Detailed information for compound 713785

Basic information

Technical information
  • TDR Targets ID: 713785
  • Name: N-(2-methylpropyl)-2-(naphthalen-2-ylsulfonyl amino)benzamide
  • MW: 382.476 | Formula: C21H22N2O3S
  • H donors: 2 H acceptors: 3 LogP: 4.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CNC(=O)c1ccccc1NS(=O)(=O)c1ccc2c(c1)cccc2)C
  • InChi: 1S/C21H22N2O3S/c1-15(2)14-22-21(24)19-9-5-6-10-20(19)23-27(25,26)18-12-11-16-7-3-4-8-17(16)13-18/h3-13,15,23H,14H2,1-2H3,(H,22,24)
  • InChiKey: MTPMRDGPPDCRCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-isobutyl-2-(2-naphthylsulfonylamino)benzamide
  • ZINC02871301

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.1847 0.155
Loa Loa (eye worm) intermediate filament protein 0.0027 0.4211 0.4001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.1847 0.5
Leishmania major hypothetical protein, conserved 0.0025 0.352 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 1 1
Trypanosoma brucei unspecified product 0.0019 0.1847 0.5246
Echinococcus multilocularis musashi 0.0027 0.4211 0.29
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.1847 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.1847 0.5246
Schistosoma mansoni lamin 0.0027 0.4211 0.29
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.1847 0.5246
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Onchocerca volvulus 0.0027 0.4211 0.5
Echinococcus multilocularis lamin dm0 0.0027 0.4211 0.29
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.1847 0.5246
Schistosoma mansoni lamin 0.0027 0.4211 0.29
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.352 1
Echinococcus granulosus lamin dm0 0.0027 0.4211 0.29
Echinococcus granulosus lamin 0.0027 0.4211 0.29
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.1847 0.155
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.1847 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.4211 0.4001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.4211 0.4001
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.1847 0.5
Brugia malayi intermediate filament protein 0.0027 0.4211 0.4001
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.352 1
Brugia malayi hypothetical protein 0.0016 0.0818 0.0485
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.352 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.4059 0.3843
Echinococcus granulosus intermediate filament protein 0.0027 0.4211 0.29
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.1847 0.5
Giardia lamblia DINP protein human, muc B family 0.0019 0.1847 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.1847 0.5
Echinococcus multilocularis lamin 0.0027 0.4211 0.29
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.1847 0.5246
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Loa Loa (eye worm) hypothetical protein 0.0025 0.352 0.3285
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Loa Loa (eye worm) hypothetical protein 0.0027 0.4211 0.4001
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.352 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.352 0.5
Schistosoma mansoni intermediate filament proteins 0.0027 0.4211 0.29
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.352 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.352 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.1847 0.155
Onchocerca volvulus 0.0027 0.4211 0.5
Brugia malayi hypothetical protein 0.0025 0.352 0.3285
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.1847 0.5246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.1847 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.1847 0.155

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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