Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.3523 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.3178 | 0.9021 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.3523 | 0.0506 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.3523 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.3178 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.3178 | 0.9021 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.3523 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.3523 | 0.3523 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.1937 | 0.55 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.3178 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.3523 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.1937 | 0.55 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.1937 | 0.55 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.3523 | 0.3523 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.3178 | 0.3178 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.3523 | 0.0506 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.3178 | 0.3178 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.3178 | 0.3178 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.3178 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.3523 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.3523 | 0.3523 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.4144 | 0.4144 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.1937 | 0.55 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.3178 | 0.3178 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.3178 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.3523 | 0.0506 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.3523 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3523 | 0.3523 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.3523 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.3523 | 0.3523 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.1937 | 0.55 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.3178 | 0.9021 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.3523 | 0.0506 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.3523 | 0.0506 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.3523 | 0.3523 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.3178 | 0.9021 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.3178 | 0.9021 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.3523 | 0.3523 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.4144 | 0.4144 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.3178 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.3523 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.3523 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.3178 | 0.9021 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.3523 | 0.0506 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.