TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 467.569 | Formula: C26H29N9
H donors: 1 H acceptors: 6 LogP: 4.93 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(c1ncnc2c1nc(n2C)CC)Cc1ccc(cc1)c1ccccc1c1n[nH]nn1
InChi: 1S/C26H29N9/c1-4-6-15-35(26-23-25(27-17-28-26)34(3)22(5-2)29-23)16-18-11-13-19(14-12-18)20-9-7-8-10-21(20)24-30-32-33-31-24/h7-14,17H,4-6,15-16H2,1-3H3,(H,30,31,32,33)
InChiKey: RJQAXYIODHNWGR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Angiotensin II type 1a (AT-1a) receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	355 aa	23.9 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	308 aa	27.3 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II type 1a (AT-1a) receptor	359 aa	306 aa	21.9 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	306 aa	25.8 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	341 aa	23.2 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	364 aa	23.1 %
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	348 aa	26.4 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	303 aa	25.4 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	325 aa	20.9 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	399 aa	25.3 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	314 aa	25.5 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	317 aa	24.3 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	307 aa	22.5 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	296 aa	23.0 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	356 aa	22.2 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	346 aa	18.2 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	328 aa	20.7 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	333 aa	21.3 %
Brugia malayi	GnHR receptor homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	364 aa	20.3 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	22.8 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	404 aa	19.6 %
Echinococcus granulosus	growth hormone secretagogue receptor type 1	Angiotensin II type 1a (AT-1a) receptor	359 aa	342 aa	22.2 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	335 aa	23.0 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	404 aa	19.1 %
Schistosoma mansoni	adenoreceptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	23.7 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	299 aa	25.1 %
Echinococcus granulosus	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	348 aa	26.4 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	313 aa	25.6 %
Brugia malayi	putative neuropeptide receptor NPR1	Angiotensin II type 1a (AT-1a) receptor	359 aa	295 aa	27.1 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II type 1a (AT-1a) receptor	359 aa	306 aa	21.9 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	317 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0013	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Brugia malayi	Furin-like cysteine rich region family protein	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/ALK protein kinase	0.0008	0.3524	0.3524
Brugia malayi	Tyrosine-protein kinase abl-1	0.0013	1	1
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Schistosoma mansoni	hypothetical protein	0.0008	0.3524	0.3524
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0008	0.4521	0.4521
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	CAMK family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0008	0.4521	0.4521
Loa Loa (eye worm)	TK/CSK protein kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0008	0.4521	0.4521
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0008	0.3524	0.3524
Brugia malayi	C-terminal src kinase protein 1	0.0008	0.3524	0.3524
Plasmodium falciparum	protein kinase, putative	0.0008	0.3524	0.5
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosin kinase, putative	0.0008	0.3524	0.3524
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/ACK protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.3524	0.3524
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.4521	0.4521
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0008	0.3524	0.3524
Brugia malayi	Receptor family ligand binding region containing protein	0.0008	0.3524	0.3524
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.4521	0.4521
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0008	0.3524	0.3524
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK protein kinase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/EPH protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0013	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Leishmania major	protein kinase, putative	0.0008	0.3524	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Brugia malayi	hypothetical protein	0.0013	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0008	0.3524	0.3524
Brugia malayi	Tyrosine-protein kinase PR2	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0008	0.3524	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0008	0.3524	0.3524
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Schistosoma mansoni	tyrosine kinase	0.0013	1	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.4521	0.4521
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0008	0.4521	0.4521
Loa Loa (eye worm)	TK protein kinase	0.0008	0.3524	0.3524
Brugia malayi	ephrin receptor 1 precursor	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0008	0.4521	0.4521
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.3524	0.3524
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0013	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	SRC-1	0.0013	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0013	1	1
Brugia malayi	nuclear receptor NHR-88	0.0008	0.4521	0.4521
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0013	1	1
Schistosoma mansoni	ephrin receptor	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0013	1	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0008	0.3524	0.3524
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0008	0.3524	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosin kinase, putative	0.0008	0.3524	0.3524
Echinococcus multilocularis	insulin receptor	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0013	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK protein kinase	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0008	0.3524	0.3524
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0008	0.3524	0.3524
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0008	0.4521	0.4521
Echinococcus multilocularis	tyrosine protein kinase csk	0.0008	0.3524	0.3524
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.3524	0.3524
Schistosoma mansoni	nuclear hormone receptor	0.0008	0.4521	0.4521
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0013	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	receptor protein kinase, putative	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0013	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0008	0.4521	0.4521
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Trypanosoma brucei	Pseudokinase, putative	0.0008	0.3524	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0013	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine kinase	0.0008	0.3524	0.3524
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0008	0.3524	0.3524
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0008	0.4521	0.4521
Echinococcus granulosus	activated cdc42 kinase 1	0.0008	0.3524	0.3524
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0008	0.4521	0.4521
Echinococcus multilocularis	tyrosine protein kinase shark	0.0013	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0008	0.3524	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	receptor protein kinase, putative	0.0008	0.3524	0.3524
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0008	0.3524	0.3524
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase csk	0.0008	0.3524	0.3524
Schistosoma mansoni	serine/threonine RGC	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.4521	0.4521
Onchocerca volvulus		0.0008	0.3524	0.3524
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.3524	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0008	0.3524	0.3524
Onchocerca volvulus	Bile acid receptor homolog	0.0008	0.4521	0.4521
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Plasmodium falciparum	protein kinase, putative	0.0008	0.3524	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0008	0.3524	0.3524
Onchocerca volvulus	Protein ultraspiracle homolog	0.0008	0.4521	0.4521
Brugia malayi	protein-tyrosine kinase	0.0013	1	1
Echinococcus granulosus	activin receptor type	0.0008	0.3524	0.3524
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0008	0.4521	0.4521
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.3524	0.3524
Echinococcus granulosus	epidermal growth factor receptor	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	TK protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0013	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0008	0.4521	0.4521
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.4521	0.4521
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0013	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0008	0.4521	0.4521
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0008	0.4521	0.4521
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0008	0.3524	0.3524
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus granulosus	protein kinase	0.0008	0.3524	0.3524
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0008	0.3524	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0008	0.3524	0.5
Brugia malayi	integrin-linked kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0013	1	1
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Echinococcus granulosus	integrin linked protein kinase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.4521	0.4521
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0008	0.4521	0.4521
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FAK protein kinase	0.0008	0.3524	0.3524
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0008	0.3524	0.3524
Schistosoma mansoni	coup transcription factor	0.0008	0.4521	0.4521
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase shark	0.0013	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0008	0.3524	0.3524
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Echinococcus granulosus	epidermal growth factor receptor	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0013	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0013	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.4521	0.4521
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0013	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0008	0.3524	0.3524
Trichomonas vaginalis	protein kinase atn1, putative	0.0008	0.3524	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0013	1	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.4521	0.4521
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Onchocerca volvulus	Tyrosine kinase homolog	0.0008	0.3524	0.3524
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0008	0.4521	0.4521
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0008	0.3524	0.3524
Loa Loa (eye worm)	SRC-1	0.0013	1	1
Onchocerca volvulus		0.0008	0.3524	0.3524
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trypanosoma cruzi	protein kinase, putative	0.0008	0.3524	0.5
Onchocerca volvulus		0.0013	1	1
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Leishmania major	protein kinase, putative	0.0008	0.3524	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0008	0.3524	0.3524
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.4521	0.4521
Trypanosoma cruzi	protein kinase, putative	0.0008	0.3524	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.4521	0.4521
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0008	0.3524	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.4521	0.4521
Loa Loa (eye worm)	TK/ROR protein kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.3524	0.3524
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0008	0.3524	0.3524
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0013	1	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/ABL protein kinase	0.0013	1	1
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0008	0.3524	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0013	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0008	0.3524	0.3524
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0008	0.4521	0.4521
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0008	0.3524	0.3524
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0008	0.3524	0.3524
Entamoeba histolytica	cysteine surface protein, putative	0.0008	0.3524	0.3524
Echinococcus multilocularis	heat shock protein 70	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0008	0.3524	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0013	1	1
Onchocerca volvulus		0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0008	0.3524	0.3524
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0008	0.3524	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0013	1	1
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0013	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Giardia lamblia	Kinase, NEK	0.0008	0.3524	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	c src tyrosine kinase	0.0013	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0008	0.4521	0.4521
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0008	0.3524	0.3524
Echinococcus multilocularis	FL cytokine receptor	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase csk	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine kinase	0.0008	0.3524	0.3524
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0013	1	1
Echinococcus multilocularis	integrin linked protein kinase	0.0008	0.3524	0.3524
Giardia lamblia	Protein 21.1	0.0008	0.3524	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	epidermal growth factor receptor	0.0008	0.3524	0.3524
Echinococcus multilocularis	FTZ F1 alpha	0.0008	0.4521	0.4521
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0008	0.4521	0.4521
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0008	0.3524	0.3524
Toxoplasma gondii	protein kinase domain-containing protein	0.0008	0.3524	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0008	0.4521	0.4521
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0013	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.4521	0.4521
Echinococcus granulosus	tyrosine protein kinase Blk	0.0013	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Echinococcus multilocularis	protein tyrosine kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0013	1	1
Schistosoma mansoni	tyrosine kinase	0.0013	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0008	0.4521	0.4521
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0013	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.3524	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Schistosoma mansoni	tyrosine kinase	0.0013	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus multilocularis	tyrosine kinase	0.0013	1	1
Entamoeba histolytica	ankyrin repeat protein	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Brugia malayi	ecdysteroid receptor	0.0008	0.4521	0.4521
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	TK protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0008	0.3524	0.3524
Plasmodium falciparum	protein kinase, putative	0.0008	0.3524	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0008	0.3524	0.3524
Echinococcus granulosus	ecdysone induced protein 78C	0.0008	0.4521	0.4521
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.4521	0.4521
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0008	0.3524	0.3524
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosin kinase, putative	0.0008	0.3524	0.3524
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Schistosoma mansoni	protein tyrosine kinase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Onchocerca volvulus		0.0008	0.3524	0.3524
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0008	0.3524	0.3524
Plasmodium falciparum	tyrosine kinase-like protein	0.0008	0.3524	0.5
Trypanosoma brucei	protein kinase, putative	0.0008	0.3524	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0013	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0013	1	1
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	epidermal growth factor receptor	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0008	0.3524	0.3524
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0008	0.3524	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0013	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0008	0.4521	0.4521
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.4521	0.4521
Brugia malayi	steroid hormone receptor	0.0008	0.4521	0.4521
Brugia malayi	hypothetical protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0013	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	serine/threonine kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/RYK protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TK family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Echinococcus multilocularis	protein kinase	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0013	1	1
Brugia malayi	hypothetical protein	0.0008	0.3524	0.3524
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0008	0.4521	0.4521
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine kinase	0.0013	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.3524	0.5
Echinococcus granulosus	protein tyrosine kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase csk	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase csk	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.3524	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0008	0.4521	0.4521
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0008	0.4521	0.4521
Loa Loa (eye worm)	TK protein kinase	0.0013	1	1
Giardia lamblia	Kinase	0.0008	0.3524	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	transfer RNA-Thr	0.0008	0.3524	0.3524
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0013	1	1
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus granulosus	FTZ F1 alpha	0.0008	0.4521	0.4521
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0013	1	1
Echinococcus granulosus	insulin receptor	0.0008	0.3524	0.3524
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0008	0.3524	0.3524
Brugia malayi	nuclear hormone receptor	0.0008	0.4521	0.4521
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0008	0.4521	0.4521
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Giardia lamblia	Kinase, NEK	0.0008	0.3524	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Toxoplasma gondii	protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0008	0.4521	0.4521
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0013	1	1
Plasmodium vivax	protein kinase, putative	0.0008	0.3524	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0013	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.3524	0.3524
Brugia malayi	Steroid receptor seven-up type 2	0.0008	0.4521	0.4521
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0008	0.3524	0.3524
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0008	0.4521	0.4521
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0008	0.4521	0.4521
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	SH2 domain containing protein	0.0013	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0008	0.4521	0.4521
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.3524	0.3524
Schistosoma mansoni	ephrin receptor	0.0008	0.3524	0.3524
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0008	0.4521	0.4521
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.3524	0.3524
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus multilocularis	activin receptor type	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Onchocerca volvulus		0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0008	0.4521	0.4521
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Leishmania major	hypothetical protein, conserved	0.0008	0.3524	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0008	0.3524	0.3524
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0008	0.3524	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0013	1	1
Brugia malayi	Protein kinase domain containing protein	0.0013	1	1
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0008	0.4521	0.4521
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.4521	0.4521
Brugia malayi	Guanylyl cyclase protein 23	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.4521	0.4521
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0013	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0008	0.4521	0.4521
Echinococcus multilocularis	activated cdc42 kinase 1	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK/FER protein kinase	0.0008	0.3524	0.3524
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.4521	0.4521
Brugia malayi	photoreceptor-specific nuclear receptor	0.0008	0.4521	0.4521
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.4521	0.4521
Echinococcus granulosus	kinase suppressor of Ras 1	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine kinase	0.0013	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.4521	0.4521
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	0.4521	0.4521
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0013	1	1
Schistosoma mansoni	protein kinase	0.0008	0.3524	0.3524
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.3524	0.5
Onchocerca volvulus		0.0013	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0008	0.4521	0.4521
Trichomonas vaginalis	STE family protein kinase	0.0008	0.3524	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0008	0.3524	0.3524
Loa Loa (eye worm)	TK protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0008	0.3524	0.3524
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein, conserved	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0008	0.3524	0.3524
Brugia malayi	SH2 domain containing protein	0.0013	1	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Echinococcus granulosus	tyrosine protein kinase Srms	0.0013	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0013	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0013	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.4521	0.4521
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0008	0.3524	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Schistosoma mansoni	tyrosine kinase	0.0008	0.3524	0.3524
Plasmodium falciparum	tyrosine kinase-like protein	0.0008	0.3524	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.4521	0.4521
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0013	1	1
Echinococcus multilocularis	protein kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	hypothetical protein	0.0008	0.3524	0.3524
Trichomonas vaginalis	TKL family protein kinase	0.0008	0.3524	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0013	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0008	0.3524	0.3524
Echinococcus granulosus	activated cdc42 kinase 1	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase, putative	0.0008	0.3524	0.3524
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0008	0.4521	0.4521
Brugia malayi	Raf kinase	0.0008	0.3524	0.3524
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.3524	0.3524
Brugia malayi	Protein kinase domain containing protein	0.0008	0.3524	0.3524
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0008	0.4521	0.4521
Toxoplasma gondii	STE kinase	0.0008	0.3524	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0008	0.3524	0.3524

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 7.52	pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings	ChEMBL.	No reference
pA2 (binding)	= 7.52	pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 71101