TDR Targets

Basic information

Technical information

TDR Targets ID: 711638
Name: IVK/2009081
MW: 492.838 | Formula: C22H18ClFN2O8
H donors: 1 H acceptors: 5 LogP: 4.23 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C1=CN(C=C(C1c1cc(OC)c(c(c1)[N+](=O)[O-])O)C(=O)OC)c1ccc(c(c1)Cl)F
InChi: 1S/C22H18ClFN2O8/c1-32-18-7-11(6-17(20(18)27)26(30)31)19-13(21(28)33-2)9-25(10-14(19)22(29)34-3)12-4-5-16(24)15(23)8-12/h4-10,19,27H,1-3H3
InChiKey: USLUWKVTVLYDLQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0764	0.2337
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0764	0.2337
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0323	0.0323
Onchocerca volvulus		0.0029	0.1612	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.3377	1
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0323	0.0323
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0323	0.1053
Brugia malayi	nuclear receptor NHR-88	0.001	0.0323	0.1053
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0117	0.0382
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0117	0.0117
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0323	0.0323
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0117	0.046
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0323	0.1117
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.1268	0.1555
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0117	0.0085
Entamoeba histolytica	hypothetical protein	0.0036	0.2074	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0305	0.323
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0856	0.2667
Echinococcus granulosus	GPCR family 2	0.0016	0.0722	0.2502
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0117	0.0382
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0856	0.1029
Schistosoma mansoni	apoferritin-2	0.0009	0.0221	0.0221
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.1268	1
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0117	0.0085
Loa Loa (eye worm)	hypothetical protein	0.001	0.0323	0.1053
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0323	0.1117
Loa Loa (eye worm)	glutathione reductase	0.0048	0.2888	0.9424
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.1268	0.4153
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0722	0.2502
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0129	0.0446
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0305	0.323
Echinococcus multilocularis	ferritin	0.0009	0.0221	0.0766
Schistosoma mansoni	cpg binding protein	0.0031	0.1724	0.1724
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.1268	1
Entamoeba histolytica	hypothetical protein	0.0036	0.2074	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1268	0.4137
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0789	0.0944
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0117	0.0382
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.2888	1
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0117	0.0405
Plasmodium falciparum	glutathione reductase	0.0017	0.0764	0.2337
Loa Loa (eye worm)	hypothetical protein	0.001	0.0305	0.0995
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0323	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0035	0.198	0.6463
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0305	0.323
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0117	0.0085
Loa Loa (eye worm)	hypothetical protein	0.001	0.0323	0.1053
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0323	0.1117
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.1268	0.1483
Schistosoma mansoni	topbp1	0.001	0.0305	0.0305
Loa Loa (eye worm)	hypothetical protein	0.001	0.0323	0.1053
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0323	0.1053
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0323	0.1117
Treponema pallidum	NADH oxidase	0.0017	0.0764	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0117	0.0405
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.2888	0.9424
Echinococcus granulosus	ferritin	0.0009	0.0221	0.0766
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0722	0.2502
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0856	0.2793
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0323	0.1053
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0305	0.0679
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.1268	0.5881
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0129	0.0446
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.1268	0.4137
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0117	0.0085
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0722	0.2358
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0323	0.0323
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0123	0.7877	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0249	0.0863
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0323	0.0323
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0017	0.0764	0.0912
Brugia malayi	hypothetical protein	0.001	0.0305	0.0995
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0129	0.0446
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.2888	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0722	0.0722
Entamoeba histolytica	hypothetical protein	0.001	0.0305	0.0961
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0117	0.0382
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0323	0.1376
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0323	0.1053
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0117	0.0382
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0764	0.2337
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0856	0.2793
Loa Loa (eye worm)	hypothetical protein	0.001	0.0323	0.1053
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0323	0.1053
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0305	0.0679
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0241	0.0788
Schistosoma mansoni	ferritin	0.0009	0.0221	0.0221
Entamoeba histolytica	hypothetical protein	0.0036	0.2074	1
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0764	1
Echinococcus multilocularis	nibrin	0.001	0.0305	0.1056
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.1268	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0323	0.1053
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0764	0.0764
Echinococcus granulosus	expressed protein	0.0009	0.0221	0.0766
Onchocerca volvulus		0.001	0.0323	0.1376
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0764	0.2337
Schistosoma mansoni	ferritin light chain	0.0009	0.0221	0.0221
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.1268	0.4153
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0323	0.1053
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0856	0.2667
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0323	0.1053
Brugia malayi	Thioredoxin reductase	0.0048	0.2888	0.9424
Brugia malayi	steroid hormone receptor	0.001	0.0323	0.1053
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0722	0.2502
Loa Loa (eye worm)	hypothetical protein	0.0051	0.3064	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0117	0.0085
Schistosoma mansoni	ferritin	0.0009	0.0221	0.0221
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0323	0.1117
Schistosoma mansoni	cpg binding protein	0.0029	0.1612	0.1612
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0764	0.2337
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0323	0.1117
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0466	0.152
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.2888	0.3625
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0323	0.1053
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.1268	0.1555
Plasmodium falciparum	glutathione reductase	0.0048	0.2888	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0129	0.0446
Onchocerca volvulus		0.001	0.0305	0.1258
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.1268	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0111	0.705	0.8943
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0323	0.1376
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0323	0.1053
Onchocerca volvulus		0.0024	0.1268	0.7697
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0117	0.0085
Brugia malayi	topoisomerase	0.001	0.0305	0.0995
Echinococcus granulosus	cpg binding protein	0.0031	0.1724	0.5972
Trichomonas vaginalis	ferritin, putative	0.0009	0.0221	0.1995
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0305	0.0995
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.1268	0.5881
Brugia malayi	hypothetical protein	0.001	0.0305	0.0995
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0764	1
Schistosoma mansoni	ferritin	0.0009	0.0221	0.0221
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.3064	1
Entamoeba histolytica	hypothetical protein	0.0036	0.2074	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0856	0.6421
Loa Loa (eye worm)	hypothetical protein	0.001	0.0305	0.0995
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0009	0.0221	0.0134
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0117	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0305	0.323
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0323	0.1117
Schistosoma mansoni	ferritin light chain	0.0009	0.0221	0.0221
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.1268	0.4137
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0305	0.0679
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0017	0.0764	0.5627
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.1268	1
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0764	0.2647
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0111	0.705	0.8943
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0323	0.1053
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.2888	1
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0323	0.1053
Loa Loa (eye worm)	hypothetical protein	0.001	0.0305	0.0995
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0009	0.0221	0.0218
Mycobacterium ulcerans	bacterioferritin BfrB	0.0009	0.0221	0.0906
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0323	0.1053
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0305	0.0242
Echinococcus granulosus	nibrin	0.001	0.0305	0.1056
Schistosoma mansoni	hypothetical protein	0.0016	0.0722	0.0722
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0305	0.0577
Brugia malayi	DKFZp564C0469 protein	0.001	0.0305	0.0995
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0111	0.705	0.8943
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0323	0.0323
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.2074	0.2074
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0129	0.0129
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0764	0.2337
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0722	0.2502
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0764	0.1986
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0117	0.0382
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.198	0.6463
Echinococcus multilocularis	cpg binding protein	0.0031	0.1724	0.5972
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0009	0.0221	0.0218
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0323	0.0323
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0117	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0856	0.2793
Schistosoma mansoni	DNA ligase IV	0.001	0.0305	0.0305
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0323	0.1053
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0764	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0305	0.323
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0323	0.1117
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0111	0.705	0.8934
Echinococcus multilocularis	expressed protein	0.0009	0.0221	0.0766
Loa Loa (eye worm)	hypothetical protein	0.001	0.0305	0.0995
Schistosoma mansoni	coup transcription factor	0.001	0.0323	0.0323
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0789	0.0944
Plasmodium vivax	glutathione reductase, putative	0.0048	0.2888	1
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0305	0.323
Brugia malayi	nuclear hormone receptor	0.001	0.0323	0.1053
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0323	0.1053
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0117	0.0085
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0305	0.0995
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0323	0.1117
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0764	0.2337
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0789	0.0944
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0323	0.1117
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0305	0.323
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.1268	0.5881
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0117	0.0382
Schistosoma mansoni	apoferritin-2	0.0009	0.0221	0.0221
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0323	0.1053
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0305	0.0305
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0305	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1268	0.4137
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.3064	1
Mycobacterium tuberculosis	Probable reductase	0.0111	0.705	0.8943
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0117	0.0382
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0323	0.0323
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0323	0.1117
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0323	0.1053
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0323	0.1053
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0305	0.0679
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0764	0.2337
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0764	0.2337
Brugia malayi	glutathione reductase	0.0048	0.2888	0.9424
Loa Loa (eye worm)	hypothetical protein	0.001	0.0323	0.1053
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.3824	0.3824
Schistosoma mansoni	topbp1	0.001	0.0305	0.0305
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0305	0.0679
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0323	0.1117
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0305	0.323
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0017	0.0764	0.2337
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0323	0.1117
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0722	0.2502
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0323	0.0323
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0305	0.1056
Schistosoma mansoni	hypothetical protein	0.0016	0.0722	0.0722
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0323	0.1117
Schistosoma mansoni	ferritin	0.0009	0.0221	0.0221
Leishmania major	trypanothione reductase	0.0048	0.2888	1
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0764	0.2337
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0764	0.8342
Mycobacterium tuberculosis	Probable oxidoreductase	0.0123	0.7877	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0305	0.0995
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0764	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0764	0.2337
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0123	0.7877	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0764	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0323	0.1117
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0764	0.2337
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0017	0.0764	0.5627
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.1268	0.4137
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0117	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1268	0.4137
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0764	0.2337
Treponema pallidum	DNA ligase (lig)	0.001	0.0305	0.1543
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0111	0.705	0.8943
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.3064	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0764	0.1986
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.1268	0.1483
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0117	0.0085
Trypanosoma brucei	trypanothione reductase	0.0048	0.2888	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0017	0.0764	0.5627
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0764	0.2495
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0856	0.2793
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0017	0.0764	0.2337
Schistosoma mansoni	cpg binding protein	0.0031	0.1724	0.1724
Schistosoma mansoni	hypothetical protein	0.0036	0.2074	0.2074
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0323	0.1053
Mycobacterium ulcerans	bacterioferritin BfrA	0.0009	0.0221	0.0906
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0323	0.1053
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0249	0.0813
Schistosoma mansoni	hypothetical protein	0.0016	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.001	0.0305	0.0995
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0117	0.0085
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0764	0.2337
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0117	0.046
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.2074	0.7182
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0117	0.0382
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0323	0.1117
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0323	0.0323
Loa Loa (eye worm)	hypothetical protein	0.001	0.0323	0.1053
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0323	0.1053
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0123	0.7877	1
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0305	0.323
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.1268	0.4153
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0249	0.0863
Mycobacterium ulcerans	hypothetical protein	0.0024	0.1268	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0323	0.1053
Loa Loa (eye worm)	hypothetical protein	0.001	0.0323	0.1053
Brugia malayi	CXXC zinc finger family protein	0.0029	0.1612	0.5261
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0466	0.152
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.1268	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0117	0.0382
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0764	0.2337
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0305	0.1543
Mycobacterium tuberculosis	Probable dehydrogenase	0.0111	0.705	0.8943
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0305	0.0679
Brugia malayi	hypothetical protein	0.0036	0.2074	0.6768
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0764	0.2337
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0305	0.0577
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0722	0.2358
Brugia malayi	ecdysteroid receptor	0.001	0.0323	0.1053
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0305	0.1634
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0722	0.2358
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0856	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0764	0.2647
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.2888	1
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0305	0.0961
Plasmodium falciparum	thioredoxin reductase	0.0048	0.2888	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0323	0.0323
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0764	0.2337
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.2074	0.7182
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.1612	0.5261
Toxoplasma gondii	thioredoxin reductase	0.0048	0.2888	0.8498
Loa Loa (eye worm)	hypothetical protein	0.001	0.0323	0.1053
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.1268	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0764	0.2337
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0856	0.2793
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0323	0.0323
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0323	0.1117
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0789	0.0944
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0323	0.1117
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0323	0.1053
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0305	0.0679
Schistosoma mansoni	hypothetical protein	0.0035	0.198	0.198
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0323	0.1053
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0305	0.323
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0722	0.2358
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0764	0.2337
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0764	0.2337

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 711638