TDR Targets

Basic information

Technical information

TDR Targets ID: 711240
Name: N-(2,4-dimethylphenyl)-2-morpholin-4-ylacetam ide
MW: 248.321 | Formula: C14H20N2O2
H donors: 1 H acceptors: 1 LogP: 1.52 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1C)C)CN1CCOCC1
InChi: 1S/C14H20N2O2/c1-11-3-4-13(12(2)9-11)15-14(17)10-16-5-7-18-8-6-16/h3-4,9H,5-8,10H2,1-2H3,(H,15,17)
InChiKey: CWQMKKNBDINQER-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,4-dimethylphenyl)-2-morpholino-acetamide
N-(2,4-dimethylphenyl)-2-morpholinoacetamide
N-(2,4-dimethylphenyl)-2-morpholin-4-yl-ethanamide
T5301987

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0736	0.0911
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.2458	0.3043
Echinococcus granulosus	ecdysone induced protein 78C	0.0042	0.0613	0.0613
Brugia malayi	Steroid receptor seven-up type 2	0.0042	0.0613	0.0759
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0736	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0042	0.0613	0.0613
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0309	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0042	0.0613	0.0759
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0613	0.0613
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0309	0.0382
Brugia malayi	ecdysteroid receptor	0.0042	0.0613	0.0759
Loa Loa (eye worm)	glutaminase 2	0.0287	0.8075	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0309	0.0309
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.2919	1
Brugia malayi	nuclear receptor NHR-88	0.0042	0.0613	0.0759
Onchocerca volvulus	Bile acid receptor homolog	0.0042	0.0613	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.2904	0.3596
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0042	0.0613	0.0613
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0042	0.0613	0.0759
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.2557	0.8342
Loa Loa (eye worm)	hypothetical protein	0.007	0.1463	0.1812
Trichomonas vaginalis	glutaminase, putative	0.0287	0.8075	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0613	0.0759
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0309	0.0309
Plasmodium falciparum	glutathione reductase	0.0047	0.0736	0.5
Mycobacterium tuberculosis	Probable reductase	0.0106	0.2557	0.8342
Echinococcus multilocularis	tar DNA binding protein	0.0194	0.5233	0.5233
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0042	0.0613	0.0613
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0613	0.0759
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.5233	0.5233
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0042	0.0613	0.0613
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0736	0.0736
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0309	0.0309
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0042	0.0613	0.0613
Trypanosoma brucei	trypanothione reductase	0.0047	0.0736	0.5
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0736	0.0911
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0042	0.0613	0.0759
Brugia malayi	TAR-binding protein	0.0194	0.5233	0.6481
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.2458	0.3043
Schistosoma mansoni	hypothetical protein	0.0033	0.0309	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0042	0.0613	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0613	0.0759
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0042	0.0613	0.0759
Echinococcus multilocularis	ecdysone induced protein 78C	0.0042	0.0613	0.0613
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.2458	0.3043
Schistosoma mansoni	RAR-like nuclear receptor	0.0042	0.0613	0.0613
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.2919	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.2557	0.8342
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0042	0.0613	0.0613
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0042	0.0613	0.0613
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0613	0.0613
Loa Loa (eye worm)	glutaminase	0.0287	0.8075	1
Mycobacterium ulcerans	glutaminase	0.0287	0.8075	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.5233	0.5233
Leishmania major	trypanothione reductase	0.0047	0.0736	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0042	0.0613	0.0613
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0309	0.0309
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.2919	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0613	0.0759
Onchocerca volvulus	Protein ultraspiracle homolog	0.0042	0.0613	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0042	0.0613	0.0759
Brugia malayi	Thioredoxin reductase	0.0047	0.0736	0.0911
Schistosoma mansoni	hypothetical protein	0.0033	0.0309	0.0309
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0736	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0042	0.0613	0.0613
Schistosoma mansoni	hypothetical protein	0.007	0.1463	0.1463
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0042	0.0613	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0613	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0613	0.0759
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.2904	0.3596
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0042	0.0613	0.0613
Brugia malayi	photoreceptor-specific nuclear receptor	0.0042	0.0613	0.0759
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0613	0.0759
Echinococcus granulosus	GPCR family 2	0.0033	0.0309	0.0309
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0042	0.0613	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0613	0.0759
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.5233	0.5233
Brugia malayi	steroid hormone receptor	0.0042	0.0613	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2458	0.3043
Schistosoma mansoni	glutaminase	0.0287	0.8075	0.8075
Loa Loa (eye worm)	RNA binding protein	0.0194	0.5233	0.6481
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0309	0.0382
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0042	0.0613	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0613	0.0759
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0042	0.0613	0.0613
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0309	0.0309
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0736	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0042	0.0613	0.0613
Echinococcus multilocularis	geminin	0.035	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0613	0.0613
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0042	0.0613	0.0759
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0613	0.0613
Schistosoma mansoni	hypothetical protein	0.035	1	1
Echinococcus granulosus	tar DNA binding protein	0.0194	0.5233	0.5233
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0309	0.0382
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0042	0.0613	0.0759
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0613	0.0759
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0042	0.0613	0.0759
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0042	0.0613	0.0759
Schistosoma mansoni	hypothetical protein	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0613	0.0759
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0042	0.0613	0.0759
Loa Loa (eye worm)	TAR-binding protein	0.0194	0.5233	0.6481
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.1463	0.1812
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.5233	0.5233
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0613	0.0759
Brugia malayi	MH2 domain containing protein	0.0117	0.2904	0.3596
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.2919	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0736	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.5233	0.5233
Brugia malayi	RNA recognition motif domain containing protein	0.0194	0.5233	0.6481
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0042	0.0613	0.0759
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0613	0.0613
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0613	0.0613
Brugia malayi	nuclear hormone receptor	0.0042	0.0613	0.0759
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.2557	0.8342
Schistosoma mansoni	thyroid hormone receptor	0.0042	0.0613	0.0613
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0736	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0613	0.0759
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0042	0.0613	0.0613
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0613	0.0613
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0042	0.0613	0.0613
Echinococcus multilocularis	FTZ F1 alpha	0.0042	0.0613	0.0613
Schistosoma mansoni	hypothetical protein	0.0033	0.0309	0.0309
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0194	0.5233	0.6481
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0613	0.0759
Loa Loa (eye worm)	steroid hormone receptor	0.0042	0.0613	0.0759
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.2557	0.8342
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0042	0.0613	0.0613
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0042	0.0613	0.0613
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0309	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0613	0.0759
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.2557	0.8342
Brugia malayi	glutathione reductase	0.0047	0.0736	0.0911
Onchocerca volvulus		0.0042	0.0613	0.5
Brugia malayi	RNA binding protein	0.0194	0.5233	0.6481
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0042	0.0613	0.0613
Echinococcus granulosus	FTZ F1 alpha	0.0042	0.0613	0.0613
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0736	0.0736
Brugia malayi	glutaminase DH11.1	0.0287	0.8075	1
Schistosoma mansoni	coup transcription factor	0.0042	0.0613	0.0613

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 711240