Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | thioredoxin reductase, putative | 0.0062 | 0.3209 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0022 | 0.0396 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0062 | 0.3209 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0062 | 0.3209 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0022 | 0.0396 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0022 | 0.0396 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0022 | 0.0396 | 0.5 |
Leishmania major | trypanothione reductase | 0.0062 | 0.3209 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.016 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0022 | 0.0396 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0022 | 0.0396 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0062 | 0.3209 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0022 | 0.0396 | 0.0396 |
Plasmodium falciparum | glutathione reductase | 0.0062 | 0.3209 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0022 | 0.0396 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.016 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0022 | 0.0396 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0022 | 0.0396 | 0.5 |
Brugia malayi | glutathione reductase | 0.0062 | 0.3209 | 0.3209 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.016 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0022 | 0.0396 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0709 | 0.0709 |
Schistosoma mansoni | serine/threonine protein kinase | 0.016 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.016 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0062 | 0.3209 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.016 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0062 | 0.3209 | 0.269 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.016 | 1 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0062 | 0.3209 | 0.2929 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0062 | 0.3209 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0062 | 0.3209 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0022 | 0.0396 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0062 | 0.3209 | 0.3209 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0062 | 0.3209 | 0.269 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0062 | 0.3209 | 0.2929 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 nM | Inhibitory concentration of the compound against recombinant human hormone sensitive lipase (HSL); Not tested | ChEMBL. | 15026062 |
Inhibition (binding) | = 2 % | Inhibition of recombinant human hormone sensitive lipase (HSL) | ChEMBL. | 15026062 |
Inhibition (binding) | = 2 % | Inhibition of recombinant human hormone sensitive lipase (HSL) | ChEMBL. | 15026062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.