Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2763 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2763 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2763 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0734 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2763 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0734 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2763 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2763 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0734 | 0.2657 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0734 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0734 | 0.2406 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0734 | 0.207 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2763 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0734 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.096 | 0.3475 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0734 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0734 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2763 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0734 | 0.2657 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2763 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2763 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0734 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0734 | 0.207 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0734 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0731 | 0.2393 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0734 | 0.2657 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0731 | 0.2393 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0734 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.2037 | 0.7371 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0734 | 0.2406 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2763 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0734 | 0.2657 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.2596 | 0.9348 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2392 | 0.8657 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2763 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0734 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0847 | 0.3065 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0734 | 0.2657 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0734 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0734 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0734 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0734 | 0.2657 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0734 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0734 | 0.5 | |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0734 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1051 | 0.3805 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0844 | 0.2499 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1866 | 0.6641 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0734 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0734 | 0.5 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0734 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0734 | 0.2657 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1866 | 0.6641 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0091 | 0.033 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0734 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0734 | 0.2657 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0734 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0734 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0734 | 0.5 | |
Onchocerca volvulus | 0.0035 | 0.0734 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2763 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0734 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0734 | 0.2657 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.