Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0096 | 0.2989 | 1 |
Treponema pallidum | NADH oxidase | 0.003 | 0.0422 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.003 | 0.0422 | 0.1612 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0087 | 0.2639 | 0.8831 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.003 | 0.0422 | 0.0542 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0047 | 0.1104 | 0.3695 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2989 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0086 | 0.2619 | 0.3366 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.003 | 0.0422 | 0.1612 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0025 | 0.0225 | 0.0289 |
Giardia lamblia | Kinase, PLK | 0.0096 | 0.2989 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.003 | 0.0422 | 0.1612 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.2989 | 0.3901 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.003 | 0.0422 | 0.0422 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0086 | 0.2619 | 0.8764 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.2989 | 0.3901 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.003 | 0.0422 | 0.1413 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.003 | 0.0422 | 0.0551 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0086 | 0.2619 | 0.3419 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0025 | 0.0225 | 0.0752 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0047 | 0.1104 | 0.3695 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0096 | 0.2989 | 0.3901 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0087 | 0.2639 | 0.8831 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0197 | 0.6927 | 0.89 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0096 | 0.2989 | 1 |
Schistosoma mansoni | kinase | 0.0049 | 0.1154 | 0.1154 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0216 | 0.7661 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.003 | 0.0422 | 0.1612 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Plasmodium falciparum | thioredoxin reductase | 0.003 | 0.0422 | 0.1612 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0022 | 0.0113 | 0.0378 |
Toxoplasma gondii | thioredoxin reductase | 0.0086 | 0.2619 | 1 |
Brugia malayi | glutathione reductase | 0.0086 | 0.2619 | 0.8764 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.003 | 0.0422 | 1 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0025 | 0.0225 | 0.0294 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0219 | 0.7783 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.003 | 0.0422 | 0.1413 |
Leishmania major | trypanothione reductase | 0.0086 | 0.2619 | 0.3419 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.003 | 0.0422 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0022 | 0.0113 | 0.0378 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.003 | 0.0422 | 0.0551 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2989 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0197 | 0.6927 | 0.89 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.2989 | 0.2989 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0197 | 0.6927 | 0.89 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.003 | 0.0422 | 0.0551 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0225 | 0.5326 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0197 | 0.6927 | 0.89 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0219 | 0.7783 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0096 | 0.2989 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.003 | 0.0422 | 0.1413 |
Plasmodium vivax | glutathione reductase, putative | 0.0086 | 0.2619 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.003 | 0.0422 | 0.1413 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0025 | 0.0225 | 0.5326 |
Trypanosoma brucei | polo-like protein kinase | 0.0096 | 0.2989 | 0.3901 |
Trichomonas vaginalis | mercuric reductase, putative | 0.003 | 0.0422 | 0.1413 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0086 | 0.2619 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2989 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0096 | 0.2989 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Trichomonas vaginalis | glutathione reductase, putative | 0.003 | 0.0422 | 0.1413 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2989 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.003 | 0.0422 | 0.1612 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.003 | 0.0422 | 0.0551 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0219 | 0.7783 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0086 | 0.2619 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0086 | 0.2619 | 0.3419 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2989 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0086 | 0.2619 | 1 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0025 | 0.0225 | 0.5326 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.003 | 0.0422 | 0.0551 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0096 | 0.2989 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0096 | 0.2989 | 1 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0025 | 0.0225 | 0.0294 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0025 | 0.0225 | 0.5326 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0025 | 0.0225 | 0.0752 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Mycobacterium tuberculosis | Conserved protein | 0.0025 | 0.0225 | 0.0289 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0025 | 0.0225 | 0.0294 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.003 | 0.0422 | 0.0551 |
Brugia malayi | Thioredoxin reductase | 0.0086 | 0.2619 | 0.8764 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2989 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0219 | 0.7783 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0216 | 0.7661 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0216 | 0.7661 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0216 | 0.7661 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0197 | 0.6927 | 0.89 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.003 | 0.0422 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2989 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0.0422 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0.0422 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0225 | 0.5326 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0025 | 0.0225 | 0.0752 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.003 | 0.0422 | 0.1612 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.003 | 0.0422 | 0.0551 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.003 | 0.0422 | 0.0551 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0197 | 0.6927 | 0.89 |
Loa Loa (eye worm) | glutathione reductase | 0.0086 | 0.2619 | 0.8764 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.003 | 0.0422 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.003 | 0.0422 | 0.1612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.