoma mansoni hypothetical protein 0.0107 0.1096 0.1096
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0251 0.303 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.056 0.0827
Loa Loa (eye worm) pyruvate kinase 0.0036 0.013 0.0193
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0083 0.0774 0.0884
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.0343 0.0508
Loa Loa (eye worm) MH2 domain-containing protein 0.0381 0.4789 0.7105
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0072 0.0107
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0083 0.0774 0.0884
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0482 0.1048
Echinococcus multilocularis peptidase Clp (S14 family) 0.0164 0.1865 0.2755
Brugia malayi Cytochrome P450 family protein 0.0051 0.0334 0.0496
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0083 0.0774 0.0884
Echinococcus granulosus tar DNA binding protein 0.0062 0.049 0.0724
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0549 0.7048 0.8942
Onchocerca volvulus Huntingtin homolog 0.0141 0.1546 0.7034
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0594 0.0881
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0083 0.0774 0.222
Loa Loa (eye worm) pyruvate kinase 0.0036 0.013 0.0193
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.056 0.0831
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0251 0.303 1
Plasmodium falciparum glutathione reductase 0.0083 0.0774 0.222
Toxoplasma gondii NADPH-glutathione reductase 0.0083 0.0774 0.2372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.033 0.0489
Brugia malayi mbt repeat family protein 0.0051 0.0336 0.0499
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0251 0.303 0.3791
Brugia malayi hypothetical protein 0.0526 0.6739 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.061 0.7874 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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