Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.114063 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.114063 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.114063 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.00558807 | 0.000792866 | 0.00538865 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.114063 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.114063 | 1 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.114063 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.114063 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.00589637 | 0.00363271 | 0.0028421 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.00558807 | 0.000792866 | 0.00171144 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.00558807 | 0.000792866 | 0.00538865 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0557955 | 0.463275 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.00589637 | 0.00363271 | 0.0028421 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.114063 | 1 | 1 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0557955 | 0.463275 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.00558807 | 0.000792866 | 0.00538865 |
Loa Loa (eye worm) | oxidoreductase | 0.00558807 | 0.000792866 | 0.00538865 |
Echinococcus multilocularis | dual specificity protein phosphatase | 0.0214752 | 0.147136 | 0.3176 |
Plasmodium vivax | multidrug resistance-associated protein 1, putative | 0.0243569 | 0.17368 | 0.173025 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.00589637 | 0.00363271 | 1 |
Giardia lamblia | Dual specificity phosphatase, catalytic | 0.0214752 | 0.147136 | 0.5 |
Onchocerca volvulus | 0.0214752 | 0.147136 | 1 | |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.114063 | 1 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.00558807 | 0.000792866 | 0.00538865 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.00589637 | 0.00363271 | 0.0028421 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.00558807 | 0.000792866 | 0.00538865 |
Trypanosoma brucei | oxidoreductase-like protein | 0.00589637 | 0.00363271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00558807 | 0.000792866 | 0.00538865 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.00589637 | 0.00363271 | 0.0028421 |
Brugia malayi | Dual specificity phosphatase, catalytic domain containing protein | 0.0214752 | 0.147136 | 1 |
Schistosoma mansoni | dual specificity protein phosphatase | 0.0214752 | 0.147136 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.00589637 | 0.00363271 | 0.0028421 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.00558807 | 0.000792866 | 0.5 |
Loa Loa (eye worm) | dual specificity phosphatase | 0.0214752 | 0.147136 | 1 |
Leishmania major | oxidoreductase-like protein | 0.00589637 | 0.00363271 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.00589637 | 0.00363271 | 0.0028421 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.00558807 | 0.000792866 | 0.00171144 |
Onchocerca volvulus | 0.00589637 | 0.00363271 | 0.0194054 | |
Echinococcus granulosus | dual specificity protein phosphatase | 0.0214752 | 0.147136 | 0.3176 |
Leishmania major | pteridine reductase 1 | 0.00589637 | 0.00363271 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.00558807 | 0.000792866 | 0.00538865 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 68.11 % | Cytotoxicity against human HT-29 cells assessed as cell viability at 100 uM after 48 hrs by MTT assay relative to control | ChEMBL. | 23602620 |
IC50 (functional) | = 8.23 uM | Antiamoebic activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 72 hrs by microdilution method | ChEMBL. | 23602620 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Entamoeba histolytica | 23602620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.