Detailed information for compound 71359

Basic information

Technical information
  • TDR Targets ID: 71359
  • Name: 3-isothiocyanato-6-nitrobicyclo[2.2.1]heptane
  • MW: 198.242 | Formula: C8H10N2O2S
  • H donors: 0 H acceptors: 2 LogP: 2.6 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C=NC1CC2CC1CC2[N+](=O)[O-]
  • InChi: 1S/C8H10N2O2S/c11-10(12)8-3-5-1-6(8)2-7(5)9-4-13/h5-8H,1-3H2
  • InChiKey: ITUCJPDMMFEDSF-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-isothiocyanato-5-nitro-norbornane
  • 2-isothiocyanato-5-nitronorbornane
  • 3-isothiocyanato-6-nitro-bicyclo[2.2.1]heptane

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei heat shock protein, putative 0.0049 0.0145 0.2924
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0255 0.6374
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0032 0.0061 0.5
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0231 0.0609
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0071 0.0255 0.0696
Loa Loa (eye worm) hypothetical protein 0.0071 0.0255 0.0696
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0071
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0255 0.5983
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0038 0.0092 0.011
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0255 0.0696
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0231 0.0609
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0125 0.0533 0.1694
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0103 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0255 0.6374
Trichomonas vaginalis MYB, putative 0.0039 0.0092 0.2393
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Mycobacterium tuberculosis Probable dehydrogenase 0.0226 0.1046 0.1378
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0255 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0231 0.0609
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0509 0.2488 0.8711
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0071 0.0034
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Loa Loa (eye worm) hypothetical protein 0.0071 0.0255 0.0696
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0145 0.3613
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.04 0.1217
Treponema pallidum heat shock protein 90 0.0046 0.0129 0.0059
Trypanosoma brucei heat shock protein 90, putative 0.0049 0.0145 0.2924
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0091 0.3566
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0071 0.0255 0.0696
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0071 0.0876
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0145 0.3613
Trypanosoma brucei heat shock protein, putative 0.0049 0.0145 0.2924
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0129 0.414
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0091 0.2349
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0166 0.0577
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0071 0.1765
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0081 0.023
Trypanosoma brucei heat shock protein, putative 0.0049 0.0145 0.2924
Leishmania major hypothetical protein, conserved 0.0071 0.0255 0.5721
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0103 0.1248
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0226 0.1046 0.1378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0144 0.0298
Giardia lamblia DINP protein human, muc B family 0.0041 0.0103 0.0118
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0071 0.0876
Brugia malayi hypothetical protein 0.0038 0.0091 0.0272
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0091 0.2349
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0071 0.0034
Plasmodium falciparum heat shock protein 90, putative 0.0185 0.0838 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0091 0.3566
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0071 0.0255 0.0696
Giardia lamblia Grp94/Hsp90 0.0046 0.0129 0.0211
Trypanosoma cruzi heat shock protein 85, putative 0.0042 0.0109 0.2715
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0103 0.0152
Brugia malayi heat shock protein 90 0.0049 0.0145 0.0489
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0103 0.5068
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0231 0.0609
Plasmodium falciparum glutathione reductase 0.0099 0.04 0.4507
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0103 0.0046
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0091 0.2349
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0071 0.0255 0.0937
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0103 0.2584
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0251 0.1174 0.1559
Schistosoma mansoni hypothetical protein 0.0355 0.1703 0.5894
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0129 0.414
Trypanosoma brucei unspecified product 0.0041 0.0103 0.1784
Plasmodium falciparum phosphodiesterase gamma, putative 0.0071 0.0255 0.2689
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0071 0.0255 0.0696
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.36
Giardia lamblia Heat shock protein HSP 90-alpha 0.0042 0.0109 0.0137
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0103 0.2584
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0509 0.2488 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Toxoplasma gondii heat shock protein 90, putative 0.0049 0.0145 0.03
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0255 0.5983
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.058 0.2847 1
Plasmodium vivax endoplasmin, putative 0.0049 0.0145 0.1074
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Trypanosoma cruzi heat shock protein, putative 0.0032 0.0061 0.1527
Trypanosoma brucei heat shock protein, putative 0.0049 0.0145 0.2924
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0103 0.0321
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.058 0.2847 1
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0255 0.6374
Echinococcus granulosus heat shock protein 90 0.0049 0.0145 0.03
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0071 0.1406
Schistosoma mansoni hypothetical protein 0.0036 0.0081 0.0071
Echinococcus granulosus dna polymerase kappa 0.0041 0.0103 0.0152
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0071 0.1765
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0255 0.6374
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.056 0.2744 0.2693
Plasmodium vivax phosphodiesterase gamma, putative 0.0071 0.0255 0.2495
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1426 0.7152 1
Echinococcus multilocularis geminin 0.0355 0.1703 0.5894
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0071 0.0255 0.6374
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0071 0.0255 0.0696
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0091 0.0108
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0103 0.2933
Echinococcus granulosus heat shock protein 90 0.0042 0.0109 0.0171
Trypanosoma brucei Heat shock protein 83, putative 0.0049 0.0145 0.2924
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0125 0.0533 0.2065
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0231 0.0609
Loa Loa (eye worm) hypothetical protein 0.0053 0.0166 0.0378
Brugia malayi TAR-binding protein 0.0066 0.0231 0.0839
Trypanosoma brucei heat shock protein, putative 0.0049 0.0145 0.2924
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Schistosoma mansoni endoplasmin 0.0049 0.0145 0.03
Plasmodium vivax glutathione reductase, putative 0.0099 0.04 0.4361
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0071 0.0255 0.0696
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0071 0.0255 0.0696
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0231 0.0609
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0255 0.6374
Toxoplasma gondii thioredoxin reductase 0.0099 0.04 0.1217
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0091 0.2349
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0144 0.0298
Trypanosoma brucei heat shock protein, putative 0.0049 0.0145 0.2924
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0046 0.0129 0.0059
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0071 0.0281
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0049 0.0145 0.0266
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0251 0.1174 0.1488
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Trichomonas vaginalis MYB72, putative 0.0038 0.0091 0.2349
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0071 0.0255 0.0937
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0091 0.2349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0144 0.0298
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1986 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0103 0.1784
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0071 0.1765
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0071 0.0255 0.2689
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0071 0.0876
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.056 0.2744 0.9632
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0226 0.1046 0.1378
Echinococcus multilocularis heat shock protein 0.0049 0.0145 0.03
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0231 0.0839
Leishmania major DNA polymerase kappa, putative 0.0041 0.0103 0.1248
Schistosoma mansoni heat shock protein 0.0049 0.0145 0.03
Loa Loa (eye worm) heat shock protein 90 0.0049 0.0145 0.03
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1986 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0226 0.1046 0.1378
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0103 0.0046
Trypanosoma cruzi heat shock protein 85, putative 0.0049 0.0145 0.3613
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0103 0.0033
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0071 0.0255 0.2689
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0071 0.0255 0.0696
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.04 0.1217
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.04 0.4361
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 0.2495
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0103 0.2584
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0103 0.0152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0071 0.1765
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0226 0.1046 0.1378
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0255 0.6374
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0071 0.0281
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 0.2689
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0109 0.3178
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0071 0.1765
Schistosoma mansoni heat shock protein 0.0049 0.0145 0.03
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.36
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0071 0.0281
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0255 0.6374
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.012 0.0504 0.159
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.04 0.1217
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0071 0.1765
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0255 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0071 0.0255 0.0696
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.056 0.2744 0.3724
Brugia malayi Endoplasmin precursor 0.0049 0.0145 0.0489
Entamoeba histolytica heat shock protein 90, putative 0.0049 0.0145 1
Brugia malayi Thioredoxin reductase 0.0099 0.04 0.1526
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0103 0.0152
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0071 0.0255 0.5983
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0071 0.0255 0.0696
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0103 0.1784
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0103 0.2584
Trichomonas vaginalis heat shock protein, putative 0.0049 0.0145 0.4852
Echinococcus multilocularis dna polymerase eta 0.0068 0.024 0.0644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0144 0.0298
Brugia malayi glutathione reductase 0.0099 0.04 0.1526
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Echinococcus multilocularis heat shock protein 90 0.0049 0.0145 0.03
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.056 0.2744 0.2693
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 0.2689
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0509 0.2488 0.8711
Leishmania major cAMP-specific phosphodiesterase, putative 0.0071 0.0255 0.5721
Echinococcus granulosus geminin 0.0355 0.1703 0.5894
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0255 0.6374
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0091 0.2349
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0144 0.0298
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.024 0.0877
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.04 0.0465
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Loa Loa (eye worm) endoplasmin 0.0049 0.0145 0.03
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0071 0.0188
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.058 0.2847 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0255 0.6374
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0509 0.2488 0.8711
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Leishmania major DNA polymerase eta, putative 0.0068 0.024 0.5288
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0071 0.0255 0.0696
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0255 0.6374
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0071 0.0255 0.0937
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0255 0.5983
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0097 0.243
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0071 0.1765
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0071 0.0255 0.0696
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Leishmania major DNA polymerase eta, putative 0.004 0.0097 0.1066
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.36
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0071 0.0255 0.0696
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0046 0.0129 0.2012
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0071 0.1406
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0255 0.0696
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.058 0.2847 1
Echinococcus multilocularis heat shock protein 90 0.0042 0.0109 0.0171
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0255 0.0696
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0166 0.0378
Giardia lamblia hypothetical protein 0.0071 0.0255 0.0664
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1986 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0049 0.0145 0.3613
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0091 0.3566
Trichomonas vaginalis endoplasmin, putative 0.0035 0.0076 0.1674
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0125 0.0533 0.1694
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Schistosoma mansoni hypothetical protein 0.0355 0.1703 0.5894
Plasmodium falciparum phosphodiesterase delta, putative 0.0071 0.0255 0.2689
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.36
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0091 0.3566
Trypanosoma brucei heat shock protein 90, putative 0.0049 0.0145 0.2924
Plasmodium falciparum endoplasmin, putative 0.0035 0.0076 0.045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Brugia malayi RNA binding protein 0.0066 0.0231 0.0839
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.1169 0.3977
Echinococcus granulosus endoplasmin 0.0046 0.0129 0.0245
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0071 0.0034
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.024 0.6007
Trypanosoma cruzi Heat shock protein 83, putative 0.0049 0.0145 0.3613
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0226 0.1046 0.1306
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 0.2495
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0071 0.0876
Plasmodium falciparum thioredoxin reductase 0.0099 0.04 0.4507
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Loa Loa (eye worm) RNA binding protein 0.0066 0.0231 0.0609
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0071 0.0255 0.0937
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0125 0.0533 0.1694
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1426 0.7152 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.058 0.2847 1
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Schistosoma mansoni DNA polymerase eta 0.0068 0.024 0.0644
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma brucei heat shock protein, putative 0.0049 0.0145 0.2924
Schistosoma mansoni hypothetical protein 0.0038 0.0091 0.0108
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Leishmania major hypothetical protein, conserved 0.0071 0.0255 0.5721
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0103 0.0152
Echinococcus granulosus heat shock protein 0.0049 0.0145 0.03
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0071 0.0255 0.0696
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0092 0.2393
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0071 0.0122
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.04 1
Plasmodium vivax heat shock protein 86, putative 0.0049 0.0145 0.1074
Brugia malayi MH2 domain containing protein 0.025 0.1169 0.4647
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0042 0.0109 0.0171
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0071 0.1765
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0231 0.0609
Trichomonas vaginalis C-MYB, putative 0.0038 0.0091 0.2349
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0071 0.0255 0.0696
Toxoplasma gondii heat shock protein HSP90 0.0049 0.0145 0.03
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0071 0.0255 0.0696
Loa Loa (eye worm) hypothetical protein 0.058 0.2847 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0091 0.2349
Loa Loa (eye worm) PDE1B protein 0.0071 0.0255 0.0696
Trypanosoma brucei trypanothione reductase 0.0099 0.04 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0091 0.0108
Trypanosoma brucei heat shock protein 84, putative 0.0032 0.0061 0.0612
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0071 0.0255 0.6374
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0071 0.0034
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0071 0.0255 0.0696
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0071 0.0255 0.0696
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.1169 0.3977
Trichomonas vaginalis MYB3r3, putative 0.0038 0.0091 0.2349
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0071 0.0378
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0166 0.0577
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Leishmania major trypanothione reductase 0.0099 0.04 1
Plasmodium falciparum thioredoxin reductase 0.0034 0.0071 0.0378
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0071 0.0255 0.0696
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0144 0.0487
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0071 0.0281
Mycobacterium tuberculosis Probable oxidoreductase 0.0251 0.1174 0.1559
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0071 0.0255 0.0937
Entamoeba histolytica heat shock protein 90, putative 0.0049 0.0145 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0071 0.0122
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0097 0.013
Plasmodium vivax heat shock protein, putative 0.0185 0.0838 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 0.5983
Echinococcus multilocularis endoplasmin 0.0046 0.0129 0.0245
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0231 0.0609
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0071 0.1765
Plasmodium falciparum heat shock protein 90 0.0049 0.0145 0.1305
Loa Loa (eye worm) glutathione reductase 0.0099 0.04 0.1217
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 0.5983
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0071 0.0255 0.6374
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0144 0.0298
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0103 0.2933
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0144 0.0298
Mycobacterium tuberculosis Probable reductase 0.0226 0.1046 0.1378
Loa Loa (eye worm) hypothetical protein 0.0068 0.024 0.0644
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0103 0.0033
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0071 0.0255 0.5721
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Giardia lamblia Hypothetical protein 0.0071 0.0255 0.0664
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0091 0.0108
Leishmania major heat shock protein 83-1 0.0049 0.0145 0.2462
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0109 0.2715
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0071 0.0255 0.0696
Giardia lamblia Myb 1-like protein 0.0038 0.0092 0.0076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.058 0.2847 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.058 0.2847 1
Plasmodium falciparum glutathione reductase 0.0034 0.0071 0.0378
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0091 0.2349
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0251 0.1174 0.1559
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0071 0.0378
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0071 0.0255 0.5983
Echinococcus granulosus tar DNA binding protein 0.0066 0.0231 0.0609
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0071 0.0255 0.0937
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0255 0.0696
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0103 0.0152
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0255 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0071 0.0255 0.0696
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0144 0.0298
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0103 0.1784
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0046 0.0129 0.0083
Trichomonas vaginalis C-MYB, putative 0.0038 0.0091 0.2349
Toxoplasma gondii Hsp90 domain-containing protein 0.0185 0.0838 0.279
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0071 0.0255 0.2495
Trypanosoma brucei heat shock protein, putative 0.0049 0.0145 0.2924
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0103 0.1784
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0071 0.0255 0.6374
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0092 0.2393
Brugia malayi Hsp90 protein 0.0032 0.0061 0.015
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0091 0.3566
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0255 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0255 1
Echinococcus granulosus dna polymerase eta 0.0068 0.024 0.0644
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0076 0.1674
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0071 0.0034
Mycobacterium ulcerans heat shock protein 90 0.0046 0.0129 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0255 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0255 1
Schistosoma mansoni endoplasmin 0.0049 0.0145 0.03
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.024 0.5576

Activities

Activity type Activity value Assay description Source Reference
CD (binding) = 1.1 uM In vitro potency of the compound to induce quinone reductase activity in murine hepatoma cells was determined ChEMBL. 8289191
CD (binding) = 1.1 uM In vitro potency of the compound to induce quinone reductase activity in murine hepatoma cells was determined ChEMBL. 8289191

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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