Detailed information for compound 712214

Basic information

Technical information
  • TDR Targets ID: 712214
  • Name: N-(3-chloro-4-fluorophenyl)-2-[2-oxo-2-(pheny lamino)ethyl]sulfanylacetamide
  • MW: 352.811 | Formula: C16H14ClFN2O2S
  • H donors: 2 H acceptors: 2 LogP: 3.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(c(c1)Cl)F)CSCC(=O)Nc1ccccc1
  • InChi: 1S/C16H14ClFN2O2S/c17-13-8-12(6-7-14(13)18)20-16(22)10-23-9-15(21)19-11-4-2-1-3-5-11/h1-8H,9-10H2,(H,19,21)(H,20,22)
  • InChiKey: BTIQJQHGGATUAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-4-fluoro-phenyl)-2-[2-oxo-2-(phenylamino)ethyl]sulfanyl-acetamide
  • N-(3-chloro-4-fluorophenyl)-2-[[2-oxo-2-(phenylamino)ethyl]thio]acetamide
  • N-(3-chloro-4-fluoro-phenyl)-2-[[2-keto-2-(phenylamino)ethyl]thio]acetamide
  • N-(3-chloro-4-fluoro-phenyl)-2-[2-oxo-2-(phenylamino)ethyl]sulfanyl-ethanamide
  • ZINC00941407
  • ST5202179

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum thioredoxin reductase 0.0059 0.0898 0.2803
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0114 0.0393
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0016 0.0114 0.0393
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0171 0.0588
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0016 0.0114 0.0393
Trypanosoma brucei trypanothione reductase 0.017 0.2909 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.0016 0.0114 0.0147
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0016 0.0114 0.0197
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0016 0.0114 0.0393
Plasmodium falciparum glutathione reductase 0.0059 0.0898 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.0898 0.3086
Brugia malayi Latrophilin receptor protein 2 0.0011 0.0029 0.0099
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0059 0.0898 0.2803
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0285 0.0978
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0114 0.0147
Schistosoma mansoni hypothetical protein 0.0024 0.0258 0.0238
Leishmania major alpha glucosidase II subunit, putative 0.0025 0.0285 0.0978
Brugia malayi nuclear receptor NHR-88 0.0014 0.009 0.0308
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0059 0.0898 0.3086
Mycobacterium tuberculosis Probable oxidoreductase 0.0432 0.7636 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0059 0.0898 0.3086
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0068 0.1068 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0025 0.0285 0.0366
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0099 0.0073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.009 0.0308
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0388 0.6853 0.8958
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0043 0.0615 0.2113
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.009 0.1452 0.4991
Loa Loa (eye worm) RecQ helicase 0.0019 0.0171 0.0588
Echinococcus granulosus neuropeptide s receptor 0.0324 0.5693 0.6178
Loa Loa (eye worm) hypothetical protein 0.0163 0.2781 0.9559
Schistosoma mansoni survival motor neuron protein 0.0033 0.0433 0.0418
Toxoplasma gondii thioredoxin reductase 0.017 0.2909 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0014 0.009 0.0308
Plasmodium falciparum glutathione reductase 0.017 0.2909 1
Echinococcus granulosus ecdysone induced protein 78C 0.0014 0.009 0.0066
Loa Loa (eye worm) hypothetical protein 0.0035 0.0456 0.1568
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.009 0.1452 0.1779
Schistosoma mansoni transcription factor LCR-F1 0.0025 0.028 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0439 0.7778 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0025 0.0285 0.0794
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0016 0.0114 0.0147
Trichomonas vaginalis glutamate synthase, putative 0.0016 0.0114 0.0147
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0016 0.0114 0.0147
Echinococcus granulosus survival motor neuron protein 1 0.0163 0.2781 0.3002
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0016 0.0114 0.0086
Onchocerca volvulus Protein ultraspiracle homolog 0.0014 0.009 0.0839
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0258 0.0889
Mycobacterium ulcerans aldehyde dehydrogenase 0.009 0.1452 0.3717
Trypanosoma cruzi trypanothione reductase, putative 0.017 0.2909 1
Entamoeba histolytica hypothetical protein 0.0025 0.028 0.036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0439 0.7778 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0016 0.0114 0.0086
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0033 0.0433 0.1488
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0014 0.009 0.0308
Mycobacterium ulcerans aldehyde dehydrogenase 0.009 0.1452 0.3717
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0025 0.0285 0.0366
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0013 0.0044
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0388 0.6853 0.8958
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0308
Schistosoma mansoni hypothetical protein 0.0117 0.1956 0.1997
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0308
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0043 0.0615 0.2113
Leishmania major trypanothione reductase 0.017 0.2909 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0059 0.0898 0.2945
Brugia malayi Thioredoxin reductase 0.017 0.2909 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0059 0.0898 0.3086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0456 0.1568
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0014 0.009 0.0308
Trypanosoma brucei NADH dehydrogenase 0.0016 0.0114 0.0393
Echinococcus multilocularis FTZ F1 alpha 0.0014 0.009 0.0061
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0014 0.009 0.0063
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0114 0.0147
Entamoeba histolytica hypothetical protein 0.0025 0.028 0.036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.009 0.0308
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0456 0.1568
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0059 0.0898 0.3086
Echinococcus granulosus microtubule associated protein 2 0.0518 0.9197 1
Entamoeba histolytica thioredoxin reductase, putative 0.0016 0.0114 0.0147
Trichomonas vaginalis glutathione reductase, putative 0.0059 0.0898 0.1154
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0059 0.0898 0.3086
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0016 0.0114 0.0086
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0014 0.009 0.0066
Echinococcus multilocularis lysosomal alpha glucosidase 0.0113 0.1874 0.1851
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0059 0.0898 0.2177
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0059 0.0898 0.2938
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0439 0.7778 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0439 0.7778 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0014 0.009 0.0308
Schistosoma mansoni hypothetical protein 0.0033 0.0433 0.0418
Schistosoma mansoni alpha-glucosidase 0.0097 0.159 0.1617
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0439 0.7778 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0016 0.0114 0.0393
Mycobacterium tuberculosis Probable reductase 0.0388 0.6853 0.8958
Echinococcus granulosus neutral alpha glucosidase AB 0.0025 0.0285 0.0279
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0016 0.0114 0.0393
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0016 0.0114 0.0187
Schistosoma mansoni hypothetical protein 0.0016 0.0114 0.0088
Schistosoma mansoni glutamate synthase 0.0016 0.0114 0.0088
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0285 0.0366
Entamoeba histolytica hypothetical protein 0.0025 0.028 0.036
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0114 0.0393
Leishmania major hypothetical protein, conserved 0.0016 0.0114 0.0393
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0059 0.0898 0.3086
Echinococcus multilocularis microtubule associated protein 2 0.0518 0.9197 0.9195
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0059 0.0898 0.0948
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0059 0.0898 0.0871
Mycobacterium tuberculosis Probable dehydrogenase 0.0388 0.6853 0.8958
Echinococcus multilocularis ecdysone induced protein 78C 0.0014 0.009 0.0061
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0016 0.0114 0.0147
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0059 0.0898 0.2177
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0059 0.0898 0.2803
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0014 0.009 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0308
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0025 0.0285 0.0366
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0113 0.1874 0.6442
Trichomonas vaginalis maltase-glucoamylase, putative 0.0025 0.0285 0.0366
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0016 0.0114 0.0093
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0013 0.0044
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0016 0.0114 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0014 0.009 0.0308
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0114 0.0393
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0439 0.7778 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.009 0.0308
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0432 0.7636 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.009 0.1452 0.1427
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0114 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0114 0.0393
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0059 0.0898 0.3086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0456 0.1568
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0016 0.0114 0.0147
Brugia malayi hypothetical protein 0.0025 0.028 0.0962
Giardia lamblia NADH oxidase lateral transfer candidate 0.0059 0.0898 0.1022
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0308
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0016 0.0114 0.0393
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0114 0.0393
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.009 0.0308
Loa Loa (eye worm) latrophilin receptor protein 2 0.0011 0.0029 0.0099
Echinococcus multilocularis thyroid hormone receptor alpha 0.0014 0.009 0.0061
Brugia malayi glutathione reductase 0.017 0.2909 1
Treponema pallidum fructose-bisphosphate aldolase 0.0439 0.7778 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0114 0.0393
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0016 0.0114 0.0187
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0059 0.0898 0.1042
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0171 0.0142
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0059 0.0898 0.2177
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0215 0.3713 0.4785
Echinococcus multilocularis neutral alpha glucosidase AB 0.0025 0.0285 0.0256
Leishmania major NADH dehydrogenase, putative 0.0016 0.0114 0.0393
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0114 0.0147
Schistosoma mansoni steroid hormone receptor ad4bp 0.0014 0.009 0.0063
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0016 0.0114 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0014 0.009 0.0308
Brugia malayi steroid hormone receptor 0.0014 0.009 0.0308
Schistosoma mansoni alpha glucosidase 0.0025 0.0285 0.0265
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0016 0.0114 0.0147
Schistosoma mansoni sulfide quinone reductase 0.0016 0.0114 0.0088
Schistosoma mansoni glutamate synthase 0.0016 0.0114 0.0088
Onchocerca volvulus 0.0014 0.009 0.0839
Schistosoma mansoni nuclear hormone receptor 0.0014 0.009 0.0063
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0025 0.0285 0.0978
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0439 0.7778 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0025 0.0285 0.0366
Schistosoma mansoni sulfide quinone reductase 0.0016 0.0114 0.0088
Onchocerca volvulus Bile acid receptor homolog 0.0014 0.009 0.0839
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0308
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.009 0.0308
Loa Loa (eye worm) thioredoxin reductase 0.017 0.2909 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0059 0.0898 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0016 0.0114 0.0393
Brugia malayi Steroid receptor seven-up type 2 0.0014 0.009 0.0308
Plasmodium vivax glutathione reductase, putative 0.017 0.2909 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0059 0.0898 0.09
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0285 0.0366
Echinococcus granulosus thioredoxin glutathione reductase 0.0172 0.2943 0.3178
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0432 0.7636 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0114 0.0393
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0014 0.009 0.0061
Schistosoma mansoni hypothetical protein 0.0117 0.1956 0.1997
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0016 0.0114 0.0147
Schistosoma mansoni coup transcription factor 0.0014 0.009 0.0063
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0016 0.0114 0.0393
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0014 0.009 0.0063
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0017 0.013 0.0055
Toxoplasma gondii NADPH-glutathione reductase 0.0059 0.0898 0.2945
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0011 0.0029 0.0099
Loa Loa (eye worm) hypothetical protein 0.0095 0.1542 0.5299
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.0898 0.3086
Leishmania major hypothetical protein, conserved 0.0016 0.0114 0.0393
Echinococcus multilocularis neuropeptide receptor A26 0.0324 0.5693 0.5681
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0014 0.009 0.0308
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0016 0.0114 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0439 0.7778 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0059 0.0898 0.2938
Schistosoma mansoni aldehyde dehydrogenase 0.009 0.1452 0.1474
Echinococcus multilocularis glutamate synthase 0.0016 0.0114 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0014 0.009 0.0308
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0388 0.6853 0.8958
Toxoplasma gondii aldehyde dehydrogenase 0.009 0.1452 0.4889
Trichomonas vaginalis glutamate synthase, putative 0.0016 0.0114 0.0147
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0215 0.3713 1
Entamoeba histolytica heat shock transcription factor, putative 0.0068 0.1068 0.1373
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0285 0.0366
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0016 0.0114 0.0147
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0439 0.7778 1
Loa Loa (eye worm) glutathione reductase 0.017 0.2909 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.009 0.0066
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0016 0.0114 0.0093
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0014 0.009 0.0063
Schistosoma mansoni RAR-like nuclear receptor 0.0014 0.009 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0059 0.0898 0.3086
Echinococcus granulosus bloom syndrome protein 0.0019 0.0171 0.0155
Toxoplasma gondii selenide, water dikinase 0.0016 0.0114 0.0197
Echinococcus multilocularis lysosomal alpha glucosidase 0.0113 0.1874 0.1851
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0016 0.0114 0.0086
Brugia malayi ecdysteroid receptor 0.0014 0.009 0.0308
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.0898 0.3086
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0014 0.009 0.0061
Schistosoma mansoni alpha-glucosidase 0.0097 0.159 0.1617
Onchocerca volvulus 0.0016 0.0114 0.107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.0898 0.3086
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0285 0.0366
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0016 0.0114 0.0393
Echinococcus multilocularis neuropeptide s receptor 0.0324 0.5693 0.5681
Onchocerca volvulus 0.0065 0.1013 0.9483
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0285 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.009 0.0308
Mycobacterium ulcerans aldehyde dehydrogenase 0.009 0.1452 0.3717
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0014 0.009 0.0063
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0059 0.0898 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0439 0.7778 1
Entamoeba histolytica hypothetical protein 0.0025 0.028 0.036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.0898 0.3086
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0308
Brugia malayi hypothetical protein 0.0163 0.2781 0.9559
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0014 0.009 0.0061
Brugia malayi glutamate synthase 0.0016 0.0114 0.0393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0014 0.009 0.0308
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0016 0.0114 0.0197
Trichomonas vaginalis DNA helicase recq, putative 0.001 0.0013 0.0016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0025 0.028 0.0274
Echinococcus granulosus FTZ F1 alpha 0.0014 0.009 0.0066
Echinococcus multilocularis geminin 0.0117 0.1956 0.1933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0014 0.009 0.0308
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0014 0.009 0.0308
Brugia malayi nuclear hormone receptor 0.0014 0.009 0.0308
Trypanosoma cruzi trypanothione reductase, putative 0.0059 0.0898 0.3086
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0016 0.0114 0.0093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.009 0.0061
Schistosoma mansoni microtubule-associated protein tau 0.0518 0.9197 0.9499
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0016 0.0114 0.0086
Loa Loa (eye worm) steroid hormone receptor 0.0014 0.009 0.0308
Onchocerca volvulus 0.0033 0.0433 0.4053
Plasmodium vivax ferrodoxin reductase, putative 0.0016 0.0114 0.0187
Trypanosoma brucei glucosidase, putative 0.0025 0.0285 0.0978
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0014 0.009 0.0066
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0114 0.0393
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0388 0.6853 0.8958
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0013 0.0044
Plasmodium falciparum thioredoxin reductase 0.017 0.2909 1
Schistosoma mansoni thyroid hormone receptor 0.0014 0.009 0.0063
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.009 0.0063
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0016 0.0114 0.0197
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0114 0.0147
Schistosoma mansoni hypothetical protein 0.0025 0.028 0.026
Treponema pallidum NADH oxidase 0.0059 0.0898 0.1022
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.017 0.2909 0.3716
Brugia malayi Glycosyl hydrolases family 31 protein 0.0025 0.0285 0.0978
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0016 0.0114 0.0147
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0016 0.0114 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0014 0.009 0.0308
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0059 0.0898 1
Entamoeba histolytica recQ family helicase, putative 0.001 0.0013 0.0016
Echinococcus granulosus neuropeptide receptor A26 0.0324 0.5693 0.6178
Schistosoma mansoni retinoic acid receptor RXR 0.0014 0.009 0.0063
Schistosoma mansoni glutamate synthase 0.0016 0.0114 0.0088
Echinococcus granulosus geminin 0.0117 0.1956 0.2102
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0171 0.022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0016 0.0114 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.009 0.0308
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0388 0.6853 0.8958
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0308
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.0898 0.3086
Entamoeba histolytica disulphide oxidoreductase, putative 0.0016 0.0114 0.0147
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0016 0.0114 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0258 0.0889
Echinococcus granulosus lysosomal alpha glucosidase 0.0113 0.1874 0.2013
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0016 0.0114 0.0086
Leishmania major hypothetical protein, conserved 0.0016 0.0114 0.0393
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0025 0.028 0.0252
Trichomonas vaginalis mercuric reductase, putative 0.0059 0.0898 0.1154
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0014 0.009 0.0061
Loa Loa (eye worm) hypothetical protein 0.0068 0.1068 0.3671
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0014 0.009 0.0839
Brugia malayi HSF-type DNA-binding domain containing protein 0.0068 0.1068 0.3671
Trichomonas vaginalis sucrase-isomaltase, putative 0.0025 0.0285 0.0366
Entamoeba histolytica heat shock transcription factor, putative 0.0068 0.1068 0.1373
Loa Loa (eye worm) programmed cell death 8 0.0016 0.0114 0.0393
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0432 0.7636 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0114 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0014 0.009 0.0308
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.009 0.0061
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0308
Schistosoma mansoni disulfide oxidoreductase 0.0016 0.0114 0.0088
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0014 0.009 0.0066
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0059 0.0898 0.3086
Schistosoma mansoni aldehyde dehydrogenase 0.009 0.1452 0.1474
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0215 0.3713 0.4785
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.009 0.1452 0.1552
Plasmodium vivax thioredoxin reductase, putative 0.017 0.2909 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0439 0.7778 1
Echinococcus multilocularis survival motor neuron protein 1 0.0163 0.2781 0.276
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0059 0.0898 0.3086
Trypanosoma cruzi NADH dehydrogenase, putative 0.0016 0.0114 0.0393
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0059 0.0898 0.3086
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0014 0.009 0.0066
Echinococcus granulosus glutamate synthase 0.0016 0.0114 0.0093
Brugia malayi photoreceptor-specific nuclear receptor 0.0014 0.009 0.0308
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0016 0.0114 0.0093
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0016 0.0114 0.0393
Schistosoma mansoni thyroid hormone receptor 0.0014 0.009 0.0063
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0016 0.0114 0.0393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0014 0.009 0.0308
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.009 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0285 0.0978
Entamoeba histolytica heat shock transcription factor, putative 0.0068 0.1068 0.1373
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0171 0.022
Echinococcus multilocularis thioredoxin glutathione reductase 0.0172 0.2943 0.2922
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0014 0.009 0.0066
Brugia malayi Glycosyl hydrolases family 31 protein 0.0113 0.1874 0.6442

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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