Detailed information for compound 711264

Basic information

Technical information
  • TDR Targets ID: 711264
  • Name: 4-methyl-6-(4-nitrophenyl)-N-(phenylmethyl)-2 -sulfanylidene-3,6-dihydro-1H-pyrimidine-5-ca rboxamide
  • MW: 382.436 | Formula: C19H18N4O3S
  • H donors: 2 H acceptors: 3 LogP: 2.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1=C(C)N=C(NC1c1ccc(cc1)[N+](=O)[O-])S)NCc1ccccc1
  • InChi: 1S/C19H18N4O3S/c1-12-16(18(24)20-11-13-5-3-2-4-6-13)17(22-19(27)21-12)14-7-9-15(10-8-14)23(25)26/h2-10,17H,11H2,1H3,(H,20,24)(H2,21,22,27)
  • InChiKey: DTQBSOQGHXJVIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-6-(4-nitrophenyl)-N-(phenylmethyl)-2-thioxo-3,6-dihydro-1H-pyrimidine-5-carboxamide
  • N-(benzyl)-4-methyl-6-(4-nitrophenyl)-2-thioxo-3,6-dihydro-1H-pyrimidine-5-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0183 0.1003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.3316 0.3316
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0362 0.0981
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Mycobacterium tuberculosis Conserved protein 0.0035 0.0707 0.1152
Loa Loa (eye worm) RNA binding protein 0.0064 0.1431 0.424
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0309 0.081
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.066 0.1891
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0074 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0528 0.1481
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0183 0.0323
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.074 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.3316 0.3316
Onchocerca volvulus 0.0035 0.0707 0.6487
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.0074 0.0101
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.001 0.0074 0.0101
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Brugia malayi jmjC domain containing protein 0.0017 0.0249 0.0637
Loa Loa (eye worm) hypothetical protein 0.0014 0.0183 0.0426
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0362 0.3412
Schistosoma mansoni hypothetical protein 0.0015 0.021 0.021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.105 0.3214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0528 0.1488
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.2758 0.4958
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0285 0.1939
Brugia malayi jmjC domain containing protein 0.0064 0.1423 0.4221
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0707 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0362 0.2694
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0183 0.0945
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0528 0.1488
Mycobacterium tuberculosis Conserved protein 0.0035 0.0707 0.1152
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.001 0.0074 0.0092
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.105 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0285 0.1939
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0528 0.0528
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0097 0.0102
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0155 0.0836
Loa Loa (eye worm) hypothetical protein 0.0049 0.105 0.3077
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.001 0.0074 0.0074
Brugia malayi hypothetical protein 0.0015 0.0195 0.0472
Loa Loa (eye worm) hypothetical protein 0.0028 0.0528 0.1481
Loa Loa (eye worm) hypothetical protein 0.0021 0.0362 0.0973
Onchocerca volvulus 0.0049 0.105 1
Trypanosoma brucei trypanothione reductase 0.0051 0.1109 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1431 0.4245
Loa Loa (eye worm) hypothetical protein 0.0017 0.0249 0.0629
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.105 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0362 0.0362
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0528 0.1488
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.105 0.9423
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0285 0.1939
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0528 0.1481
Brugia malayi Cation transporter family protein 0.001 0.0074 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0183 0.1003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0195 0.0195
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0195 0.0195
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0285 0.0745
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0268 0.1781
Leishmania major hypothetical protein, conserved 0.0017 0.0249 0.1594
Schistosoma mansoni nAChR subunit 0.001 0.0074 0.0074
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0707 0.0707
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.001 0.0074 0.0101
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0155 0.0155
Echinococcus granulosus glycine receptor subunit alpha 1 0.001 0.0074 0.0074
Echinococcus granulosus bloom syndrome protein 0.0021 0.0362 0.0362
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0183 0.0183
Loa Loa (eye worm) ACC-1 protein 0.001 0.0074 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0165
Plasmodium vivax JmjC domain containing protein 0.0017 0.0249 0.1588
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.105 1
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.1109 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0268 0.1781
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0155 0.0155
Schistosoma mansoni DNA helicase recq1 0.0021 0.0362 0.0362
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0285 0.0285
Brugia malayi ecdysone receptor 0.0013 0.0155 0.035
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.105 0.9423
Schistosoma mansoni hypothetical protein 0.0015 0.021 0.021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0528 0.0528
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0155 0.0155
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.0074 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0528 0.1481
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0707 0.1152
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.105 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.105 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0707 0.0707
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0183 0.1003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.3316 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.2758 0.4958
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0707 0.6441
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0528 0.0528
Schistosoma mansoni thyroid hormone receptor 0.0155 0.3724 0.3724
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.105 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1431 0.1431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.3316 0.3316
Loa Loa (eye worm) hypothetical protein 0.0028 0.0528 0.1481
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0183 0.1003
Loa Loa (eye worm) hypothetical protein 0.0049 0.1048 0.3068
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Loa Loa (eye worm) hypothetical protein 0.0033 0.066 0.1884
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0183 0.018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.0074 0.0101
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.001 0.0074 0.0074
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0087 0.0087
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0183 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0528 0.1488
Onchocerca volvulus 0.0035 0.0707 0.6487
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.105 1
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.1109 0.3257
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0362 0.2694
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.105 1
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0155 0.035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0528 0.0528
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0309 0.2174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0195 0.0464
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0555 0.1564
Brugia malayi nuclear receptor NHR-67 0.0013 0.0155 0.035
Loa Loa (eye worm) DR-78 0.0013 0.0155 0.0342
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.5475 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0528 0.0528
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0155 0.0155
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0285 0.0368
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.021 0.0517
Brugia malayi cytochrome P450 0.001 0.0086 0.0139
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1048 0.3068
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0528 0.0528
Schistosoma mansoni DNA helicase recq5 0.0021 0.0362 0.0362
Brugia malayi Latrophilin receptor protein 2 0.0015 0.021 0.0517
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.2758 0.4958
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0155 0.035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0183 0.0426
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0362 0.2528
Brugia malayi steroid hormone receptor 0.0028 0.0528 0.1488
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0528 0.0528
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.1464 0.1464
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0183 0.0183
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0087 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0707 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.001 0.0074 0.0092
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0183 0.018
Trichomonas vaginalis esterase, putative 0.0035 0.0707 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.001 0.0074 0.0074
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0249 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.105 0.1789
Loa Loa (eye worm) hypothetical protein 0.0015 0.0195 0.0464
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0707 0.607
Echinococcus multilocularis glycine receptor subunit alpha 1 0.001 0.0074 0.0074
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0309 0.2307
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.074 0.678
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.069 0.112
Onchocerca volvulus 0.0014 0.0183 0.1119
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0183 0.0887
Brugia malayi jmjC domain containing protein 0.0065 0.1464 0.4346
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0268 0.1775
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.0074 0.0101
Onchocerca volvulus 0.0028 0.0528 0.4653
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0707 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.047 0.3755
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0309 0.2174
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0528 0.0528
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0268 0.1781
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.029 0.029
Schistosoma mansoni nAChR subunit 0.001 0.0074 0.0074
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0285 0.1939
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.047 0.3755
Loa Loa (eye worm) hypothetical protein 0.0035 0.0707 0.2028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0528 0.1488
Schistosoma mansoni hypothetical protein 0.0405 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0528 0.4653
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0268 0.1781
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0097 0.0243
Echinococcus granulosus GPCR family 2 0.0015 0.021 0.021
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0183 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0183 0.1003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Loa Loa (eye worm) hypothetical protein 0.0017 0.0249 0.0629
Loa Loa (eye worm) oxidoreductase 0.0014 0.0183 0.0426
Echinococcus granulosus glycine receptor subunit beta 0.001 0.0074 0.0074
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0155 0.035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.021 0.021
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0183 0.0945
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0528 0.0528
Brugia malayi AMP-binding enzyme family protein 0.0049 0.105 0.3083
Echinococcus multilocularis dnaJ subfamily B 0.0405 1 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0249 0.0629
Plasmodium falciparum thioredoxin reductase 0.0051 0.1109 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1431 0.424
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.105 1
Echinococcus multilocularis nAChR subunit 0.001 0.0074 0.0074
Schistosoma mansoni ap endonuclease 0.0018 0.0285 0.0285
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.3086 0.5566
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0249 0.1496
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0268 0.1781
Brugia malayi conserved hypotetical protein 0.0013 0.0155 0.035
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0195 0.0464
Echinococcus multilocularis glycine receptor subunit alpha 1 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.0097 0.0165
Schistosoma mansoni cytochrome P450 0.001 0.0086 0.0086
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0268 0.189
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0528 0.1488
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.021 0.021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0195 0.0464
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0155 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0528 0.1488
Loa Loa (eye worm) hypothetical protein 0.0035 0.0707 0.2028
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.3019 0.3019
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0155 0.0155
Plasmodium falciparum glutathione reductase 0.0018 0.0268 0.0922
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0049 0.105 0.3077
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0249 0.1594
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.0074 0.0101
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0249 0.1594
Leishmania major trypanothione reductase 0.0051 0.1109 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0097 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.3316 0.3316
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0195 0.0195
Brugia malayi ecdysteroid receptor 0.0028 0.0528 0.1488
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0183 0.0323
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.001 0.0074 0.0074
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0528 0.0528
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0362 0.2694
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0183 0.1003
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0309 0.2174
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0528 0.1481
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Loa Loa (eye worm) hypothetical protein 0.0035 0.0707 0.2028
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Loa Loa (eye worm) hypothetical protein 0.0036 0.074 0.2128
Brugia malayi nuclear hormone receptor 0.0028 0.0528 0.1488
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0183 0.0434
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0362 0.4625
Brugia malayi AMP-binding enzyme family protein 0.0049 0.105 0.3083
Toxoplasma gondii ABC1 family protein 0.0035 0.0707 0.5697
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0707 0.1152
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0183 0.1003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1048 0.3074
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.029 0.029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1338 0.1338
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.001 0.0074 0.0101
Schistosoma mansoni cpg binding protein 0.0028 0.0537 0.0537
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0268 0.1781
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0528 0.1488
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.001 0.0074 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.021 0.0509
Brugia malayi AMP-binding enzyme family protein 0.0049 0.105 0.3083
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.001 0.0074 0.0074
Echinococcus multilocularis flap endonuclease 1 0.0026 0.047 0.047
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0285 0.1934
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0268 0.163
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.001 0.0074 0.0074
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0362 0.0362
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.047 0.1305
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0249 0.1496
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0074 0.0101
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0155 0.035
Toxoplasma gondii exonuclease III APE 0.0018 0.0285 0.182
Onchocerca volvulus 0.0014 0.0183 0.1119
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.3316 0.3316
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.3086 0.5566
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0097 0.0109
Loa Loa (eye worm) hypothetical protein 0.0028 0.0528 0.1481
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0183 0.018
Brugia malayi beta-lactamase family protein 0.0035 0.0707 0.2035
Brugia malayi Cytochrome P450 family protein 0.001 0.0086 0.0139
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.0074 0.0101
Brugia malayi Cytochrome P450 family protein 0.0029 0.0555 0.1571
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.3086 0.5566
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.001 0.0074 0.0092
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.021 0.0509
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1431 0.1431
Entamoeba histolytica Flap nuclease, putative 0.0026 0.047 0.4062
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0074 0.0101
Mycobacterium ulcerans lipase LipD 0.0035 0.0707 0.6441
Plasmodium falciparum glutathione reductase 0.0051 0.1109 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0155 0.035
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0183 0.1003
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0036 0.074 0.2128
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0155 0.0155
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0268 0.0695
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.105 0.9423
Loa Loa (eye worm) hypothetical protein 0.0049 0.105 0.3077
Schistosoma mansoni nuclear receptor 0.0013 0.0155 0.0155
Plasmodium falciparum thioredoxin reductase 0.0018 0.0268 0.0922
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0183 0.0945
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0268 0.1671
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0528 0.0528
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0707 0.607
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0707 0.1152
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0155 0.0342
Brugia malayi Cation transporter family protein 0.001 0.0074 0.0101
Brugia malayi CXXC zinc finger family protein 0.0028 0.0537 0.1516
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0087 0.0136
Plasmodium vivax glutathione reductase, putative 0.0051 0.1109 1
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0249 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0528 0.1488
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0183 0.018
Echinococcus granulosus glycine receptor subunit beta 0.001 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0528 0.1488
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.1423 0.1423
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0528 0.0528
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0155 0.035
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.001 0.0074 0.0092
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0183 0.0945
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0285 0.0737
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0268 0.1781
Brugia malayi jmjC domain containing protein 0.0017 0.0249 0.0637
Schistosoma mansoni nAChR subunit 0.001 0.0074 0.0074
Onchocerca volvulus 0.0035 0.0707 0.6487
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0268 0.1781
Brugia malayi jmjC domain containing protein 0.0017 0.0249 0.0637
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.1423 0.1423
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0268 0.0268
Onchocerca volvulus 0.0013 0.0155 0.0836
Schistosoma mansoni hypothetical protein 0.0127 0.3019 0.3019
Brugia malayi nuclear receptor RXR 0.0015 0.0195 0.0472
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0183 0.0945
Onchocerca volvulus 0.0013 0.0155 0.0836
Toxoplasma gondii thioredoxin reductase 0.0051 0.1109 0.9386
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0074 0.0074
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0268 0.1781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0528 0.1481
Echinococcus granulosus glycine receptor subunit alpha 1 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0074 0.0101
Mycobacterium ulcerans hypothetical protein 0.0035 0.0707 0.6441
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0528 0.0528
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0249 0.0249
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0074 0.0101
Schistosoma mansoni cpg binding protein 0.003 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0015 0.0195 0.0464
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0268 0.1781
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0362 0.1931
Echinococcus multilocularis cpg binding protein 0.003 0.0578 0.0578
Brugia malayi nuclear hormone receptor 0.0013 0.0155 0.035
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0155 0.0342
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.001 0.0074 0.0074
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0268 0.1775
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.1423 0.1423
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.001 0.0074 0.0074
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0249 0.0249
Brugia malayi hypothetical protein 0.0015 0.0195 0.0472
Schistosoma mansoni zinc finger protein 0.0013 0.0155 0.0155
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.047 0.3755
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.3316 0.3316
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.1109 0.1109
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0183 0.018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.001 0.0074 0.0074
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.3724 0.3724
Brugia malayi jmjC domain containing protein 0.0017 0.0249 0.0637
Brugia malayi nuclear receptor RXR 0.0013 0.0155 0.035
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Leishmania major cytochrome p450-like protein 0.0019 0.0309 0.2174
Brugia malayi RNA binding protein 0.0064 0.1431 0.4245
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0183 0.0183
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.1464 0.1464
Loa Loa (eye worm) hypothetical protein 0.0015 0.0195 0.0464
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.015 0.0334
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Loa Loa (eye worm) beta-lactamase 0.0035 0.0707 0.2028
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Schistosoma mansoni coup transcription factor 0.0028 0.0528 0.0528
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0528 0.0528
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0183 0.0434
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0183 0.1119
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Schistosoma mansoni hypothetical protein 0.0033 0.066 0.066
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0183 0.1003
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.047 0.5483
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1431 0.1431
Plasmodium falciparum flap endonuclease 1 0.0026 0.047 0.3103
Echinococcus granulosus tar DNA binding protein 0.0064 0.1431 0.1431
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.069 0.112
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0249 0.0629
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.047 0.3751
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0183 0.1003
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0155 0.0342
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0183 0.0434
Echinococcus multilocularis glycine receptor subunit alpha 1 0.001 0.0074 0.0074
Brugia malayi tailless protein 0.0013 0.0155 0.035
Loa Loa (eye worm) hypothetical protein 0.0036 0.074 0.2128
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0285 0.1939
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0528 0.0528
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.0074 0.0101
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.001 0.0074 0.0074
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.2758 0.4958
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0183 0.018
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0528 0.1488
Echinococcus multilocularis GPCR, family 2 0.0015 0.021 0.021
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0707 0.1152
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0528 0.4653
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0528 0.1488
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.001 0.0074 0.0074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0268 0.189
Treponema pallidum NADH oxidase 0.0018 0.0268 0.9134
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0195 0.0195
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.001 0.0074 0.0092
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0183 0.1003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0183 0.0426
Brugia malayi Cytochrome P450 family protein 0.0019 0.0309 0.0818
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0707 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1048 0.3074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0268 0.1781
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0362 0.3412
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0707 0.1152
Mycobacterium ulcerans hypothetical protein 0.0049 0.105 1
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0268 0.1781
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0268 0.0922
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0362 0.0362
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.1464 0.4341
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0707 0.607
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1431 0.1431
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0528 0.0528
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0707 0.2035
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0285 0.216
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.2758 0.8908
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0285 0.1097
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0707 0.1152
Loa Loa (eye worm) LGC-31 protein 0.001 0.0074 0.0092
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.001 0.0074 0.0092
Brugia malayi beta-lactamase family protein 0.0035 0.0707 0.2035
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0362 0.3412
Schistosoma mansoni cpg binding protein 0.003 0.0578 0.0578
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0528 0.0528
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0528 0.0528
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0249 0.0629
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.1109 0.1899
Loa Loa (eye worm) hypothetical protein 0.0028 0.0528 0.1481
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0707 0.207
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0183 0.0945
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0183 0.0434
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0183 0.1003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0528 0.1481
Brugia malayi hypothetical protein 0.0013 0.0155 0.035
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0285 0.0285
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0183 0.0434
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0285 1
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0528 0.1488
Brugia malayi hypothetical protein 0.0013 0.0155 0.035
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.047 0.3525
Onchocerca volvulus 0.0014 0.0183 0.1119
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.1109 0.1109
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0309 0.081
Loa Loa (eye worm) hypothetical protein 0.0009 0.0045 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0155 0.0155
Schistosoma mansoni nuclear receptor 0.0013 0.0155 0.0155
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.021 0.021
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0183 0.0939
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0074 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0183 0.018
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0195 0.0472
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0528 0.0528
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.3019 0.3019
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Brugia malayi nuclear receptor NHR-88 0.0013 0.0155 0.035
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0097 0.0109
Echinococcus multilocularis nAChR subunit 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0707 0.2028
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0362 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0528 0.1488
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Onchocerca volvulus 0.0014 0.0183 0.1119
Loa Loa (eye worm) hypothetical protein 0.0036 0.074 0.2128
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0183 0.0434
Mycobacterium leprae Probable lipase LipE 0.0035 0.0707 0.207
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.3086 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.001 0.0074 0.0101
Echinococcus multilocularis glycine receptor subunit beta 0.001 0.0074 0.0074
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.047 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0249 0.0249
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0183 0.1003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0249 0.0629
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0074 0.0101
Brugia malayi glutathione reductase 0.0051 0.1109 0.3263
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0528 0.0528
Schistosoma mansoni hypothetical protein 0.0015 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Mycobacterium tuberculosis Conserved protein 0.0035 0.0707 0.1152
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0528 0.0528
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0528 0.0528
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0074 0.0074
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0268 0.189
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0528 0.0528
Onchocerca volvulus 0.0028 0.0537 0.4745
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0155 0.0155
Mycobacterium tuberculosis Probable reductase 0.0117 0.2758 0.4958
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0249 0.0249
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0268 0.0268
Brugia malayi nuclear receptor NHR-88 0.0028 0.0528 0.1488
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0268 0.1781
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0707 0.6067
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0362 0.0981
Schistosoma mansoni flap endonuclease-1 0.0023 0.0408 0.0408
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0183 0.018
Mycobacterium ulcerans beta-lactamase 0.0035 0.0707 0.6441
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.3316 0.3316
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Echinococcus granulosus nAChR subunit 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Brugia malayi Cytochrome P450 family protein 0.0019 0.0309 0.0818
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0183 0.1003
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0183 0.0323
Loa Loa (eye worm) hypothetical protein 0.0036 0.074 0.2128
Schistosoma mansoni ap endonuclease 0.0018 0.0285 0.0285
Schistosoma mansoni nAChR subunit 0.001 0.0074 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1431 0.1431
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0183 0.0887
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Echinococcus granulosus flap endonuclease 1 0.0026 0.047 0.047
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0528 0.1488
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.105 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.105 0.1789
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0249 0.1594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0528 0.1481
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1431 0.424
Schistosoma mansoni jumonji domain containing protein 0.0064 0.1423 0.1423
Loa Loa (eye worm) cytochrome P450 0.001 0.0086 0.013
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0362 0.1931
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0362 0.2528
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0155 0.0155
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0183 0.0945
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0285 0.2058
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0268 0.1671
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.3316 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0155 0.0155
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.105 0.3214
Loa Loa (eye worm) GABA receptor subunit 0.001 0.0074 0.0092
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0268 0.0338
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.069 0.112
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.069 0.112
Brugia malayi beta-lactamase 0.0035 0.0707 0.2035
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0183 0.018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0528 0.0528
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0285 0.0802
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0074 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0707 0.0707
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.074 0.6012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0268 0.1781
Echinococcus granulosus phd:f box containing protein 0.0017 0.0249 0.0249
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.001 0.0074 0.0074
Schistosoma mansoni nAChR subunit 0.001 0.0074 0.0074
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0249 0.0249
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0183 0.0945
Brugia malayi Flap endonuclease-1 0.0026 0.047 0.1312
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0183 0.0945
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0183 0.1003
Brugia malayi Thioredoxin reductase 0.0051 0.1109 0.3263
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0342
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0183 0.0887
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.074 0.1213
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0097 0.0097
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0249 0.0249
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0183 0.1003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0528 0.1481
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.2758 0.4958
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0249 0.0249
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1176 1
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0155 0.0155
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.001 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0528 0.1488
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0707 0.2028
Echinococcus multilocularis 0.001 0.0086 0.0086
Echinococcus granulosus cpg binding protein 0.003 0.0578 0.0578
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0183 0.1003
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0362 0.0362
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0268 0.0922
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.001 0.0074 0.0074
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.1464 0.1464
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0528 0.0528
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.001 0.0074 0.0074
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0028 0.0528 0.1481
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0195 0.0472
Brugia malayi excitatory GABA receptor EXP-1A 0.001 0.0074 0.0101
Brugia malayi TAR-binding protein 0.0064 0.1431 0.4245
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0707 0.6441
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0537 0.1508
Schistosoma mansoni thyroid hormone receptor 0.0155 0.3724 0.3724
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0155 0.0155
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.015 0.0334
Schistosoma mansoni nAChR subunit 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0707 0.2028
Loa Loa (eye worm) RecQ helicase 0.0021 0.0362 0.0973
Loa Loa (eye worm) glutathione reductase 0.0051 0.1109 0.3257
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0155 0.0155
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0362 0.0973
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0074 0.0074
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.001 0.0074 0.0074
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0362 0.2951
Echinococcus multilocularis glycine receptor subunit beta 0.001 0.0074 0.0074
Loa Loa (eye worm) ACC-1 protein 0.001 0.0074 0.0092
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0268 0.163
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0092
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0249 0.0249
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.1109 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0528 0.4653
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.074 0.6387
Brugia malayi Cation transporter family protein 0.001 0.0074 0.0101
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0309 0.081
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0285 0.1939
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0268 0.1781
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.001 0.0074 0.0074
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.0074 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0268 0.1781
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0249 0.0716
Loa Loa (eye worm) hypothetical protein 0.0028 0.0528 0.1481
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0035 0.0707 0.2028
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0183 0.018
Leishmania major hypothetical protein, conserved 0.0035 0.0707 0.607
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.001 0.0074 0.0101
Schistosoma mansoni hypothetical protein 0.001 0.0086 0.0086
Echinococcus granulosus glycine receptor subunit alpha 1 0.001 0.0074 0.0074
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0268 0.1781
Schistosoma mansoni nAChR subunit 0.001 0.0074 0.0074
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0707 0.1152
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0133 0.0087
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0362 0.0981
Schistosoma mansoni hypothetical protein 0.0015 0.021 0.021
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0707 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0528 0.1481
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1431 0.1431
Echinococcus granulosus nAChR subunit 0.001 0.0074 0.0074
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0528 0.1481
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0707 0.0707

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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