Detailed information for compound 71361

Basic information

Technical information
  • TDR Targets ID: 71361
  • Name: 4-(acridin-9-ylamino)phenol
  • MW: 286.327 | Formula: C19H14N2O
  • H donors: 2 H acceptors: 2 LogP: 4.71 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)Nc1c2ccccc2nc2c1cccc2
  • InChi: 1S/C19H14N2O/c22-14-11-9-13(10-12-14)20-19-15-5-1-3-7-17(15)21-18-8-4-2-6-16(18)19/h1-12,22H,(H,20,21)
  • InChiKey: YJRBRXLARFRAFB-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(9-acridinylamino)phenol
  • 61421-83-8
  • 9-(4-Hydroxyanilino)acridine
  • BRN 1623943
  • CCRIS 4547
  • Phenol, 4-(9-acridinylamino)-
  • Phenol, p-(9-acridinylamino)-
  • SN 8342
  • p-(9-Acridinylamino)phenol
  • 4-(Acridin-9-ylamino)-phenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0078 0.0311
Brugia malayi Smad1 0.0027 0.007 0.0318
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0006 0.0141
Trichomonas vaginalis MYB, putative 0.0061 0.0224 0.8616
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0069 0.026 0.0811
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0021 0.0074
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0105
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.002 0.0038 0.0175
Schistosoma mansoni DNA polymerase eta 0.0096 0.038 0.1185
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0118 0.2598
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0224 0.8616
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0177 0.3985
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0569 0.2501 0.7804
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.026 0.104
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0223 0.8565
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Trichomonas vaginalis pc-MYB2, putative 0.0061 0.0223 0.8565
Brugia malayi Thioredoxin reductase 0.0108 0.0435 0.1985
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0017 0.0025 0.0078
Brugia malayi CHD4 protein 0.0011 0.000000000018114 0.000000000082702
Mycobacterium tuberculosis Probable reductase 0.0247 0.1056 0.1473
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 0.5981
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.026 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0012 0.0003 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0118 0.2705
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.026 0.5922
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2598
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.026 0.5922
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0065 0.0243 0.0759
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.026 0.5922
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0118 0.0537
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0118 0.0117
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Echinococcus granulosus tar DNA binding protein 0.0069 0.026 0.0812
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0569 0.2501 0.7804
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0631 0.2783 1
Trypanosoma brucei unspecified product 0.0045 0.0152 0.3402
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0069 0.026 0.5922
Loa Loa (eye worm) RNA binding protein 0.0069 0.026 0.1041
Brugia malayi Na,K-ATPase alpha subunit 0.0017 0.0025 0.0114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2598
Loa Loa (eye worm) hypothetical protein 0.0096 0.038 0.1518
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0341
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.000000000018114 0.000000000056524
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0177 0.0636
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0175 0.0629
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2598
Entamoeba histolytica hypothetical protein 0.0111 0.0448 1
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0063 0.0195
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0223 0.8565
Brugia malayi MH1 domain containing protein 0.0015 0.0016 0.0073
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0069 0.026 0.1187
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0069 0.026 0.0811
Echinococcus granulosus Smad4 0.0027 0.007 0.0217
Echinococcus multilocularis dna polymerase eta 0.0096 0.038 0.1185
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0006 0.0242
Brugia malayi MH2 domain containing protein 0.0393 0.1714 0.7824
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0152 0.3402
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0069 0.026 0.5922
Trypanosoma brucei hypothetical protein, conserved 0.0069 0.026 0.5922
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0108 0.0435 0.0606
Loa Loa (eye worm) hypothetical protein 0.0039 0.0123 0.049
Trichomonas vaginalis MYB3r3, putative 0.0061 0.0223 0.8565
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0118 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0223 0.4971
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0041 0.0935
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.026 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0069 0.026 0.0811
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0175 0.3938
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0069 0.026 0.1187
Trypanosoma brucei DNA polymerase eta, putative 0.0096 0.038 0.8714
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Loa Loa (eye worm) MH2 domain-containing protein 0.0012 0.0003 0.0013
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0051 0.0158
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1609 0.7167 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0029 0.0078 0.2987
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Giardia lamblia Myb 1-like protein 0.0061 0.0224 0.0859
Echinococcus granulosus Chromo domain 0.0011 0.000000000018114 0.000000000056524
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.000000000018114 0.00000000041671
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.007 0.0217
Schistosoma mansoni tar DNA-binding protein 0.0069 0.026 0.0812
Brugia malayi glutathione reductase 0.0108 0.0435 0.1985
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0069 0.026 0.0811
Schistosoma mansoni tar DNA-binding protein 0.0069 0.026 0.0812
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Schistosoma mansoni Smad4 0.0027 0.007 0.0217
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0247 0.1056 0.1473
Mycobacterium ulcerans hypothetical protein 0.002 0.0041 0.004
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0025 0.0435
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0069 0.026 0.5981
Plasmodium falciparum thioredoxin reductase 0.0108 0.0435 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0117 0.0467
Echinococcus multilocularis calcium transporting atpase 0.0025 0.0063 0.0195
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0118 0.2598
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0041 0.0801
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0041 0.0146
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0041 0.0801
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0025 0.0959
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0056 0.2149
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Echinococcus granulosus calcium transporting atpase 0.0025 0.0063 0.0195
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0569 0.2501 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0243 0.0338
Echinococcus multilocularis mothers against decapentaplegic 2 0.0012 0.0003 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0027 0.0084
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0118 0.2598
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0041 0.0801
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.224 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2598
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0069 0.026 0.0811
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0118 0.0367
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0223 0.8565
Schistosoma mansoni smad1 5 8 and 0.0027 0.007 0.0217
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0069 0.026 0.0811
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0013
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0017 0.0025 0.0959
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0021 0.0492
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0025 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.026 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0118 0.2598
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.026 0.5922
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 0.5922
Leishmania major DNA damage repair protein, putative 0.002 0.0041 0.0801
Brugia malayi Membrane calcium atpase protein 3 0.0013 0.001 0.0045
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0065 0.0243 0.0973
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Brugia malayi MH2 domain containing protein 0.0027 0.007 0.0318
Schistosoma mansoni hypothetical protein 0.0726 0.3205 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0118 0.0433
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 0.5981
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0069 0.026 0.0811
Toxoplasma gondii thioredoxin reductase 0.0108 0.0435 0.1562
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.0243 0.9355
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0069 0.026 0.1187
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.0084
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0499 0.219 0.6835
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0069 0.026 0.0811
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0069 0.026 0.5922
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0041 0.0801
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0069 0.026 0.0811
Plasmodium falciparum thioredoxin reductase 0.0037 0.0118 0.2705
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0013 0.001 0.0031
Plasmodium vivax glutathione reductase, putative 0.0108 0.0435 1
Leishmania major hypothetical protein, conserved 0.0069 0.026 0.5922
Loa Loa (eye worm) TAR-binding protein 0.0069 0.026 0.1041
Trypanosoma brucei calcium-translocating P-type ATPase 0.0025 0.0063 0.1314
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0136 0.522
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0069 0.026 0.0811
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0448 0.1398
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000018114 0.000000000056524
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0069 0.026 0.1187
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0025 0.0435
Echinococcus granulosus smad 0.0027 0.007 0.0217
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0013 0.001 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.026 0.1189
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.026 0.104
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.0243 0.5531
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0118 0.0367
Trichomonas vaginalis MYB72, putative 0.0061 0.0223 0.8565
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.224 1 1
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0041 0.0801
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0028 0.0073 0.0333
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 0.5981
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0064
Leishmania major cAMP-specific phosphodiesterase, putative 0.0069 0.026 0.5922
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0069 0.026 0.0811
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.007 0.0217
Entamoeba histolytica hypothetical protein 0.0111 0.0448 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0118 0.2705
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.007 0.0217
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 0.5981
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.007 0.0217
Schistosoma mansoni smad1 5 8 and 0.0027 0.007 0.0217
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0274 0.118 0.1645
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0274 0.118 0.1645
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0025 0.0959
Echinococcus multilocularis Smad4 0.0027 0.007 0.0217
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Echinococcus multilocularis thioredoxin glutathione reductase 0.0108 0.0435 0.1356
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0065 0.0243 0.0759
Echinococcus granulosus dna polymerase eta 0.0096 0.038 0.1185
Giardia lamblia hypothetical protein 0.0069 0.026 0.1004
Schistosoma mansoni hypothetical protein 0.0011 0.000000000018114 0.000000000056524
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0011 0.0001 0.0003
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0069 0.026 0.0811
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0025 0.0959
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.0084
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0065 0.0243 0.0759
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0069 0.026 0.0811
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0175 0.4026
Leishmania major calcium motive p-type ATPase, putative 0.0013 0.001 0.0083
Echinococcus multilocularis dna polymerase kappa 0.0065 0.0243 0.0759
Entamoeba histolytica deoxycytidyl transferase, putative 0.0065 0.0243 0.543
Trichomonas vaginalis C-MYB, putative 0.0061 0.0223 0.8565
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.0084
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0175 0.3938
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0027 0.0084
Echinococcus granulosus geminin 0.0726 0.3205 1
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0013 0.001 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0041 0.0801
Entamoeba histolytica hypothetical protein 0.0011 0.000000000018114 0.00000000040436
Giardia lamblia Hypothetical protein 0.0069 0.026 0.1004
Trypanosoma brucei unspecified product 0.0065 0.0243 0.5531
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.000000000018114 0.000000000072432
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0027 0.0123
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0069 0.026 0.0811
Leishmania major calcium-translocating P-type ATPase 0.0029 0.0078 0.1666
Echinococcus multilocularis Chromo domain 0.0011 0.000000000018114 0.000000000056524
Loa Loa (eye worm) MH1 domain-containing protein 0.0012 0.0003 0.0013
Echinococcus multilocularis chromobox protein 1 0.0069 0.0258 0.0806
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0258 0.9935
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0485 0.194
Brugia malayi MH1 domain containing protein 0.0027 0.007 0.0318
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0631 0.2783 0.2697
Loa Loa (eye worm) transcription factor SMAD2 0.0393 0.1714 0.6852
Brugia malayi hypothetical protein 0.0032 0.0095 0.0434
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0041 0.0801
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0069 0.026 0.0811
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.007 0.0217
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0025 0.0959
Loa Loa (eye worm) PDE1B protein 0.0069 0.026 0.104
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Brugia malayi RNA binding protein 0.0069 0.026 0.1189
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000018114 0.000000000072432
Entamoeba histolytica hypothetical protein 0.0111 0.0448 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.000000000018114 0.000000000056524
Trichomonas vaginalis C-MYB, putative 0.0061 0.0223 0.8565
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0069 0.026 0.1187
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0123 0.4715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2598
Mycobacterium tuberculosis Probable dehydrogenase 0.0247 0.1056 0.1473
Plasmodium vivax calcium-transporting ATPase, putative 0.0029 0.0078 0.1787
Toxoplasma gondii P-type ATPase4, putative 0.0017 0.0025 0.009
Leishmania major P-type ATPase, putative 0.0013 0.001 0.0083
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0243 0.111
Echinococcus multilocularis smad 0.0027 0.007 0.0217
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0013 0.001 0.0083
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0018 0.003 0.0544
Schistosoma mansoni smad1 5 8 and 0.0027 0.007 0.0217
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0223 0.8565
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0118 0.4523
Echinococcus granulosus chromobox protein 1 0.0069 0.0258 0.0806
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0056 0.0255
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.01
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0027 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0069 0.026 0.0812
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0069 0.026 0.0811
Schistosoma mansoni smad 0.0012 0.0003 0.001
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0011 0.0001 0.0003
Trypanosoma brucei unspecified product 0.0045 0.0152 0.3402
Schistosoma mansoni hypothetical protein 0.0111 0.0448 0.1398
Leishmania major DNA polymerase kappa, putative 0.002 0.0041 0.0801
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0027 0.0107
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.002 0.0038 0.0153
Schistosoma mansoni ATPase 0.0029 0.0078 0.0242
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0056 0.0174
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.026 0.5922
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018114 0.00000000040436
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0223 0.4971
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0056 0.2149
Plasmodium vivax phosphodiesterase gamma, putative 0.0069 0.026 0.5981
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.026 0.5922
Giardia lamblia DINP protein human, muc B family 0.0065 0.0243 0.0937
Loa Loa (eye worm) hypothetical protein 0.0055 0.0194 0.0776
Loa Loa (eye worm) RecQ helicase 0.0024 0.0056 0.0223
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0025 0.0435
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0029 0.0078 0.1787
Brugia malayi polk-prov protein 0.002 0.0041 0.0185
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0175 0.3938
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.000000000018114 0.000000000065092
Loa Loa (eye worm) MH2 domain-containing protein 0.0393 0.1714 0.6852
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0118 0.0423
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2598
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0499 0.219 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2598
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0065 0.0243 0.0759
Schistosoma mansoni Smad4 0.0012 0.0003 0.001
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0069 0.026 0.5922
Echinococcus granulosus thioredoxin glutathione reductase 0.0108 0.0435 0.1356
Echinococcus multilocularis mothers against decapentaplegic 6 0.0012 0.0003 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0123 0.4715
Leishmania major DNA polymerase eta, putative 0.0096 0.038 0.8714
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.000000000018114 0.000000000082702
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0118 0.2705
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0025 0.0557
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.000000000018114 0.000000000056524
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0258 0.1033
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0017 0.0025 0.0061
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0017 0.0025 0.0557
Brugia malayi MH1 domain containing protein 0.0027 0.007 0.0318
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0118 0.2598
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Echinococcus multilocularis GPCR, family 2 0.0017 0.0027 0.0084
Schistosoma mansoni Smad4 0.0012 0.0003 0.001
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0029 0.0078 0.0279
Leishmania major DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0223 0.4971
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0194 0.0886
Onchocerca volvulus 0.003 0.0085 0.6276
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0069 0.026 0.5922
Giardia lamblia DNA damage repair protein 0.002 0.0041 0.0124
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0025 0.0435
Schistosoma mansoni chromobox protein 0.0069 0.0258 0.0806
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.001 0.0379
Brugia malayi TAR-binding protein 0.0069 0.026 0.1189
Leishmania major trypanothione reductase 0.0108 0.0435 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0069 0.026 0.0811
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0243 0.5531
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0025 0.0959
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0448 0.1398
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.026 0.1041
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0118 0.2705
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018114 0.00000000040436
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.07
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0569 0.2501 0.8987
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0499 0.219 0.8758
Loa Loa (eye worm) thioredoxin reductase 0.0108 0.0435 0.1738
Brugia malayi chromobox protein homolog 3 0.0039 0.0123 0.056
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0017 0.0025 0.01
Schistosoma mansoni hypothetical protein 0.0037 0.0117 0.0364
Schistosoma mansoni smad 0.0027 0.007 0.0217
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0017 0.0025 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0072 0.277
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Schistosoma mansoni hypothetical protein 0.0726 0.3205 1
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0118 0.0423
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Onchocerca volvulus 0.0017 0.0025 0.1837
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.026 0.5922
Brugia malayi MH1 domain containing protein 0.0015 0.0016 0.0073
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0051 0.0158
Trichomonas vaginalis cation-transporting ATPase, putative 0.0029 0.0078 0.2987
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Brugia malayi hypothetical protein 0.0111 0.0448 0.2045
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0175 0.4026
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0063 0.0286
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0069 0.026 0.104
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.001 0.0083
Trypanosoma cruzi trypanothione reductase, putative 0.0108 0.0435 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.224 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0107
Schistosoma mansoni hypothetical protein 0.0023 0.0051 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0152 0.3402
Trichomonas vaginalis pc-MYB2, putative 0.0061 0.0223 0.8565
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0247 0.1056 0.1473
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.001 0.0083
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Leishmania major calcium-transporting ATPase, putative 0.0013 0.001 0.0083
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0027 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0152 0.3402
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0017 0.0025 0.0078
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0041 0.0127
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0123 0.9031
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.026 0.5922
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.0243 0.0338
Brugia malayi MH2 domain containing protein 0.0027 0.007 0.0318
Loa Loa (eye worm) hypothetical protein 0.0069 0.026 0.104
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0247 0.1056 0.1473
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0017 0.0025 0.0024
Brugia malayi mothers against decapentaplegic homolog 3 0.0012 0.0003 0.0014
Echinococcus granulosus GPCR family 2 0.0017 0.0027 0.0084
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0118 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Brugia malayi MH2 domain containing protein 0.0012 0.0003 0.0014
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.001 0.0031
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0043 0.0988
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0243 0.0243
Leishmania major hypothetical protein, conserved 0.0069 0.026 0.5922
Loa Loa (eye worm) glutathione reductase 0.0108 0.0435 0.1738
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0012 0.0003 0.0234
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.0243 0.9355
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0017 0.0025 0.0435
Loa Loa (eye worm) hypothetical protein 0.0569 0.2501 1
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.026 0.5922
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0013 0.001 0.0035
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0569 0.2501 0.7804
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.026 0.5922
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0569 0.2501 0.7804
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0017 0.0025 0.0078
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.0084
Leishmania major hypothetical protein, conserved 0.005 0.0175 0.3938
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0243 0.5531
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0801
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0569 0.2501 0.7804
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Trypanosoma brucei trypanothione reductase 0.0108 0.0435 1
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0243 0.0243
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0118 0.4523
Echinococcus multilocularis tar DNA binding protein 0.0069 0.026 0.0812
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0247 0.1056 0.1473
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.000000000018114 0.000000000056524
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.007 0.0279
Plasmodium falciparum glutathione reductase 0.0108 0.0435 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0194 0.0776
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 0.5922
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0224 0.8616
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0028 0.0073 0.0333
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0017 0.0025 0.0435
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0041 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.026 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0274 0.118 0.1645
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0025 0.0557
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0499 0.219 0.6835
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0029 0.0078 0.0242
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0029 0.0078 0.0242
Loa Loa (eye worm) nuclear factor I 0.0015 0.0016 0.0064
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0448 0.1398
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0631 0.2783 0.2782
Brugia malayi hypothetical protein 0.005 0.0175 0.0799
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.007 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0801
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.001 0.0031
Echinococcus granulosus Na:K ATPase alpha subunit 0.0013 0.001 0.0031
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0223 0.8565
Brugia malayi Heterochromatin protein 1 0.0069 0.0258 0.1179
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 0.5981
Leishmania major DNA polymerase eta, putative 0.0051 0.0177 0.3985
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0069 0.026 0.5922
Echinococcus granulosus dna polymerase kappa 0.0065 0.0243 0.0759
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.000000000018114 0.000000000082702
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0029 0.0078 0.0242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0069 0.026 0.1187
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000018114 0.00000000040436
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0063 0.0195
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0027 0.0084
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0631 0.2783 0.3882
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0041 0.0935
Brugia malayi ImpB/MucB/SamB family protein 0.0096 0.038 0.1733
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0118 0.0163
Entamoeba histolytica hypothetical protein 0.0111 0.0448 1
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0025 0.0063 0.0195
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0029 0.0078 0.0077
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0033 0.0104
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Plasmodium vivax thioredoxin reductase, putative 0.0108 0.0435 1
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0041 0.0801
Mycobacterium tuberculosis Probable oxidoreductase 0.0274 0.118 0.1645
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0072 0.277
Schistosoma mansoni tar DNA-binding protein 0.0069 0.026 0.0812
Plasmodium vivax P-type ATPase4, putative 0.0029 0.0078 0.1787
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000018114 0.000000000056524
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0041 0.0801
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0069 0.026 0.0811
Plasmodium falciparum calcium-transporting ATPase 0.0025 0.0063 0.144
Plasmodium falciparum glutathione reductase 0.0037 0.0118 0.2705
Trypanosoma cruzi DNA polymerase eta, putative 0.0096 0.038 0.8714
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1609 0.7167 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0069 0.026 0.0811
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0118 0.2598
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0069 0.026 0.5981
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0223 0.4971
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0118 0.2598
Plasmodium vivax hypothetical protein, conserved 0.0011 0.000000000018114 0.00000000041671
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0061 0.0224 0.0805
Schistosoma mansoni tar DNA-binding protein 0.0069 0.026 0.0812
Plasmodium falciparum phosphodiesterase gamma, putative 0.0069 0.026 0.5981
Loa Loa (eye worm) Smad1 0.0027 0.007 0.0279
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0029 0.0078 0.1666
Echinococcus multilocularis chromobox protein 1 0.0069 0.0258 0.0806
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0118 0.2598
Echinococcus granulosus bloom syndrome protein 0.0024 0.0056 0.0174
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0017 0.0025 0.0435
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0013 0.001 0.0031
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0118 0.2598
Schistosoma mansoni chromobox protein 0.0069 0.0258 0.0806
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0118 0.2598
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0194 0.0886
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0118 0.0117
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.026 0.0934
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0013 0.001 0.0031
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0117 0.0533
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0069 0.026 0.5922
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0223 0.4971
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0025 0.0959
Echinococcus multilocularis geminin 0.0726 0.3205 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.026 1
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0012 0.0002 0.0002
Plasmodium falciparum phosphodiesterase delta, putative 0.0069 0.026 0.5981
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0012 0.0003 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0243 0.5531
Schistosoma mansoni ATPase 0.0029 0.0078 0.0242
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0069 0.026 0.0811
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0029 0.0078 0.0242
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0175 0.4026
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0069 0.026 0.5922
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0136 0.522
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0247 0.1056 0.1473
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000018114 0.0000000006967
Echinococcus granulosus chromobox protein 1 0.0069 0.0258 0.0806
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.5531
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0069 0.026 0.5922
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0069 0.026 0.0811
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0013 0.001 0.0031
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0069 0.026 0.0811
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0136 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.026 1
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0258 0.9935
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0223 0.8565

Activities

Activity type Activity value Assay description Source Reference
C50 (functional) = 5.1 uM Inhibitory concentration against ethidium binding to DNA ChEMBL. 7205885
IC50 (functional) = 250 nM Inhibitory concentration of the compound to reduce the growth of L1210 cells by 50% after 70 h . ChEMBL. 3820217
IC50 (functional) = 250 nM Inhibitory concentration of the compound to reduce the growth of L1210 cells by 50% after 70 h . ChEMBL. 3820217
ILS (functional) = 80 % Maximum percent increase in life span of mice was determined by L1210 assay ChEMBL. 7205885
ILS (functional) = 80 % Maximum percent increase in life span of mice was determined by L1210 assay ChEMBL. 7205885
LD10 (ADMET) = 180 mg kg-1 Drug dose that is lethal to 10% of animals was measured ChEMBL. 7205885
LD10 (ADMET) = 180 mg kg-1 Drug dose that is lethal to 10% of animals was measured ChEMBL. 7205885
Log 1/D50 (functional) = 3.81 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/D50 (functional) = 3.81 Dose of the drug (mol /kg) providing a 50% life extension in L1210 assays when given at qd 1-5 schedule . ChEMBL. 3820217
Log 1/LD10 (ADMET) = 3.25 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706
Log K (binding) = 6.21 Association constant for binding to poly [d(G-C)] ChEMBL. 7205885
Log K (binding) = 6.28 Association constant for binding to poly [d(A-T)] ChEMBL. 7205885
pKa = 7.91 Ionisation constant (pKa) ChEMBL. 7205885

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 3820217

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.