Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.2093 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.4515 | 0.6252 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.4515 | 0.6252 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.2008 | 0.2781 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.3234 | 0.4479 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.2008 | 0.2781 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0089 | 0.6692 | 0.8468 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.2093 | 0.0758 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4515 | 0.4515 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.2093 | 0.2899 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.2008 | 0.2008 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.2008 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0089 | 0.6692 | 0.8468 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.4515 | 0.6252 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3234 | 0.4479 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.7221 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.2093 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.2093 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.4515 | 0.6252 |
Leishmania major | trypanothione reductase | 0.0039 | 0.2093 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.2093 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.2093 | 0.2899 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.7221 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1737 | 0.2406 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0099 | 0.7606 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.2093 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.2008 | 0.2008 |
Brugia malayi | Inositol-1 | 0.0038 | 0.2008 | 0.2781 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.2141 | 0.2965 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.2008 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.7221 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0089 | 0.6692 | 0.8468 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4515 | 0.4515 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1737 | 0.1737 |
Mycobacterium tuberculosis | Probable reductase | 0.0089 | 0.6692 | 0.8468 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.2093 | 0.2899 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.4515 | 0.6252 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.2093 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.2008 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.7221 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0099 | 0.7606 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.4515 | 0.6252 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.2008 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0089 | 0.6692 | 0.8468 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1737 | 0.2406 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0089 | 0.6692 | 0.8468 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4515 | 0.4515 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.2093 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4515 | 0.4515 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.2141 | 0.2965 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.3234 | 0.4479 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0099 | 0.7606 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.4515 | 0.6252 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4515 | 0.4515 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.3234 | 0.4479 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0089 | 0.6692 | 0.8468 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.2008 | 0.2781 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0099 | 0.7606 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.7221 | 0.7221 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.7221 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.7221 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.7221 | 0.7221 |
Brugia malayi | RNA binding protein | 0.0066 | 0.4515 | 0.6252 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.7221 | 0.7221 |
Brugia malayi | glutathione reductase | 0.0039 | 0.2093 | 0.2899 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.2008 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.2008 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.