Detailed information for compound 71348

Basic information

Technical information
  • TDR Targets ID: 71348
  • Name: ethyl 2-methyl-9H-[1,3]thiazolo[5,4-b]carbazo le-10-carboxylate
  • MW: 310.37 | Formula: C17H14N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c2sc(nc2cc2c1[nH]c1c2cccc1)C
  • InChi: 1S/C17H14N2O2S/c1-3-21-17(20)14-15-11(8-13-16(14)22-9(2)18-13)10-6-4-5-7-12(10)19-15/h4-8,19H,3H2,1-2H3
  • InChiKey: QBVAMLCQOFXQMF-UHFFFAOYSA-N  

Network

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Synonyms

  • ethyl 2-methyl-9H-thiazolo[5,4-b]carbazole-10-carboxylate
  • 2-methyl-9H-thiazolo[5,4-b]carbazole-10-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0151 0.1187
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0083 0.0573
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0113 0.4894
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0002 0.0015
Mycobacterium tuberculosis Conserved protein 0.0035 0.0194 0.0237
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0205 0.1404
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0083 0.0573
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0194 0.1344
Toxoplasma gondii ABC1 family protein 0.0035 0.0194 0.0616
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0194 0.1038
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0083 0.0641
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0194 0.0169
Mycobacterium ulcerans lipase LipD 0.0035 0.0194 0.0169
Plasmodium falciparum glutathione reductase 0.0037 0.0205 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0083 0.0641
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0151 0.1187
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0184
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1346 1 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0205 0.1404
Onchocerca volvulus 0.003 0.0151 0.0903
Brugia malayi beta-lactamase family protein 0.0035 0.0194 0.1344
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.0015
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1346 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0083 0.0641
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0113 0.4894
Echinococcus multilocularis geminin 0.0178 0.1259 1
Trichomonas vaginalis MYB, putative 0.0018 0.0068 0.0264
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.038 0.3008
Loa Loa (eye worm) histone methyltransferase 0.001 0.0003 0.0003
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0018 0.0068 0.5
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0083 0.0488
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0194 0.9421
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0083 0.0641
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0151 0.1187
Brugia malayi beta-lactamase 0.0035 0.0194 0.1344
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0556 0.0744
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0083 0.0641
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0015
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0205 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0068 0.026
Trichomonas vaginalis pc-MYB2, putative 0.0018 0.0068 0.026
Brugia malayi nuclear receptor RXR 0.001 0.0002 0.0015
Brugia malayi hypothetical protein 0.0016 0.0048 0.0334
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.1332
Onchocerca volvulus 0.0028 0.0139 0.0826
Brugia malayi steroid hormone receptor 0.002 0.0083 0.0573
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0113 0.4894
Schistosoma mansoni hypothetical protein 0.0178 0.1259 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0194 0.0237
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0626 0.0842
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0966 0.7161 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0194 0.1038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0083 0.0641
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0194 0.0237
Echinococcus multilocularis cpg binding protein 0.0029 0.015 0.118
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0379 0.2769 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0113 0.4894
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0113 0.4894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0083 0.0573
Brugia malayi nuclear receptor NHR-67 0.001 0.0002 0.0015
Brugia malayi nuclear hormone receptor 0.002 0.0083 0.0573
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0139 0.1087
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0139 0.0945
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0194 0.0169
Schistosoma mansoni hypothetical protein 0.0178 0.1259 1
Brugia malayi conserved hypotetical protein 0.001 0.0002 0.0015
Schistosoma mansoni thyroid hormone receptor 0.002 0.0083 0.0641
Onchocerca volvulus 0.023 0.1653 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0113 0.032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0083 0.0641
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0003 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0083 0.0641
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0556 0.0744
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0626 0.0842
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0083 0.0641
Leishmania major hypothetical protein, conserved 0.0024 0.0113 0.4894
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.1332
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0083 0.0573
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0194 0.0237
Brugia malayi hypothetical protein 0.001 0.0002 0.0015
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0068 0.026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.1332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0083 0.0559
Brugia malayi Thioredoxin reductase 0.0037 0.0205 0.1416
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0083 0.0573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0083 0.0559
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0068 0.0264
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0083 0.0559
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0333 0.1121
Brugia malayi hypothetical protein 0.0158 0.1115 0.7718
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.1332
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0083 0.0641
Mycobacterium ulcerans hypothetical protein 0.0035 0.0194 0.0169
Loa Loa (eye worm) beta-lactamase 0.0035 0.0194 0.1332
Onchocerca volvulus 0.0035 0.0194 0.1163
Brugia malayi nuclear receptor RXR 0.0011 0.0011 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0083 0.0573
Trichomonas vaginalis MYB72, putative 0.0018 0.0068 0.026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0083 0.0641
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0205 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0083 0.0641
Plasmodium falciparum thioredoxin reductase 0.0037 0.0205 1
Onchocerca volvulus 0.0035 0.0194 0.1163
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.006
Brugia malayi hypothetical protein 0.0024 0.0113 0.0782
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0068 0.026
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0083 0.0641
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0002 0.0015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0083 0.0641
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0083 0.0573
Trichomonas vaginalis MYB3r3, putative 0.0018 0.0068 0.026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0083 0.0559
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0083 0.0641
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0559
Brugia malayi CXXC zinc finger family protein 0.0028 0.0139 0.0959
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0083 0.0641
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0083 0.0641
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0559
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0083 0.0559
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0194 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0559
Brugia malayi glutathione reductase 0.0037 0.0205 0.1416
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0194 0.9421
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0083 0.0641
Onchocerca volvulus 0.0035 0.0194 0.1163
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0559
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0083 0.0641
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0151 0.0459
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0011 0.0074
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0083 0.0573
Trichomonas vaginalis set domain proteins, putative 0.023 0.1653 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0379 0.2769 0.3696
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0556 0.0744
Brugia malayi Pre-SET motif family protein 0.003 0.0151 0.1047
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0018 0.0068 0.5
Schistosoma mansoni coup transcription factor 0.002 0.0083 0.0641
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0083 0.0641
Toxoplasma gondii thioredoxin reductase 0.0037 0.0205 0.0654
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0083 0.0573
Schistosoma mansoni cpg binding protein 0.0029 0.015 0.118
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0194 0.0237
Trichomonas vaginalis pc-MYB2, putative 0.0018 0.0068 0.026
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0205 0.0251
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0184
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0151 0.1187
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0012 0.008
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0002 0.0012
Schistosoma mansoni nuclear hormone receptor 0.002 0.0083 0.0641
Leishmania major hypothetical protein, conserved 0.0035 0.0194 0.9421
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0556 0.0744
Schistosoma mansoni thyroid hormone receptor 0.002 0.0083 0.0641
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0083 0.0559
Plasmodium vivax SET domain protein, putative 0.003 0.0151 0.7027
Trypanosoma brucei trypanothione reductase 0.0037 0.0205 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0068 0.026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0083 0.0573
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0011 0.0074
Mycobacterium tuberculosis Conserved protein 0.0035 0.0194 0.0237
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0151 0.1187
Mycobacterium tuberculosis Probable reductase 0.0084 0.0556 0.0744
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0011 0.0069
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0068 0.026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0194 0.1529
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0194 0.1038
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0556 0.0744
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0003 0.0004
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0068 0.026
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0083 0.0573
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0011 0.0069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1445 1
Trichomonas vaginalis esterase, putative 0.0035 0.0194 0.1038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0083 0.0573
Plasmodium vivax glutathione reductase, putative 0.0037 0.0205 1
Onchocerca volvulus 0.002 0.0083 0.0488
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0194 0.0237
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0025 0.0175
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0379 0.2769 0.2751
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0966 0.7161 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0018 0.0068 0.5
Schistosoma mansoni cpg binding protein 0.0029 0.015 0.118
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0083 0.0488
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0151 0.1187
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0194 0.1038
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0194 0.9421
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0208 0.164
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0194 0.1529
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.1332
Trichomonas vaginalis C-MYB, putative 0.0018 0.0068 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0083 0.0559
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0208 0.164
Loa Loa (eye worm) hypothetical protein 0.0024 0.0113 0.0769
Mycobacterium tuberculosis Conserved protein 0.0035 0.0194 0.0237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0083 0.0573
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0556 0.052
Trichomonas vaginalis C-MYB, putative 0.0018 0.0068 0.026
Giardia lamblia Myb 1-like protein 0.0018 0.0068 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1346 1 1
Leishmania major trypanothione reductase 0.0037 0.0205 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0083 0.0559
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0083 0.0641
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0626 0.0842
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0011 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0083 0.0573
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0083 0.0641
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1617 0.2231
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0559
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0068 0.0264
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0151 0.1187
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0559
Brugia malayi hypothetical protein 0.0011 0.0011 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0083 0.0573
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0194 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0194 0.9421
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.006
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0002 0.0015
Schistosoma mansoni cpg binding protein 0.0028 0.0139 0.1085
Loa Loa (eye worm) hypothetical protein 0.0158 0.1115 0.7715
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0379 0.2769 0.2751
Echinococcus granulosus FTZ F1 alpha 0.002 0.0083 0.0641
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0018 0.0068 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0012 0.008
Echinococcus granulosus cpg binding protein 0.0029 0.015 0.118
Brugia malayi nuclear receptor NHR-88 0.002 0.0083 0.0573
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0194 0.1038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0083 0.0641
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0083 0.0641
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0184
Brugia malayi Pre-SET motif family protein 0.0202 0.1445 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0083 0.0641
Onchocerca volvulus 0.0158 0.1115 0.674
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0083 0.0573
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0626 0.062
Brugia malayi ecdysteroid receptor 0.002 0.0083 0.0573
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.1332
Mycobacterium ulcerans beta-lactamase 0.0035 0.0194 0.0169
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0194 0.1529
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0018 0.0068 0.5
Brugia malayi ecdysone receptor 0.001 0.0002 0.0015
Echinococcus granulosus geminin 0.0178 0.1259 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0559
Loa Loa (eye worm) hypothetical protein 0.003 0.0151 0.1034
Brugia malayi beta-lactamase family protein 0.0035 0.0194 0.1344
Brugia malayi hypothetical protein 0.001 0.0002 0.0015
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0002 0.0015
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0083 0.0488
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0194 0.1332
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0083 0.0641
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0113 0.4894
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0011 0.0069
Brugia malayi tailless protein 0.001 0.0002 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0194 0.1529
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0018 0.0068 0.0157
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0011 0.006
Brugia malayi hypothetical protein 0.0011 0.0011 0.0074

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 48 % Glutathione peroxidase-like activity in relation to Ebselen glutathione peroxidase-like activity ChEMBL. 10794693
Activity (functional) = 33 uM Glutathione peroxidase-like activity at 10x(E -4) M concentration measured as NADP+/L/min ChEMBL. 10794693
Activity (functional) = 33 uM Glutathione peroxidase-like activity at 10x(E -4) M concentration measured as NADP+/L/min ChEMBL. 10794693
Activity (functional) = 46 uM Glutathione peroxidase-like activity at 10x(E -3) M concentration as NADP+/L/min ChEMBL. 10794693
Activity (functional) = 506 uM Glutathione peroxidase-like activity at 10x(E -2) M concentration as NADP+/L/min ChEMBL. 10794693
Effective molarity (functional) = 0.00001 M l-1 Antioxidative property against stable murine-murine hybridoma (Mark 3) cell line ChEMBL. 10794693
Effective molarity (functional) = 0.00001 M l-1 Antioxidative property against stable murine-murine hybridoma (Mark 3) cell line ChEMBL. 10794693

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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