Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | sterol O-acyltransferase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus granulosus | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma japonicum | ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus multilocularis | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma mansoni | sterol O-acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | sterol O-acyltransferase 1 | 540 aa | 509 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1952 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1952 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1952 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.039 | 0.039 |
Echinococcus granulosus | carboxylesterase 5A | 0.1952 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1952 | 1 | 1 |
Onchocerca volvulus | 0.033 | 0.039 | 0.5 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.033 | 0.039 | 0.039 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.033 | 0.039 | 0.039 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.033 | 0.039 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.033 | 0.039 | 0.5 |
Echinococcus granulosus | neuroligin | 0.033 | 0.039 | 0.039 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.033 | 0.039 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1952 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.033 | 0.039 | 0.039 |
Loa Loa (eye worm) | carboxylesterase | 0.1952 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.033 | 0.039 | 0.039 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.033 | 0.039 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.039 | 0.039 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.033 | 0.039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.039 | 0.039 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.033 | 0.039 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1952 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.039 | 0.039 |
Echinococcus multilocularis | acetylcholinesterase | 0.1952 | 1 | 1 |
Onchocerca volvulus | 0.033 | 0.039 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.039 | 0.039 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.033 | 0.039 | 0.039 |
Echinococcus multilocularis | neuroligin | 0.033 | 0.039 | 0.039 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.033 | 0.039 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.039 | 0.039 |
Echinococcus granulosus | BC026374 protein S09 family | 0.033 | 0.039 | 0.039 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.033 | 0.039 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.033 | 0.039 | 0.039 |
Loa Loa (eye worm) | carboxylesterase | 0.033 | 0.039 | 0.039 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1952 | 1 | 1 |
Onchocerca volvulus | 0.033 | 0.039 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.033 | 0.039 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.039 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.1952 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1952 | 1 | 1 |
Onchocerca volvulus | 0.033 | 0.039 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.033 | 0.039 | 0.039 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.033 | 0.039 | 0.039 |
Schistosoma mansoni | acetylcholinesterase | 0.033 | 0.039 | 0.039 |
Onchocerca volvulus | 0.033 | 0.039 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.033 | 0.039 | 0.039 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Compound was tested for in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rat hepatic microsomes; ND means not determined | ChEMBL. | No reference |
IC50 (binding) | 0 uM | Compound was tested for in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rat hepatic microsomes; ND means not determined | ChEMBL. | No reference |
IC50 (binding) | = 3.43 uM | Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture | ChEMBL. | No reference |
IC50 (binding) | = 3.43 uM | Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.