Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin C | 0.0488 | 0.0148 | 0.0148 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.1431 | 0.2689 | 0.2579 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1431 | 0.2689 | 0.5883 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.162 | 0.3195 | 0.3266 |
Onchocerca volvulus | Cathepsin F homolog | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.1148 | 0.1926 | 0.4117 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.2091 | 0.4466 | 0.4383 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.061 | 0.0469 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.1148 | 0.1926 | 0.1926 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.162 | 0.3195 | 0.7056 |
Schistosoma mansoni | cathepsin S (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0988 | 0.1493 | 0.1365 |
Schistosoma mansoni | cathepsin B (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1148 | 0.1926 | 0.1805 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4146 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.4146 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4146 | 1 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 3 | 0.0568 | 0.0363 | 0.0499 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.066 | 0.061 | 0.0469 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.162 | 0.3195 | 0.3093 |
Plasmodium vivax | vivapain-2 | 0.2091 | 0.4466 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0568 | 0.0363 | 0.0707 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Toxoplasma gondii | cathepsin B | 0.162 | 0.3195 | 0.6901 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0699 | 0.0716 | 0.0716 |
Echinococcus multilocularis | cathepsin L | 0.1148 | 0.1926 | 0.1805 |
Loa Loa (eye worm) | hypothetical protein | 0.1431 | 0.2689 | 0.2579 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.4117 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.066 | 0.061 | 0.0469 |
Leishmania major | cathepsin L-like protease | 0.2591 | 0.5812 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.2091 | 0.4466 | 0.4383 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0699 | 0.0716 | 0.0858 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0716 | 0.0762 | 0.1421 |
Plasmodium vivax | unspecified product | 0.1148 | 0.1926 | 0.4117 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0568 | 0.0363 | 0.0707 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2091 | 0.4466 | 0.4466 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.2091 | 0.4466 | 0.4383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1431 | 0.2689 | 0.2579 |
Echinococcus multilocularis | cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0699 | 0.0716 | 0.1314 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0699 | 0.0716 | 0.1314 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0716 | 0.0762 | 0.0623 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.066 | 0.061 | 0.0469 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Echinococcus granulosus | cathepsin l1 | 0.2091 | 0.4466 | 0.4383 |
Echinococcus granulosus | cysteine protease | 0.1148 | 0.1926 | 0.1805 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1148 | 0.1926 | 0.4117 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.2591 | 0.5812 | 0.5749 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.4117 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2091 | 0.4466 | 0.4383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Echinococcus granulosus | cathepsin L | 0.1148 | 0.1926 | 0.1805 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.4146 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2091 | 0.4466 | 0.4466 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Onchocerca volvulus | 0.1431 | 0.2689 | 0.5883 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.2091 | 0.4466 | 0.4383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Echinococcus multilocularis | cathepsin b | 0.4146 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4146 | 1 | 1 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2591 | 0.5812 | 0.5749 |
Plasmodium vivax | vivapain-3 | 0.1148 | 0.1926 | 0.4117 |
Onchocerca volvulus | Cathepsin L homolog | 0.2091 | 0.4466 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1431 | 0.2689 | 0.2579 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1431 | 0.2689 | 0.5883 |
Brugia malayi | Cathepsin L-like precursor | 0.1431 | 0.2689 | 0.2579 |
Leishmania major | cathepsin L-like protease | 0.2591 | 0.5812 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2591 | 0.5812 | 0.5749 |
Echinococcus granulosus | cathepsin b | 0.4146 | 1 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.066 | 0.061 | 0.0469 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.1148 | 0.1926 | 0.4117 |
Loa Loa (eye worm) | fibroinase | 0.2091 | 0.4466 | 0.4383 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2091 | 0.4466 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.1805 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.2091 | 0.4466 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0699 | 0.0716 | 0.1863 |
Loa Loa (eye worm) | ctsf protein | 0.2091 | 0.4466 | 0.4383 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.1148 | 0.1926 | 0.1926 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.2091 | 0.4466 | 1 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0699 | 0.0716 | 0.1314 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2091 | 0.4466 | 0.4383 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.162 | 0.3195 | 0.3093 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Loa Loa (eye worm) | hypothetical protein | 0.1431 | 0.2689 | 0.2579 |
Entamoeba histolytica | cysteine proteinase 2 | 0.1148 | 0.1926 | 0.4117 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1931 | 0.4034 | 0.3944 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.1148 | 0.1926 | 0.1926 |
Loa Loa (eye worm) | hypothetical protein | 0.1431 | 0.2689 | 0.2579 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.4146 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1148 | 0.1926 | 0.1805 |
Echinococcus multilocularis | cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0716 | 0.0762 | 0.0623 |
Brugia malayi | Cathepsin L-like precursor | 0.066 | 0.061 | 0.0469 |
Schistosoma mansoni | subfamily C1A non-peptidase homologue (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.061 | 0.0469 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0716 | 0.0762 | 0.1421 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.0568 | 0.0363 | 0.0499 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.2091 | 0.4466 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.2091 | 0.4466 | 0.4859 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.2091 | 0.4466 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.162 | 0.3195 | 0.3195 |
Plasmodium vivax | vivapain-1 | 0.1148 | 0.1926 | 0.4117 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.162 | 0.3195 | 1 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0716 | 0.0762 | 0.0623 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Leishmania major | cathepsin L-like protease | 0.2591 | 0.5812 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.066 | 0.061 | 0.0469 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1148 | 0.1926 | 0.1805 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1148 | 0.1926 | 0.4117 |
Brugia malayi | Cathepsin L-like precursor | 0.2091 | 0.4466 | 0.4383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0619 | 0.05 | 0.0816 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.1148 | 0.1926 | 0.1805 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.1148 | 0.1926 | 0.1805 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1431 | 0.2689 | 0.2689 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2091 | 0.4466 | 0.4383 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1431 | 0.2689 | 0.2579 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.2091 | 0.4466 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Giardia lamblia | Encystation-specific protease | 0.0568 | 0.0363 | 0.0707 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1431 | 0.2689 | 0.5883 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.4117 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2591 | 0.5812 | 0.5749 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0716 | 0.0762 | 0.2014 |
Entamoeba histolytica | cysteine protease, putative | 0.1148 | 0.1926 | 0.4117 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.066 | 0.061 | 0.0469 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.4117 |
Toxoplasma gondii | cathepsin CPC1 | 0.0699 | 0.0716 | 0.0858 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0699 | 0.0716 | 0.1314 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0716 | 0.0762 | 0.1421 |
Trypanosoma cruzi | cysteine protease, putative | 0.1148 | 0.1926 | 0.1805 |
Giardia lamblia | Cathepsin B precursor | 0.162 | 0.3195 | 1 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.2091 | 0.4466 | 0.4383 |
Echinococcus granulosus | cathepsin b | 0.4146 | 1 | 1 |
Schistosoma mansoni | cathepsin s | 0.066 | 0.061 | 0.061 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Plasmodium vivax | unspecified product | 0.066 | 0.061 | 0.1071 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.162 | 0.3195 | 1 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0488 | 0.0148 | 0.0148 |
Leishmania major | cathepsin L-like protease | 0.2091 | 0.4466 | 0.4859 |
Onchocerca volvulus | 0.2091 | 0.4466 | 1 | |
Plasmodium vivax | vivapain-2 | 0.2091 | 0.4466 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.2091 | 0.4466 | 0.4383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0716 | 0.0762 | 0.1421 |
Loa Loa (eye worm) | cysteine protease | 0.2091 | 0.4466 | 0.4383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2091 | 0.4466 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.1148 | 0.1926 | 0.1805 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2591 | 0.5812 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.64 ug ml-1 | Concentration required to inhibit the growth of L1210 leukemia cells | ChEMBL. | 2754697 |
ED50 (functional) | = 0.64 ug ml-1 | Concentration required to inhibit the growth of L1210 leukemia cells | ChEMBL. | 2754697 |
ID50 (functional) | = 0.0038 ug ml-1 | The compound was tested for its antitumor activity against L1210 cells | ChEMBL. | 1875336 |
ID50 (functional) | = 0.0038 ug ml-1 | The compound was tested for its antitumor activity against L1210 cells | ChEMBL. | 1875336 |
LTS (functional) | 0 | At 50 mg/kg dose CDF1 mice were injected ip on (1,5,9) days after tumor transplantation to evaluate Long-term survivors at the end of the experiment; 0/6 | ChEMBL. | 1875336 |
LTS (functional) | 0 | At 25 mg/kg dose CDF1 mice were injected ip on (1,5,9) days after tumor transplantation to evaluate Long-term survivors at the end of the experiment; 0/6 | ChEMBL. | 1875336 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound 80 at mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 40 mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 20 mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 10 mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
Survival (functional) | = 6 | Survivors of CDF1 mice on day 4 after 1st injection of compound at 5 mg/kg in six mice; 6/6 | ChEMBL. | 2754697 |
T/C (functional) | = 144 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 5 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 144 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 5 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 145 % | At 50 mg/kg dose CDF1 mice were injected ip on (1,5,9) days after tumor transplantation to evaluate mean survival time | ChEMBL. | 1875336 |
T/C (functional) | = 145 % | At 50 mg/kg dose CDF1 mice were injected ip on (1,5,9) days after tumor transplantation to evaluate mean survival time | ChEMBL. | 1875336 |
T/C (functional) | = 148 % | At 25 mg/kg dose CDF1 mice were injected ip on (1,5,9) days after tumor transplantation to evaluate mean survival time | ChEMBL. | 1875336 |
T/C (functional) | = 148 % | At 25 mg/kg dose CDF1 mice were injected ip on (1,5,9) days after tumor transplantation to evaluate mean survival time | ChEMBL. | 1875336 |
T/C (functional) | = 151 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 10 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 151 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 10 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 173 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 20 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 173 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 20 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 192 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 80 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 192 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 40 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 192 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 80 mg/kg | ChEMBL. | 2754697 |
T/C (functional) | = 192 % | Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 40 mg/kg | ChEMBL. | 2754697 |
TOX (functional) | 0 | At 50 mg/kg dose CDF1 mice were injected ip on (1,5,9) days after tumor transplantation to evaluate Number of toxic deaths/total number of mice; 0/6 | ChEMBL. | 1875336 |
TOX (functional) | 0 | At 25 mg/kg dose CDF1 mice were injected ip on (1,5,9) days after tumor transplantation to evaluate Number of toxic deaths/total number of mice; 0/6 | ChEMBL. | 1875336 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.