Detailed information for compound 71465

Basic information

Technical information
  • TDR Targets ID: 71465
  • Name: 2-tert-butyl-8-[(2-fluorophenyl)methyl]-6-(3- methoxyphenyl)-7-methyl-3-[(pyridin-2-ylmethy lamino)methyl]imidazo[1,2-a]pyrimidin-5-one
  • MW: 539.643 | Formula: C32H34FN5O2
  • H donors: 1 H acceptors: 3 LogP: 5.37 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cccc(c1)c1c(C)n(Cc2ccccc2F)c2n(c1=O)c(CNCc1ccccn1)c(n2)C(C)(C)C
  • InChi: 1S/C32H34FN5O2/c1-21-28(22-12-10-14-25(17-22)40-5)30(39)38-27(19-34-18-24-13-8-9-16-35-24)29(32(2,3)4)36-31(38)37(21)20-23-11-6-7-15-26(23)33/h6-17,34H,18-20H2,1-5H3
  • InChiKey: MAQQVBNGFCLRTM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-tert-butyl-8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[(2-pyridylmethylamino)methyl]imidazo[1,2-a]pyrimidin-5-one
  • 2-tert-butyl-8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[(2-pyridylmethylamino)methyl]-5-imidazo[1,2-a]pyrimidinone
  • 2-tert-butyl-8-(2-fluorobenzyl)-6-(3-methoxyphenyl)-7-methyl-3-[(2-pyridylmethylamino)methyl]imidazo[1,2-a]pyrimidin-5-one
  • 2-tert-butyl-8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[(pyridin-2-ylmethylamino)methyl]imidazo[2,1-b]pyrimidin-5-one
  • 2-tert-butyl-8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[(2-pyridylmethylamino)methyl]imidazo[2,1-b]pyrimidin-5-one
  • 2-tert-butyl-8-[(2-fluorophenyl)methyl]-6-(3-methoxyphenyl)-7-methyl-3-[(2-pyridylmethylamino)methyl]-5-imidazo[2,1-b]pyrimidinone
  • 2-tert-butyl-8-(2-fluorobenzyl)-6-(3-methoxyphenyl)-7-methyl-3-[(2-pyridylmethylamino)methyl]imidazo[2,1-b]pyrimidin-5-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fatty acid amide hydrolase 1 0.0141 0.097 0.097
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1282 0.1282
Entamoeba histolytica protein kinase, putative 0.0058 0.0241 0.056
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0098 0.0098
Echinococcus multilocularis serine:threonine protein kinase N2 0.0058 0.0241 0.0241
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0141 0.097 0.2257
Echinococcus multilocularis protein kinase c eta type 0.0041 0.0091 0.0091
Loa Loa (eye worm) tyrosinase 1 0.0102 0.0629 0.0629
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0518 0.4296 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0098
Echinococcus granulosus myotubularin protein 13 0.0041 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0098 0.0227
Echinococcus multilocularis expressed protein 0.081 0.687 0.687
Trypanosoma brucei monoglyceride lipase, putative 0.0518 0.4296 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0518 0.4296 1
Echinococcus multilocularis unc 13 (munc13) 0.0046 0.0137 0.0137
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0102 0.0629 0.0629
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Brugia malayi protein kinase C II. 0.0176 0.1282 0.1282
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0088 0.0504 0.0504
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0046 0.0137 0.0137
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0141 0.097 0.2257
Brugia malayi putative amidase 0.0141 0.097 0.097
Onchocerca volvulus 0.0046 0.0137 0.0211
Echinococcus granulosus protein kinase C gamma type 0.0186 0.1368 0.1368
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0058 0.0241 0.0241
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1165 1 1
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0042 0.0102 0.0102
Brugia malayi protein kinase C3,putative 0.0042 0.0102 0.0102
Schistosoma mansoni unc-13 (munc13) 0.0046 0.0137 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.018 0.042
Echinococcus multilocularis serine threonine protein kinase 0.0186 0.1368 0.1368
Plasmodium falciparum lysophospholipase, putative 0.0518 0.4296 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0057 0.023 0.0535
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0041 0.0091 0.0091
Mycobacterium ulcerans amidase 0.0141 0.097 0.2257
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0098 0.0227
Entamoeba histolytica hypothetical protein 0.0042 0.0098 0.0227
Brugia malayi Protein kinase domain containing protein 0.0042 0.0102 0.0102
Leishmania major monoglyceride lipase, putative 0.0518 0.4296 1
Echinococcus granulosus jun protein 0.0088 0.0504 0.0504
Echinococcus granulosus fatty acid amide hydrolase 1 0.1165 1 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.013 0.0876 0.0876
Echinococcus granulosus RNA directed DNA polymerase 0.0123 0.0812 0.0812
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0141 0.097 0.097
Mycobacterium ulcerans amidase 0.0141 0.097 0.2257
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0042 0.0102 0.0102
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0102 0.0629 0.0629
Echinococcus multilocularis Diacylglycerol kinase theta 0.0041 0.0091 0.0091
Echinococcus multilocularis serine:threonine protein kinase 38 0.0058 0.0241 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0123 0.0812 0.0812
Schistosoma mansoni atypical protein kinase C 0.0099 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Schistosoma mansoni serine/threonine kinase 0.0058 0.0241 0.0241
Schistosoma mansoni jun-related protein 0.0071 0.0359 0.0359
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0518 0.4296 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0102 0.0629 0.0629
Brugia malayi Hr1 repeat family protein 0.0058 0.0241 0.0241
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0098 0.0098
Entamoeba histolytica hypothetical protein 0.0042 0.0098 0.0227
Echinococcus granulosus expressed protein 0.081 0.687 0.687
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0141 0.097 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Loa Loa (eye worm) raf kinase 0.0041 0.0091 0.0091
Schistosoma mansoni rac gtpase activating protein 0.0041 0.0091 0.0091
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0031 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0288 0.2271 0.2271
Entamoeba histolytica diacylglycerol kinase, putative 0.0041 0.0091 0.0213
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0098 0.0227
Loa Loa (eye worm) hypothetical protein 0.1165 1 1
Plasmodium falciparum lysophospholipase, putative 0.0518 0.4296 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0253 0.0589
Echinococcus multilocularis beta adrenergic receptor kinase 0.0043 0.0109 0.0109
Entamoeba histolytica protein kinase, putative 0.0058 0.0241 0.056
Brugia malayi Amidase family protein 0.0141 0.097 0.097
Brugia malayi RhoGAP domain containing protein 0.0041 0.0091 0.0091
Schistosoma mansoni fatty-acid amide hydrolase 0.0141 0.097 0.097
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0141 0.097 0.2257
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0518 0.4296 1
Trypanosoma brucei monoglyceride lipase, putative 0.0518 0.4296 1
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0098 0.0098
Mycobacterium ulcerans hypothetical protein 0.0518 0.4296 1
Schistosoma mansoni unc-13 (munc13) 0.0046 0.0137 0.0137
Brugia malayi bZIP transcription factor family protein 0.0088 0.0504 0.0504
Brugia malayi GnHR receptor homolog 0.0585 0.489 0.489
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0241 0.0241
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0109 0.0109
Echinococcus granulosus protein kinase c iota type 0.0099 0.0601 0.0601
Leishmania major cathepsin L-like protease 0.0065 0.0303 0.0705
Echinococcus granulosus raf serine:threonine protein kinase 0.0041 0.0091 0.0091
Schistosoma mansoni tyrosinase precursor 0.0102 0.0629 0.0629
Onchocerca volvulus 0.0102 0.0629 0.2466
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0476 0.0476
Loa Loa (eye worm) RGS-3 protein 0.0042 0.0098 0.0098
Echinococcus multilocularis protein kinase c iota type 0.0099 0.0601 0.0601
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0041 0.0091 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0109 0.0109
Echinococcus granulosus Diacylglycerol kinase theta 0.0041 0.0091 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0241 0.0241
Echinococcus multilocularis myotubularin protein 13 0.0041 0.0091 0.0091
Onchocerca volvulus 0.0102 0.0629 0.2466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0043 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0518 0.4296 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0042 0.0098 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0043 0.0109 0.0109
Trypanosoma cruzi amidase, putative 0.0141 0.097 0.2257
Brugia malayi Common central domain of tyrosinase family protein 0.0102 0.0629 0.0629
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0043 0.0109 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0091 0.0091
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0518 0.4296 1
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Mycobacterium ulcerans lysophospholipase 0.0518 0.4296 1
Echinococcus granulosus protein kinase c eta type 0.0041 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0518 0.4296 1
Onchocerca volvulus 0.0102 0.0629 0.2466
Leishmania major hypothetical protein, conserved 0.0141 0.097 0.2257
Mycobacterium ulcerans peptide amidase, GatA 0.0141 0.097 0.2257
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0042 0.0098 0.0098
Brugia malayi Ras association domain family 1 isoform A 0.0041 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0098
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0058 0.0241 0.0241
Brugia malayi Protein kinase domain containing protein 0.0058 0.0241 0.0241
Brugia malayi Protein kinase domain containing protein 0.0058 0.0241 0.0241
Entamoeba histolytica protein kinase, putative 0.0058 0.0241 0.056
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0141 0.097 0.097
Loa Loa (eye worm) hypothetical protein 0.0329 0.2631 0.2631
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0098 0.0098
Brugia malayi PXA domain containing protein 0.0042 0.0098 0.0098
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0098 0.0098
Schistosoma mansoni protein kinase C 0.0046 0.0137 0.0137
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0518 0.4296 1
Loa Loa (eye worm) amidase 0.0141 0.097 0.097
Echinococcus multilocularis N chimaerin 0.0041 0.0091 0.0091
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0377 0.0377
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0042 0.0098 0.0098
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0518 0.4296 1
Mycobacterium ulcerans amidase 0.0141 0.097 0.2257
Loa Loa (eye worm) hypothetical protein 0.0288 0.2271 0.2271
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0476 0.0476
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0476 0.0476
Schistosoma mansoni amidase 0.1165 1 1
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0098 0.0098
Brugia malayi hypothetical protein 0.0042 0.0098 0.0098
Plasmodium vivax PST-A protein 0.0518 0.4296 1
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0141 0.097 1
Brugia malayi small heat shock protein 0.0603 0.5046 0.5046
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0141 0.097 0.2257
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0129 0.0869 0.0869
Leishmania major cathepsin L-like protease 0.0065 0.0303 0.0705
Echinococcus multilocularis raf serine:threonine protein kinase 0.0041 0.0091 0.0091
Schistosoma mansoni z-protein (S1r protein) 0.0042 0.0098 0.0098
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0058 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0603 0.5046 0.5046
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0042 0.0102 0.0102
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0042 0.0102 0.0102
Echinococcus multilocularis jun protein 0.0088 0.0504 0.0504
Brugia malayi Pleckstrin Homology Domain 0.0041 0.0091 0.0091
Entamoeba histolytica protein kinase, putative 0.0058 0.0241 0.056
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0476 0.0476
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0303 0.0705
Onchocerca volvulus 0.0085 0.0476 0.1766
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Echinococcus granulosus Regulator of G protein signaling 20 0.0042 0.0098 0.0098
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0058 0.0241 0.0241
Toxoplasma gondii diacylglycerol kinase, putative 0.0041 0.0091 0.3796
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0098 0.0227
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0041 0.0091 0.0091
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0098 0.0098
Loa Loa (eye worm) PXA domain-containing protein 0.0042 0.0098 0.0098
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0141 0.097 0.2257
Entamoeba histolytica diacylglycerol kinase, putative 0.0041 0.0091 0.0213
Schistosoma mansoni fatty-acid amide hydrolase 0.1165 1 1
Trypanosoma cruzi amidase, putative 0.0141 0.097 0.2257
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0098 0.0098
Mycobacterium tuberculosis Possible lysophospholipase 0.0518 0.4296 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0041 0.0091 0.0091
Echinococcus granulosus serine:threonine protein kinase N2 0.0058 0.0241 0.0241
Brugia malayi diacylglycerol kinase 0.0041 0.0091 0.0091
Echinococcus granulosus protein kinase c epsilon type 0.0176 0.1282 0.1282
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0042 0.0098 0.0098
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0042 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0102 0.0629 0.0629
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0141 0.097 0.2257
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0098 0.0098
Schistosoma mansoni diacylglycerol kinase theta 0.0041 0.0091 0.0091
Mycobacterium ulcerans amidase 0.0141 0.097 0.2257
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0098 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0241 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Loa Loa (eye worm) hypothetical protein 0.0288 0.2271 0.2271
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.1729 0.1729
Schistosoma mansoni protein kinase C mu 0.0041 0.0091 0.0091
Trypanosoma brucei rac serine-threonine kinase, putative 0.0058 0.0241 0.056
Brugia malayi p70 ribosomal S6 kinase beta 0.0058 0.0241 0.0241
Echinococcus granulosus NDR protein kinase 0.0058 0.0241 0.0241
Toxoplasma gondii AGC kinase 0.0058 0.0241 1
Schistosoma mansoni tyrosinase precursor 0.0102 0.0629 0.0629
Mycobacterium ulcerans amidase 0.0141 0.097 0.2257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Brugia malayi C1-like domain containing protein 0.0042 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0098 0.0227
Echinococcus granulosus fatty acid amide hydrolase 1 0.1165 1 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1165 1 1
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Brugia malayi Protein kinase c protein 2 0.017 0.123 0.123
Schistosoma mansoni protein kinase C mu 0.0042 0.0102 0.0102
Brugia malayi ShTK domain containing protein 0.0102 0.0629 0.0629
Loa Loa (eye worm) AGC/PKN protein kinase 0.0058 0.0241 0.0241
Echinococcus multilocularis regulator of G protein signaling 0.0042 0.0098 0.0098
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0227 0.1729 0.1729
Loa Loa (eye worm) hypothetical protein 0.0102 0.0629 0.0629
Brugia malayi regulator of G-protein signaling rgs-7 0.0042 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0346 0.2781 0.2781
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0098 0.0098
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0041 0.0091 0.0091
Schistosoma mansoni vav2 0.0041 0.0091 0.0091
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0303 0.0705
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0058 0.0241 0.0241
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0098 0.0098
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0046 0.0137 0.0137
Schistosoma mansoni diacylglycerol kinase theta 0.0041 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0098 0.0227
Brugia malayi regulator of G-protein signaling egl-10 0.0042 0.0098 0.0098
Onchocerca volvulus 0.0102 0.0629 0.2466
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0303 0.0705
Leishmania major cathepsin L-like protease 0.0065 0.0303 0.0705
Brugia malayi PXA domain containing protein 0.0042 0.0098 0.0098
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0042 0.0098 0.0098
Entamoeba histolytica hypothetical protein 0.0041 0.0091 0.0213
Loa Loa (eye worm) hypothetical protein 0.0046 0.0137 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0058 0.0241 0.0241
Loa Loa (eye worm) ShTK domain-containing protein 0.0102 0.0629 0.0629
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0176 0.1282 0.1282
Loa Loa (eye worm) hypothetical protein 0.0085 0.0482 0.0482
Plasmodium falciparum lysophospholipase, putative 0.0518 0.4296 1
Brugia malayi RhoGAP domain containing protein 0.0041 0.0091 0.0091
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0058 0.0241 0.0241
Loa Loa (eye worm) amidase 0.0141 0.097 0.097
Brugia malayi A-kinase anchor protein 10, precursor 0.0042 0.0098 0.0098
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0141 0.097 0.5
Brugia malayi Variant SH3 domain containing protein 0.0041 0.0091 0.0091
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0098 0.0098
Brugia malayi hypothetical protein 0.0069 0.0338 0.0338
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0098 0.0098
Loa Loa (eye worm) RasGEF domain-containing protein 0.0041 0.0091 0.0091
Echinococcus granulosus N chimaerin 0.0041 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0164 0.1173 0.1173
Echinococcus multilocularis protein kinase c epsilon type 0.0176 0.1282 0.1282
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0098 0.0098
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0098 0.0098
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0141 0.097 0.2257
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.1729 0.1729
Loa Loa (eye worm) hypothetical protein 0.0041 0.0091 0.0091
Trypanosoma cruzi monoglyceride lipase, putative 0.0518 0.4296 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0098 0.0098
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0098 0.0098
Plasmodium falciparum esterase, putative 0.0518 0.4296 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0041 0.0091 0.0091
Echinococcus granulosus Rac GTPase activating protein 1 0.0041 0.0091 0.0091
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0141 0.097 0.097
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Echinococcus granulosus unc 13 munc13 0.0046 0.0137 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Loa Loa (eye worm) ShTK domain-containing protein 0.0102 0.0629 0.0629
Echinococcus multilocularis RNA directed DNA polymerase 0.0123 0.0812 0.0812
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0377 0.0877
Brugia malayi diacylglycerol kinase 0.0041 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0123 0.0812 0.0812
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0088 0.0504 0.0504
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0141 0.097 0.097
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0042 0.0098 0.0227
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0102 0.0102
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0141 0.097 0.2257
Echinococcus multilocularis Rac GTPase activating protein 1 0.0041 0.0091 0.0091
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0518 0.4296 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0058 0.0241 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0518 0.4296 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0476 0.0476
Onchocerca volvulus 0.0069 0.0338 0.113
Brugia malayi Amidase family protein 0.0141 0.097 0.097
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0041 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0071 0.0359 0.0359
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0058 0.0241 0.0241
Echinococcus granulosus Protein kinase C brain isozyme 0.0227 0.1729 0.1729
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0241 0.056
Schistosoma mansoni hypothetical protein 0.0041 0.0091 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Echinococcus granulosus beta-adrenergic receptor kinase 0.0043 0.0109 0.0109
Onchocerca volvulus 0.0288 0.2271 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0098 0.0098
Brugia malayi hypothetical protein 0.0042 0.0098 0.0098
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0058 0.0241 0.0241
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0141 0.097 0.2257
Brugia malayi Protein kinase domain containing protein 0.0058 0.0241 0.0241
Loa Loa (eye worm) AGC/AKT protein kinase 0.0058 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0042 0.0098 0.0098
Entamoeba histolytica hypothetical protein 0.0042 0.0098 0.0227
Brugia malayi RhoGEF domain containing protein 0.0041 0.0091 0.0091
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0303 0.0705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.0705
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0098 0.0098
Loa Loa (eye worm) AGC/NDR protein kinase 0.0058 0.0241 0.0241
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0102 0.0629 0.0629
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0241 0.0241

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 30 nM Binding affinity against human gonadotropin-releasing hormone receptor ChEMBL. 12699396
Ki (binding) = 30 nM Binding affinity against human gonadotropin-releasing hormone receptor ChEMBL. 12699396

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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