Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1556 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.1556 | 0.1556 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.1556 | 0.1556 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.1556 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.1556 | 0.1556 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.1556 | 0.1556 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1556 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.1556 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.1556 | 0.1556 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.1556 | 0.1556 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.1556 | 0.1556 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.1556 | 0.1556 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.1556 | 0.1556 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.1556 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.1556 | 0.1556 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.1556 | 0.1556 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.1556 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1556 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.1556 | 0.1556 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.1556 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.1556 | 0.1556 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.1556 | 1 |
Onchocerca volvulus | 0.0012 | 0.1556 | 0.5 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.1556 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1556 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.1556 | 0.1556 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.1556 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.1556 | 0.1556 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.1556 | 0.1556 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.1556 | 0.1556 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.1556 | 0.1556 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.1556 | 0.1556 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1556 | 1 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.1556 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1556 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.1556 | 0.1556 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.1556 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.1556 | 0.1556 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.1556 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1556 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.1556 | 0.1556 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.1556 | 0.1556 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.1556 | 0.1556 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.1556 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1556 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2818 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.5012 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 2.0596 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.