Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Bos taurus | Alpha-2a adrenergic receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | amine GPCR | Alpha-2a adrenergic receptor | 452 aa | 440 aa | 29.1 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Adrenergic receptor alpha-2 | 450 aa | 473 aa | 24.1 % |
Echinococcus multilocularis | serotonin receptor | Alpha-2a adrenergic receptor | 452 aa | 421 aa | 33.0 % |
Echinococcus multilocularis | fmrfamide receptor | Alpha-2a adrenergic receptor | 452 aa | 453 aa | 19.2 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adrenergic receptor alpha-2 | 450 aa | 433 aa | 27.9 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Alpha-2a adrenergic receptor | 452 aa | 420 aa | 32.6 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Alpha-2a adrenergic receptor | 452 aa | 381 aa | 21.8 % |
Loa Loa (eye worm) | TYRA-2 protein | Alpha-2a adrenergic receptor | 452 aa | 491 aa | 24.4 % |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Alpha-2a adrenergic receptor | 452 aa | 452 aa | 20.6 % |
Onchocerca volvulus | Alpha-2a adrenergic receptor | 452 aa | 471 aa | 27.4 % | |
Echinococcus multilocularis | neuropeptides capa receptor | Adrenergic receptor alpha-2 | 450 aa | 486 aa | 20.6 % |
Onchocerca volvulus | Alpha-2a adrenergic receptor | 452 aa | 426 aa | 18.3 % | |
Echinococcus granulosus | alpha 1A adrenergic receptor | Alpha-2a adrenergic receptor | 452 aa | 456 aa | 21.1 % |
Echinococcus multilocularis | fmrfamide receptor | Adrenergic receptor alpha-2 | 450 aa | 366 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2227 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2227 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.2227 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2227 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2227 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2227 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2227 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2227 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2227 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2227 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2227 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2227 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.0000016 M | Agonist activity against alpha-1 adrenergic receptor from rat vas deferens | ChEMBL. | 6139481 |
EC50 (functional) | = 0.0000016 M | Agonist activity against alpha-1 adrenergic receptor from rat vas deferens | ChEMBL. | 6139481 |
EC50 (functional) | > 0.00001 M | Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from rats | ChEMBL. | 6139481 |
EC50 (functional) | > 0.00001 M | Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from rats | ChEMBL. | 6139481 |
Ki (binding) | = 14 nM | Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]-clonidine as the radioligand | ChEMBL. | 6139481 |
Ki (binding) | = 14 nM | Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]-clonidine as the radioligand | ChEMBL. | 6139481 |
Ki (binding) | = 300 nM | Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligand | ChEMBL. | 6139481 |
Ki (binding) | = 300 nM | Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligand | ChEMBL. | 6139481 |
pA1 (functional) | = 7.1 | Clonidine antagonistic activity against alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from rats | ChEMBL. | 6139481 |
pA1 (functional) | = 7.1 | Clonidine antagonistic activity against alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from rats | ChEMBL. | 6139481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.