Detailed information for compound 71673

Basic information

Technical information
  • TDR Targets ID: 71673
  • Name: 2-[2-(3-piperidin-1-ylpropoxy)phenyl]indolizi ne
  • MW: 334.455 | Formula: C22H26N2O
  • H donors: 0 H acceptors: 0 LogP: 5.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN(CC1)CCCOc1ccccc1c1cc2n(c1)cccc2
  • InChi: 1S/C22H26N2O/c1-5-12-23(13-6-1)14-8-16-25-22-11-3-2-10-21(22)19-17-20-9-4-7-15-24(20)18-19/h2-4,7,9-11,15,17-18H,1,5-6,8,12-14,16H2
  • InChiKey: OGQKJZPIDFFUTC-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[2-[3-(1-piperidyl)propoxy]phenyl]indolizine
  • 2-[2-(3-piperidinopropoxy)phenyl]indolizine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0118 0.103
Schistosoma mansoni chromobox protein 0.0152 0.0723 0.209
Echinococcus granulosus copper transporting ATPase 1 0.0032 0.0097 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0402 0.3501
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0032 0.0205
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0118 0.234
Loa Loa (eye worm) Smad1 0.0016 0.0016 0.0105
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0016 0.0047
Schistosoma mansoni alpha-glucosidase 0.0138 0.065 0.1879
Schistosoma mansoni lipoxygenase 0.0019 0.0034 0.0099
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0409
Echinococcus multilocularis lamin 0.0027 0.0071 0.0206
Loa Loa (eye worm) hypothetical protein 0.0313 0.1555 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0111 0.2206
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0766 0.4927
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.011 0.0505 0.4401
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0048 0.0184 0.2655
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0224 0.1955
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0089 0.0258
Echinococcus multilocularis cysteine protease 0.0056 0.0224 0.0648
Onchocerca volvulus Cathepsin L homolog 0.0056 0.0224 0.1954
Trypanosoma brucei chrX additional, unordered contigs 0.0028 0.0079 0.1123
Onchocerca volvulus Cathepsin F homolog 0.0056 0.0224 0.1954
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0163 0.0471
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0016 0.0047
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0548 0.2771 0.3869
Schistosoma mansoni lamin 0.0027 0.0071 0.0206
Plasmodium vivax serine-repeat antigen (SERA) 0.0018 0.0028 0.0406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.001 0.003
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1944 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0014 0.0092
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.011 0.0505 0.4401
Echinococcus multilocularis cathepsin b 0.0018 0.0028 0.0081
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0184 0.0275
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0028 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0437 0.6196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0224 0.1955
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0018 0.0028 0.0406
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0733
Schistosoma mansoni hypothetical protein 0.0014 0.0007 0.002
Brugia malayi cathepsin L-like precursor 0.0034 0.0111 0.0951
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0291 0.4128
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0018 0.0028 0.0245
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0766 0.2214
Entamoeba histolytica hypothetical protein 0.0108 0.0493 0.9762
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0053 0.0074
Entamoeba histolytica cysteine protease, putative 0.0018 0.0028 0.0558
Loa Loa (eye worm) glutathione reductase 0.014 0.0658 0.4229
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0067 0.0432
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0085 0.0374 0.7395
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0091 0.0403 0.1165
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0032 0.0097 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0141 0.1232
Brugia malayi Na,K-ATPase alpha subunit 0.01 0.0453 0.3872
Plasmodium falciparum serine repeat antigen 8 0.0018 0.0028 0.0406
Trypanosoma brucei calcium motive p-type ATPase, putative 0.008 0.0349 0.4946
Trichomonas vaginalis glutathione reductase, putative 0.0048 0.0184 0.1607
Brugia malayi Cathepsin L-like precursor 0.0034 0.0111 0.0951
Leishmania major proton motive ATPase, putative 0.0032 0.0097 0.1379
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0111 0.0971
Echinococcus multilocularis chromobox protein 1 0.0152 0.0723 0.209
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0716
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0044 0.016 0.0578
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0018 0.0028 0.0081
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.009 0.0401 0.116
Echinococcus multilocularis bloom syndrome protein 0.0046 0.0172 0.0496
Schistosoma mansoni netrin receptor unc5 0.0014 0.0007 0.002
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0053 0.0191
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0032 0.0115
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0068 0.0286 0.0286
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0018 0.0028 0.0081
Leishmania major P-type ATPase, putative 0.009 0.0401 0.569
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0032 0.0097 0.0097
Echinococcus granulosus lamin dm0 0.0027 0.0071 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0018 0.0028 0.0245
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0548 0.2771 0.2771
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0068 0.0286 0.0399
Brugia malayi Valyl-tRNA synthetase 0.0034 0.0111 0.0953
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.011 0.0505 0.1459
Onchocerca volvulus 0.0027 0.0074 0.0647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0028 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0291 0.4128
Plasmodium falciparum cysteine proteinase falcipain 1 0.004 0.0141 0.2036
Giardia lamblia Cathepsin L precursor 0.0018 0.0028 0.0558
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.011 0.0505 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0019
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0002 0.0019
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.096
Onchocerca volvulus 0.0027 0.0074 0.0647
Loa Loa (eye worm) hypothetical protein 0.0032 0.0097 0.0625
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0042 0.0596
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0032 0.0115
Leishmania major DNA damage repair protein, putative 0.0028 0.0079 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.1012
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0007 0.002
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0733
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0085 0.0374 0.7395
Schistosoma mansoni hypothetical protein 0.0034 0.0111 0.0322
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0181
Plasmodium vivax vivapain-3 0.004 0.0141 0.2036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0071 0.0616
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0143 0.2058
Brugia malayi Cathepsin L-like precursor 0.0056 0.0224 0.192
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0093 0.0334
Brugia malayi Uncoordinated protein 44 0.0014 0.0007 0.0059
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0061 0.0091
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0047 0.0299
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0118 0.103
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0048 0.0184 0.2613
Echinococcus granulosus peroxidasin 0.0027 0.0074 0.0215
Echinococcus multilocularis calcium transporting atpase 0.0127 0.0591 0.1706
Onchocerca volvulus 0.0019 0.0034 0.0298
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0141 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0018 0.0028 0.0042
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0002 0.0019
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0393 0.1135
Giardia lamblia Cysteine protease 0.0018 0.0028 0.0558
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1142 0.33
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.011 0.0505 0.716
Plasmodium vivax P-type ATPase4, putative 0.0147 0.0694 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0048 0.0184 0.0184
Mycobacterium tuberculosis Probable reductase 0.0319 0.1585 0.2214
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0097 0.0437 0.061
Trypanosoma cruzi cysteine peptidase, putative 0.0149 0.0705 0.1053
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0074 0.0636
Entamoeba histolytica cysteine proteinase 1, putative 0.004 0.0141 0.2799
Brugia malayi Cathepsin L-like precursor 0.0022 0.0047 0.0399
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0018 0.0028 0.0245
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0085
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0019
Schistosoma mansoni rab6-interacting 0.0019 0.0034 0.0099
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0034 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0118 0.0176
Onchocerca volvulus 0.0018 0.0028 0.0245
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0539 0.0805
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.009 0.0401 0.116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0908
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0116 0.1649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.013 0.1129
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0163 0.2312
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.009 0.0401 0.116
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0069 0.0103
Brugia malayi Cytochrome P450 family protein 0.0026 0.0067 0.0574
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0048 0.0184 0.2655
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0141 0.2004
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0194 0.3838
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0163 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0028 0.0245
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0048 0.0184 0.0184
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0786
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0181
Schistosoma mansoni hypothetical protein 0.0284 0.1406 0.4063
Brugia malayi Cathepsin L-like precursor 0.0034 0.0111 0.0951
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0127 0.0591 0.1706
Plasmodium falciparum calcium-transporting ATPase 0.0127 0.0591 0.8507
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.011 0.0505 0.4401
Entamoeba histolytica hypothetical protein 0.0108 0.0493 0.9762
Echinococcus granulosus intermediate filament protein 0.0027 0.0071 0.0206
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0355 0.177 0.2471
Loa Loa (eye worm) RNA binding protein 0.0062 0.0254 0.1632
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0018 0.0028 0.0406
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0181
Echinococcus multilocularis cysteine protease 0.0056 0.0224 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.1012
Entamoeba histolytica hypothetical protein 0.0034 0.0111 0.2206
Giardia lamblia Cathepsin L precursor 0.0018 0.0028 0.0558
Loa Loa (eye worm) hypothetical protein 0.01 0.0453 0.291
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0032 0.0097 0.0136
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0018 0.0028 0.0406
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0149 0.0432
Schistosoma mansoni cation-transporting atpase worm 0.0032 0.0097 0.0281
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1147 1
Plasmodium vivax SET domain protein, putative 0.003 0.0089 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Loa Loa (eye worm) hypothetical protein 0.0121 0.056 0.3599
Echinococcus multilocularis X box binding protein 1 0.0284 0.1406 0.4063
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0061 0.0861
Toxoplasma gondii P-type ATPase PMA1 0.0064 0.0264 0.0952
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0032 0.0097 0.0832
Leishmania major DNA polymerase kappa, putative 0.0028 0.0079 0.1123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Plasmodium falciparum serine repeat antigen 6 0.0018 0.0028 0.0406
Toxoplasma gondii cathepsin CPL 0.0056 0.0224 0.081
Echinococcus multilocularis cathepsin L 0.004 0.0141 0.0408
Brugia malayi Cathepsin L-like precursor 0.0056 0.0224 0.192
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0014 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0141 0.2799
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0118 0.103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.002 0.0037 0.0055
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0032 0.0097 0.0136
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0018 0.0028 0.0081
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0013 0.0038
Schistosoma mansoni smad1 5 8 and 0.0016 0.0016 0.0047
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0032 0.0097 0.0351
Trypanosoma cruzi cysteine protease, putative 0.004 0.0141 0.0211
Schistosoma mansoni terminal deoxycytidyl transferase 0.0091 0.0403 0.1165
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0116 0.1649
Loa Loa (eye worm) hypothetical protein 0.0032 0.0097 0.0625
Leishmania major calcium motive p-type ATPase, putative 0.008 0.0349 0.4946
Echinococcus granulosus cpg binding protein 0.003 0.0089 0.0256
Schistosoma mansoni cathepsin B (C01 family) 0.0018 0.0028 0.0081
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0048 0.0184 0.0257
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.009 0.0401 0.1448
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0028 0.0081
Schistosoma mansoni cation-transporting ATPase 0.0032 0.0097 0.0281
Giardia lamblia Cathepsin L-like protease 0.0018 0.0028 0.0558
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Trypanosoma cruzi cysteine proteinase, putative 0.004 0.0141 0.0211
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0002 0.0003
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0069 0.0981
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0194 0.1689
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0457 0.132
Schistosoma mansoni cpg binding protein 0.0028 0.008 0.0232
Leishmania major cathepsin L-like protease 0.0149 0.0705 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0018 0.0028 0.0406
Echinococcus multilocularis musashi 0.0027 0.0071 0.0206
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0048 0.0184 0.1577
Plasmodium falciparum serine repeat antigen 2 0.0018 0.0028 0.0406
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0007 0.002
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0032 0.0097 0.0136
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0111 0.0322
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0013 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0018 0.0028 0.0245
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.0403 0.3451
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0028 0.0241
Plasmodium falciparum serine repeat antigen 4 0.0018 0.0028 0.0406
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0053 0.0053
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0034 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0091
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1944 1 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0085 0.0374 0.7395
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0733
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0071 0.0458
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.002 0.0037 0.0134
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0089 0.0258
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0048 0.0184 0.2613
Loa Loa (eye worm) hypothetical protein 0.0123 0.0571 0.3675
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0085 0.0374 0.3255
Echinococcus granulosus tar DNA binding protein 0.0062 0.0254 0.0733
Trichomonas vaginalis Heterochromatin protein, putative 0.0034 0.0111 0.0971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Brugia malayi E1-E2 ATPase family protein 0.0064 0.0264 0.2257
Loa Loa (eye worm) hypothetical protein 0.0049 0.0185 0.1193
Plasmodium falciparum heterochromatin protein 1 0.0034 0.0111 0.1605
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0018 0.0028 0.0406
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0053 0.0762
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0074 0.0478
Brugia malayi hypothetical protein 0.0123 0.0571 0.489
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.011 0.0505 0.4401
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0267 0.0772
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0539 0.7645
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0048 0.0184 0.2613
Echinococcus granulosus cathepsin b 0.0018 0.0028 0.0081
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0118 0.103
Trypanosoma cruzi cruzipain precursor, putative 0.1307 0.67 1
Loa Loa (eye worm) calcium ATPase 0.0022 0.0046 0.0296
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.0224 0.0648
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.014 0.0658 0.0918
Brugia malayi polk-prov protein 0.0054 0.0215 0.1841
Mycobacterium tuberculosis Conserved hypothetical protein 0.0091 0.0403 0.0563
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1142 0.33
Trypanosoma cruzi cysteine proteinase, putative 0.004 0.0141 0.0211
Plasmodium vivax calcium-transporting ATPase, putative 0.0147 0.0694 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0733
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0079 0.1123
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.2024 0.5849
Schistosoma mansoni smad 0.0016 0.0016 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0539 0.7645
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0185 0.1587
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0444 0.1284
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.002 0.0037 0.0134
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0766 0.6556
Echinococcus granulosus chromobox protein 2 0.0034 0.0111 0.0322
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0068 0.0286 0.0399
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.011 0.0505 1
Loa Loa (eye worm) fibroinase 0.0056 0.0224 0.1443
Schistosoma mansoni rab6-interacting 0.0019 0.0034 0.0099
Plasmodium vivax thioredoxin reductase, putative 0.014 0.0658 0.9472
Trypanosoma cruzi cysteine peptidase, putative 0.0149 0.0705 0.1053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0129 0.1126
Echinococcus multilocularis Chromo domain 0.0034 0.0111 0.0322
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0028 0.0241
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.009 0.0401 0.116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0048
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0044 0.016 0.137
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0127 0.0592 0.0884
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0074 0.0478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Schistosoma mansoni polycystin 1-related 0.0019 0.0034 0.0099
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0032 0.0097 0.1925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Loa Loa (eye worm) hypothetical protein 0.0058 0.0235 0.151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0141 0.1232
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0061 0.0861
Brugia malayi cathepsin L-like cysteine proteinase 0.0018 0.0028 0.0241
Giardia lamblia DNA damage repair protein 0.0028 0.0079 0.1569
Toxoplasma gondii thioredoxin reductase 0.014 0.0658 0.2373
Schistosoma mansoni hypothetical protein 0.0048 0.018 0.052
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0539 0.0539
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0014 0.0021
Toxoplasma gondii preprocathepsin c precursor, putative 0.0018 0.0028 0.0102
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0147 0.0694 0.1036
Plasmodium vivax DNA repair protein REV1, putative 0.0028 0.0079 0.1141
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1 0.6434
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0048 0.0184 0.0533
Loa Loa (eye worm) hypothetical protein 0.0051 0.0198 0.1273
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.008 0.0349 0.1008
Schistosoma mansoni na+/k+ atpase alpha subunit 0.008 0.0349 0.1008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0016 0.0105
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0194 0.056
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.01 0.0453 0.0453
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.009 0.0401 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0291 0.4128
Echinococcus multilocularis lamin dm0 0.0027 0.0071 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0111 0.0969
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0037 0.0107
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0032 0.0272
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0032 0.0272
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0457 0.132
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0319 0.1585 0.2214
Trypanosoma brucei trypanothione reductase 0.014 0.0658 0.9322
Plasmodium vivax vivapain-2 0.0056 0.0224 0.3231
Loa Loa (eye worm) calcium ATPase 0.0067 0.0278 0.179
Toxoplasma gondii cathepsin CPC1 0.0018 0.0028 0.0102
Echinococcus multilocularis cation transporting ATPase 13A3 0.0032 0.0097 0.0281
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0194 0.0289
Entamoeba histolytica cysteine protease, putative 0.0018 0.0028 0.0558
Loa Loa (eye worm) hypothetical protein 0.0062 0.0255 0.1639
Trypanosoma brucei cation-transporting ATPase, putative 0.0032 0.0097 0.1379
Plasmodium falciparum serine repeat antigen 5 0.0018 0.0028 0.0406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0028 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0071 0.0616
Echinococcus granulosus Chromo domain 0.0034 0.0111 0.0322
Echinococcus multilocularis dna polymerase kappa 0.0117 0.0539 0.1558
Onchocerca volvulus 0.0056 0.0224 0.1954
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0074 0.0636
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Giardia lamblia Cysteine protease 0.0018 0.0028 0.0558
Schistosoma mansoni alpha-glucosidase 0.0138 0.065 0.1879
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0181
Brugia malayi Pre-SET motif family protein 0.0206 0.1 0.8561
Brugia malayi intermediate filament protein 0.0027 0.0071 0.061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0069 0.0442
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.01 0.0453 0.291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0908
Entamoeba histolytica hypothetical protein 0.0034 0.0111 0.2206
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0048 0.0184 0.2613
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0032 0.0097 0.1925
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0118 0.1676
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.0172 0.1497
Leishmania major calcium-transporting ATPase, putative 0.008 0.0349 0.4946
Brugia malayi RNA binding protein 0.0062 0.0254 0.2171
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0409
Plasmodium vivax heterochromatin protein 1, putative 0.0034 0.0111 0.1605
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.031 0.0895
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.2345 0.6774
Trypanosoma cruzi cruzipain precursor, putative 0.0149 0.0705 0.1053
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0548 0.2771 0.2771
Loa Loa (eye worm) hypothetical protein 0.0026 0.0069 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0539 0.7645
Echinococcus multilocularis cpg binding protein 0.003 0.0089 0.0256
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0224 0.1955
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0224 0.195
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.022
Plasmodium vivax glutathione reductase, putative 0.014 0.0658 0.9472
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0032 0.0097 0.0847
Leishmania major trypanothione reductase 0.014 0.0658 0.9322
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0089 0.0393 0.1135
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.0224 0.1955
Trypanosoma cruzi trypanothione reductase, putative 0.014 0.0658 0.0981
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0032 0.0097 0.1925
Plasmodium falciparum serine repeat antigen 1 0.0018 0.0028 0.0406
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0028 0.0241
Giardia lamblia Cathepsin B precursor 0.0018 0.0028 0.0558
Echinococcus multilocularis smad 0.0016 0.0016 0.0047
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.011 0.0505 0.716
Giardia lamblia Cathepsin L precursor 0.0018 0.0028 0.0558
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0019
Giardia lamblia Cathepsin B precursor 0.0018 0.0028 0.0558
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0056 0.0224 0.3231
Echinococcus granulosus thioredoxin glutathione reductase 0.014 0.0658 0.19
Giardia lamblia Hypothetical protein 0.0018 0.0028 0.0558
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0299
Echinococcus granulosus dnaJ subfamily B 0.0404 0.2024 0.5849
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0018 0.0028 0.0558
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0044 0.016 0.0239
Entamoeba histolytica plasma membrane calcium-transporting ATPase, putative 0.0022 0.0046 0.0912
Loa Loa (eye worm) hypothetical protein 0.0079 0.0342 0.2197
Entamoeba histolytica cysteine protease, putative 0.0018 0.0028 0.0558
Schistosoma mansoni DNA polymerase IV / kappa 0.0028 0.0079 0.0229
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0068 0.0286 0.1839
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0007 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0028 0.0245
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.0172 0.147
Loa Loa (eye worm) RecQ helicase 0.0046 0.0172 0.1105
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0111 0.0971
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0032 0.0097 0.1925
Toxoplasma gondii Alpha-galactosidase 0.0014 0.0007 0.0027
Brugia malayi MAP kinase sur-1 0.005 0.0194 0.1659
Leishmania major P-type H -ATPase, putative 0.0064 0.0264 0.3739
Brugia malayi Pre-SET motif family protein 0.003 0.0089 0.0763
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0163 0.1049
Echinococcus multilocularis cathepsin L 0.0018 0.0028 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0069 0.0604
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0129 0.1126
Trichomonas vaginalis mercuric reductase, putative 0.0048 0.0184 0.1607
Schistosoma mansoni peroxidasin 0.0027 0.0074 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0111 0.0971
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0127 0.0591 0.5053
Trypanosoma cruzi cation-transporting ATPase, putative 0.0032 0.0097 0.0145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.001 0.0089
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0118 0.103
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0141 0.2799
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0118 0.0342
Echinococcus granulosus Chromobox protein 3 0.0034 0.0111 0.0322
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0067 0.0278 0.5511
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0118 0.234
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0319 0.1585 0.2214
Brugia malayi hypothetical protein 0.0121 0.056 0.4789
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.031 0.0895
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0018 0.0028 0.0406
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0008 0.0022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0002 0.0019
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0079 0.0118
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0048 0.0184 0.2613
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0056 0.0224 0.3231
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0224 0.192
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0085 0.0374 0.3255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Brugia malayi MH1 domain containing protein 0.0016 0.0016 0.014
Echinococcus granulosus cation transporting ATPase 13A1 0.0032 0.0097 0.0281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0184 0.0275
Brugia malayi hypothetical protein 0.0019 0.0034 0.0292
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0028 0.0081
Brugia malayi glutathione reductase 0.014 0.0658 0.5627
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0074 0.0636
Mycobacterium ulcerans hypothetical protein 0.0028 0.0079 0.0079
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0018 0.0028 0.0181
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0194 0.1689
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0539 0.0539
Entamoeba histolytica hypothetical protein 0.0018 0.0028 0.0558
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0044 0.016 0.1029
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.1169 0.7515
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0036 0.012 0.0346
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0016 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0224 0.0335
Echinococcus granulosus death domain containing protein 0.0014 0.0007 0.002
Schistosoma mansoni cathepsin C 0.0018 0.0028 0.0081
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.0224 0.0648
Loa Loa (eye worm) helicase 0.0034 0.0111 0.0716
Trypanosoma cruzi major cysteine proteinase, putative 0.0018 0.0028 0.0042
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0007 0.002
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0071 0.0458
Trypanosoma brucei DNA polymerase IV, putative 0.011 0.0506 0.7167
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0111 0.0971
Trichomonas vaginalis MYB, putative 0.0085 0.0376 0.3273
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0032 0.0458
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0224 0.4442
Trypanosoma brucei unspecified product 0.011 0.0506 0.7167
Plasmodium falciparum DNA repair protein REV1, putative 0.0028 0.0079 0.1141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0038
Echinococcus multilocularis GPCR, family 2 0.0015 0.0013 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0224 0.1955
Schistosoma mansoni hypothetical protein 0.0051 0.0198 0.0571
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0018 0.0028 0.0406
Brugia malayi Smad1 0.0016 0.0016 0.014
Loa Loa (eye worm) E1-E2 ATPase 0.0064 0.0264 0.1696
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0539 0.0805
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0111 0.0971
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.018 0.154
Loa Loa (eye worm) hypothetical protein 0.0067 0.0283 0.1817
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0002 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0283 0.0816
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0036 0.012 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0018 0.0028 0.0245
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0145 0.1261
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0409
Trichomonas vaginalis cation-transporting ATPase, putative 0.011 0.0505 0.4401
Echinococcus granulosus microtubule associated protein 2 0.0681 0.3461 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0716
Leishmania major cathepsin L-like protease 0.0056 0.0224 0.318
Plasmodium falciparum glutathione reductase 0.0048 0.0184 0.2655
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.001 0.003
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0002 0.0003
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0163 0.2312
Trichomonas vaginalis cation-transporting ATPase, putative 0.0147 0.0694 0.605
Leishmania major DNA polymerase eta, putative 0.0079 0.0341 0.4828
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0118 0.103
Echinococcus multilocularis cation transporting ATPase 13A1 0.0032 0.0097 0.0281
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0341 0.1229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0085 0.0376 0.3273
Toxoplasma gondii NADPH-glutathione reductase 0.0048 0.0184 0.0665
Brugia malayi M-phase phosphoprotein, mpp8 0.0123 0.0571 0.4884
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.011 0.0505 0.716
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0013 0.0113
Onchocerca volvulus 0.0093 0.0415 0.3615
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0457 0.132
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0147 0.0694 0.0694
Trichomonas vaginalis C-MYB, putative 0.0085 0.0374 0.3255
Schistosoma mansoni atpase class VI type 11c 0.002 0.0037 0.0107
Giardia lamblia Cathepsin B precursor 0.0018 0.0028 0.0558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0028 0.0245
Loa Loa (eye worm) hypothetical protein 0.0032 0.01 0.0642
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.011 0.0505 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0028 0.0245
Leishmania major cathepsin L-like protease 0.0056 0.0224 0.318
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0032 0.0092
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0716
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0194 0.0289
Giardia lamblia Cathepsin L-like protease 0.0018 0.0028 0.0558
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0216 0.0623
Onchocerca volvulus 0.0235 0.1148 1
Trypanosoma brucei unspecified product 0.0063 0.0257 0.365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.0224 0.0648
Echinococcus granulosus chromobox protein 1 0.0152 0.0723 0.209
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0032 0.0092
Onchocerca volvulus 0.0062 0.0255 0.222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0224 0.1955
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0032 0.0097 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0539 0.7645
Plasmodium vivax unspecified product 0.0022 0.0047 0.0671
Loa Loa (eye worm) hypothetical protein 0.0056 0.0224 0.1443
Brugia malayi cathepsin B-like cysteine proteinase 0.0018 0.0028 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0091
Plasmodium vivax serine-repeat antigen (SERA) 0.0018 0.0028 0.0406
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0085 0.0374 0.7395
Onchocerca volvulus 0.01 0.0453 0.3942
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1396 0.7162 1
Brugia malayi Thioredoxin reductase 0.014 0.0658 0.5627
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0022 0.0047 0.0399
Trichomonas vaginalis hypothetical protein 0.0034 0.0111 0.0971
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0111 0.0971
Plasmodium vivax unspecified product 0.004 0.0141 0.2036
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0194 0.056
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0319 0.1585 0.2214
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0053 0.0053
Giardia lamblia Cathepsin L precursor 0.0018 0.0028 0.0558
Treponema pallidum cation-transporting ATPase, P-type 0.0032 0.0097 0.0097
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0216 0.0623
Onchocerca volvulus 0.0056 0.0224 0.1954
Leishmania major cathepsin L-like protease 0.0056 0.0224 0.318
Leishmania major cathepsin L-like protease 0.0056 0.0224 0.318
Schistosoma mansoni hypothetical protein 0.0404 0.2024 0.5849
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0018 0.0028 0.0406
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0074 0.0478
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0163 0.323
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0061 0.1203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0083 0.0719
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0184 0.0275
Toxoplasma gondii P-type ATPase4, putative 0.01 0.0453 0.1633
Trypanosoma brucei DNA polymerase eta, putative 0.0141 0.0665 0.9423
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0111 0.0971
Loa Loa (eye worm) thioredoxin reductase 0.014 0.0658 0.4229
Schistosoma mansoni hypothetical protein 0.0677 0.3442 0.9944
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0048 0.0184 0.0665
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0122 0.0351
Echinococcus granulosus cathepsin L cysteine protease 0.004 0.0141 0.0408
Echinococcus granulosus cathepsin l1 0.0056 0.0224 0.0648
Schistosoma mansoni survival motor neuron protein 0.0048 0.018 0.052
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0074 0.0647
Giardia lamblia Cathepsin L precursor 0.0018 0.0028 0.0558
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0013 0.0038
Giardia lamblia Cathepsin B precursor 0.0018 0.0028 0.0558
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0089 0.0258
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0032 0.0097 0.0097
Onchocerca volvulus Peroxidase homolog 0.0027 0.0074 0.0647
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0493 0.1425
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0715
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0118 0.103
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0194 0.056
Schistosoma mansoni lamin 0.0027 0.0071 0.0206
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0032 0.0097 0.0281
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0096 0.0433 0.377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0299
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Leishmania major cathepsin L-like protease 0.0149 0.0705 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0018 0.0028 0.0406
Brugia malayi E1-E2 ATPase family protein 0.0032 0.0097 0.0832
Schistosoma mansoni cpg binding protein 0.003 0.0089 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0091
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0019 0.0034 0.0099
Trypanosoma brucei calcium-transporting ATPase, putative 0.0048 0.0182 0.2585
Echinococcus granulosus cathepsin b 0.0018 0.0028 0.0081
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.2345 0.6774
Trichomonas vaginalis DNA polymerase eta, putative 0.0117 0.0539 0.47
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0032 0.0097 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0908
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0437 0.3736
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.001 0.003
Loa Loa (eye worm) ctsf protein 0.0056 0.0224 0.1443
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0091 0.0403 0.2594
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0037 0.0107
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0028 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0539 0.7645
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0018 0.0028 0.0406
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0766 0.2214
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0091 0.0403 0.1165
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0548 0.2771 1
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0147 0.0694 0.2006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0089 0.0258
Onchocerca volvulus Huntingtin homolog 0.0121 0.056 0.4875
Echinococcus granulosus cation transporting ATPase 13A3 0.0032 0.0097 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0908
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0087 0.0762
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0224 0.4442
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0061 0.0529
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0074 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0149 0.1302
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0299
Trypanosoma cruzi proton motive ATPase 1, putative 0.002 0.0037 0.0055
Trichomonas vaginalis cation-transporting ATPase, putative 0.0147 0.0694 0.605
Loa Loa (eye worm) hypothetical protein 0.0054 0.0215 0.1384
Loa Loa (eye worm) hypothetical protein 0.0027 0.0071 0.0458
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0217 0.0784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0224 0.1955
Brugia malayi Melibiase family protein 0.0067 0.0283 0.2418
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0028 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0908
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0018 0.0028 0.0406
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0111 0.1605
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0068 0.0286 0.2448
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0079 0.1123
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0032 0.0097 0.0136
Brugia malayi Peroxidasin 0.0027 0.0074 0.0636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0141 0.2004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0057 0.0499
Brugia malayi Cytochrome P450 family protein 0.0016 0.0014 0.0123
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.001 0.0148
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0028 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0079 0.0118
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0002 0.0019
Brugia malayi hypothetical protein 0.0017 0.0021 0.018
Brugia malayi chromobox protein homolog 3 0.009 0.0402 0.3437
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0118 0.1007
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0111 0.0402
Onchocerca volvulus 0.0056 0.0224 0.1954
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0095 0.1362
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0254 0.1632
Leishmania major cathepsin L-like protease 0.0149 0.0705 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0194 0.056
Entamoeba histolytica cysteine proteinase 2 0.004 0.0141 0.2799
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0032 0.0097 0.0145
Echinococcus multilocularis protein dispatched 1 0.0048 0.018 0.052
Echinococcus granulosus Na:K ATPase alpha subunit 0.008 0.0349 0.1008
Echinococcus multilocularis chromobox protein 1 0.0152 0.0723 0.209
Mycobacterium tuberculosis Probable oxidoreductase 0.0355 0.177 0.2471
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0053 0.075
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0147 0.0694 1
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0048 0.0182 0.0272
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0085 0.0374 0.3255
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0145 0.1261
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0079 0.1123
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0118 0.0176
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0053 0.0762
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0118 0.0426
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0032 0.0092
Plasmodium falciparum thioredoxin reductase 0.014 0.0658 0.9472
Schistosoma mansoni lipoxygenase 0.0054 0.0216 0.0623
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0013 0.0038
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0457 0.132
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0111 0.0322
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0069 0.0997
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0014 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Brugia malayi ImpB/MucB/SamB family protein 0.0141 0.0665 0.5687
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1396 0.7162 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0018 0.0028 0.0558
Giardia lamblia Encystation-specific protease 0.0018 0.0028 0.0558
Echinococcus granulosus Smad4 0.0016 0.0016 0.0047
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0085 0.0374 0.7395
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0079 0.1123
Brugia malayi Cathepsin L-like precursor 0.0056 0.0224 0.192
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0118 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0104 0.0908
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0034 0.0111 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0028 0.0245
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.0509 0.076
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0111 0.0321
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.3461 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0018 0.0028 0.0081
Plasmodium falciparum glutathione reductase 0.014 0.0658 0.9472
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.0141 0.0211
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0141 0.0665 0.4274
Schistosoma mansoni loxhd1 0.0019 0.0034 0.0099
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0013 0.0085
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0018 0.0028 0.0399
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.008 0.0349 0.6908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.1012
Entamoeba histolytica cysteine protease, putative 0.0018 0.0028 0.0558
Brugia malayi Doublecortin family protein 0.0019 0.0034 0.0292
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0048 0.0184 0.2655
Schistosoma mansoni Smad4 0.0016 0.0016 0.0047
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0104 0.0376
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0002 0.0044
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0254 0.0733
Loa Loa (eye worm) heterochromatin protein 1 0.0152 0.0723 0.465
Leishmania major cytochrome p450-like protein 0.0016 0.0014 0.0204
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0007 0.0047
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0028 0.0081
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0032 0.063
Schistosoma mansoni alpha glucosidase 0.0036 0.0118 0.0342
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0163 0.2312
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.012 0.0346
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0034 0.0099
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0127 0.0591 0.1706
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0358 0.1036
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0083 0.0364 0.0543
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0053 0.0191
Echinococcus granulosus X box binding protein 1 0.0284 0.1406 0.4063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Entamoeba histolytica cysteine protease, putative 0.0018 0.0028 0.0558
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0085 0.0376 0.3273
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0048 0.0184 0.0275
Schistosoma mansoni cation-transporting atpase worm 0.0032 0.0097 0.0281
Entamoeba histolytica cysteine protease, putative 0.0056 0.0224 0.4442
Schistosoma mansoni peroxidasin 0.0027 0.0074 0.0215
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0032 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0056 0.0224 0.1443
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0111 0.2206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.1012
Plasmodium falciparum copper-transporting ATPase 0.0032 0.0097 0.1401
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0194 0.1689
Schistosoma mansoni phosphoserine phosphatase 0.002 0.0037 0.0107
Echinococcus multilocularis peroxidasin 0.0027 0.0074 0.0215
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0181
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0085 0.0374 0.3255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0057 0.0501
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0393 0.1135
Plasmodium falciparum serine repeat antigen 7 0.0018 0.0028 0.0406
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0089 0.0258
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0254 0.1632
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0085 0.0374 0.3255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0057 0.0499
Trypanosoma cruzi cysteine peptidase, putative 0.0149 0.0705 0.1053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0028 0.0245
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.2345 0.6774
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0457 0.132
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0032 0.0097 0.0281
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0149 0.0432
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0194 0.1689
Brugia malayi Protein cec-1. 0.0034 0.0111 0.0953
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0018 0.0028 0.0558
Echinococcus granulosus dna polymerase kappa 0.0117 0.0539 0.1558
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0254 0.2171
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0539 0.7645
Schistosoma mansoni cathepsin s 0.0022 0.0047 0.0135
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0053 0.075
Giardia lamblia Cathepsin L precursor 0.0018 0.0028 0.0558
Leishmania major P-type H -ATPase, putative 0.0064 0.0264 0.3739
Brugia malayi Death domain containing protein 0.0014 0.0007 0.0059
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.0123 0.0571 0.3671
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0457 0.132
Trichomonas vaginalis chromobox protein, putative 0.0096 0.0433 0.3772
Leishmania major hypothetical protein, conserved 0.0026 0.0069 0.0981
Plasmodium vivax copper-transporting ATPase, putative 0.0032 0.0097 0.1401
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0016 0.0047
Echinococcus multilocularis dna polymerase eta 0.0141 0.0665 0.192
Schistosoma mansoni hypothetical protein 0.0033 0.0106 0.0305
Schistosoma mansoni patched 1 0.0042 0.0149 0.0432
Onchocerca volvulus 0.0056 0.0224 0.1954
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0127 0.0591 0.1706
Echinococcus multilocularis protein patched 0.0042 0.0149 0.0432
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0118 0.0342
Onchocerca volvulus 0.0027 0.0071 0.0621
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0163 0.0471
Leishmania major cysteine peptidase A (CPA) 0.0056 0.0224 0.318
Giardia lamblia Hypothetical protein 0.0018 0.0028 0.0558
Giardia lamblia Cathepsin B precursor 0.0018 0.0028 0.0558
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.009 0.0401 0.3498
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0079 0.0286
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0048 0.0184 0.2613
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Onchocerca volvulus 0.0056 0.0224 0.1954
Brugia malayi Cathepsin L-like precursor 0.0056 0.0224 0.192
Schistosoma mansoni hypothetical protein 0.0677 0.3442 0.9944
Echinococcus granulosus cathepsin L cysteine proteinase 0.0056 0.0224 0.0648
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0032 0.0097 0.0847
Giardia lamblia Cathepsin B precursor 0.0018 0.0028 0.0558
Loa Loa (eye worm) hypothetical protein 0.0142 0.0671 0.4317
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0539 0.7645
Schistosoma mansoni chromobox protein 0.0034 0.0111 0.0322
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0002 0.0019
Plasmodium falciparum serine repeat antigen 9 0.0018 0.0028 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0163 0.1422
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0034 0.0111 0.1605
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0035 0.0113 0.0408
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0071 0.061
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0034 0.0111 0.0322
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0141 0.2799
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0163 0.323
Echinococcus granulosus lamin 0.0027 0.0071 0.0206
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0074 0.0478
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0014 0.0092
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0053 0.0074
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.011 0.0505 0.4401
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0355 0.177 0.2471
Echinococcus granulosus cathepsin l cysteine peptidase 0.0056 0.0224 0.0648
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0079 0.0118
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0766 0.2214
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0149 0.096
Onchocerca volvulus 0.0049 0.0186 0.1622
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0437 0.1262
Echinococcus multilocularis tumor protein p63 0.0333 0.1661 0.4798
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0032 0.0097 0.0832
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0018 0.0028 0.0081
Brugia malayi CHE-14 protein 0.0042 0.0149 0.1278
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0034 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0069 0.0604
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0147 0.0694 0.2006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0028 0.0081
Loa Loa (eye worm) hypothetical protein 0.0097 0.0437 0.2808
Schistosoma mansoni ATPase 0.0147 0.0694 0.2006
Brugia malayi Associated with TFs and helicases family protein 0.0034 0.0111 0.0953
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Trypanosoma cruzi P-type H+-ATPase, putative 0.0044 0.016 0.0239
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0048 0.0184 0.0533
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0074 0.0647
Entamoeba histolytica hypothetical protein 0.0108 0.0493 0.9762
Echinococcus granulosus cathepsin L 0.004 0.0141 0.0408
Brugia malayi Membrane calcium atpase protein 3 0.009 0.0401 0.3435
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0141 0.0408
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0048 0.0184 0.2613
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0186 0.0538
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0147 0.0694 0.2006
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0215 0.305
Brugia malayi hypothetical protein 0.0026 0.0069 0.0592
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.008 0.0349 0.0521
Trichomonas vaginalis pc-MYB2, putative 0.0085 0.0374 0.3255
Brugia malayi cathepsin L precursor 0.0018 0.0028 0.0241
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0141 0.0408
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.3461 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0163 0.1396
Echinococcus multilocularis cathepsin b 0.0018 0.0028 0.0081
Brugia malayi follicle stimulating hormone receptor 0.0239 0.1169 1
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0037 0.0107
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0013 0.0113
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Echinococcus multilocularis Smad4 0.0016 0.0016 0.0047
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0457 0.132
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0032 0.0097 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Echinococcus multilocularis cation transporting atpase worm 0.0032 0.0097 0.0281
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0018 0.0028 0.0558
Echinococcus granulosus cysteine protease 0.004 0.0141 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0163 0.1422
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.011 0.0505 0.1822
Brugia malayi Blistered cuticle protein 3 0.0027 0.0074 0.0636
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0018 0.0028 0.0406
Echinococcus multilocularis thioredoxin glutathione reductase 0.014 0.0658 0.19
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0056 0.0226 0.1933
Leishmania major copper-transporting ATPase-like protein, putative 0.0032 0.0097 0.1379
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0007 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0205
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0716
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0056 0.0224 0.0648
Onchocerca volvulus 0.0027 0.0071 0.0621
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0111 0.0971
Brugia malayi hypothetical protein 0.0027 0.0074 0.0636
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.011 0.0505 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0016 0.0047
Trypanosoma cruzi copper-transporting ATPase, putative 0.002 0.0037 0.0055
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0163 0.0471
Schistosoma mansoni copper ABC transporter ATPase 0.0032 0.0097 0.0281
Giardia lamblia Cysteine protease 0.0018 0.0028 0.0558
Echinococcus multilocularis Chromobox protein 3 0.0034 0.0111 0.0322
Schistosoma mansoni smad1 5 8 and 0.0016 0.0016 0.0047
Brugia malayi hypothetical protein 0.002 0.0037 0.0317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0069 0.0103
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0181
Brugia malayi calcium ATPase 0.0047 0.0175 0.1495
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0224 0.195
Onchocerca volvulus 0.0034 0.0111 0.0968
Schistosoma mansoni chromobox protein 0.0034 0.0111 0.0322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0028 0.0245
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.002 0.0037 0.0055
Toxoplasma gondii cathepsin B 0.0018 0.0028 0.0102
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.011 0.0505 0.0754
Echinococcus granulosus dna polymerase eta 0.0141 0.0665 0.192
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0194 0.1247
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0034 0.0099
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0037 0.0107
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0032 0.0097 0.0097
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0095 0.0424 0.3629
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0028 0.0245
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0141 0.1209
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.009 0.0401 0.116
Plasmodium falciparum serine repeat antigen 3 0.0018 0.0028 0.0406
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0018 0.0028 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0091
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0118 0.076
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0048 0.0184 0.0275
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0493 0.1425
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0079 0.0118
Brugia malayi fibroinase precursor 0.0018 0.0028 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0057 0.0499
Plasmodium vivax cation transporting ATPase, putative 0.0032 0.0097 0.1401
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0539 0.7645
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0074 0.0647
Leishmania major DNA polymerase kappa, putative 0.0097 0.0437 0.6196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0184 0.0275
Trypanosoma brucei cysteine peptidase C (CPC) 0.0018 0.0028 0.0399
Schistosoma mansoni hypothetical protein 0.0108 0.0493 0.1425
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0095 0.0424 0.2727
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0034 0.022
Echinococcus multilocularis copper transporting ATPase 1 0.0032 0.0097 0.0281
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0341 0.0508
Brugia malayi MH2 domain containing protein 0.0016 0.0016 0.014
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0069 0.025
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0032 0.0097 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.1012
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.1152 0.7405
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.001 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0184 0.0275
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0032 0.0097 0.1379
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.004 0.0141 0.0211
Echinococcus granulosus phospholipid transporting ATPase VA 0.002 0.0037 0.0107
Loa Loa (eye worm) hypothetical protein 0.0082 0.0358 0.2305
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0032 0.0097 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Echinococcus granulosus Ankyrin 0.0014 0.0008 0.0022
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0111 0.0322
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.001 0.0016
Leishmania major DNA polymerase eta, putative 0.0141 0.0665 0.9423
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.022
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0111 0.2206
Treponema pallidum hypothetical protein 0.002 0.0037 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0145 0.1261
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0147 0.0694 0.2505
Loa Loa (eye worm) hypothetical protein 0.0147 0.0694 0.4464
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0184 0.0275
Trichomonas vaginalis pc-MYB2, putative 0.0085 0.0374 0.3255
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0018 0.0028 0.0245
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0319 0.1585 0.2214
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0053 0.0053
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1944 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0111 0.0951
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0037 0.0107
Onchocerca volvulus 0.0056 0.0224 0.1954
Echinococcus granulosus cathepsin L 0.0018 0.0028 0.0081
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0118 0.103
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0111 0.0971
Loa Loa (eye worm) hypothetical protein 0.0054 0.0213 0.1367
Echinococcus granulosus cathepsin l1 0.0034 0.0111 0.0321
Brugia malayi Cytochrome P450 family protein 0.0016 0.0014 0.0123
Schistosoma mansoni cathepsin S (C01 family) 0.0018 0.0028 0.0081
Brugia malayi hypothetical protein 0.0019 0.0034 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0111 0.0971
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.001 0.0148
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.011 0.0505 0.0754
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0402 0.3501
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0127 0.1105
Schistosoma mansoni DNA helicase recq1 0.0019 0.0032 0.0092
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0181
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0194 0.2748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0028 0.0245
Onchocerca volvulus 0.0048 0.018 0.1567
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0111 0.0402
Trichomonas vaginalis MYB72, putative 0.0085 0.0374 0.3255
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0085 0.0376 0.1355
Loa Loa (eye worm) hypothetical protein 0.009 0.0402 0.2583
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0044
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0048 0.0184 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0539 0.7645
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0715
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0194 0.07
Chlamydia trachomatis metal transport ATPase 0.0032 0.0097 0.0097
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0034 0.0099
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0089 0.0258
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0074 0.0636
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0016 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0111 0.0971
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.1152 0.7405
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0018 0.0028 0.0241
Echinococcus multilocularis expressed conserved protein 0.0091 0.0406 0.1173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0539 0.0805
Plasmodium vivax vivapain-1 0.004 0.0141 0.2036
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0194 0.056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0145 0.1261
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0018 0.0028 0.0558
Schistosoma mansoni chromobox protein 0.0152 0.0723 0.209
Entamoeba histolytica cysteine protease, putative 0.004 0.0141 0.2799
Echinococcus multilocularis Ankyrin 0.0014 0.0008 0.0022
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0007 0.002
Brugia malayi SET domain containing protein 0.0036 0.012 0.1029
Toxoplasma gondii cation-transporting atpase family protein 0.002 0.0037 0.0134
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0283 0.0816
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0185 0.1193
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0149 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0215 0.305
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0028 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0539 0.0805
Trypanosoma cruzi P-type H+-ATPase, putative 0.0064 0.0264 0.0394
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0034 0.0111 0.0322
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0097 0.0437 0.6196
Trypanosoma cruzi cysteine peptidase, putative 0.1307 0.67 1
Onchocerca volvulus 0.0019 0.0034 0.0298
Echinococcus granulosus cation transporting atpase worm 0.0032 0.0097 0.0281
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0106 0.0905
Schistosoma mansoni intermediate filament proteins 0.0027 0.0071 0.0206
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0032 0.0092
Echinococcus granulosus expressed conserved protein 0.0091 0.0406 0.1173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.001 0.0091
Leishmania major calcium-translocating P-type ATPase 0.0147 0.0694 0.9842
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0358 0.1036
Echinococcus multilocularis cathepsin L cysteine protease 0.0056 0.0224 0.0648
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0194 0.2748
Brugia malayi Protein kinase domain containing protein 0.0015 0.0009 0.0079
Echinococcus multilocularis chromobox protein 2 0.0034 0.0111 0.0322
Trichomonas vaginalis C-MYB, putative 0.0085 0.0374 0.3255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0224 0.1955
Trypanosoma cruzi P-type H+-ATPase, putative 0.0064 0.0264 0.0394
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0283 0.2462
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0355 0.177 0.2471
Plasmodium vivax unspecified product 0.0018 0.0028 0.0406
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0493 0.1425
Brugia malayi hypothetical protein 0.0233 0.1142 0.9773
Giardia lamblia NADH oxidase lateral transfer candidate 0.0048 0.0184 0.365
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.008 0.0232
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0089 0.0322
Entamoeba histolytica deoxycytidyl transferase, putative 0.0091 0.0403 0.7986
Plasmodium falciparum thioredoxin reductase 0.0048 0.0184 0.2655
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0118 0.1007
Giardia lamblia Cathepsin B precursor 0.0018 0.0028 0.0558
Entamoeba histolytica hypothetical protein 0.0023 0.0053 0.1048
Trichomonas vaginalis chromobox protein, putative 0.0152 0.0723 0.6302
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0069 0.0997
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.001 0.0148
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0034 0.0492
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0194 0.0289
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0007 0.0062
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.011 0.0505 0.716
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.025 0.0723
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0194 0.2748
Brugia malayi TAR-binding protein 0.0062 0.0254 0.2171
Schistosoma mansoni cathepsin F (C01 family) 0.0056 0.0224 0.0648
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0194 0.0289
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0028 0.0081
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0116 0.0174
Brugia malayi cathepsin F-like cysteine proteinase 0.0022 0.0047 0.0399
Onchocerca volvulus Heterochromatin protein 1 homolog 0.009 0.0402 0.3499
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.01 0.0453 0.896
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0019
Giardia lamblia Copper-transporting P-type ATPase 0.0032 0.0097 0.1925
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0018 0.0028 0.0558
Schistosoma mansoni type V p-type atpase isoform 0.0032 0.0097 0.0281
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.002 0.0037 0.0134
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0716
Trichomonas vaginalis chromobox protein, putative 0.0096 0.0433 0.3772
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0048 0.0184 0.2655
Loa Loa (eye worm) hypothetical protein 0.003 0.0089 0.0574
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0014
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0054 0.0213 0.4209
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0111 0.0971
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0048 0.0184 0.2613
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0074 0.0636
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0111 0.1605
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0224 0.1955
Loa Loa (eye worm) cathepsin B 0.0018 0.0028 0.0181
Onchocerca volvulus 0.0064 0.0267 0.2327
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.008 0.0349 0.6908
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0032 0.0097 0.0145
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0457 0.1649
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0048 0.0184 0.0184
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0028 0.0081
Brugia malayi CHD4 protein 0.0036 0.012 0.1025
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0002 0.0031
Echinococcus multilocularis RUN 0.0019 0.0034 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0111 0.0971
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0111 0.2201
Trypanosoma brucei protein kinase, putative 0.005 0.0194 0.2748
Onchocerca volvulus Cathepsin L homolog 0.0056 0.0224 0.1954
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0111 0.0971
Trypanosoma brucei glucosidase, putative 0.0036 0.0118 0.1676
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0028 0.0081
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.011 0.0505 0.716
Giardia lamblia GTOR 0.0044 0.0163 0.323
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0141 0.1209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0111 0.0969
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0014 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0018 0.0028 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0224 0.1955
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0037 0.0107
Trypanosoma brucei calcium-translocating P-type ATPase 0.0127 0.0591 0.8373
Brugia malayi Cathepsin L-like precursor 0.0056 0.0224 0.192
Loa Loa (eye worm) CHromoDomain protein family member 0.0036 0.012 0.077
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0016 0.0105
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0048 0.0184 0.0184
Echinococcus multilocularis phospholipid transporting ATPase VA 0.002 0.0037 0.0107
Trypanosoma brucei P-type H+-ATPase, putative 0.0064 0.0264 0.3739
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0089 0.0393 0.1135
Schistosoma mansoni ATPase 0.0147 0.0694 0.2006
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0085 0.0374 0.3255
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0254 0.0733
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0034 0.0111 0.0953
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0653 0.1886
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0018 0.0028 0.0042
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0047 0.0175 0.0244
Entamoeba histolytica cysteine protease, putative 0.0018 0.0028 0.0558
Giardia lamblia Cathepsin B precursor 0.0018 0.0028 0.0558
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0147 0.0694 0.2006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0186 0.1197
Onchocerca volvulus 0.0123 0.0571 0.4972
Onchocerca volvulus 0.0082 0.0358 0.3122
Plasmodium falciparum cysteine proteinase falcipain 3 0.0056 0.0224 0.3231
Echinococcus granulosus GPCR family 2 0.0015 0.0013 0.0038
Giardia lamblia DINP protein human, muc B family 0.0097 0.0437 0.8654
Trichomonas vaginalis cation-transporting ATPase, putative 0.0032 0.0097 0.0847
Onchocerca volvulus 0.0123 0.0571 0.4972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0163 0.1422
Entamoeba histolytica hypothetical protein 0.0034 0.0111 0.2206
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.011 0.0505 0.1459
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0319 0.1585 0.2214
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0018 0.0028 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0071 0.0616
Trypanosoma cruzi DNA polymerase eta, putative 0.0141 0.0665 0.0992
Loa Loa (eye worm) hypothetical protein 0.0121 0.056 0.3599
Giardia lamblia Cysteine protease 0.0018 0.0028 0.0558
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0358 0.3067
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0032 0.0097 0.0136
Echinococcus granulosus calcium transporting atpase 0.0127 0.0591 0.1706
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0184 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0057 0.0501
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.001 0.0148
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0091 0.0403 0.1165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0007 0.0059
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0437 0.1262
Loa Loa (eye worm) hypothetical protein 0.0032 0.0097 0.0625
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0018 0.0028 0.0245
Schistosoma mansoni DNA helicase recq5 0.0019 0.0032 0.0092
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.01 0.0453 0.1308
Echinococcus granulosus RUN 0.0019 0.0034 0.0099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0145 0.1261
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Brugia malayi calcium ATPase 0.0044 0.016 0.137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0057 0.0501
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0032 0.0097 0.1925
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0056 0.0224 0.1955
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0172 0.1497
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0539 0.7645
Leishmania major cathepsin L-like protease 0.0056 0.0224 0.318
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0539 0.7645
Echinococcus granulosus geminin 0.0677 0.3442 0.9944
Onchocerca volvulus 0.0027 0.0074 0.0647
Onchocerca volvulus Huntingtin homolog 0.0121 0.056 0.4875
Echinococcus granulosus bloom syndrome protein 0.0046 0.0172 0.0496
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0074 0.0478
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0069 0.0997
Echinococcus granulosus tumor protein p63 0.0333 0.1661 0.4798
Onchocerca volvulus 0.0056 0.0224 0.1954
Brugia malayi Heterochromatin protein 1 0.0152 0.0723 0.6188
Brugia malayi MH2 domain containing protein 0.0016 0.0016 0.014
Trichomonas vaginalis cation-transporting ATPase, putative 0.0064 0.0264 0.2299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0056 0.0224 0.1955
Trichomonas vaginalis chromobox protein, putative 0.0152 0.0723 0.6302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0057 0.0501
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0163 0.2312
Trypanosoma brucei unspecified product 0.0063 0.0257 0.365
Schistosoma mansoni DNA polymerase eta 0.0141 0.0665 0.192
Trypanosoma brucei P-type H+-ATPase, putative 0.0064 0.0264 0.3739
Entamoeba histolytica hypothetical protein 0.0108 0.0493 0.9762
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0018 0.0028 0.0081
Onchocerca volvulus Peroxidase homolog 0.0027 0.0074 0.0647
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.011 0.0505 0.4401
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0067 0.0278 0.5511
Loa Loa (eye worm) hypothetical protein 0.0233 0.1142 0.7345
Schistosoma mansoni cpg binding protein 0.003 0.0089 0.0256
Mycobacterium tuberculosis Probable dehydrogenase 0.0319 0.1585 0.2214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0149 0.0705 1
Plasmodium vivax vivapain-2 0.0056 0.0224 0.3231
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0044 0.016 0.0239
Giardia lamblia Myb 1-like protein 0.0085 0.0376 0.7435
Brugia malayi cathepsin Z-like cysteine proteinase 0.0018 0.0028 0.0241
Brugia malayi hypothetical protein 0.0108 0.0493 0.4219
Trichomonas vaginalis MYB3r3, putative 0.0085 0.0374 0.3255
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0653 0.1886
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0715
Onchocerca volvulus 0.0028 0.008 0.0699
Brugia malayi Cathepsin L-like precursor 0.0056 0.0224 0.192
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0141 0.2799
Brugia malayi MH2 domain containing protein 0.0235 0.1152 0.9854
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0358 0.1036
Loa Loa (eye worm) cysteine protease 0.0056 0.0224 0.1443
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0048 0.0184 0.0184
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.008 0.0516
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0111 0.1605
Brugia malayi hypothetical protein 0.012 0.0556 0.4754
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0437 0.8646
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.0224 0.1443
Schistosoma mansoni hypothetical protein 0.004 0.0142 0.0409
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0048 0.0184 0.0533
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0145 0.1261
Echinococcus granulosus chromobox protein 1 0.0152 0.0723 0.209
Brugia malayi MH1 domain containing protein 0.0016 0.0016 0.014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.068
Echinococcus granulosus neuropeptide s receptor 0.0466 0.2345 0.6774
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Brugia malayi CXXC zinc finger family protein 0.0028 0.008 0.0686
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0117 0.0539 0.47
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0163 0.0243
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0118 0.1011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0145 0.1261
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0145 0.1261
Treponema pallidum NADH oxidase 0.0048 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0478
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0185 0.1587
Echinococcus multilocularis geminin 0.0677 0.3442 0.9944
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0038
Toxoplasma gondii cathepsin CPC2 0.0018 0.0028 0.0102
Brugia malayi cathepsin Z-like cysteine proteinase 0.0018 0.0028 0.0241
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.008 0.0349 0.0521
Echinococcus granulosus smad 0.0016 0.0016 0.0047
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0029 0.0408

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 236 nM Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand ChEMBL. 12729661
Ki (binding) = 236 nM Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand ChEMBL. 12729661
Ki (functional) = 236 nM Antagonist activity at human histamine H3 receptor ChEMBL. 21937153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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