Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.7513 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.2958 | 0.3743 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1009 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0164 | 0.5375 | 0.5375 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.2641 | 0.3308 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.1046 | 0.1117 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.1009 | 0.1781 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.437 | 0.437 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0177 | 0.0177 |
Leishmania major | trypanothione reductase | 0.0037 | 0.1046 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0013 | 0.0233 | 0.0412 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.437 | 0.7718 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0757 | 0.0757 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0811 | 0.1432 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.437 | 0.7718 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.1046 | 0.5903 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.2641 | 0.3308 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.1565 | 0.2764 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0177 | 0.0313 |
Echinococcus granulosus | geminin | 0.0173 | 0.5663 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0052 | 0.1565 | 0.2764 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0811 | 0.1432 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0052 | 0.1565 | 0.1565 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1565 | 0.2764 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0177 | 0.0313 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0177 | 0.0313 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0039 | 0.0069 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0177 | 0.0177 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0177 | 0.0313 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.1565 | 0.2764 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.1009 | 0.1009 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0177 | 0.0177 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.1009 | 0.9537 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0013 | 0.0233 | 0.217 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.437 | 0.437 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0039 | 0.0069 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0177 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.1046 | 0.1046 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.3612 | 0.3612 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.1611 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0177 | 0.0313 |
Echinococcus multilocularis | tar DNA binding protein | 0.0134 | 0.437 | 0.7718 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.1009 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.1046 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1009 | 0.1065 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.2958 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0177 | 0.0313 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1009 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1009 | 0.1781 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.1009 | 0.9537 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1565 | 0.2764 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.1009 | 0.1065 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.1009 | 0.1009 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.1009 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0177 | 0.0313 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.1046 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5375 | 0.5375 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1009 | 0.9537 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0177 | 0.0313 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.1009 | 0.1065 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0177 | 0.0177 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0164 | 0.5375 | 0.5375 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5663 | 1 |
Echinococcus multilocularis | geminin | 0.0173 | 0.5663 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5663 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0177 | 0.0313 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0177 | 0.0313 |
Brugia malayi | beta-lactamase | 0.0036 | 0.1009 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1009 | 0.1009 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.1009 | 0.9537 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0177 | 0.0177 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0177 | 0.0313 |
Treponema pallidum | NADH oxidase | 0.0013 | 0.0233 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0233 | 0.0233 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1009 | 0.1065 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.437 | 0.437 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.1009 | 0.1065 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0097 | 0.0172 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0177 | 0.0177 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0177 | 0.0177 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0039 | 0.0069 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.1009 | 0.1065 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.1046 | 0.1046 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0093 | 0.0093 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0097 | 0.0097 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0177 | 0.0313 |
Brugia malayi | RNA binding protein | 0.0134 | 0.437 | 0.437 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0177 | 0.0313 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.2958 | 0.3743 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0177 | 0.0177 |
Onchocerca volvulus | 0.0028 | 0.0757 | 0.059 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.1827 | 0.3227 |
Echinococcus granulosus | tar DNA binding protein | 0.0134 | 0.437 | 0.7718 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0757 | 0.0757 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.437 | 0.7718 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.1046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1009 | 0.1009 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0177 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.1009 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.1009 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1565 | 0.2764 |
Echinococcus granulosus | GPCR family 2 | 0.0052 | 0.1565 | 0.2764 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1009 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0177 | 0.0177 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.3612 | 0.6378 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1009 | 0.1009 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0233 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0177 | 0.0313 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0177 | 0.0313 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0177 | 0.0177 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.1046 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0039 | 0.0069 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.1565 | 0.2764 |
Onchocerca volvulus | 0.0036 | 0.1009 | 0.0847 | |
Trichomonas vaginalis | mercuric reductase, putative | 0.0013 | 0.0233 | 0.217 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1009 | 0.1009 |
Onchocerca volvulus | 0.03 | 1 | 1 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0177 | 0.0313 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.1063 | 0.1877 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1009 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0177 | 0.0313 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0009 | 0.0119 | 0.0119 |
Onchocerca volvulus | 0.0036 | 0.1009 | 0.0847 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0177 | 0.0313 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0233 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.437 | 0.437 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0177 | 0.0177 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.1565 | 0.2764 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.2641 | 0.3308 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0177 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.2958 | 0.3743 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0177 | 0.0177 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0009 | 0.0119 | 0.0119 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0177 | 0.0313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.437 | 0.7718 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.1046 | 0.1046 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0177 | 0.0177 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0811 | 0.1432 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0177 | 0.0313 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0013 | 0.0233 | 0.0412 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1009 | 0.9537 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.2641 | 0.3308 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.1565 | 0.2764 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.1046 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0177 | 0.0177 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0112 | 0.3612 | 0.3612 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0757 | 0.1336 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.1009 | 0.1781 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.1009 | 0.1009 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1009 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0177 | 0.0177 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0052 | 0.1565 | 0.1565 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0052 | 0.1565 | 0.1565 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0084 | 0.2641 | 0.8374 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1009 | 0.1009 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1009 | 0.1781 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0177 | 0.0177 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0177 | 0.0313 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0177 | 0.0313 |
Onchocerca volvulus | 0.0036 | 0.1009 | 0.0847 | |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0013 | 0.0233 | 0.0412 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0177 | 0.0313 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0811 | 0.1432 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0164 | 0.5375 | 0.5375 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.1046 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0177 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0177 | 0.0177 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0039 | 0.0069 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0177 | 0.0177 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0177 | 0.0313 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0177 | 0.0313 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0097 | 0.0172 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.2641 | 0.3308 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.1009 | 0.1065 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.1009 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0177 | 0.0313 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.1009 | 0.563 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.1009 | 0.1065 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1009 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.1009 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1009 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1009 | 0.1009 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0177 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 1 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.1009 | 0.1065 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0233 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1009 | 0.1009 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0177 | 0.0313 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.2641 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0177 | 0.0177 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0.0233 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1565 | 0.1565 |
Brugia malayi | TAR-binding protein | 0.0134 | 0.437 | 0.437 |
Brugia malayi | glutathione reductase | 0.0037 | 0.1046 | 0.1046 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0177 | 0.0313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.437 | 0.7718 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.1063 | 0.1877 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0177 | 0.0177 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.