Detailed information for compound 713786

Basic information

Technical information
  • TDR Targets ID: 713786
  • Name: N-(2-ethylphenyl)-4-[(4-methoxyphenyl)sulfony l-methylamino]benzamide
  • MW: 424.513 | Formula: C23H24N2O4S
  • H donors: 1 H acceptors: 3 LogP: 4.23 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccccc1NC(=O)c1ccc(cc1)N(S(=O)(=O)c1ccc(cc1)OC)C
  • InChi: 1S/C23H24N2O4S/c1-4-17-7-5-6-8-22(17)24-23(26)18-9-11-19(12-10-18)25(2)30(27,28)21-15-13-20(29-3)14-16-21/h5-16H,4H2,1-3H3,(H,24,26)
  • InChiKey: JGHMWBLXYDWCIL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-ethylphenyl)-4-[(4-methoxyphenyl)sulfonyl-methyl-amino]benzamide
  • ZINC01057375

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2305 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0025 0.0242 0.0438
Brugia malayi Thioredoxin reductase 0.027 0.3097 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0052 0.0563 0.427
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0025 0.0242 0.0513
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0205 0.0384
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0094 0.1042 0.198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0027 0.0103
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0025 0.0242 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0027 0.0103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1042 0.198
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0027 0.0103
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.1042 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.1042 0.198
Trypanosoma brucei trypanothione reductase 0.027 0.3097 0.5897
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0025 0.0242 0.0245
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0282 0.09
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0242 0.077
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0242 0.1035
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0242 0.0454
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0242 0.077
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0094 0.1042 0.3358
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0094 0.1042 0.1042
Plasmodium vivax ferrodoxin reductase, putative 0.0025 0.0242 0.077
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0242 0.1035
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0242 0.1035
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0025 0.0242 0.077
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0684 0.7926 1
Plasmodium falciparum glutathione reductase 0.027 0.3097 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0242 0.1035
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0242 0.0242
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0025 0.0242 0.0438
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0242 0.0454
Plasmodium falciparum thioredoxin reductase 0.0094 0.1042 0.3358
Toxoplasma gondii thioredoxin reductase 0.027 0.3097 1
Mycobacterium tuberculosis Probable reductase 0.0616 0.7126 0.899
Trypanosoma cruzi hypothetical protein, conserved 0.0455 0.525 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0242 0.077
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0242 0.0301
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0616 0.7126 0.899
Toxoplasma gondii NADPH-glutathione reductase 0.0094 0.1042 0.3358
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0242 0.0454
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0242 0.1035
Onchocerca volvulus Serine\/threonine kinase homolog 0.0202 0.2305 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0242 0.0454
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0069 0.0753 0.2423
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.1042 0.198
Echinococcus granulosus citrate lyase subunit beta protein 0.0052 0.0563 0.1205
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0004 0.0004 0.0004
Mycobacterium ulcerans ferredoxin reductase 0.0025 0.0242 0.0438
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0242 0.1035
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0027 0.0103
Schistosoma mansoni cpg binding protein 0.0028 0.0282 0.0282
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0052 0.0563 0.1066
Plasmodium falciparum thioredoxin reductase 0.027 0.3097 1
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0242 0.1035
Echinococcus granulosus thioredoxin glutathione reductase 0.0271 0.3116 0.6707
Plasmodium falciparum ferrodoxin reductase-like protein 0.0025 0.0242 0.077
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0205 0.0207
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0025 0.0242 0.0454
Schistosoma mansoni cript-related 0.0004 0.0004 0.0004
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0052 0.0563 0.2429
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0242 0.0454
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0025 0.0242 0.1035
Onchocerca volvulus 0.0025 0.0242 0.1035
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0205 0.0254
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0205 0.0876
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0838 0.9721 1
Echinococcus multilocularis cpg binding protein 0.003 0.0301 0.0306
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0242 0.077
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0053 0.016
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.4644 0.4775
Schistosoma mansoni ap endonuclease 0.0022 0.0205 0.0205
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0242 0.077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0027 0.0103
Leishmania major hypothetical protein, conserved 0.0025 0.0242 0.0454
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0035 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0242 0.0454
Loa Loa (eye worm) glutathione reductase 0.027 0.3097 1
Echinococcus granulosus cpg binding protein 0.003 0.0301 0.064
Loa Loa (eye worm) thioredoxin reductase 0.027 0.3097 1
Leishmania major hypothetical protein, conserved 0.0025 0.0242 0.0454
Mycobacterium ulcerans hypothetical protein 0.0052 0.0563 0.427
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0055 0.0165
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0025 0.0242 0.0454
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0242 0.0438
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1042 0.198
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0094 0.1042 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0242 0.077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0027 0.0103
Plasmodium vivax thioredoxin reductase, putative 0.027 0.3097 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0242 0.077
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.2305 0.2305
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0027 0.0103
Brugia malayi serine/threonine-protein kinase plk-2 0.0202 0.2305 0.7438
Schistosoma mansoni cpg binding protein 0.003 0.0301 0.0301
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0025 0.0242 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1042 0.198
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0205 0.0434
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0242 0.1035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1042 0.198
Schistosoma mansoni disulfide oxidoreductase 0.0025 0.0242 0.0242
Trypanosoma brucei NADH dehydrogenase 0.0025 0.0242 0.0454
Giardia lamblia NADH oxidase lateral transfer candidate 0.0094 0.1042 0.4514
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0616 0.7126 0.899
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0027 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1117 0.4838
Echinococcus multilocularis thioredoxin glutathione reductase 0.0271 0.3116 0.3203
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0616 0.7126 0.899
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0025 0.0242 0.0301
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.2305 0.4386
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0242 0.1035
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0025 0.0242 0.0438
Schistosoma mansoni neutral sphingomyelinase 0.0004 0.0004 0.0004
Echinococcus multilocularis glutamate synthase 0.0025 0.0242 0.0245
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0205 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.0455 0.525 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0651 0.0651
Leishmania major NADH dehydrogenase, putative 0.0025 0.0242 0.0454
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0242 0.1035
Loa Loa (eye worm) programmed cell death 8 0.0025 0.0242 0.077
Echinococcus granulosus glutamate synthase 0.0025 0.0242 0.0513
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0094 0.1042 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0027 0.0103
Leishmania major hypothetical protein, conserved 0.0025 0.0242 0.0454
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0242 0.1035
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0094 0.1042 0.3358
Trichomonas vaginalis apoptosis inducing factor, putative 0.0025 0.0242 0.1035
Schistosoma mansoni hypothetical protein 0.0004 0.0004 0.0004
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0035 0.0032
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.1042 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0025 0.0242 0.077
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2305 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0205 0.0876
Entamoeba histolytica thioredoxin reductase, putative 0.0025 0.0242 0.1035
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0094 0.1042 0.3358
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0202 0.2305 0.7438
Treponema pallidum thioredoxin reductase (trxB) 0.0025 0.0242 0.2294
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0025 0.0242 0.1035
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0094 0.1042 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0052 0.0563 0.427
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0025 0.0242 0.0438
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0055 0.011
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0035 0.0066
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.1042 0.198
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.1042 0.198
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0027 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2305 1
Trichomonas vaginalis glutathione reductase, putative 0.0094 0.1042 0.4514
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0025 0.0242 0.0513
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0684 0.7926 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0205 0.0876
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0094 0.1042 0.1069
Giardia lamblia Glutamate synthase 0.0025 0.0242 0.1035
Brugia malayi glutathione reductase 0.027 0.3097 1
Schistosoma mansoni synaptojanin 0.0004 0.0004 0.0004
Giardia lamblia Kinase, PLK 0.0202 0.2305 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0403 0.4644 0.4644
Mycobacterium tuberculosis Probable oxidoreductase 0.0684 0.7926 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0616 0.7126 0.8958
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0242 0.0438
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0242 0.1035
Trypanosoma brucei polo-like protein kinase 0.0202 0.2305 0.4386
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0025 0.0242 0.077
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0025 0.0242 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0027 0.0103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1042 0.198
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0025 0.0242 0.0438
Mycobacterium ulcerans monoxygenase 0.0025 0.0242 0.0438
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2305 1
Schistosoma mansoni nocturnin 0.0004 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0455 0.525 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0242 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0027 0.0103
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0052 0.0563 0.1066
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1117 0.4838
Mycobacterium ulcerans dehydrogenase 0.0025 0.0242 0.0438
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0205 0.0876
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0094 0.1042 0.3358
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0242 0.0438
Plasmodium vivax glutathione reductase, putative 0.027 0.3097 1
Mycobacterium ulcerans hypothetical protein 0.0052 0.0563 0.427
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0205 0.0384
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0025 0.0242 0.077
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0205 0.0652
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0094 0.1042 0.198
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0242 0.0513
Schistosoma mansoni kinase 0.0103 0.1148 0.1148
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0055 0.0052
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0025 0.0242 0.0245
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0027 0.0103
Trichomonas vaginalis helicase, putative 0.0006 0.0027 0.0103
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0242 0.0454
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0242 0.0454
Leishmania major trypanothione reductase 0.027 0.3097 0.5897
Schistosoma mansoni glutamate synthase 0.0025 0.0242 0.0242
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0025 0.0242 0.0438
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2305 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0025 0.0242 0.0454
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0027 0.0103
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0202 0.2305 0.4386
Schistosoma mansoni glutamate synthase 0.0025 0.0242 0.0242
Brugia malayi CXXC zinc finger family protein 0.0028 0.0282 0.09
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0052 0.0563 0.0706
Mycobacterium ulcerans glutamate synthase subunit beta 0.0025 0.0242 0.0438
Schistosoma mansoni glutamate synthase 0.0025 0.0242 0.0242
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.2305 0.4386
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0094 0.1042 0.2239
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0094 0.1042 0.198
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0577 0.1852
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0205 0.0384
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0205 0.0652
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0242 0.0454
Schistosoma mansoni cpg binding protein 0.003 0.0301 0.0301
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0025 0.0242 0.1035
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0025 0.0242 0.1035
Giardia lamblia Thioredoxin reductase 0.0025 0.0242 0.1035
Toxoplasma gondii exonuclease III APE 0.0022 0.0205 0.0652
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0025 0.0242 0.0301
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0094 0.1042 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0205 0.1941
Trypanosoma cruzi trypanothione reductase, putative 0.027 0.3097 0.5897
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0035 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0027 0.0103
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0242 0.1035
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0025 0.0242 0.0301
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0242 0.0513
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.027 0.3097 0.3905
Onchocerca volvulus 0.0028 0.0282 0.121
Mycobacterium tuberculosis Conserved protein 0.0052 0.0563 0.0706
Trypanosoma brucei hypothetical protein, conserved 0.0455 0.525 1
Brugia malayi glutamate synthase 0.0025 0.0242 0.077
Entamoeba histolytica disulphide oxidoreductase, putative 0.0025 0.0242 0.1035
Entamoeba histolytica serine/threonine protein kinase, putative 0.0202 0.2305 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0094 0.1042 0.3358
Plasmodium falciparum glutathione reductase 0.0094 0.1042 0.3358
Treponema pallidum oxidoreductase 0.0025 0.0242 0.2294
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0684 0.7926 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0094 0.1042 0.1311
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0242 0.0454
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2305 1
Trichomonas vaginalis mercuric reductase, putative 0.0094 0.1042 0.4514
Schistosoma mansoni hypothetical protein 0.0025 0.0242 0.0242
Toxoplasma gondii selenide, water dikinase 0.0025 0.0242 0.077
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0242 0.0454
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0205 0.0652
Echinococcus granulosus dnaJ subfamily B 0.0403 0.4644 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.1042 0.198
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0025 0.0242 0.1035
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0025 0.0242 0.077
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0052 0.0563 0.1066
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0242 0.0438
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0052 0.0563 0.427
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0025 0.0242 0.0513
Echinococcus multilocularis citrate lyase subunit beta protein 0.0052 0.0563 0.0575
Schistosoma mansoni ap endonuclease 0.0022 0.0205 0.0205
Schistosoma mansoni synaptojanin 0.0004 0.0004 0.0004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.1042 0.198
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0242 0.0245
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0094 0.1042 0.198
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0202 0.2305 0.2368
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.1042 0.198
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0242 0.0454
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0069 0.0753 0.2423
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0094 0.1042 0.3358
Treponema pallidum NADH oxidase 0.0094 0.1042 1
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.2305 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0025 0.0242 0.0301
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0205 0.0652
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0242 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0027 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0027 0.0103
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0616 0.7126 0.899
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0202 0.2305 0.4959
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.1042 0.198
Mycobacterium tuberculosis Probable dehydrogenase 0.0616 0.7126 0.899
Mycobacterium ulcerans NADH dehydrogenase 0.0025 0.0242 0.0438
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0025 0.0242 0.0245
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0242 0.077
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0025 0.0242 0.077
Mycobacterium ulcerans hypothetical protein 0.0025 0.0242 0.0438
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0242 0.0454
Schistosoma mansoni carbon catabolite repressor protein 0.0004 0.0004 0.0004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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