Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Aldose reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0028 | 0.0104 | 0.0104 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.105 | 0.0955 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0133 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0133 | 1 | 1 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0133 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus granulosus | tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0028 | 0.0104 | 0.0104 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0058 | 0.2915 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0028 | 0.0104 | 0.0104 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0133 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0028 | 0.0104 | 0.0104 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0028 | 0.0104 | 0.0104 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.105 | 0.0955 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 1 |
Echinococcus multilocularis | 0.0133 | 1 | 1 | |
Schistosoma mansoni | pol-related | 0.0038 | 0.105 | 0.0955 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0028 | 0.0104 | 0.0104 |
Mycobacterium ulcerans | hypothetical protein | 0.0058 | 0.2915 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0038 | 0.105 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0028 | 0.0104 | 0.0104 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.105 | 0.0955 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.105 | 0.105 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 1 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0133 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Onchocerca volvulus | 0.0038 | 0.105 | 1 | |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0028 | 0.0104 | 0.0104 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0028 | 0.0104 | 0.0104 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0028 | 0.0104 | 0.0104 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.105 | 0.0955 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.105 | 0.0955 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0133 | 1 | 1 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0133 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0028 | 0.0104 | 0.0104 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.