Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0089 | 0.3299 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0089 | 0.3299 | 0.6044 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0063 | 0.1785 | 0.3271 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 1 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (small chain) | 0.0036 | 0.0126 | 0.0382 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0089 | 0.3299 | 0.6044 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0063 | 0.1785 | 0.5411 |
Echinococcus multilocularis | carboxylesterase 5A | 0.02 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.02 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.02 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.02 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.02 | 1 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0188 | 0.9277 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.02 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0063 | 0.1785 | 0.3271 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0124 | 0.5459 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0188 | 0.9277 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0188 | 0.9277 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0036 | 0.0126 | 0.0231 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0036 | 0.0126 | 0.0231 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.02 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.02 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.02 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0056 | 0.1319 | 0.2417 |
Echinococcus multilocularis | acetylcholinesterase | 0.02 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.