Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.4377 | 0.4377 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0934 | 0.0534 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4377 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.4377 | 0.4377 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.4377 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.4377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0934 | 0.0934 |
Schistosoma mansoni | lamin | 0.0061 | 0.3166 | 0.6484 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2636 | 0.2636 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4377 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4377 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0061 | 0.3166 | 0.7164 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.4377 | 0.4377 |
Brugia malayi | RNA binding protein | 0.0074 | 0.4377 | 0.4129 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0061 | 0.3166 | 0.2865 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.4377 | 0.4129 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3058 | 0.3058 |
Echinococcus multilocularis | lamin dm0 | 0.0061 | 0.3166 | 0.7164 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0108 | 0.0108 |
Echinococcus granulosus | lamin | 0.0061 | 0.3166 | 0.7164 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.2636 | 0.2312 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0033 | 0.0422 | 0.0422 |
Loa Loa (eye worm) | intermediate filament protein | 0.0061 | 0.3166 | 0.3166 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.4377 | 0.4129 |
Brugia malayi | intermediate filament protein | 0.0061 | 0.3166 | 0.2865 |
Schistosoma mansoni | intermediate filament proteins | 0.0061 | 0.3166 | 0.6484 |
Onchocerca volvulus | 0.0061 | 0.3166 | 0.5 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0061 | 0.3166 | 0.3166 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.2636 | 0.2312 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3166 | 0.3166 |
Echinococcus granulosus | intermediate filament protein | 0.0061 | 0.3166 | 0.7164 |
Echinococcus multilocularis | musashi | 0.0061 | 0.3166 | 0.7164 |
Schistosoma mansoni | lamin | 0.0061 | 0.3166 | 0.6484 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.2636 | 0.2636 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4377 | 1 |
Onchocerca volvulus | 0.0061 | 0.3166 | 0.5 | |
Echinococcus multilocularis | lamin | 0.0061 | 0.3166 | 0.7164 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.