Detailed information for compound 713633

Basic information

Technical information
  • TDR Targets ID: 713633
  • Name: 2-[(4-methoxy-3-methylphenyl)sulfonyl-(phenyl methyl)amino]-N-(2-methoxyphenyl)acetamide
  • MW: 454.539 | Formula: C24H26N2O5S
  • H donors: 1 H acceptors: 3 LogP: 3.77 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C)S(=O)(=O)N(Cc1ccccc1)CC(=O)Nc1ccccc1OC
  • InChi: 1S/C24H26N2O5S/c1-18-15-20(13-14-22(18)30-2)32(28,29)26(16-19-9-5-4-6-10-19)17-24(27)25-21-11-7-8-12-23(21)31-3/h4-15H,16-17H2,1-3H3,(H,25,27)
  • InChiKey: PTYPYFCECLIYHI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-methoxy-3-methyl-phenyl)sulfonyl-(phenylmethyl)amino]-N-(2-methoxyphenyl)acetamide
  • 2-[benzyl-(4-methoxy-3-methyl-phenyl)sulfonyl-amino]-N-(2-methoxyphenyl)acetamide
  • 2-[(4-methoxy-3-methyl-phenyl)sulfonyl-(phenylmethyl)amino]-N-(2-methoxyphenyl)ethanamide
  • ZINC01116945

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) retinol dehydrogenase 12 0.0105 0.06 0.1716
Mycobacterium tuberculosis Cell division protein FtsZ 0.0316 0.1975 0.197
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0092 0.0092
Onchocerca volvulus 0.0169 0.1021 0.6133
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0215 0.0595
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0016 0.002 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.002 0.0005
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0105 0.06 0.116
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.0615 0.103
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.0961 0.4488
Echinococcus granulosus Ankyrin 0.0028 0.0101 0.0171
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0228 0.1007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0702 0.2002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0081 0.0448 0.0744
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0105 0.06 0.1159
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0076 0.0411 0.1152
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0214 0.0342
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0092 0.0368
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0099 0.0561 0.0555
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0215 0.0397
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0023 0.0068 0.0052
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0538 0.1523
Onchocerca volvulus 0.0031 0.0119 0.0603
Schistosoma mansoni microtubule-associated protein tau 0.079 0.5065 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0015 0.0001
Trypanosoma cruzi ISWI complex protein 0.0035 0.0143 0.0608
Echinococcus granulosus epidermal growth factor receptor 0.0246 0.1522 0.2986
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.013 0.0348
Schistosoma mansoni tyrosine kinase 0.0242 0.1494 0.2928
Toxoplasma gondii thioredoxin reductase 0.0043 0.02 0.0185
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0101 0.0171
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0016 0.002 0.0021
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0105 0.06 0.0581
Schistosoma mansoni hypothetical protein 0.0458 0.2903 0.5719
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0538 0.1035
Echinococcus multilocularis musashi 0.0031 0.0119 0.0179
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0016 0.002 0.0009
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0074 0.0399 0.1821
Onchocerca volvulus 0.0031 0.0119 0.0603
Leishmania major trypanothione reductase 0.0043 0.02 0.0875
Plasmodium falciparum glutathione reductase 0.0015 0.0015 0.0015
Leishmania major acetyl-CoA synthetase, putative 0.0016 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0031 0.0119 0.0314
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0165 0.0159
Leishmania major hypothetical protein, conserved 0.0035 0.0143 0.0608
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0542 0.3446 0.5893
Loa Loa (eye worm) hypothetical protein 0.0169 0.1021 0.294
Echinococcus granulosus cpg binding protein 0.0038 0.0167 0.0302
Schistosoma mansoni tyrosine kinase 0.0246 0.1522 0.2985
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0348
Giardia lamblia Fructose-bisphosphate aldolase 0.0335 0.2098 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.1548 1 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.002 0.0014
Brugia malayi Cell division protein ftsZ 0.0152 0.0905 0.2593
Loa Loa (eye worm) hypothetical protein 0.0092 0.0519 0.1479
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0119 0.0314
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0016 0.002 0.0021
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0016 0.002 0.0024
Trypanosoma brucei ISWI complex protein 0.0035 0.0143 0.0608
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0026 0.002
Brugia malayi Death domain containing protein 0.0028 0.0101 0.025
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0028 0.0101 0.0412
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.02 0.0875
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.2122 1
Schistosoma mansoni hypothetical protein 0.0035 0.0143 0.0254
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0027
Echinococcus multilocularis cpg binding protein 0.0038 0.0167 0.0262
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0105 0.06 0.2777
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.013 0.0115
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.004 0.018 0.0782
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0186 0.0294
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.002 0.0014
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0016 0.002 0.0026
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.2098 0.2085
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0074 0.0399 0.1821
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0016 0.002 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0295 0.1329
Giardia lamblia PHD finger protein 15 0.0033 0.013 0.0552
Schistosoma mansoni tyrosine kinase 0.0246 0.1522 0.2985
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0015 0.0015
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0471 0.0903
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.002 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.06 0.0595
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.0615 0.1188
Loa Loa (eye worm) hypothetical protein 0.0098 0.0559 0.1595
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.002 0.0014
Schistosoma mansoni cpg binding protein 0.0038 0.0167 0.0301
Brugia malayi glutathione reductase 0.0043 0.02 0.0538
Loa Loa (eye worm) hypothetical protein 0.016 0.0961 0.2767
Leishmania major acetyl-CoA synthetase, putative 0.0016 0.002 0.0024
Schistosoma mansoni tyrosine kinase 0.0242 0.1494 0.2928
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.004 0.018 0.0782
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0016 0.002 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0263
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.012 0.0702 0.326
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0016 0.002 0.0024
Schistosoma mansoni tyrosine kinase 0.0242 0.1494 0.2928
Brugia malayi PHD-finger family protein 0.0058 0.0297 0.0822
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.2098 0.2085
Brugia malayi intermediate filament protein 0.0031 0.0119 0.0301
Loa Loa (eye worm) oxidoreductase 0.0105 0.06 0.1716
Brugia malayi Protein kinase domain containing protein 0.0542 0.3446 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0105 0.06 0.0586
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0087 0.021
Onchocerca volvulus 0.0095 0.0538 0.3172
Echinococcus granulosus microtubule associated protein 2 0.079 0.5065 1
Schistosoma mansoni tyrosine kinase 0.0542 0.3446 0.6793
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0027 0.0092 0.0348
Echinococcus granulosus methyl CpG binding domain protein 2 0.0039 0.0169 0.0306
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0016 0.002 0.0024
Echinococcus multilocularis peregrin 0.0038 0.0165 0.0259
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0268 0.1192
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0268 0.0262
Trypanosoma brucei trypanothione reductase 0.0043 0.02 0.0875
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0165 0.0159
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.0961 0.4488
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0268 0.1197
Echinococcus granulosus intermediate filament protein 0.0031 0.0119 0.0206
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.004 0.018 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0073 0.0392 0.0745
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.0961 0.4488
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Loa Loa (eye worm) phosphatidylinositol 3 0.0096 0.0542 0.1546
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0101 0.017
Schistosoma mansoni rotamase 0.0076 0.0411 0.0783
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0016 0.002 0.0021
Loa Loa (eye worm) oxidoreductase 0.0016 0.002 0.0027
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0123 0.0719 0.2062
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0198 0.0315
Loa Loa (eye worm) PHD-finger family protein 0.0047 0.0222 0.0615
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.002 0.0021
Loa Loa (eye worm) TK/EGFR protein kinase 0.0246 0.1522 0.4401
Loa Loa (eye worm) bromodomain containing protein 0.004 0.0178 0.0487
Brugia malayi hypothetical protein 0.0169 0.1021 0.2931
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.013 0.0228
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0015 0.0015
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0054 0.0268 0.0262
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0092 0.0077
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0016 0.002 0.0021
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0105 0.06 0.1706
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.004 0.018 0.0165
Trypanosoma cruzi ISWI complex protein 0.0035 0.0143 0.0608
Schistosoma mansoni hypothetical protein 0.0041 0.0186 0.0338
Echinococcus multilocularis lamin 0.0031 0.0119 0.0179
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0101 0.0149
Schistosoma mansoni hypothetical protein 0.0028 0.0101 0.017
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.02 0.0194
Brugia malayi Cell division protein ftsZ 0.0156 0.0933 0.2675
Loa Loa (eye worm) hypothetical protein 0.0073 0.0392 0.1109
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0426 0.1196
Brugia malayi STAT protein, DNA binding domain containing protein 0.0162 0.0972 0.279
Entamoeba histolytica acyl-coA synthetase, putative 0.0054 0.0268 0.1192
Echinococcus granulosus epidermal growth factor receptor 0.0246 0.1522 0.2986
Brugia malayi PHD-finger family protein 0.0033 0.013 0.0335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.2098 0.2085
Loa Loa (eye worm) hypothetical protein 0.0054 0.0268 0.0747
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0123 0.0719 0.3341
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0083 0.0456 0.0442
Onchocerca volvulus 0.0032 0.0127 0.0655
Mycobacterium ulcerans hypothetical protein 0.0178 0.1079 0.1065
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0016 0.002 0.0024
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0015 0.0009
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0105 0.06 0.0586
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0489
Loa Loa (eye worm) STAT protein 0.0162 0.0972 0.2799
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0411 0.0396
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0016 0.002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0087 0.0484 0.1377
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0105 0.06 0.0586
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.2098 0.2085
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0268 0.0248
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.018 0.0771
Schistosoma mansoni protein kinase 0.0407 0.2567 0.5053
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0083 0.0456 0.0442
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0262 0.0425
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0092 0.0077
Schistosoma mansoni bromodomain containing protein 0.0145 0.0863 0.168
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0303
Trichomonas vaginalis antibiotic synthetase, putative 0.0016 0.002 0.0005
Brugia malayi Pre-SET motif family protein 0.0034 0.014 0.0364
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0016 0.002 0.0004
Echinococcus granulosus insulin receptor 0.0542 0.3446 0.6794
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.012 0.0702 0.326
Brugia malayi Bromodomain containing protein 0.0087 0.0483 0.1363
Echinococcus multilocularis zinc finger protein 0.0046 0.0219 0.035
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0105 0.06 0.0586
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0105 0.06 0.0595
Treponema pallidum fructose-bisphosphate aldolase 0.0335 0.2098 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0054 0.0268 0.0253
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0092 0.0092
Plasmodium vivax enoyl-acyl carrier protein reductase 0.1548 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0119 0.0314
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0105 0.06 0.06
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0538 0.0898
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.1548 1 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0058 0.0296 0.1349
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.0179 0.0164
Loa Loa (eye worm) hypothetical protein 0.0056 0.0282 0.079
Brugia malayi hypothetical protein 0.0041 0.0186 0.0497
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0215 0.0396
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0105 0.06 0.0586
Loa Loa (eye worm) hypothetical protein 0.0042 0.0194 0.0533
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0268 0.1197
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0204 0.0374
Leishmania major oxidoreductase-like protein 0.0105 0.06 0.2777
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0358 0.0343
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.018 0.0771
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0092 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0027
Echinococcus multilocularis geminin 0.0384 0.2418 0.4129
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0117 0.0679 0.3172
Chlamydia trachomatis oxoacy-ACP reductase 0.0105 0.06 0.0586
Plasmodium falciparum thioredoxin reductase 0.0043 0.02 0.02
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0105 0.06 0.2777
Brugia malayi Pre-SET motif family protein 0.0234 0.1441 0.4157
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0127 0.0338
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.014 0.0125
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.011 0.0633 0.0627
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0092 0.0077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0011
Brugia malayi jmjC domain containing protein 0.0107 0.0615 0.1747
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0105 0.06 0.06
Brugia malayi AMP-binding enzyme family protein 0.0016 0.002 0.0014
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0339 0.2122 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0268 0.0747
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0076 0.0411 0.1163
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0407 0.2567 0.4384
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0268 0.1197
Onchocerca volvulus Alhambra homolog 0.0033 0.013 0.0675
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0016 0.002 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0016 0.002 0.0014
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0105 0.06 0.0595
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0123 0.0719 0.3341
Schistosoma mansoni lamin 0.0031 0.0119 0.0205
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0105 0.06 0.0595
Trichomonas vaginalis hypothetical protein 0.1548 1 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0016 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0489
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0105 0.06 0.1706
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0016 0.002 0.0014
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0016 0.002 0.0004
Schistosoma mansoni lamin 0.0031 0.0119 0.0205
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0016 0.002 0.0014
Brugia malayi jmjC domain containing protein 0.0046 0.0215 0.0583
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0105 0.06 0.0586
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0164 0.0983 0.0964
Brugia malayi Furin-like cysteine rich region family protein 0.0246 0.1522 0.4393
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0268 0.1192
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0164 0.0983 0.0977
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0105 0.06 0.0586
Echinococcus granulosus death domain containing protein 0.0028 0.0101 0.0171
Echinococcus granulosus expressed protein 0.0076 0.0411 0.0784
Plasmodium falciparum thioredoxin reductase 0.0015 0.0015 0.0015
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0105 0.06 0.2777
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0023 0.0068 0.0052
Loa Loa (eye worm) hypothetical protein 0.0122 0.0715 0.2051
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0092 0.0072
Mycobacterium tuberculosis Probable dehydrogenase 0.0099 0.0561 0.0555
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0542 0.3446 0.6794
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0316 0.1975 0.1963
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0099 0.0561 0.0555
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.1441 0.4165
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.1548 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0016 0.002 0.0004
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0105 0.06 0.0586
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0016 0.002 0.0005
Echinococcus granulosus dnaJ subfamily B 0.0458 0.2903 0.572
Echinococcus multilocularis microtubule associated protein 2 0.079 0.5065 0.8674
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0068 0.0247
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.1079 0.1073
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0105 0.06 0.0586
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.002 0.0005
Schistosoma mansoni acetyl-CoA synthetase 0.0016 0.002 0.001
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0016 0.002 0.0005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0101 0.025
Trichomonas vaginalis set domain proteins, putative 0.0266 0.1651 0.1638
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0101 0.0496
Schistosoma mansoni netrin receptor unc5 0.0028 0.0101 0.017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0268 0.0253
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0037 0.0157 0.0671
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.013 0.0199
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.012 0.0702 0.1181
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0489
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0263
Mycobacterium tuberculosis Possible oxidoreductase 0.0105 0.06 0.0595
Plasmodium falciparum glutathione reductase 0.0043 0.02 0.02
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0105 0.06 0.0586
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0179 0.0164
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0105 0.06 0.0595
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0105 0.06 0.0586
Plasmodium falciparum enoyl-acyl carrier reductase 0.1548 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0016 0.002 0.002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0039 0.0169 0.0266
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0137 0.0811 0.1367
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.002 0.0027
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0186 0.0338
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.002 0.0005
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0262 0.0489
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0268 0.0735
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.2098 0.2085
Schistosoma mansoni zinc finger protein 0.0035 0.0143 0.0254
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0074 0.0399 0.1825
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.2098 0.2085
Brugia malayi Bromodomain containing protein 0.0172 0.1036 0.2977
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.012 0.0702 0.0688
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0074 0.0399 0.1821
Toxoplasma gondii hypothetical protein 0.0055 0.0273 0.0258
Plasmodium falciparum acyl-CoA synthetase 0.004 0.0179 0.0179
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.2098 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0016 0.002 0.0013
Schistosoma mansoni tumor necrosis factor receptor related 0.0043 0.0198 0.0361
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.012 0.0702 0.3284
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0204 0.0324
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0068 0.0247
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0016 0.002 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Echinococcus multilocularis Ankyrin 0.0028 0.0101 0.0149
Loa Loa (eye worm) TK/INSR protein kinase 0.0542 0.3446 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.0179 0.0173
Trypanosoma brucei oxidoreductase-like protein 0.0105 0.06 0.2777
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0053 0.0266 0.1183
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0054 0.0268 0.0253
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0081 0.0448 0.0858
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.013 0.0115
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.004 0.018 0.0165
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0016 0.002 0.0014
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0407 0.2567 0.5054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0073 0.0392 0.0648
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.037 0.0703
Plasmodium vivax glutathione reductase, putative 0.0043 0.02 0.02
Brugia malayi AMP-binding enzyme family protein 0.0016 0.002 0.0014
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0105 0.06 0.0586
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0538 0.1036
Onchocerca volvulus 0.0105 0.06 0.3557
Echinococcus granulosus lamin 0.0031 0.0119 0.0206
Trichomonas vaginalis rotamase, putative 0.0076 0.0411 0.0396
Onchocerca volvulus 0.0266 0.1651 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.014 0.0247
Toxoplasma gondii propionate-CoA ligase 0.0016 0.002 0.0005
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0105 0.06 0.2794
Toxoplasma gondii peptidylprolyl isomerase 0.0074 0.0399 0.0384
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0074 0.0399 0.1821
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.2098 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.011 0.0633 0.0627
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0101 0.0171
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0268 0.0735
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0016 0.002 0.0024
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Entamoeba histolytica hypothetical protein 0.0041 0.0186 0.08
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0092 0.0077
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0105 0.06 0.0586
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0073 0.0392 0.0745
Plasmodium falciparum phd finger protein, putative 0.0033 0.013 0.013
Echinococcus granulosus peregrin 0.0038 0.0165 0.0298
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0186 0.0339
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0489
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0043 0.0198 0.0363
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0214 0.0394
Echinococcus granulosus histone lysine methyltransferase setb 0.0073 0.0392 0.0747
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.012 0.0702 0.136
Loa Loa (eye worm) hypothetical protein 0.0295 0.1841 0.5327
Loa Loa (eye worm) phosphatidylinositol 3 0.0037 0.0157 0.0425
Loa Loa (eye worm) glutathione reductase 0.0043 0.02 0.055
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0228 0.1007
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0016 0.002 0.0005
Schistosoma mansoni hypothetical protein 0.0047 0.0222 0.0409
Echinococcus multilocularis epidermal growth factor receptor 0.0246 0.1522 0.259
Onchocerca volvulus 0.0054 0.0268 0.1515
Schistosoma mansoni dihydropteridine reductase 0.0105 0.06 0.1159
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0016 0.002 0.0009
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0016 0.002 0.001
Leishmania major pteridine reductase 1 0.0105 0.06 0.2777
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.2098 0.2085
Entamoeba histolytica hypothetical protein 0.0096 0.0542 0.2513
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.1548 1 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.0426 0.0814
Plasmodium vivax hypothetical protein, conserved 0.0033 0.013 0.013
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0198 0.0363
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0099 0.0561 0.0555
Mycobacterium tuberculosis Probable reductase 0.0099 0.0561 0.0555
Schistosoma mansoni hypothetical protein 0.0384 0.2418 0.4759
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.004 0.018 0.0326
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0268 0.0248
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.002 0.0014
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Trypanosoma brucei pteridine reductase 1 0.0105 0.06 0.2777
Mycobacterium ulcerans cell division protein FtsZ 0.0316 0.1975 0.1963
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0016 0.002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0078 0.0426 0.1208
Brugia malayi Bromodomain containing protein 0.0038 0.0165 0.0437
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0092 0.0364
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0096 0.0542 0.2513
Schistosoma mansoni protein kinase 0.0407 0.2567 0.5053
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0015 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0165 0.0159
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.012 0.0702 0.0688
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.002 0.0005
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.012 0.0702 0.1361
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0489
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0101 0.0263
Trichomonas vaginalis antibiotic synthetase, putative 0.0016 0.002 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0268 0.0253
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.0101 0.017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.014 0.0215
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.2098 0.2085
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0105 0.06 0.2777
Mycobacterium ulcerans hypothetical protein 0.0054 0.0268 0.0253
Leishmania major mitochondrial DNA polymerase beta 0.0339 0.2122 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0268 0.0253
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0105 0.06 0.2777
Schistosoma mansoni hypothetical protein 0.0033 0.013 0.0228
Echinococcus multilocularis Zinc finger, PHD finger 0.0016 0.002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0105 0.06 0.1716
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0025 0.0029
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0016 0.002 0.0014
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0105 0.06 0.1716
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0016 0.002 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0016 0.002 0.0005
Schistosoma mansoni hypothetical protein 0.0384 0.2418 0.4759
Brugia malayi CXXC zinc finger family protein 0.0032 0.0127 0.0326
Mycobacterium leprae cell division protein FtsZ 0.0316 0.1975 0.1959
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.002 0.0014
Schistosoma mansoni zinc finger protein 0.0046 0.0219 0.0402
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.013 0.0229
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0016 0.002 0.0014
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.1548 1 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0016 0.002 0.0005
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0101 0.0149
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0246 0.1522 0.2986
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0909 0.5837 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0268 0.0253
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0016 0.002 0.0014
Schistosoma mansoni intermediate filament proteins 0.0031 0.0119 0.0205
Schistosoma mansoni cpg binding protein 0.0038 0.0167 0.0301
Treponema pallidum cell division protein FtsZ 0.0316 0.1975 0.9411
Schistosoma mansoni methyl-cpg binding protein mbd 0.0039 0.0169 0.0305
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0105 0.06 0.2777
Plasmodium vivax acetyl-CoA synthetase, putative 0.0016 0.002 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.002 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0165 0.0159
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0262 0.049
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0105 0.06 0.0586
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0128 0.0223
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.002 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.002 0.0005
Plasmodium vivax SET domain protein, putative 0.0034 0.014 0.014
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0357 0.1007
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0105 0.06 0.0586
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0105 0.06 0.0586
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.018 0.048
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0016 0.002 0.0005
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.002 0.0027
Brugia malayi Protein kinase domain containing protein 0.03 0.1869 0.5404
Brugia malayi AMP-binding enzyme family protein 0.0016 0.002 0.0014
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0016 0.002 0.0024
Schistosoma mansoni cpg binding protein 0.0032 0.0127 0.0222
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.002 0.0014
Echinococcus multilocularis dnaJ subfamily B 0.0458 0.2903 0.4961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.014 0.0247
Loa Loa (eye worm) hypothetical protein 0.0054 0.0268 0.0747
Echinococcus multilocularis insulin receptor 0.0542 0.3446 0.5893
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0026 0.0023
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0105 0.06 0.0595
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.012 0.0702 0.0688
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0047 0.0063
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0016 0.002 0.0004
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.0426 0.0706
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0215 0.0396
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0105 0.06 0.0586
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0016 0.002 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0015 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0099 0.0561 0.0542
Schistosoma mansoni tyrosine kinase 0.0542 0.3446 0.6793
Echinococcus multilocularis lamin dm0 0.0031 0.0119 0.0179
Brugia malayi Protein kinase domain containing protein 0.0029 0.0105 0.0262
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0068 0.0247
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0016 0.002 0.001
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0016 0.002 0.0014
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0016 0.002 0.0005
Schistosoma mansoni tyrosine kinase 0.0246 0.1522 0.2985
Brugia malayi Thioredoxin reductase 0.0043 0.02 0.0538
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0092 0.0086
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0054 0.0268 0.0253
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0043 0.0198 0.0315
Mycobacterium ulcerans oxidoreductase 0.0105 0.06 0.0586
Mycobacterium ulcerans acetyl-CoA synthetase 0.0016 0.002 0.0005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0023 0.0068 0.0247
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.02 0.02
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0016 0.002 0.0024
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0105 0.06 0.2777
Brugia malayi PHD-finger family protein 0.0017 0.0027 0.0035
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0092 0.0077
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0047
Mycobacterium ulcerans short chain dehydrogenase 0.0105 0.06 0.0586
Onchocerca volvulus 0.0034 0.014 0.0734
Echinococcus multilocularis epidermal growth factor receptor 0.0246 0.1522 0.259
Onchocerca volvulus 0.0105 0.06 0.3557
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0105 0.06 0.0586
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0105 0.06 0.1006
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0105 0.06 0.0595
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0228 0.1007
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0105 0.06 0.0581
Mycobacterium tuberculosis Possible oxidoreductase 0.0105 0.06 0.0595
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.02 0.055
Loa Loa (eye worm) hypothetical protein 0.0406 0.2563 0.743
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.0179 0.0179
Echinococcus multilocularis 0.0071 0.0379 0.0625
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.0633 0.0627
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0105 0.06 0.0586
Echinococcus granulosus geminin 0.0384 0.2418 0.476
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.2122 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0039 0.0169 0.0305
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0228 0.1007
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0164 0.0983 0.0969
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0175 0.0276
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0268 0.0735
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0105 0.06 0.0586
Entamoeba histolytica hypothetical protein 0.0041 0.0186 0.08
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.011 0.0633 0.0614
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0137 0.0811 0.1576
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0092 0.0364
Echinococcus granulosus zinc finger protein 0.0046 0.0219 0.0404
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0025 0.0042
Entamoeba histolytica hypothetical protein 0.0041 0.0186 0.08
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0119 0.0301
Entamoeba histolytica hypothetical protein 0.0041 0.0186 0.08
Loa Loa (eye worm) hypothetical protein 0.0095 0.0538 0.1534
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0105 0.06 0.0586
Echinococcus multilocularis expressed protein 0.0076 0.0411 0.068
Echinococcus granulosus lamin dm0 0.0031 0.0119 0.0206
Brugia malayi Uncoordinated protein 44 0.0028 0.0101 0.025
Trichomonas vaginalis rotamase, putative 0.0074 0.0399 0.0384
Brugia malayi Neuronal symmetry protein 1 0.0407 0.2567 0.7438
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0099 0.0561 0.0555

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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